WO2004038484A3 - Method and device for 3 dimensional imaging of suspended micro-objects providing high-resolution microscopy - Google Patents

Method and device for 3 dimensional imaging of suspended micro-objects providing high-resolution microscopy Download PDF

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Publication number
WO2004038484A3
WO2004038484A3 PCT/EP2003/011818 EP0311818W WO2004038484A3 WO 2004038484 A3 WO2004038484 A3 WO 2004038484A3 EP 0311818 W EP0311818 W EP 0311818W WO 2004038484 A3 WO2004038484 A3 WO 2004038484A3
Authority
WO
WIPO (PCT)
Prior art keywords
dimensional imaging
providing high
resolution microscopy
microscope
objects providing
Prior art date
Application number
PCT/EP2003/011818
Other languages
French (fr)
Other versions
WO2004038484A2 (en
Inventor
Spencer Shorte
Torsten Mueller
Thomas Schnelle
Original Assignee
Evotec Technologies Gmbh
Pasteur Institut
Spencer Shorte
Torsten Mueller
Thomas Schnelle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Technologies Gmbh, Pasteur Institut, Spencer Shorte, Torsten Mueller, Thomas Schnelle filed Critical Evotec Technologies Gmbh
Priority to US10/532,147 priority Critical patent/US7738695B2/en
Priority to AU2003298099A priority patent/AU2003298099A1/en
Publication of WO2004038484A2 publication Critical patent/WO2004038484A2/en
Publication of WO2004038484A3 publication Critical patent/WO2004038484A3/en

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/18—Arrangements with more than one light path, e.g. for comparing two specimens
    • G02B21/20—Binocular arrangements
    • G02B21/22—Stereoscopic arrangements
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/144—Imaging characterised by its optical setup
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/144—Imaging characterised by its optical setup
    • G01N2015/1445—Three-dimensional imaging, imaging in different image planes, e.g. under different angles or at different depths, e.g. by a relative motion of sample and detector, for instance by tomography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/1452—Adjustment of focus; Alignment

Abstract

A method for high-resolution image recording of at least one object with a microscope, comprises the steps of: positioning the object in a receptacle being arranged in the optical axis of the microscope, generating at least two first data sets per object which represent intermediate images of the object with at least two different orientations relative to the optical axis of the microscope, wherein the different orientations of the object are provided by moving the object relative to the receptacle, and evaluating the data sets for obtaining quantitative three dimensional information.
PCT/EP2003/011818 2002-10-25 2003-10-24 Method and device for 3 dimensional imaging of suspended micro-objects providing high-resolution microscopy WO2004038484A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/532,147 US7738695B2 (en) 2002-10-25 2003-10-24 Method and device for 3 dimensional imaging of suspended micro-objects providing high-resolution microscopy
AU2003298099A AU2003298099A1 (en) 2002-10-25 2003-10-24 Method and device for 3 dimensional imaging of suspended micro-objects providing high-resolution microscopy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02292658A EP1413911B1 (en) 2002-10-25 2002-10-25 Method and device for 3 dimensional imaging of suspended micro-objects providing high-resolution microscopy
EP02292658.8 2002-10-25

Publications (2)

Publication Number Publication Date
WO2004038484A2 WO2004038484A2 (en) 2004-05-06
WO2004038484A3 true WO2004038484A3 (en) 2004-05-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/011818 WO2004038484A2 (en) 2002-10-25 2003-10-24 Method and device for 3 dimensional imaging of suspended micro-objects providing high-resolution microscopy

Country Status (6)

Country Link
US (1) US7738695B2 (en)
EP (1) EP1413911B1 (en)
AT (1) ATE285590T1 (en)
AU (1) AU2003298099A1 (en)
DE (1) DE60202374T2 (en)
WO (1) WO2004038484A2 (en)

