WO2004043995A3 - Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine - Google Patents
Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine Download PDFInfo
- Publication number
- WO2004043995A3 WO2004043995A3 PCT/CA2003/001744 CA0301744W WO2004043995A3 WO 2004043995 A3 WO2004043995 A3 WO 2004043995A3 CA 0301744 W CA0301744 W CA 0301744W WO 2004043995 A3 WO2004043995 A3 WO 2004043995A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alanine
- tyrosine
- lysine
- polypeptide
- glutamate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003283152A AU2003283152A1 (en) | 2002-11-13 | 2003-11-13 | Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine |
EP03775017A EP1565486A2 (en) | 2002-11-13 | 2003-11-13 | Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2,411,786 | 2002-11-13 | ||
CA002411786A CA2411786C (en) | 2002-11-13 | 2002-11-13 | A process for the preparation of polypeptides from n-carboxyanhydrides of amino acids |
US10/326,994 US7049399B2 (en) | 2002-11-13 | 2002-12-24 | Process for the preparation of polypeptide 1 |
US10/326,994 | 2002-12-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004043995A2 WO2004043995A2 (en) | 2004-05-27 |
WO2004043995A3 true WO2004043995A3 (en) | 2004-10-07 |
Family
ID=32313425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2003/001744 WO2004043995A2 (en) | 2002-11-13 | 2003-11-13 | Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1565486A2 (en) |
AU (1) | AU2003283152A1 (en) |
WO (1) | WO2004043995A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9402874B2 (en) | 2009-08-20 | 2016-08-02 | Yeda Research & Development Co., Ltd. | Low frequency glatiramer acetate therapy |
US9499868B2 (en) | 2011-10-10 | 2016-11-22 | Teva Pharmaceutical Industries, Ltd. | Determination of single nucleotide polymorphisms useful to predict response for glatiramer acetate |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1308683C (en) | 2001-12-04 | 2007-04-04 | 特瓦制药工业有限公司 | Process for the measurement of the potency of glatiramer acetate |
WO2006029411A2 (en) * | 2004-09-09 | 2006-03-16 | Yeda Research And Development Co. Ltd. | Mixtures of polypeptides, compositions containing and processes for preparing same, and uses thereof |
EP1799703B1 (en) * | 2004-09-09 | 2010-01-06 | Teva Pharmaceutical Industries Ltd | Process for preparation of mixtures of polypeptides using purified hydrobromic acid |
ES2331015T3 (en) * | 2004-10-29 | 2009-12-18 | Sandoz Ag | PROCESS FOR THE PREPARATION OF A GLATIRAMERO. |
AU2006211510B8 (en) * | 2005-02-02 | 2011-04-21 | Teva Pharmaceutical Industries, Ltd. | Process for producing polypeptide mixtures using hydrogenolysis |
ES2338488T3 (en) * | 2006-07-05 | 2010-05-07 | Momenta Pharmaceuticals, Inc. | IMPROVED PROCESS FOR THE PREPARATION OF COPOLIMERO-1. |
ES2477232T5 (en) | 2007-06-21 | 2017-11-23 | Momenta Pharmaceuticals, Inc. | Copolymer Analysis |
CA2705046C (en) | 2007-07-31 | 2015-03-03 | Natco Pharma Limited | Process for the preparation glatiramer acetate (copolymer-1) |
EP2277050B2 (en) | 2008-04-16 | 2022-09-28 | Momenta Pharmaceuticals, Inc. | Analysis of amino acid copolymer compositions |
USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
US8759302B2 (en) | 2010-03-16 | 2014-06-24 | Teva Pharmaceutical Industries, Ltd. | Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis |
EP2627669B1 (en) | 2010-10-11 | 2016-08-17 | Teva Pharmaceutical Industries Ltd. | Cytokine biomarkers as predictive biomarkers of clinical response for glatiramer acetate |
WO2013009885A2 (en) | 2011-07-11 | 2013-01-17 | Momenta Pharmaceuticals, Inc. | Evaluation of copolymer diethylamide |
CN110382052A (en) | 2017-03-26 | 2019-10-25 | Mapi医药公司 | The copaxone store system of multiple sclerosis for therapeutic advance type form |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3849550A (en) * | 1971-04-21 | 1974-11-19 | Yeda Res & Dev | Therapeutic copolymer |
-
2003
- 2003-11-13 AU AU2003283152A patent/AU2003283152A1/en not_active Abandoned
- 2003-11-13 WO PCT/CA2003/001744 patent/WO2004043995A2/en not_active Application Discontinuation
- 2003-11-13 EP EP03775017A patent/EP1565486A2/en not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3849550A (en) * | 1971-04-21 | 1974-11-19 | Yeda Res & Dev | Therapeutic copolymer |
Non-Patent Citations (3)
Title |
---|
EPTON R ET AL: "CATALYTIC TRANSFER HYDROGENATION OF POLY(ACRYLOYLMORPHOLINE)-BASED PEPTIDE-RESIN ASSEMBLIES AND OF DERIVED PEPTIDE SEGMENTS", POLYMER OCT 1982, vol. 23, no. 11, October 1982 (1982-10-01), pages 1685 - 1687, XP001180305 * |
FELIX A M ET AL: "RAPID REMOVAL OF PROTECTING GROUPS FROM PEPTIDES BY CATALYTIC TRANSFER HYDROGENATION WITH 1 4 CYCLO HEXADIENE", JOURNAL OF ORGANIC CHEMISTRY, vol. 43, no. 21, 1978, pages 4194 - 4196, XP002273767, ISSN: 0022-3263 * |
GOWDA D CHANNE ET AL: "Heterogeneous catalytic transfer hydrogenation in peptide synthesis.", LETTERS IN PEPTIDE SCIENCE, vol. 9, no. 4-5, 2002, pages 153 - 165, XP009027879, ISSN: 0929-5666 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9402874B2 (en) | 2009-08-20 | 2016-08-02 | Yeda Research & Development Co., Ltd. | Low frequency glatiramer acetate therapy |
US9499868B2 (en) | 2011-10-10 | 2016-11-22 | Teva Pharmaceutical Industries, Ltd. | Determination of single nucleotide polymorphisms useful to predict response for glatiramer acetate |
Also Published As
Publication number | Publication date |
---|---|
WO2004043995A2 (en) | 2004-05-27 |
AU2003283152A8 (en) | 2004-06-03 |
EP1565486A2 (en) | 2005-08-24 |
AU2003283152A1 (en) | 2004-06-03 |
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