WO2004011904A3 - Quality assurance for high-throughput bioassay methods - Google Patents

Quality assurance for high-throughput bioassay methods Download PDF

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Publication number
WO2004011904A3
WO2004011904A3 PCT/US2003/023506 US0323506W WO2004011904A3 WO 2004011904 A3 WO2004011904 A3 WO 2004011904A3 US 0323506 W US0323506 W US 0323506W WO 2004011904 A3 WO2004011904 A3 WO 2004011904A3
Authority
WO
WIPO (PCT)
Prior art keywords
model
centroid
bioassay
comparing
quality assurance
Prior art date
Application number
PCT/US2003/023506
Other languages
French (fr)
Other versions
WO2004011904A2 (en
Inventor
Ben Hitt
Peter J Levine
Timothy A Coleman
Original Assignee
Correlogic Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Correlogic Systems Inc filed Critical Correlogic Systems Inc
Priority to AU2003261273A priority Critical patent/AU2003261273A1/en
Publication of WO2004011904A2 publication Critical patent/WO2004011904A2/en
Publication of WO2004011904A3 publication Critical patent/WO2004011904A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

The invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method permits monitoring of an entire system for obtaining spectral data from biological samples. Generally, the method includes generating a bioassay process model, comparing a test sample against the bioassay process model. The bioassay process model may be based on the position of a centroid in n-dimensional space. The comparing may include comparing the location of a centroid associated with the test model against the centroid associated with the control model to determine the distance between the two centroids. By generating a trend plot of the distance between the centroid associated with the test sample and the centroid associated with the control model, overall system performance may be monitored over time.
PCT/US2003/023506 2002-07-29 2003-07-28 Quality assurance for high-throughput bioassay methods WO2004011904A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003261273A AU2003261273A1 (en) 2002-07-29 2003-07-28 Quality assurance for high-throughput bioassay methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60/389,831 2002-06-19
US39883102P 2002-07-29 2002-07-29

Publications (2)

Publication Number Publication Date
WO2004011904A2 WO2004011904A2 (en) 2004-02-05
WO2004011904A3 true WO2004011904A3 (en) 2004-07-08

Family

ID=32312442

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2003/023505 WO2004106887A2 (en) 2002-07-29 2003-07-28 Quality assurance/quality control for high throughput bioassay process
PCT/US2003/023506 WO2004011904A2 (en) 2002-07-29 2003-07-28 Quality assurance for high-throughput bioassay methods
PCT/US2003/023507 WO2004011905A2 (en) 2002-07-29 2003-07-28 Quality assurance/quality control for electrospray ionization processes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2003/023505 WO2004106887A2 (en) 2002-07-29 2003-07-28 Quality assurance/quality control for high throughput bioassay process

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2003/023507 WO2004011905A2 (en) 2002-07-29 2003-07-28 Quality assurance/quality control for electrospray ionization processes

Country Status (5)

Country Link
US (5) US7395160B2 (en)
AR (3) AR040713A1 (en)
AU (3) AU2003268031A1 (en)
TW (3) TW200407540A (en)
WO (3) WO2004106887A2 (en)

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Also Published As

Publication number Publication date
US7333895B2 (en) 2008-02-19
WO2004011905A8 (en) 2004-05-21
US20040053333A1 (en) 2004-03-18
TW200407540A (en) 2004-05-16
US20080103063A1 (en) 2008-05-01
US20080195323A1 (en) 2008-08-14
US7333896B2 (en) 2008-02-19
WO2004011904A2 (en) 2004-02-05
WO2004011905A2 (en) 2004-02-05
WO2004106887A2 (en) 2004-12-09
WO2004011905A3 (en) 2004-07-15
AU2003268031A1 (en) 2004-02-16
WO2004106887A3 (en) 2005-05-12
US20040058372A1 (en) 2004-03-25
AU2003304161A8 (en) 2005-01-21
US20040058388A1 (en) 2004-03-25
TW200407543A (en) 2004-05-16
AU2003268031A8 (en) 2004-02-16
AR040713A1 (en) 2005-04-20
TW200403434A (en) 2004-03-01
AU2003261273A1 (en) 2004-02-16
AR040711A1 (en) 2005-04-13
AU2003261273A8 (en) 2004-02-16
AR040712A1 (en) 2005-04-20
AU2003304161A1 (en) 2005-01-21
US7395160B2 (en) 2008-07-01

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