WO2004029031A3 - Therapeutic piperazine compounds - Google Patents

Therapeutic piperazine compounds Download PDF

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Publication number
WO2004029031A3
WO2004029031A3 PCT/US2003/030185 US0330185W WO2004029031A3 WO 2004029031 A3 WO2004029031 A3 WO 2004029031A3 US 0330185 W US0330185 W US 0330185W WO 2004029031 A3 WO2004029031 A3 WO 2004029031A3
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WO
WIPO (PCT)
Prior art keywords
piperazine compounds
compound
therapeutic
animal
disclosed
Prior art date
Application number
PCT/US2003/030185
Other languages
French (fr)
Other versions
WO2004029031A2 (en
Inventor
Qun Sun
Xiaoming Zhou
Original Assignee
Euro Celtque S A
Qun Sun
Xiaoming Zhou
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE60312544T priority Critical patent/DE60312544T2/en
Priority to JP2004539882A priority patent/JP4560610B2/en
Priority to AU2003272685A priority patent/AU2003272685A1/en
Priority to CA2500113A priority patent/CA2500113C/en
Priority to EP03754883A priority patent/EP1562936B1/en
Priority to BR0314699-5A priority patent/BR0314699A/en
Priority to NZ539205A priority patent/NZ539205A/en
Priority to DK03754883T priority patent/DK1562936T3/en
Application filed by Euro Celtque S A, Qun Sun, Xiaoming Zhou filed Critical Euro Celtque S A
Priority to MXPA05003302A priority patent/MXPA05003302A/en
Priority to SI200330815T priority patent/SI1562936T1/en
Publication of WO2004029031A2 publication Critical patent/WO2004029031A2/en
Publication of WO2004029031A3 publication Critical patent/WO2004029031A3/en
Priority to HK06102046A priority patent/HK1083216A1/en
Priority to CY20071100730T priority patent/CY1106634T1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61P25/34—Tobacco-abuse
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

A compound of formula: wherein Ar, Ar1, Ar2, R3-R6, R13, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a 'Hydroxyiminopiperazine Compound'); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Hydroxyiminopiperazine Compound are disclosed.
PCT/US2003/030185 2002-09-24 2003-09-24 Therapeutic piperazine compounds WO2004029031A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
NZ539205A NZ539205A (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds
AU2003272685A AU2003272685A1 (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds
CA2500113A CA2500113C (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds
EP03754883A EP1562936B1 (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds
BR0314699-5A BR0314699A (en) 2002-09-24 2003-09-24 Compound, composition and methods for treating pain and inhibiting vr1 function in a cell
DE60312544T DE60312544T2 (en) 2002-09-24 2003-09-24 THERAPEUTIC PIPERAZINE COMPOUNDS.
DK03754883T DK1562936T3 (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds
JP2004539882A JP4560610B2 (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds
MXPA05003302A MXPA05003302A (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds.
SI200330815T SI1562936T1 (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds
HK06102046A HK1083216A1 (en) 2002-09-24 2006-02-16 Terapeutic piperazine compounds
CY20071100730T CY1106634T1 (en) 2002-09-24 2007-06-04 THERAPEUTIC DERIVATIVES OF PIPERAZINE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41284702P 2002-09-24 2002-09-24
US60/412,847 2002-09-24

Publications (2)

Publication Number Publication Date
WO2004029031A2 WO2004029031A2 (en) 2004-04-08
WO2004029031A3 true WO2004029031A3 (en) 2004-08-05

Family

ID=32043195

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/030185 WO2004029031A2 (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds

Country Status (20)

Country Link
US (4) US7157462B2 (en)
EP (2) EP1562936B1 (en)
JP (1) JP4560610B2 (en)
KR (1) KR20050052514A (en)
CN (1) CN100393713C (en)
AT (2) ATE467627T1 (en)
AU (1) AU2003272685A1 (en)
BR (1) BR0314699A (en)
CA (1) CA2500113C (en)
CY (1) CY1106634T1 (en)
DE (2) DE60312544T2 (en)
DK (1) DK1562936T3 (en)
ES (1) ES2285170T3 (en)
HK (1) HK1083216A1 (en)
MX (1) MXPA05003302A (en)
NZ (1) NZ539205A (en)
PT (1) PT1562936E (en)
SI (1) SI1562936T1 (en)
WO (1) WO2004029031A2 (en)
ZA (1) ZA200502326B (en)

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