WO2004025247A3 - Sample block apparatus and method for maintaining a microcard on a sample block - Google Patents

Sample block apparatus and method for maintaining a microcard on a sample block Download PDF

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Publication number
WO2004025247A3
WO2004025247A3 PCT/US2003/023750 US0323750W WO2004025247A3 WO 2004025247 A3 WO2004025247 A3 WO 2004025247A3 US 0323750 W US0323750 W US 0323750W WO 2004025247 A3 WO2004025247 A3 WO 2004025247A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample block
microcard
maintaining
channels
thermal cycling
Prior art date
Application number
PCT/US2003/023750
Other languages
French (fr)
Other versions
WO2004025247A2 (en
Inventor
Adrian Fawcett
Original Assignee
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31186680&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2004025247(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Applera Corp filed Critical Applera Corp
Priority to AT03795576T priority Critical patent/ATE483790T1/en
Priority to AU2003296707A priority patent/AU2003296707A1/en
Priority to EP03795576A priority patent/EP1539920B1/en
Priority to JP2004535990A priority patent/JP2005534342A/en
Priority to CA002493278A priority patent/CA2493278A1/en
Priority to DE60334465T priority patent/DE60334465D1/en
Publication of WO2004025247A2 publication Critical patent/WO2004025247A2/en
Publication of WO2004025247A3 publication Critical patent/WO2004025247A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/523—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/809—Incubators or racks or holders for culture plates or containers

Abstract

A thermal cycling device (10) for thermally cycling samples of biological material contained in a microcard (12) having a top and bottom surface. The thermal cycling device (10) can include a sample block (34) having an upper surface configured for engaging the bottom surface of a microcard (12), a vacuum device, and a temperature control system (44) operatively connected with the sample block (34). The upper surface of the sample block (34) may include a plurality of channels (54, 56), the channels defining spaces between the sample block and the bottom surface of a microcard that may be positioned thereon. The vacuum device may be in fluid communication with the sample block for drawing gas out of the spaces defined by the channels in the sample block. The vacuum device may be configured for substantially maintaining a vacuum between the sample block and microcard so that the retention force is imparted on the microcard to urge the microcard toward the sample block. Methods of maintaining a microcard on a sample block of a thermal cycling device are also provided.
PCT/US2003/023750 2002-07-30 2003-07-30 Sample block apparatus and method for maintaining a microcard on a sample block WO2004025247A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AT03795576T ATE483790T1 (en) 2002-07-30 2003-07-30 SAMPLE BLOCK DEVICE AND METHOD FOR MAINTAINING A MICRO CARD ON A SAMPLE BLOCK
AU2003296707A AU2003296707A1 (en) 2002-07-30 2003-07-30 Sample block apparatus and method for maintaining a microcard on a sample block
EP03795576A EP1539920B1 (en) 2002-07-30 2003-07-30 Sample block apparatus and method for maintaining a microcard on a sample block
JP2004535990A JP2005534342A (en) 2002-07-30 2003-07-30 Sample block apparatus and method for maintaining a microcard on a sample block
CA002493278A CA2493278A1 (en) 2002-07-30 2003-07-30 Sample block apparatus and method for maintaining a microcard on a sample block
DE60334465T DE60334465D1 (en) 2002-07-30 2003-07-30 SAMPLE BLOCKING DEVICE AND METHOD FOR MAINTAINING A MICROCARD ON A SAMPLE BLOCK

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/207,263 2002-07-30
US10/207,263 US7452712B2 (en) 2002-07-30 2002-07-30 Sample block apparatus and method of maintaining a microcard on a sample block

Publications (2)

Publication Number Publication Date
WO2004025247A2 WO2004025247A2 (en) 2004-03-25
WO2004025247A3 true WO2004025247A3 (en) 2004-12-23

Family

ID=31186680

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/023750 WO2004025247A2 (en) 2002-07-30 2003-07-30 Sample block apparatus and method for maintaining a microcard on a sample block

Country Status (8)

Country Link
US (5) US7452712B2 (en)
EP (3) EP2402427A3 (en)
JP (1) JP2005534342A (en)
AT (1) ATE483790T1 (en)
AU (1) AU2003296707A1 (en)
CA (1) CA2493278A1 (en)
DE (1) DE60334465D1 (en)
WO (1) WO2004025247A2 (en)

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