WO2004043292A2 - Medical devices having porous layers and methods for making same - Google Patents
Medical devices having porous layers and methods for making same Download PDFInfo
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- WO2004043292A2 WO2004043292A2 PCT/US2003/036451 US0336451W WO2004043292A2 WO 2004043292 A2 WO2004043292 A2 WO 2004043292A2 US 0336451 W US0336451 W US 0336451W WO 2004043292 A2 WO2004043292 A2 WO 2004043292A2
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- alloy
- medical device
- implantable medical
- porous layer
- porous
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/901—Method of manufacturing prosthetic device
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/12—All metal or with adjacent metals
- Y10T428/12458—All metal or with adjacent metals having composition, density, or hardness gradient
Definitions
- the present invention relates generally to medical devices and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices.
- Implantable medical devices are increasingly being used to deliver one or more therapeutic agents to a site within a body. Such agents may provide their own benefits to treatment and/or may enhance the efficacy of the implantable device. For example, much research has been conducted into the use of drug eluting stents for use in percutaneous transluminal coronary angioplasty (PTCA) procedures. Although some implantable devices are simply coated with one or more therapeutic agents, other devices include means for containing, attaching or otherwise holding therapeutic agents to provide the agents at a treatment location over a longer duration, in a controlled-release manner, or the like.
- Porous materials for example, are commonly used in medical implants as matrices for the retention of therapeutic agents.
- Materials that have been used for this purpose include ceramics such as hydroxyapatites and porous alumina, as well as sintered metal powders.
- Polymeric materials such as poly(ethylene glycol)/poly(L-lactic acid) (PLGA) have also been used for this purpose. These materials are typically applied as coatings to the medical implant, raising issues regarding coating adhesion, mechanical properties, and material biocompatibility. Further, application of these coatings introduces additional complexity to the fabrication process, increasing overall production costs.
- Methods of the present invention provide means for fabricating an implantable medical device having at least one porous layer.
- a method of fabricating an implantable medical device having a porous layer for releasably containing at least one therapeutic agent includes providing an implantable medical device comprising at least one alloy and removing at least one component of the alloy to form the porous layer.
- the component is removed to form the porous layer as a biocompatible material, such as gold.
- the medical device comprises a tubular stent device having an outer surface and an inner surface.
- the stent device may comprise a coronary artery stent for use in a percutaneous transluminal coronary angioplasty (PTCA) procedure.
- the alloy is disposed along the outer surface of the stent device.
- providing the implantable medical device may also include depositing the alloy on at least one surface of the medical device.
- the alloy may be disposed along an outer surface of the implantable medical device, such that the dissolving step forms the porous layer on the outer surface of the device.
- the alloy includes one or more metals, such as but not limited to gold, silver, nitinol, steel, chromium, iron, nickel, copper, aluminum, titanium, tantalum, cobalt, tungsten, palladium, vanadium, platinum and/or niobium.
- the alloy comprises at least one metal and at least one non-metal.
- at least one substance may be embedded within the alloy.
- a salt or an oxide particle may be embedded in the alloy to enhance pore formation upon dissolution.
- Dissolving one or more components of the alloy may involve exposing the alloy to a dissolving substance.
- a stainless steel alloy may be exposed to sodium hydroxide in one embodiment.
- the device may be coated after the dissolving step with titanium, gold and or platinum.
- Some embodiments further include introducing at least one therapeutic agent into the porous layer.
- the therapeutic agent may be introduced by liquid immersion, vacuum dessication, high pressure infusion or vapor loading in various embodiments.
- the therapeutic agent may be any suitable agent or combination of agents, such as but not limited to anti-restenotic agent(s) or anti-inflammatory agent(s), such as Rapamycin, Sirolimus, Taxol, Prednisone, and/or the like.
- live cells may be encapsulated by the porous layer, thereby allowing transport of selected molecules, such as oxygen, glucose, or insulin, to and from the cells, while shielding the cells from the immune system of the patient.
