WO2004009769A3 - COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS - Google Patents

COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS Download PDF

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Publication number
WO2004009769A3
WO2004009769A3 PCT/US2003/022444 US0322444W WO2004009769A3 WO 2004009769 A3 WO2004009769 A3 WO 2004009769A3 US 0322444 W US0322444 W US 0322444W WO 2004009769 A3 WO2004009769 A3 WO 2004009769A3
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WO
WIPO (PCT)
Prior art keywords
vegf
angiogenesis
compositions
methods
small interfering
Prior art date
Application number
PCT/US2003/022444
Other languages
French (fr)
Other versions
WO2004009769A2 (en
Inventor
Michael J Tolentino
Samuel Jotham Reich
Original Assignee
Univ Pennsylvania
Michael J Tolentino
Samuel Jotham Reich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2493499A priority Critical patent/CA2493499C/en
Priority to MXPA05001000A priority patent/MXPA05001000A/en
Application filed by Univ Pennsylvania, Michael J Tolentino, Samuel Jotham Reich filed Critical Univ Pennsylvania
Priority to IL16627403A priority patent/IL166274A0/en
Priority to NZ537833A priority patent/NZ537833A/en
Priority to DK03765708T priority patent/DK1578933T3/en
Priority to KR20057001330A priority patent/KR101280269B1/en
Priority to AU2003253995A priority patent/AU2003253995B2/en
Priority to AT03765708T priority patent/ATE460500T1/en
Priority to EP20030765708 priority patent/EP1578933B9/en
Priority to JP2004523550A priority patent/JP5337337B2/en
Priority to DE60331683T priority patent/DE60331683D1/en
Publication of WO2004009769A2 publication Critical patent/WO2004009769A2/en
Priority to IL166274A priority patent/IL166274A/en
Publication of WO2004009769A3 publication Critical patent/WO2004009769A3/en
Priority to IL196798A priority patent/IL196798A/en
Priority to CY20101100495T priority patent/CY1110141T1/en

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Abstract

RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt­1 and Flk-l/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
PCT/US2003/022444 2002-07-24 2003-07-18 COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS WO2004009769A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
EP20030765708 EP1578933B9 (en) 2002-07-24 2003-07-18 Compositions and methods for si-rna inhibition of angiogenesis
AT03765708T ATE460500T1 (en) 2002-07-24 2003-07-18 COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ANGIOGENesis
IL16627403A IL166274A0 (en) 2002-07-24 2003-07-18 Compositions and methods for sirna inhibition of angiogenesis
MXPA05001000A MXPA05001000A (en) 2002-07-24 2003-07-18 COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS.
DK03765708T DK1578933T3 (en) 2002-07-24 2003-07-18 Compositions and Methods for SI-RNA Inhibition of Angiogenesis
KR20057001330A KR101280269B1 (en) 2002-07-24 2003-07-18 Compositions and Methods for siRNA Inhibition of Angiogenesis
JP2004523550A JP5337337B2 (en) 2002-07-24 2003-07-18 Compositions and methods for siRNA inhibition of angiogenesis
CA2493499A CA2493499C (en) 2002-07-24 2003-07-18 Compositions and methods for sirna inhibition of angiogenesis
NZ537833A NZ537833A (en) 2002-07-24 2003-07-18 Compositions and methods for VEGF siRNA inhibition of angiogenesis
AU2003253995A AU2003253995B2 (en) 2002-07-24 2003-07-18 Compositions and methods for siRNA inhibition of angiogenesis
DE60331683T DE60331683D1 (en) 2002-07-24 2003-07-18 COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS
IL166274A IL166274A (en) 2002-07-24 2005-01-13 COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS
IL196798A IL196798A (en) 2002-07-24 2009-01-29 siRNA COMPOSITIONS FOR INHIBITION OF ANGIOGENESIS
CY20101100495T CY1110141T1 (en) 2002-07-24 2010-06-04 COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39841702P 2002-07-24 2002-07-24
US60/398,417 2002-07-24
US10/294,228 2002-11-14
US10/294,228 US7148342B2 (en) 2002-07-24 2002-11-14 Compositions and methods for sirna inhibition of angiogenesis

Publications (2)

Publication Number Publication Date
WO2004009769A2 WO2004009769A2 (en) 2004-01-29
WO2004009769A3 true WO2004009769A3 (en) 2006-04-13

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Application Number Title Priority Date Filing Date
PCT/US2003/022444 WO2004009769A2 (en) 2002-07-24 2003-07-18 COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS

Country Status (16)

Country Link
US (13) US7148342B2 (en)
EP (3) EP2345718A3 (en)
JP (1) JP5337337B2 (en)
KR (2) KR20110063597A (en)
AT (1) ATE460500T1 (en)
AU (1) AU2003253995B2 (en)
CA (1) CA2493499C (en)
CY (1) CY1110141T1 (en)
DE (1) DE60331683D1 (en)
DK (1) DK1578933T3 (en)
ES (1) ES2340843T3 (en)
IL (3) IL166274A0 (en)
MX (1) MXPA05001000A (en)
NZ (1) NZ537833A (en)
PT (1) PT1578933E (en)
WO (1) WO2004009769A2 (en)

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