WO2004041324A3 - Transdermal delivery of fentanyl - Google Patents

Transdermal delivery of fentanyl Download PDF

Info

Publication number
WO2004041324A3
WO2004041324A3 PCT/US2003/034403 US0334403W WO2004041324A3 WO 2004041324 A3 WO2004041324 A3 WO 2004041324A3 US 0334403 W US0334403 W US 0334403W WO 2004041324 A3 WO2004041324 A3 WO 2004041324A3
Authority
WO
WIPO (PCT)
Prior art keywords
fentanyl
transdermal delivery
formulations
suspended
matrix
Prior art date
Application number
PCT/US2003/034403
Other languages
French (fr)
Other versions
WO2004041324A2 (en
Inventor
Kenneth J Ii Miller
Sharad K Govil
Kuljit Singh Bhatia
Original Assignee
Mylan Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mylan Pharmaceuticals Inc filed Critical Mylan Pharmaceuticals Inc
Priority to EP03781469A priority Critical patent/EP1585470B1/en
Priority to CA2503722A priority patent/CA2503722C/en
Priority to DE03781469T priority patent/DE03781469T1/en
Priority to AT03781469T priority patent/ATE511393T1/en
Priority to SI200332040T priority patent/SI1585470T1/en
Priority to JP2004550226A priority patent/JP5069402B2/en
Priority to DK03781469.6T priority patent/DK1585470T3/en
Priority to AU2003288977A priority patent/AU2003288977A1/en
Publication of WO2004041324A2 publication Critical patent/WO2004041324A2/en
Publication of WO2004041324A3 publication Critical patent/WO2004041324A3/en
Priority to HK05109868.5A priority patent/HK1075816A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor

Abstract

Silicone adhesive formulations are provided, in which fentanyl particles are suspended one or more a solvated silicone adhesives. The formulations can be used for manufacturing improved, matrix-type transdermal devices for administering fentanyl.
PCT/US2003/034403 2002-10-30 2003-10-29 Transdermal delivery of fentanyl WO2004041324A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP03781469A EP1585470B1 (en) 2002-10-30 2003-10-29 Transdermal delivery of fentanyl
CA2503722A CA2503722C (en) 2002-10-30 2003-10-29 Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl
DE03781469T DE03781469T1 (en) 2002-10-30 2003-10-29 TRANSDERMAL FENTANY LAPPLICATION
AT03781469T ATE511393T1 (en) 2002-10-30 2003-10-29 TRANSDERMAL FENTANY APPLICATION
SI200332040T SI1585470T1 (en) 2002-10-30 2003-10-29 Transdermal delivery of fentanyl
JP2004550226A JP5069402B2 (en) 2002-10-30 2003-10-29 Silicone-based adhesive formulation based on fentanyl suspension and device for transdermal delivery of fentanyl
DK03781469.6T DK1585470T3 (en) 2002-10-30 2003-10-29 Transdermal delivery of fentanyl
AU2003288977A AU2003288977A1 (en) 2002-10-30 2003-10-29 Transdermal delivery of fentanyl
HK05109868.5A HK1075816A1 (en) 2002-10-30 2005-11-05 Transdermal delivery of fentanyl

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/283,355 US20040086551A1 (en) 2002-10-30 2002-10-30 Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl
US10/283,355 2002-10-30

Publications (2)

Publication Number Publication Date
WO2004041324A2 WO2004041324A2 (en) 2004-05-21
WO2004041324A3 true WO2004041324A3 (en) 2004-07-22

Family

ID=32174649

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/034403 WO2004041324A2 (en) 2002-10-30 2003-10-29 Transdermal delivery of fentanyl

Country Status (14)

Country Link
US (8) US20040086551A1 (en)
EP (1) EP1585470B1 (en)
JP (1) JP5069402B2 (en)
AT (1) ATE511393T1 (en)
AU (1) AU2003288977A1 (en)
CA (1) CA2503722C (en)
CY (1) CY1112582T1 (en)
DE (1) DE03781469T1 (en)
DK (1) DK1585470T3 (en)
ES (1) ES2249197T3 (en)
HK (1) HK1075816A1 (en)
PT (1) PT1585470E (en)
SI (1) SI1585470T1 (en)
WO (1) WO2004041324A2 (en)

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RU2708563C2 (en) * 2001-03-16 2019-12-10 Алза Корпорейшн Transdermal patch for administering fentanyl
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DE10141650C1 (en) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Safe transdermal therapeutic system for administration of fentanyl or analogous analgesics, having matrix layer of carboxy group-free polyacrylate adhesive providing high permeation rate
US20040086551A1 (en) 2002-10-30 2004-05-06 Miller Kenneth J. Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl
CA2513402A1 (en) * 2003-02-07 2004-08-19 Walter Mueller Transdermal therapeutic system suitable for heat application for promoting the permeation of active substances, and the use thereof
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EP3612170A4 (en) * 2017-04-19 2021-01-27 Inep Europe Sarl Method for making a transdermal fentanyl patch with even drug crystal distribution
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US10391065B2 (en) * 2017-04-19 2019-08-27 Inep Europe Sarl Method for making a transdermal fentanyl patch with even drug crystal distribution
KR20200024825A (en) * 2017-06-08 2020-03-09 애프리컷 지엠비에이치 Silicone pads with active substances for skin care and anti-aging
KR20200025888A (en) * 2018-08-31 2020-03-10 에스케이케미칼 주식회사 Rivastigmine patch for long-term administration
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Also Published As

Publication number Publication date
JP2006513160A (en) 2006-04-20
JP5069402B2 (en) 2012-11-07
CY1112582T1 (en) 2016-02-10
US20070259027A1 (en) 2007-11-08
PT1585470E (en) 2011-08-25
US8449907B2 (en) 2013-05-28
US20130319595A1 (en) 2013-12-05
US20040086551A1 (en) 2004-05-06
ES2249197T3 (en) 2011-09-06
US20090041831A1 (en) 2009-02-12
US20090238861A1 (en) 2009-09-24
CA2503722C (en) 2012-05-22
EP1585470A4 (en) 2008-06-18
US7556823B2 (en) 2009-07-07
ATE511393T1 (en) 2011-06-15
DK1585470T3 (en) 2011-06-27
EP1585470A2 (en) 2005-10-19
HK1075816A1 (en) 2005-12-30
DE03781469T1 (en) 2006-08-10
ES2249197T1 (en) 2006-04-01
US20070166365A1 (en) 2007-07-19
SI1585470T1 (en) 2011-10-28
US20060210617A1 (en) 2006-09-21
AU2003288977A1 (en) 2004-06-07
WO2004041324A2 (en) 2004-05-21
AU2003288977A8 (en) 2004-06-07
EP1585470B1 (en) 2011-06-01
CA2503722A1 (en) 2004-05-21
US20120145320A1 (en) 2012-06-14

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