- Some embodiments may optionally include multiple porous layers having various porosities and atomic compositions.
- a method for treating a blood vessel using an implantable medical device having a porous layer for releasably containing at least one therapeutic agent includes: providing at least one implantable stent having a porous layer for releasably containing at least one therapeutic agent; and placing the stent within the blood vessel at a desired location, wherein the stent releases the at least one therapeutic agent from the porous layer after placement.
- the desired location may comprise an area of stenosis in the blood vessel, and the at least one therapeutic agent may inhibit re-stenosis of the blood vessel.
- the therapeutic agent in some embodiments may be one or more anti-restenosis agents, anti-inflammatory agents, or a combination of both.
- the blood vessel may be a coronary artery.
- the placing step may involve placing the stent so as to contact the porous layer with at least one of a stenotic plaque in the blood vessel and an inner wall of the blood vessel.
- an implantable medical device has at least one porous layer comprising at least one remaining alloy component and interstitial spaces, wherein the interstitial spaces comprise at least one removed alloy component space of an alloy, the alloy comprising the at least one remaining alloy component and the at least one removed alloy component.
- the porous layer comprises a matrix.
- the implantable medical device comprises an implantable stent device having- an outer surface and an inner surface, and the porous layer is disposed along the outer surface.
- the stent device may comprise a coronary artery stent for use in a percutaneous transluminal coronary angioplasty procedure.
- the alloy may comprise one or more metals selected from the group consisting of gold, silver, nitinol, steel, chromium, iron, nickel, copper, aluminum, titanium, tantalum, cobalt, tungsten, palladium, vanadium, platinum and/or niobium.
- the alloy may comprise stainless steel and the porous layer may comprise iron and nickel.
- the component (or components) that is dissolved comprises a most electrochemically active component of the alloy.
- the device further includes at least one therapeutic agent disposed within the at least one porous layer. Any such agent or combination of agents is contemplated.
- the device may include a titanium or platinum coating over an outer surface of the device.
- FIG. 1 is a perspective view of an implantable stent device having a porous layer according to one embodiment of the present invention.
- Figs. 2A-2B are electron micrographs of a porous layer formed by dissolving silver from a gold-silver alloy, according to one embodiment of the present invention.
- Figs. 3A-3C are cross-sectional side views showing a method of making an implantable stent device having a porous layer, according to one embodiment of the present invention.
- Methods of the present invention provide means for fabricating an implantable medical device having at least one porous layer.
- the methods involve providing an implantable medical device containing an alloy and removing at least one component of the alloy to form the porous layer.
- an alloy may first be deposited on an implantable device and one or more components of the alloy may then be removed to form the porous layer.
- dealloying Such methods are often referred to as "dealloying.”
- dealloying methods For a general description of dealloying methods, reference may be made to "Evolution of nanoporosity in dealloying," Jonah Erlebacher et al., Nature 410, pp.
- Other devices may include, but are not limited to, other stents, stent-grafts, implantable leads, infusion pumps, vascular access devices such as implantable ports, orthopedic implants, implantable electrodes, and the like.
- devices fabricated via methods of the present invention may be used to deliver any suitable therapy or combination of therapies in a patient care context, veterinary context, research setting or the like.
- Therapeutic agents may include, for example, drugs, genes, anti-restenosis agents, anti-thrombogenic agents, antibiotic agents, anti-clotting agents, anti-inflammatory agents, cancer therapy agents and/or the like.
- an implantable medical device fabricated by methods of the present invention may include an elongate stent device 10, having two or more layers 12, 14 and a lumen 16.
- stent device 10 includes an outer porous layer 12 and an inner non-porous layer 14.
- Other embodiments may suitably include an inner porous layer 12 and an outer non-porous layer 14, multiple porous layers 12, multiple non-porous layers 14, a porous coating over an entire surface of a medical device, or any combination of porous and non-porous surfaces, layers, areas or the like to provide a desired effect.
