WO2004028620B1 - A system to deposit a drug on a surface and a method for coating a surface with a drug - Google Patents

A system to deposit a drug on a surface and a method for coating a surface with a drug

Info

Publication number
WO2004028620B1
WO2004028620B1 PCT/US2003/031040 US0331040W WO2004028620B1 WO 2004028620 B1 WO2004028620 B1 WO 2004028620B1 US 0331040 W US0331040 W US 0331040W WO 2004028620 B1 WO2004028620 B1 WO 2004028620B1
Authority
WO
WIPO (PCT)
Prior art keywords
coating
steroid
electrode
medical device
heating
Prior art date
Application number
PCT/US2003/031040
Other languages
French (fr)
Other versions
WO2004028620A1 (en
WO2004028620A9 (en
Inventor
Peter T Schroeder
Kimberly A Chaffin
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc filed Critical Medtronic Inc
Priority to DE60324297T priority Critical patent/DE60324297D1/en
Priority to JP2004540318A priority patent/JP2006517111A/en
Priority to CA002500501A priority patent/CA2500501A1/en
Priority to EP03773074A priority patent/EP1551496B1/en
Publication of WO2004028620A1 publication Critical patent/WO2004028620A1/en
Publication of WO2004028620A9 publication Critical patent/WO2004028620A9/en
Publication of WO2004028620B1 publication Critical patent/WO2004028620B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056—Transvascular endocardial electrode systems
    • A61N1/0565—Electrode heads
    • A61N1/0568—Electrode heads with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056—Transvascular endocardial electrode systems
    • A61N1/057—Anchoring means; Means for fixing the head inside the heart
    • A61N1/0573—Anchoring means; Means for fixing the head inside the heart chacterised by means penetrating the heart tissue, e.g. helix needle or hook
    • A61N1/0575—Anchoring means; Means for fixing the head inside the heart chacterised by means penetrating the heart tissue, e.g. helix needle or hook with drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrotherapy Devices (AREA)

Abstract

A method for coating a surface, in particular a surface of a medical device, with a drug, comprises depositing the drug coating on the surface; applying energy to the drug coating to increase molecular mobility; and allowing cooling of the coating to form a conformable coating without degradation of the drug. The system to deposit a drug on a surface, in particular on a surface of a medical device, comprises means for depositing the drug on the surface; means for temporarily heating the drug to increase molecular mobility and elimination of microcracks.

Claims

AMENDED CLAIM received by the International Bureau on 31 March 2004 (31.03.04)
1. A method for applying a steroid coating to a medical device electrode, the method comprising the steps of: depositing the steroid on a surface of the electrode such that a coating having a crystalline structure is formed on the surface; heating the coating to increase a molecular mobility of the coating thereby eliminating micro-cracks within the coating and making the coating more conformable to the electrode surface.
2. The method of claim 1 , further comprising the step of preparing the surface of the electrode to promote adhesion of the steroid prior to the depositing step.
3. The method of claim 1 , further comprising the step of mixing the steroid with a liquid medium prior to the depositing step.
4. The method of claim 3, wherein the liquid medium comprises an organic solvent.
5. The method of claim 3, wherein the mixture is a saturated solution.
6. The method of claim 4, wherein the solvent comprises acetone.
7. The method of claim 4, wherein the solvent comprises methanol.
8. The method of claim 4, wherein the solvent comprises chloroform.
9. The method of claim 1 , wherein the steroid is sparingly soluble in water.
10. The method of claim 9, wherein the steroid comprises beclomethasone diproprionate anhydrous.
11. The method of claim 1 , wherein the steroid comprises dexamethasone.
12. The method of claim 1, wherein the heating step heats the coating to a transition point resulting in a solid-state phase change of the coating.
13. The method of claim 1, wherein the heating step comprises directing a stream of hot air over the coating.
14. The method of claim 1, wherein the heating step comprises applying radio-frequency energy to the coating.
15. The method of claim 1, wherein the heating step comprises applying microwave energy to the coating.
AMENDED SHEET (ARTICLE 19)
16. The method of claim 12, wherein the steroid comprises beclomethasone diproprionate anhydrous and the heating step comprises heating the coating to a temperature between approximately 144 degrees Celsius and approximately 146 degrees Celsius.
17. The method of claim 3, wherein the depositing step comprises dipping the electrode into the mixture of the steroid and the liquid medium.
18. The method of claim 3, wherein the depositing step comprises dispensing the mixture of the steroid and the liquid medium from a syringe.
19. The method of claim 13, further comprising the step of mounting the electrode on a fixture prior to the heating step and the heating step further comprises controlling the heating time by means of a motorized platform to which the fixture, on which the electrode is mounted, is coupled.
20. The method of claim 1 , further comprising the step of assembling the medical device electrode into a lead.
21. A medical device, comprising an electrode including a coating of steroid conforming to a surface of the electrode, the coating having been formed by depositing the steroid on the electrode surface and then heating the steroid to eliminate micro-cracks within a crystalline structure of the deposited steroid.
22. The medical device of claim 21 , further comprising an elongate lead body and wherein the electrode is a tip electrode terminating a distal end of the lead body.
23. The medical device of claim 22, wherein the tip electrode has a helical form.
24. The medical device of claim 22, wherein the tip electrode has a generally hemispherical form.
25. The medical device of claim 21, wherein the steroid comprises beclomethasone diproprionate anhydrous.
26. The medical device of claim 21, wherein the steroid comprises dexarπethasone.
AMENDED SHEET (ARTICLE 19)
18
PCT/US2003/031040 2002-09-30 2003-09-30 A system to deposit a drug on a surface and a method for coating a surface with a drug WO2004028620A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE60324297T DE60324297D1 (en) 2002-09-30 2003-09-30 METHOD FOR APPLYING A MEDICAMENT TO A SURFACE
JP2004540318A JP2006517111A (en) 2002-09-30 2003-09-30 System for depositing a drug on a surface and method for coating a surface with a drug
CA002500501A CA2500501A1 (en) 2002-09-30 2003-09-30 A system to deposit a drug on a surface and a method for coating a surface with a drug
EP03773074A EP1551496B1 (en) 2002-09-30 2003-09-30 A method for coating a surface with a drug

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/260,659 2002-09-30
US10/260,659 US7282213B2 (en) 2002-09-30 2002-09-30 Method for applying a drug coating to a medical device

Publications (3)

Publication Number Publication Date
WO2004028620A1 WO2004028620A1 (en) 2004-04-08
WO2004028620A9 WO2004028620A9 (en) 2006-03-09
WO2004028620B1 true WO2004028620B1 (en) 2006-05-18

Family

ID=32029742

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/031040 WO2004028620A1 (en) 2002-09-30 2003-09-30 A system to deposit a drug on a surface and a method for coating a surface with a drug

Country Status (6)

Country Link
US (1) US7282213B2 (en)
EP (1) EP1551496B1 (en)
JP (1) JP2006517111A (en)
CA (1) CA2500501A1 (en)
DE (1) DE60324297D1 (en)
WO (1) WO2004028620A1 (en)

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EP1551496A1 (en) 2005-07-13
WO2004028620A1 (en) 2004-04-08
US7282213B2 (en) 2007-10-16
DE60324297D1 (en) 2008-12-04
JP2006517111A (en) 2006-07-20
CA2500501A1 (en) 2004-04-08
WO2004028620A9 (en) 2006-03-09
EP1551496B1 (en) 2008-10-22
US20040062852A1 (en) 2004-04-01

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