WO2004018058A3 - Compounds, compositions, and methods - Google Patents

Compounds, compositions, and methods Download PDF

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Publication number
WO2004018058A3
WO2004018058A3 PCT/US2003/026093 US0326093W WO2004018058A3 WO 2004018058 A3 WO2004018058 A3 WO 2004018058A3 US 0326093 W US0326093 W US 0326093W WO 2004018058 A3 WO2004018058 A3 WO 2004018058A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
compounds
methods
ksp
modulating
Prior art date
Application number
PCT/US2003/026093
Other languages
French (fr)
Other versions
WO2004018058A2 (en
Inventor
Gustave Bergnes
Original Assignee
Cytokinetics Inc
Gustave Bergnes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokinetics Inc, Gustave Bergnes filed Critical Cytokinetics Inc
Priority to JP2004531141A priority Critical patent/JP2005536553A/en
Priority to EP03793179A priority patent/EP1539180A4/en
Priority to AU2003262747A priority patent/AU2003262747A1/en
Publication of WO2004018058A2 publication Critical patent/WO2004018058A2/en
Publication of WO2004018058A3 publication Critical patent/WO2004018058A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

Compounds, compositions and methods useful for treating cellular proliferative diseases and disorders, for example, by modulating the activity of KSP, are disclosed.
PCT/US2003/026093 2002-08-21 2003-08-20 Compounds, compositions, and methods WO2004018058A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2004531141A JP2005536553A (en) 2002-08-21 2003-08-20 Compounds, compositions and methods
EP03793179A EP1539180A4 (en) 2002-08-21 2003-08-20 Compounds, compositions, and methods
AU2003262747A AU2003262747A1 (en) 2002-08-21 2003-08-20 Compounds, compositions, and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40486402P 2002-08-21 2002-08-21
US60/404,864 2002-08-21

Publications (2)

Publication Number Publication Date
WO2004018058A2 WO2004018058A2 (en) 2004-03-04
WO2004018058A3 true WO2004018058A3 (en) 2004-07-01

Family

ID=31946773

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/026093 WO2004018058A2 (en) 2002-08-21 2003-08-20 Compounds, compositions, and methods

Country Status (5)

Country Link
US (2) US20040048853A1 (en)
EP (1) EP1539180A4 (en)
JP (1) JP2005536553A (en)
AU (1) AU2003262747A1 (en)
WO (1) WO2004018058A2 (en)

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US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
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