WO2004028539A3 - 1h-imidazo dimers - Google Patents

1h-imidazo dimers Download PDF

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Publication number
WO2004028539A3
WO2004028539A3 PCT/US2003/030372 US0330372W WO2004028539A3 WO 2004028539 A3 WO2004028539 A3 WO 2004028539A3 US 0330372 W US0330372 W US 0330372W WO 2004028539 A3 WO2004028539 A3 WO 2004028539A3
Authority
WO
WIPO (PCT)
Prior art keywords
useful
imidazo dimers
compounds
imidazo
dimers
Prior art date
Application number
PCT/US2003/030372
Other languages
French (fr)
Other versions
WO2004028539A2 (en
Inventor
George W Griesgraber
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Priority to JP2004539956A priority Critical patent/JP2006503068A/en
Priority to AU2003299082A priority patent/AU2003299082A1/en
Priority to EP03756870A priority patent/EP1542688A4/en
Publication of WO2004028539A2 publication Critical patent/WO2004028539A2/en
Publication of WO2004028539A3 publication Critical patent/WO2004028539A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Abstract

1H-imidazo dimer compounds are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
PCT/US2003/030372 2002-09-26 2003-09-25 1h-imidazo dimers WO2004028539A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2004539956A JP2006503068A (en) 2002-09-26 2003-09-25 1H-Imidazo dimer
AU2003299082A AU2003299082A1 (en) 2002-09-26 2003-09-25 1h-imidazo dimers
EP03756870A EP1542688A4 (en) 2002-09-26 2003-09-25 1h-imidazo dimers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41384802P 2002-09-26 2002-09-26
US60/413,848 2002-09-26

Publications (2)

Publication Number Publication Date
WO2004028539A2 WO2004028539A2 (en) 2004-04-08
WO2004028539A3 true WO2004028539A3 (en) 2004-10-28

Family

ID=32043302

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/030372 WO2004028539A2 (en) 2002-09-26 2003-09-25 1h-imidazo dimers

Country Status (5)

Country Link
US (2) US6818650B2 (en)
EP (1) EP1542688A4 (en)
JP (1) JP2006503068A (en)
AU (1) AU2003299082A1 (en)
WO (1) WO2004028539A2 (en)

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JP2006503068A (en) 2006-01-26
US20040132766A1 (en) 2004-07-08
US6818650B2 (en) 2004-11-16
EP1542688A2 (en) 2005-06-22
WO2004028539A2 (en) 2004-04-08
US7112677B2 (en) 2006-09-26
AU2003299082A1 (en) 2004-04-19
US20050026947A1 (en) 2005-02-03
EP1542688A4 (en) 2010-06-02

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