- multiple porous layers may be layered over one another, with each layer having a different porosity and atomic composition.
- Porous layer 12 and non-porous layer 14 may have any suitable thicknesses in various embodiments.
- a very thin porous layer 12 may be desired, such as for delivery of a comparatively small amount of therapeutic agent.
- a thicker porous layer 12 may be used for delivery of a larger quantity of therapeutic agent and/or for a longer duration of agent delivery.
- Any suitable combination and configuration of porous layer 12 and non-porous layer 14 is contemplated.
- porous layer 12 may comprise the entire thickness of stent device 10, so that the device is completely porous.
- stent device 10 is only one example of a device with which porous layers may be used. Other devices may not have a lumen, for example, but may still be suitable for use in the present invention.
- any medical device may be fabricated with one or more porous layers 12 according to embodiments of the present invention.
- the device is an implantable stent device 10
- any suitable type, size and configuration of stent device may be fabricated with one or more porous layers 12.
- stent device 10 comprises an expandable stent for implantation in a coronary artery during a PTCA procedure.
- Such a stent device 10 may be fabricated from any suitable material or combination of materials.
- stent device 10 comprises a stainless steel non-porous layer 14 and an iron and nickel porous layer 12.
- porous layer 12 may be formed of a biocompatible material, such as gold.
- porous layer 12 may be formed from a cobalt-chromium alloy such as L605. Any other suitable material or combination of materials is contemplated.
- stent device 10 may include a layer or coating comprising a biocompatible material such as titanium, gold or platinum, which may provide biocompatibility, corrosion resistance or both.
- porous layer 12 is shown in greater detail. Porous layer 12 in these figures was made by selectively dissolving silver from a gold-silver alloy. As can be seen from the scanning electron micrographs, porous layer 12 comprises a matrix of pores and structural elements. In any given embodiment, the size and density of such pores may be varied by varying one or more elements of a method for making the device and forming porous layer 12. For example, one or more components of an alloy, a substance used to selectively dissolve the alloy, duration time of exposing the alloy to the dissolving substance, or the like may be chosen to give porous layer 12 certain desired characteristics.
- any implantable medical device of the present invention may include one or more therapeutic agents disposed within one or more porous layers 12. As discussed above, any agent or combination of agents may be included. Additionally, as described further below, any suitable method for introducing an agent into a porous layer may be used.
- a method for fabricating an implantable medical device 20 having a porous layer suitably includes providing an implantable device comprising at least one alloy and removing at least one component of the alloy to form the porous layer.
- a medical device 20 such as a stent may include a precursor alloy layer 22, a substrate layer 24 and a lumen.
- Precursor alloy layer 22 can be deposited onto substrate layer 24 by various processes, including but not limited to physical vapor deposition, ion implantation, sputter deposition, thermal or electron beam evaporation, chemical vapor deposition, pulsed laser deposition, or the like.
- precursor alloy layer 22 may be synthesized in situ from various materials, as described previously, such that exposure to the dealloying process will remove the sacrificial component of precursor alloy layer 22, leaving behind a porous matrix.
- precursor alloy layer 22 and substrate layer 24 may be made from the same material.
- medical device 20 may comprise any suitable stent or other device and precursor alloy layer 22, substrate layer 24 and/or other layers may be given any suitable configurations, thicknesses and the like.
- precursor alloy layer 22 is disposed along an outer surface of device 20, while in others precursor alloy layer 22 may be disposed along an inner surface, both inner and outer surfaces, or the like.
- the alloy used to form precursor alloy layer 22 may comprise any suitable alloy and may be a metal-metal alloy or a metal-non-metal alloy.
- components of precursor alloy layer 22 may include steel, nitinol, chromium, brass, copper, iron, nickel, aluminum, titanium, gold, silver, tantalum, cobalt, tungsten, palladium, vanadium, platinum and/or niobium.
