WO2004011054A3 - Injectable multimodal polymer depot compositions and uses thereof - Google Patents

Injectable multimodal polymer depot compositions and uses thereof Download PDF

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Publication number
WO2004011054A3
WO2004011054A3 PCT/US2003/023439 US0323439W WO2004011054A3 WO 2004011054 A3 WO2004011054 A3 WO 2004011054A3 US 0323439 W US0323439 W US 0323439W WO 2004011054 A3 WO2004011054 A3 WO 2004011054A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
polymer
polymers
polymer matrix
injectable
Prior art date
Application number
PCT/US2003/023439
Other languages
French (fr)
Other versions
WO2004011054A2 (en
Inventor
Guohua Chen
Paul Houston
Lothar Kleiner
Jeremy Wright
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2004524891A priority Critical patent/JP4639400B2/en
Priority to MXPA05001244A priority patent/MXPA05001244A/en
Priority to BR0313539-0A priority patent/BR0313539A/en
Priority to NZ537953A priority patent/NZ537953A/en
Priority to DE60325742T priority patent/DE60325742D1/en
Priority to CA002494400A priority patent/CA2494400A1/en
Priority to EP03771916A priority patent/EP1539101B1/en
Priority to DK03771916T priority patent/DK1539101T3/en
Application filed by Alza Corp filed Critical Alza Corp
Priority to AU2003256849A priority patent/AU2003256849A1/en
Publication of WO2004011054A2 publication Critical patent/WO2004011054A2/en
Publication of WO2004011054A3 publication Critical patent/WO2004011054A3/en
Priority to IL16646305A priority patent/IL166463A0/en
Priority to NO20051025A priority patent/NO20051025L/en
Priority to HK05111570.0A priority patent/HK1079443A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Injectable depot compositions are provided that include a polymer matrix having a plurality of bioerodible, biocompatible polymers wherein each polymer of the plurality of polymers has a specified weight average molecular weight; and the polymer matrix has a broad molecular weight distribution of the plurality of polymers; a solvent having a miscibility in water of less than or equal to 7 wt.% at 25°C, in an amount effective to plasticize the polymer and form a gel therewith; and a beneficial agent. The compositions are have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection. The most preferred polymer matrix is made of poly (lactide-co-glycolide) copolymers, commonly referred to as PLGA. The most preferred solvents are derivatives of benzoic acid, such as benzylbenzoate.
PCT/US2003/023439 2002-07-31 2003-07-28 Injectable multimodal polymer depot compositions and uses thereof WO2004011054A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
EP03771916A EP1539101B1 (en) 2002-07-31 2003-07-28 Injectable multimodal polymer depot compositions and uses thereof
BR0313539-0A BR0313539A (en) 2002-07-31 2003-07-28 Injectable multimodal polymer deposit compositions and their uses
NZ537953A NZ537953A (en) 2002-07-31 2003-07-28 Injectable multimodal polymer depot compositions and uses thereof
DE60325742T DE60325742D1 (en) 2002-07-31 2003-07-28 INJECTABLE MULTIMODAL POLYMERS DEPOT COMPOSITIONS AND THEIR USES
CA002494400A CA2494400A1 (en) 2002-07-31 2003-07-28 Injectable multimodal polymer depot compositions and uses thereof
JP2004524891A JP4639400B2 (en) 2002-07-31 2003-07-28 Injectable multimodal polymer depot composition and use thereof
DK03771916T DK1539101T3 (en) 2002-07-31 2003-07-28 Injectable, multi-modal polymeric compositions and applications thereof
MXPA05001244A MXPA05001244A (en) 2002-07-31 2003-07-28 Injectable multimodal polymer depot compositions and uses thereof.
AU2003256849A AU2003256849A1 (en) 2002-07-31 2003-07-28 Injectable multimodal polymer depot compositions and uses thereof
IL16646305A IL166463A0 (en) 2002-07-31 2005-01-24 Injectable multimodal polymer depot compositions and uses thereof
NO20051025A NO20051025L (en) 2002-07-31 2005-02-25 Injectable multimodal polymer depot preparations and applications thereof
HK05111570.0A HK1079443A1 (en) 2002-07-31 2005-12-15 Injectable multimodal polymer depot compositions and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39983202P 2002-07-31 2002-07-31
US60/399,832 2002-07-31

Publications (2)

Publication Number Publication Date
WO2004011054A2 WO2004011054A2 (en) 2004-02-05
WO2004011054A3 true WO2004011054A3 (en) 2004-04-01

Family

ID=31188625

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/023439 WO2004011054A2 (en) 2002-07-31 2003-07-28 Injectable multimodal polymer depot compositions and uses thereof

Country Status (20)

Country Link
US (2) US8501215B2 (en)
EP (2) EP1539101B1 (en)
JP (1) JP4639400B2 (en)
KR (1) KR20050083605A (en)
CN (2) CN1684663A (en)
AR (1) AR040753A1 (en)
AT (1) ATE419831T1 (en)
AU (2) AU2003256849A1 (en)
BR (1) BR0313539A (en)
CA (1) CA2494400A1 (en)
DE (1) DE60325742D1 (en)
DK (1) DK1539101T3 (en)
ES (1) ES2321505T3 (en)
HK (1) HK1079443A1 (en)
IL (1) IL166463A0 (en)
MX (1) MXPA05001244A (en)
NO (1) NO20051025L (en)
NZ (1) NZ537953A (en)
WO (1) WO2004011054A2 (en)
ZA (1) ZA200501645B (en)

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US9120919B2 (en) 2003-12-23 2015-09-01 Smith & Nephew, Inc. Tunable segmented polyacetal
US9737606B2 (en) 2004-10-01 2017-08-22 Ramscor, Inc. Sustained release eye drop formulations

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