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US8416400B2 (en) * 2009-06-03 2013-04-09 California Institute Of Technology Wavefront imaging sensor
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WO2011047053A2 (en) 2009-10-13 2011-04-21 California Institute Of Technology Holographically illuminated imaging devices
WO2011106324A2 (en) 2010-02-23 2011-09-01 California Institute Of Technology Nondiffracting beam detection devices for three-dimensional imaging
EP2550522B1 (en) 2010-03-23 2016-11-02 California Institute of Technology Super resolution optofluidic microscopes for 2d and 3d imaging
US8620065B2 (en) 2010-04-09 2013-12-31 The Regents Of The University Of Colorado Methods and systems for three dimensional optical imaging, sensing, particle localization and manipulation
US8536545B2 (en) 2010-09-09 2013-09-17 California Institute Of Technology Delayed emission detection devices and methods
US9693034B2 (en) 2011-12-13 2017-06-27 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for localizing objects for distance and/or in three dimensions using a spiral point spread function
EP2864468B1 (en) 2012-06-22 2020-08-05 The Regents of the University of Colorado, a body corporate Method and system for estimating a position and an angular orientation of a particle
US9091628B2 (en) 2012-12-21 2015-07-28 L-3 Communications Security And Detection Systems, Inc. 3D mapping with two orthogonal imaging views
US9858464B2 (en) 2013-03-15 2018-01-02 The Regents Of The University Of Colorado, A Body Corporate 3-D localization and imaging of dense arrays of particles
US10036735B2 (en) 2013-08-26 2018-07-31 The Regents Of The University Of Colorado, A Body Corporate Imaging through scattering media with high signal to noise ratio and resolution
US9810893B2 (en) 2014-03-27 2017-11-07 The Board Of Trustees Of The Leland Stanford Junior University Phase mask imaging with characterization of rotational mobility
EP3215806A4 (en) 2014-11-05 2018-06-06 The Regents Of The University Of Colorado 3d imaging, ranging, and/or tracking using active illumination and point spread function engineering
US10416065B2 (en) * 2014-12-16 2019-09-17 Celldynamics I.S.R.L. Device for real time analysis of particles suspended in a fluid and method for the analysis of said particles
WO2016157346A1 (en) * 2015-03-27 2016-10-06 株式会社ニコン Microscope device, viewing method, and control program
US10187626B2 (en) 2015-04-10 2019-01-22 The Board Of Trustees Of The Leland Stanford Junior University Apparatuses and methods for three-dimensional imaging of an object
US11327004B2 (en) 2016-03-02 2022-05-10 Arizona Board Of Regents On Behalf Of Arizona State University Live-cell computed tomography
JP6681068B2 (en) * 2016-06-14 2020-04-15 国立研究開発法人理化学研究所 Data restoration device, microscope system, and data restoration method
US11315292B2 (en) 2017-03-02 2022-04-26 Arizona Board Of Regents On Behalf Of Arizona State University Live-cell computed tomography
WO2019209345A1 (en) 2018-04-27 2019-10-31 Hewlett-Packard Development Company, L.P. Three-dimensional volume imaging
US20210033842A1 (en) * 2018-04-27 2021-02-04 Hewlett-Packard Development Company, L.P. Nonrotating nonuniform electric field object rotation
WO2020091732A1 (en) * 2018-10-29 2020-05-07 Hewlett-Packard Development Company, L.P. Rotation and flat-form imaging for microscopic objects
CN114166699A (en) * 2021-11-12 2022-03-11 清华大学深圳国际研究生院 Optical measurement device and method for volume of suspended particles
DE102022117214A1 (en) 2022-07-11 2024-01-11 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Ptychographic imaging method and system
CN115091107B (en) * 2022-08-24 2023-04-25 中国工程物理研究院激光聚变研究中心 High-precision clamping device and clamping method for laser processing

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Also Published As

Publication number Publication date
EP1413911A1 (en) 2004-04-28
AU2003298099A8 (en) 2004-05-13
WO2004038484A2 (en) 2004-05-06
DE60202374T2 (en) 2005-12-08
ATE285590T1 (en) 2005-01-15
US20060126921A1 (en) 2006-06-15
US7738695B2 (en) 2010-06-15
AU2003298099A1 (en) 2004-05-13
DE60202374D1 (en) 2005-01-27
EP1413911B1 (en) 2004-12-22

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