- one or more additional substances may be embedded within precursor alloy layer 22 to cause or enhance pore formation during the fabrication process. For example, a salt, an oxide particle or the like may be added to precursor alloy layer 22 to enhance pore formation.
- implantable medical device 20 is typically exposed to a substance (arrows) to dissolve or otherwise remove at least one component of the alloy to form the porous layer from precursor alloy layer 22.
- a substance arrows
- any suitable substance may be used for removing at least one component of the alloy.
- the alloy comprises stainless steel, such as 316L stainless steel, and dissolving at least one component of the steel comprises exposing the steel to hot sodium hydroxide to dissolve chromium and leave iron and nickel as the porous layer.
- a silver-gold alloy may be exposed to nitric acid to dissolve the silver and leave the gold as the porous layer (as shown in Figures 2A and 2B).
- a cobalt-chromium alloy such as L605
- a sacrificial material such as silver, copper or aluminum
- an appropriate solvent such as nitric acid, sulphuric acid or phosphoric acid
- a platinum-copper alloy is dealloyed in the presence of sulphuric acid to produce porous platinum.
- nitinol may be dissolved by a suitable dissolving substance to leave a porous layer. The dissolving process may include the use of electro-chemical cells to bias device 20 in solution so as to facilitate the dealloying process.
- any other suitable combination of alloy and dissolving or component-removing substance is contemplated.
- any means for exposing medical device 20 to a dissolving substance is contemplated.
- medical device 20 may be immersed in, sprayed with, coated with, etc. any suitable substance or combination of substances.
- removing at least one component of the alloy comprises dissolving one or more of the most electrochemically active components of the alloy.
- the chromium component may be dissolved, leaving the iron and nickel components.
- Additional processing of medical device 20 may include introduction of one or more therapeutic agents into porous layer 23.
- any suitable agent(s) may be introduced and they may be introduced by any desired method.
- methods for introducing therapeutic agents include, but are not limited to, liquid immersion, vacuum dessication, high pressure infusion, vapor loading, and the like.
- multiple therapeutic agents may be introduced into a porous matrix composed of a plurality of porous layer 23.
- the plurality of porous layers may vary in atomic composition, as well as in pore size and density. Compositional variations may allow for preferential binding to occur between the therapeutic agent and the coating, changing the elution kinetics of the agent. Pore size and density will also affect the transport kinetics of therapeutics from and across each layer.
- live cells may be encapsulated within lumen 26 of device 20.
- the entire device may be made porous (such that the internal lumen and the exterior of the device are separated by a porous layer). Live cells
- a protective layer or coating may be formed or added to medical device 20, such as a titanium, gold or platinum layer or coating. If there is a concern that porous layer 23 may not be biocompatible, a passivation layer may be deposited into porous layer 23 to enhance biocompatibility. For instance, a very thin layer of gold may be electroplated into the dealloyed porous layer 23.
- Electroless deposition may also be used to achieve the same effect.
