WO2004042429A3 - Fiber-optic flow cell and method relating thereto - Google Patents

Fiber-optic flow cell and method relating thereto Download PDF

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Publication number
WO2004042429A3
WO2004042429A3 PCT/US2003/034187 US0334187W WO2004042429A3 WO 2004042429 A3 WO2004042429 A3 WO 2004042429A3 US 0334187 W US0334187 W US 0334187W WO 2004042429 A3 WO2004042429 A3 WO 2004042429A3
Authority
WO
WIPO (PCT)
Prior art keywords
flow cell
sample
optical fiber
channel
fiber
Prior art date
Application number
PCT/US2003/034187
Other languages
French (fr)
Other versions
WO2004042429A2 (en
Inventor
Jennifer L Elster
Mark E Jones
Charles D Pennington
Joshua P Averett
Original Assignee
Luna Innovations Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luna Innovations Inc filed Critical Luna Innovations Inc
Priority to AU2003287236A priority Critical patent/AU2003287236A1/en
Publication of WO2004042429A2 publication Critical patent/WO2004042429A2/en
Publication of WO2004042429A3 publication Critical patent/WO2004042429A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N15/075—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/7709—Distributed reagent, e.g. over length of guide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7756—Sensor type
    • G01N2021/7763—Sample through flow

Abstract

The present invention is for a fiber optic flow cell. The flow cell (10) comprises a substrate (20) having at least one sample channel (30) and at least one optical fiber channel holder. At least one optical fiber (40) disposed within each optical fiber channel holder. Each optical fiber has at least one grating (50) wherein each grating is in contact with each sample channel, defining a sensing area (55). At least one sample port is positioned in an operable relationship to at least one sample channel. Alternatively, at least one sample outlet is positioned in an operable relationship to at least one sample channel. The flow cell (10) may be of modular design providing a flow cell kit that contains pieces that may be assembled to form custom-made flow cells. The flow cell is used for conducting measurement studies on a sample.
PCT/US2003/034187 2002-10-31 2003-10-28 Fiber-optic flow cell and method relating thereto WO2004042429A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003287236A AU2003287236A1 (en) 2002-10-31 2003-10-28 Fiber-optic flow cell and method relating thereto

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42249502P 2002-10-31 2002-10-31
US60/422,495 2002-10-31

Publications (2)

Publication Number Publication Date
WO2004042429A2 WO2004042429A2 (en) 2004-05-21
WO2004042429A3 true WO2004042429A3 (en) 2004-11-25

Family

ID=32312515

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/034187 WO2004042429A2 (en) 2002-10-31 2003-10-28 Fiber-optic flow cell and method relating thereto

Country Status (3)

Country Link
US (2) US6987897B2 (en)
AU (1) AU2003287236A1 (en)
WO (1) WO2004042429A2 (en)

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CA2568843A1 (en) * 2004-06-04 2005-12-15 Queen's University At Kingston Long period grating sensor methods and apparatus
US7835006B2 (en) * 2004-11-05 2010-11-16 Nomadics, Inc. Optical fiber sensors using grating-assisted surface plasmon-coupled emission (GASPCE)
US20060192940A1 (en) * 2005-01-20 2006-08-31 Phi-Wilson Janette T Modular flow cytometry system
CA2601030A1 (en) * 2005-03-16 2006-09-21 Philip Head Well bore sensing
US8989528B2 (en) 2006-02-22 2015-03-24 Hansen Medical, Inc. Optical fiber grating sensors and methods of manufacture
WO2007109778A1 (en) * 2006-03-22 2007-09-27 Hansen Medical, Inc. Fiber optic instrument sensing system
US20080218770A1 (en) * 2007-02-02 2008-09-11 Hansen Medical, Inc. Robotic surgical instrument and methods using bragg fiber sensors
GB0706433D0 (en) * 2007-04-02 2007-05-09 Smart Holograms Ltd Sensor housing
WO2008131303A2 (en) * 2007-04-20 2008-10-30 Hansen Medical, Inc. Optical fiber shape sensing systems
EP2179261B1 (en) * 2007-07-23 2021-09-15 Sartorius BioAnalytical Instruments, Inc Fluidic configuration for flow injection analysis system
EP2626028B1 (en) 2007-08-14 2020-04-22 Koninklijke Philips N.V. Robotic instrument systems and methods utilizing optical fiber sensors
GB0722480D0 (en) * 2007-11-15 2007-12-27 Univ Aston Surface plasmons
US7815376B2 (en) 2008-06-30 2010-10-19 Intuitive Surgical Operations, Inc. Fixture for shape-sensing optical fiber in a kinematic chain
JP5117963B2 (en) * 2008-09-17 2013-01-16 アークレイ株式会社 Analysis equipment
ES2796655T3 (en) * 2008-11-14 2020-11-27 Beckman Coulter Inc Monolithic Optical Flow Cells and Manufacturing Method
US8780339B2 (en) 2009-07-15 2014-07-15 Koninklijke Philips N.V. Fiber shape sensing systems and methods
US9314306B2 (en) 2010-09-17 2016-04-19 Hansen Medical, Inc. Systems and methods for manipulating an elongate member
US20120119101A1 (en) * 2010-11-12 2012-05-17 Endress + Hauser Conducta Gesellschaft Fur Mess-Und Regeltechnik Mbh + Co. Kg Miniature UV sensor utilizing a disposable flow cell
US9291521B2 (en) 2010-12-30 2016-03-22 Eaton Corporation Leak detection system
US8528385B2 (en) 2010-12-30 2013-09-10 Eaton Corporation Leak detection system
US20120191086A1 (en) 2011-01-20 2012-07-26 Hansen Medical, Inc. System and method for endoluminal and translumenal therapy
US9138166B2 (en) 2011-07-29 2015-09-22 Hansen Medical, Inc. Apparatus and methods for fiber integration and registration
TW201422817A (en) * 2012-12-14 2014-06-16 Ardic Instr Co Biological detecting chip
ES2751404T3 (en) 2013-03-15 2020-03-31 Beckman Coulter Inc Composite Optical Flow Cells and Method of Manufacture and Use
US11054577B1 (en) * 2017-10-31 2021-07-06 Shenzhen University Hybrid fiber coupler and manufacturing method thereof
ES2919086B2 (en) * 2022-06-28 2023-06-22 Fibsen Monitorizaciones S L MODULABLE MULTIPARAMETRIC PROBE FOR FIBER OPTIC SENSORS

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US5738825A (en) * 1993-07-20 1998-04-14 Balzers Aktiengesellschaft Optical biosensor matrix
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US6439055B1 (en) * 1999-11-15 2002-08-27 Weatherford/Lamb, Inc. Pressure sensor assembly structure to insulate a pressure sensing device from harsh environments

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Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US5216312A (en) * 1992-02-28 1993-06-01 Hewlett-Packard Company Fluid sensing device having reduced attenuation of shear transverse waves
US5738825A (en) * 1993-07-20 1998-04-14 Balzers Aktiengesellschaft Optical biosensor matrix
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US6439055B1 (en) * 1999-11-15 2002-08-27 Weatherford/Lamb, Inc. Pressure sensor assembly structure to insulate a pressure sensing device from harsh environments

Also Published As

Publication number Publication date
AU2003287236A1 (en) 2004-06-07
US6987897B2 (en) 2006-01-17
AU2003287236A8 (en) 2004-06-07
US20040086216A1 (en) 2004-05-06
US20050036140A1 (en) 2005-02-17
WO2004042429A2 (en) 2004-05-21

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