WO2004013347A3 - Methods of identifying compounds that modulate protein activity - Google Patents

Methods of identifying compounds that modulate protein activity Download PDF

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Publication number
WO2004013347A3
WO2004013347A3 PCT/US2003/024504 US0324504W WO2004013347A3 WO 2004013347 A3 WO2004013347 A3 WO 2004013347A3 US 0324504 W US0324504 W US 0324504W WO 2004013347 A3 WO2004013347 A3 WO 2004013347A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
target polypeptide
identifying compounds
protein activity
modulate protein
Prior art date
Application number
PCT/US2003/024504
Other languages
French (fr)
Other versions
WO2004013347A2 (en
WO2004013347A8 (en
Inventor
Constance Berghs
Karen Ellerman
Xiaojia Guo
Li Li
Tatiana Ort
Daniel K Rieger
Corine A M Vernet
Mei Zhong
Original Assignee
Curagen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/307,817 external-priority patent/US20040058338A1/en
Application filed by Curagen Corp filed Critical Curagen Corp
Priority to EP03767213A priority Critical patent/EP1537239A4/en
Priority to AU2003263992A priority patent/AU2003263992A1/en
Priority to CA002495123A priority patent/CA2495123A1/en
Priority to JP2005506099A priority patent/JP2006511237A/en
Publication of WO2004013347A2 publication Critical patent/WO2004013347A2/en
Publication of WO2004013347A3 publication Critical patent/WO2004013347A3/en
Publication of WO2004013347A8 publication Critical patent/WO2004013347A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes

Abstract

Methods of identifying compounds that modulate target polypeptide activity, where a test compound is combined with a target polypeptide and a substrate of the target polypeptide and where a determination is made as to whether the test compound modulates activity of the target polypeptide. The test compounds could be small molecule drugs used for treatment of obestiy, diabetes, insulin resistance, and for enhancement of insulin secretion. Target polypeptides and their corresponding nucleic acids as well as their variants are also disclosed.
PCT/US2003/024504 2002-08-06 2003-08-06 Methods of identifying compounds that modulate protein activity WO2004013347A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03767213A EP1537239A4 (en) 2002-08-06 2003-08-06 Methods of identifying compounds that modulate protein activity
AU2003263992A AU2003263992A1 (en) 2002-08-06 2003-08-06 Method of identifying compounds that modulate protein activity
CA002495123A CA2495123A1 (en) 2002-08-06 2003-08-06 Methods of identifying compounds that modulate protein activity
JP2005506099A JP2006511237A (en) 2002-08-06 2003-08-06 Methods for identifying compounds that modulate protein activity

Applications Claiming Priority (40)

Application Number Priority Date Filing Date Title
US40131602P 2002-08-06 2002-08-06
US40131502P 2002-08-06 2002-08-06
US40162702P 2002-08-06 2002-08-06
US60/401,316 2002-08-06
US60/401,627 2002-08-06
US60/401,315 2002-08-06
US40178802P 2002-08-07 2002-08-07
US60/401,788 2002-08-07
US40362002P 2002-08-15 2002-08-15
US60/403,620 2002-08-15
US40467402P 2002-08-20 2002-08-20
US40464902P 2002-08-20 2002-08-20
US40467602P 2002-08-20 2002-08-20
US60/404,649 2002-08-20
US60/404,674 2002-08-20
US60/404,676 2002-08-20
US40512102P 2002-08-22 2002-08-22
US40523202P 2002-08-22 2002-08-22
US60/405,232 2002-08-22
US60/405,121 2002-08-22
US40540002P 2002-08-23 2002-08-23
US40569802P 2002-08-23 2002-08-23
US60/405,687 2002-08-23
US60/405,698 2002-08-23
US60/405,400 2002-08-23
US60/405,684 2002-08-23
US40635302P 2002-08-26 2002-08-26
US60/406,353 2002-08-26
US40613002P 2002-08-27 2002-08-27
US40613102P 2002-08-27 2002-08-27
US60/406,130 2002-08-27
US60/406,131 2002-08-27
US40791902P 2002-09-03 2002-09-03
US60/407,919 2002-09-03
US40936602P 2002-09-09 2002-09-09
US60/409,366 2002-09-09
US42275602P 2002-10-31 2002-10-31
US60/422,756 2002-10-31
US10/307,817 US20040058338A1 (en) 2001-12-03 2002-12-02 Novel proteins and nucleic acids encoding same
US10/307,817 2002-12-02

Publications (3)

Publication Number Publication Date
WO2004013347A2 WO2004013347A2 (en) 2004-02-12
WO2004013347A3 true WO2004013347A3 (en) 2005-04-14
WO2004013347A8 WO2004013347A8 (en) 2005-06-02

Family

ID=35613909

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/024504 WO2004013347A2 (en) 2002-08-06 2003-08-06 Methods of identifying compounds that modulate protein activity

Country Status (1)

Country Link
WO (1) WO2004013347A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2532150A1 (en) * 2003-07-11 2005-01-20 Banyu Pharmaceutical Co., Ltd. Method of evaluating compound efficacious in treating obesity
US20070292888A1 (en) * 2004-03-24 2007-12-20 Gen-Path Pharmaceuticals, Inc. Methods for Measuring Enzyme Activities in Cells, Blood, Tumors and Tissues
EP1917042B1 (en) 2005-08-24 2014-10-08 Cedars-Sinai Medical Center Use of fructose-based compounds for the diagnosis of cancer
WO2009044788A1 (en) * 2007-10-05 2009-04-09 Banyu Pharmaceutical Co., Ltd. Benzoxazinone derivative

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002068579A2 (en) * 2001-01-10 2002-09-06 Pe Corporation (Ny) Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof
US6727066B2 (en) * 2000-07-28 2004-04-27 Incyte Corporation Genes expressed in treated human C3A liver cell cultures

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6727066B2 (en) * 2000-07-28 2004-04-27 Incyte Corporation Genes expressed in treated human C3A liver cell cultures
WO2002068579A2 (en) * 2001-01-10 2002-09-06 Pe Corporation (Ny) Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1537239A4 *

Also Published As

Publication number Publication date
WO2004013347A2 (en) 2004-02-12
WO2004013347A8 (en) 2005-06-02

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