WO2004033059A3 - Methods and apparatus for optophoretic diagnosis of cells and particles - Google Patents

Methods and apparatus for optophoretic diagnosis of cells and particles Download PDF

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Publication number
WO2004033059A3
WO2004033059A3 PCT/US2003/030975 US0330975W WO2004033059A3 WO 2004033059 A3 WO2004033059 A3 WO 2004033059A3 US 0330975 W US0330975 W US 0330975W WO 2004033059 A3 WO2004033059 A3 WO 2004033059A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell
optophoretic
diagnosis
cells
particles
Prior art date
Application number
PCT/US2003/030975
Other languages
French (fr)
Other versions
WO2004033059A2 (en
Inventor
Haichuan Zhang
Thomas D Y Chung
Jeff Hall
William Soohoo
Josh Kohrumel
Eugene Tu
Mark Wang
Daniel Edward Raymond
Philippe Marchand
Jonathan Diver
William F Butler
Phan Nguyen
Mirianas Chachisvilis
Andrew Katz
Norbert Hagen
Kris Lykstad
Luis Pestana
Original Assignee
Genoptix Inc
Haichuan Zhang
Thomas D Y Chung
Jeff Hall
William Soohoo
Josh Kohrumel
Eugene Tu
Mark Wang
Daniel Edward Raymond
Philippe Marchand
Jonathan Diver
William F Butler
Phan Nguyen
Mirianas Chachisvilis
Andrew Katz
Norbert Hagen
Kris Lykstad
Luis Pestana
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genoptix Inc, Haichuan Zhang, Thomas D Y Chung, Jeff Hall, William Soohoo, Josh Kohrumel, Eugene Tu, Mark Wang, Daniel Edward Raymond, Philippe Marchand, Jonathan Diver, William F Butler, Phan Nguyen, Mirianas Chachisvilis, Andrew Katz, Norbert Hagen, Kris Lykstad, Luis Pestana filed Critical Genoptix Inc
Priority to AU2003272804A priority Critical patent/AU2003272804A1/en
Publication of WO2004033059A2 publication Critical patent/WO2004033059A2/en
Publication of WO2004033059A3 publication Critical patent/WO2004033059A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1484—Electro-optical investigation, e.g. flow cytometers microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G01N2015/1027—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/1447—Spatial selection
    • G01N2015/145—Spatial selection by pattern of light, e.g. fringe pattern

Abstract

A device for characterizing a cell or particle includes a channel having an inlet and an outlet, the channel containing a moving fluid therein for carrying the cell or particle from the inlet to the outlet. The device includes detectors for monitorng the position of the cell or particle along the channel. The device further comprises a light source to provide an optical gradient and a control system to receive and process signals from the detector.The device can be used to characterize and sort cells based on a biological property.
PCT/US2003/030975 2002-10-08 2003-09-30 Methods and apparatus for optophoretic diagnosis of cells and particles WO2004033059A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003272804A AU2003272804A1 (en) 2002-10-08 2003-09-30 Methods and apparatus for optophoretic diagnosis of cells and particles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/267,914 2002-10-08
US10/267,914 US20040067167A1 (en) 2002-10-08 2002-10-08 Methods and apparatus for optophoretic diagnosis of cells and particles

Publications (2)

Publication Number Publication Date
WO2004033059A2 WO2004033059A2 (en) 2004-04-22
WO2004033059A3 true WO2004033059A3 (en) 2006-01-26

Family

ID=32042845

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/030975 WO2004033059A2 (en) 2002-10-08 2003-09-30 Methods and apparatus for optophoretic diagnosis of cells and particles

Country Status (3)

Country Link
US (1) US20040067167A1 (en)
AU (1) AU2003272804A1 (en)
WO (1) WO2004033059A2 (en)

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