- the porous coating may also be passivated chemically or in a reactive ion plasma.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03786730A EP1572032B1 (en) | 2002-11-13 | 2003-11-12 | Medical devices having porous layers and methods for making same |
AU2003295535A AU2003295535B2 (en) | 2002-11-13 | 2003-11-12 | Medical devices having porous layers and methods for making same |
JP2004552227A JP2006514848A (en) | 2002-11-13 | 2003-11-12 | Medical device having porous layer and method for producing the same |
CA002503625A CA2503625A1 (en) | 2002-11-13 | 2003-11-12 | Medical devices having porous layers and methods for making same |
DE60322581T DE60322581D1 (en) | 2002-11-13 | 2003-11-12 | MEDICAL DEVICES WITH POROUS LAYERS AND MANUFACTURING METHOD THEREFOR |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US42610602P | 2002-11-13 | 2002-11-13 | |
US60/426,106 | 2002-11-13 |
Publications (2)
Publication Number | Publication Date |
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WO2004043292A2 true WO2004043292A2 (en) | 2004-05-27 |
WO2004043292A3 WO2004043292A3 (en) | 2005-02-10 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/US2003/036451 WO2004043292A2 (en) | 2002-11-13 | 2003-11-12 | Medical devices having porous layers and methods for making same |
Country Status (10)
Country | Link |
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US (2) | US7294409B2 (en) |
EP (1) | EP1572032B1 (en) |
JP (1) | JP2006514848A (en) |
KR (1) | KR100826574B1 (en) |
CN (1) | CN1725988A (en) |
AT (1) | ATE402675T1 (en) |
AU (1) | AU2003295535B2 (en) |
CA (1) | CA2503625A1 (en) |
DE (1) | DE60322581D1 (en) |
WO (1) | WO2004043292A2 (en) |
Cited By (18)
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WO2006020742A2 (en) | 2004-08-13 | 2006-02-23 | Setagon, Inc. | Medical devices having nanoporous layers and methods for making the same |
WO2006068838A2 (en) * | 2004-12-09 | 2006-06-29 | Boston Scientific Scimed, Inc. | Medical devices having nanostructured regions |
WO2006069677A2 (en) * | 2004-12-30 | 2006-07-06 | Cinvention Ag | Combination comprising an agent providing a signal, an implant material and a drug |
WO2007031972A1 (en) * | 2005-09-16 | 2007-03-22 | Debiotech S.A. | Reinforced porous coating |
EP1765219A1 (en) * | 2004-05-28 | 2007-03-28 | Boston Scientific Limited | Medical devices composed of porous metallic materials for delivering biolgically active materials |
US7208172B2 (en) | 2003-11-03 | 2007-04-24 | Medlogics Device Corporation | Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices |
EP1779816A2 (en) | 2005-11-01 | 2007-05-02 | Nitinol Development Corporation | Stent with thin drug-eluting film |
WO2007148240A2 (en) * | 2006-05-17 | 2007-12-27 | Debiotech S.A. | Anisotropic nanoporous coatings for medical implants |
WO2008018024A2 (en) * | 2006-08-08 | 2008-02-14 | Debiotech S.A. | Porous coating incorporating fluid reservoirs |
EP1891988A1 (en) * | 2006-08-07 | 2008-02-27 | Debiotech S.A. | Anisotropic nanoporous coatings for medical implants |
WO2008034007A2 (en) * | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Medical devices |
WO2008073774A1 (en) * | 2006-12-08 | 2008-06-19 | Evident Technologies | Systems and methods for detecting infrared emitting composites and medical applications therefor |
US7713573B2 (en) | 2002-11-13 | 2010-05-11 | Medtronic Vascular, Inc. | Method for loading nanoporous layers with therapeutic agent |
US7776379B2 (en) | 2001-09-19 | 2010-08-17 | Medlogics Device Corporation | Metallic structures incorporating bioactive materials and methods for creating the same |
US7901451B2 (en) | 2004-09-24 | 2011-03-08 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
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Also Published As
Publication number | Publication date |
---|---|
EP1572032A2 (en) | 2005-09-14 |
AU2003295535B2 (en) | 2007-12-20 |
US20060271169A1 (en) | 2006-11-30 |
KR20050065643A (en) | 2005-06-29 |
KR100826574B1 (en) | 2008-04-30 |
DE60322581D1 (en) | 2008-09-11 |
ATE402675T1 (en) | 2008-08-15 |
JP2006514848A (en) | 2006-05-18 |
US20040148015A1 (en) | 2004-07-29 |
EP1572032A4 (en) | 2006-01-04 |
WO2004043292A3 (en) | 2005-02-10 |
EP1572032B1 (en) | 2008-07-30 |
AU2003295535A1 (en) | 2004-06-03 |
CN1725988A (en) | 2006-01-25 |
US7294409B2 (en) | 2007-11-13 |
CA2503625A1 (en) | 2004-05-27 |
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