WO2004045487A2 - Dry powder inhaler - Google Patents
Dry powder inhaler Download PDFInfo
- Publication number
- WO2004045487A2 WO2004045487A2 PCT/IN2003/000362 IN0300362W WO2004045487A2 WO 2004045487 A2 WO2004045487 A2 WO 2004045487A2 IN 0300362 W IN0300362 W IN 0300362W WO 2004045487 A2 WO2004045487 A2 WO 2004045487A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- blister
- dry powder
- powder inhaler
- medicament
- blister pack
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
Definitions
- the present invention relates to a dry powder inhaler for delivery of medicaments in solid, finely divided form to a patient by oral inhalation.
- the present invention provides a compact, easy to carry and use, dry powder inhaler with means for dispensing a large number of doses of the medicament.
- Dry powder inhalers are known in the prior art. Many of the dry powder inhalers are known and marketed. Some of the marketed dry powder inhalers described in prior art include Spinhaler (United States Patent No. 5,239,991), Rotahaler (United States Patent Nos. 4,210,140 and 4,206,758), Turbuhaler (United States Patent Nos. 4,524,769, 4,907,583, 4,668,218) and Diskhaler (United States Patent Nos. 4,811,731, 5,035,237) among the many others. Information about dry powder inhalers and formulations used therein is found in the art, for example textbooks like 'Particulate Interactions in Dry Powder Formulations for Inhalations" by Xian Zeng, Gary Martin and Christopher Marriott.
- United States Patent Nos. 4,811,731 (assigned to Glaxo Group Limited) and 5,035,237 relate to a diskhaler kind of a dry powder inhaler for administering medicaments in solid finely divided form to patients
- the dry powder inhaler comprises a housing, a tray mounted in the housing which is movable between first and second positions relative to the housing, a rotatable support disk provided on the tray and adapted to receive a carrier provided with the medicament container.
- a plunger is operable to penetrate a container registered therewith to open the container to a pathway leading to an inhalation mouthpiece.
- This device uses a blister pack with 8 blisters in a single circular row of blisters and thus can accommodate a single medicament pack containing 8 doses only.
- a pair of identical inhalation devices arranged back to back, which may become bulky.
- the present invention provides a dry powder inhaler for administering medicaments in solid finely divided form to patients, wherein the dry powder inhaler is in the form of a diskhaler comprising a disk shaped rotatable support and an annular blister pack containing atleast 30 blister medicament units.
- the present invention provides a dry powder inhaler for administering medicaments in solid finely divided form to patients, comprising a) a bottom unit, b) a rotatable support provided on, the bottom unit, c) an annular blister pack mounted on the rotatable support wherein the annular blister pack comprises a plurality of blister medicament units arranged in two concentric rings of blister medicament units, d) a top cover comprising a movable slider puncture pin assembly, said movable slider puncture pin assembly comprising a puncture pin and means for,
- the dry powder inhaler of the present invention is illustrated by embodiments described here in below.
- Figures 1A, IB, 1C, ID, IE and IF are the top view, bottom view, section A-A view, top isometric view, bottom isometric view and side view, respectively of the annular ring blister pack holding 30 + 30 medicament doses;
- Figures 2A, 2B show the assembly of the dry powder inhaler;
- Figures 3 is the exploded view of the dry powder inhaler
- Figures 4A, 4B, 4C are the cut section views of the dry powder inhaler
- Figures 5A, 5B, 5C, 5D are variations of scored formation of turbulence elements in the passageway connecting the air inlet hole to the air outlet hole in the mouthpiece;
- Figures 6A, 6B show the puncture pin slider position to puncture blister medicament units 0-30 in the first ring;
- Figures 6C, 6D show the puncture pin slider position to puncture blister medicament units 31-60 in the second ring;
- Figures 7A, 7B, 7C, 7D, 7E show the puncture pin slider lock positions with respect to the blister pack
- Figure 7A shows the blister pack in the position wherein blister medicament unit number 1 is to be punctured
- Figure 7B shows the blister pack indexed to medicament unit number 2
- Figure 7C shows the blister pack when it has reached the 30 th blister medicament unit in the first ring
- Figure 7D shows the position of the puncture pin slider with respect to the blister pack when the blister medicament unit number 31 is ready to be punctured
- Figure 7E shows the blister pack indexed to medicament unit number 32
- Figures 8A, 8B, 8C are the top isometric, bottom isometric and side views of the puncture pin slider assembly, respectively;
- Figures 9 A, 9B show the slider positions in the top cover for the 0-30 position and 0-31 position, respectively
- Figure 10A shows the exploded view of the rotatable support and the bottom unit
- Figures 10B and 10C are the horizontal section view and the vertical section view respectively showing the unidirectional ratchet assembly for the rotatable support with respect to the bottom unit
- Figure 11 shows the top views of a preferred embodiment of the inhaler of present invention
- Figures 12 and 13 show the internal view of the preferred embodiment of figure 11.
- Figure 14 shows the top view of the '16+16 inline' annular blister pack.
- Figure 15 shows the top view of the ' 16+16 staggered' annular blister pack.
- Figure 16 shows the top view of the '32+32 inline' annular blister pack.
- Figure 17 shows the top view of the '32+32 staggered' annular blister pack.
- Figure 1 1 annular blister pack
- annular blister pack 3 circular holes in annular blister pack for alignment pin
- bottom unit 11 rotatable support for receiving the annular blister pack
- mouthpiece 22 medicament hole for medicament unit in first ring of annular blister pack
- Figure 7 1 annular blister pack
- movable slider puncture pin assembly 16 counter window to show number of medicament unit being consumed
- bottom unit 11 rotatable support for receiving the annular blister pack
- the slider puncture pin assembly is provided with means comprising a slider lock pin (32), a puncture pin (31) and an optional ratchet lever (40).
- the annular blister pack (01) has a plurality of blister medicament units containing the specified amount of a medicament.
- a plurality of blister medicament units are arranged in two concentric rings around the blister pack. Different numbers of blister medicament units, different configurations of the two rings of the blister pack and different diameter of the blister pack are possible as described herein.
- the Figures 1A to IF give an annular blister pack used in a preferred embodiment of the invention, wherem the annular ring blister pack holds 30+30 medicament units in the first and second concentric rings where the medicament units in the first and second ring are in an in-line arrangement as shown in the Figures.
- the first ring (06) and the second ring (07) each contain 30 blister medicament units in-line with each other and the outer diameter of the blister pack is 67.5 mm.
- Each blister on the blister pack is numbered (02) to indicate the number of the medicament being consumed.
- the medicament number on the blister pack or a suitable visible element of the blister pack or the rotatable support may be colored red in the region from blister medicament units 50 to 60 in order to give an indication to the patient that only the last ten doses are remaining in the blister pack.
- the movable slider puncture pin assembly is positioned in a first position (see Figures 6A, 6B, 7A and 9A) to register the puncture pin with blister medicament units in first concentric ring for rupturing successively the medicament units, prevented by the slider lock pin (32) abutting the annular blister pack, from moving from the first position (see Figure 7A) until blister medicament units in first concentric ring are exhausted, thereafter, positioned in a second position when the slider lock pin (32) moves inwards and upwards on an inclined plane on the top cover to be engaged with the notch (05) in the blister pack (see Figures 7C & 7D), to register the puncture pin with blister medicament units in second concentric ring and rupturing successively the medicament units (see Figures 6C, 6D, 7E and 9B).
- the slider lock pin assembly is prevented from moving from the second position by means of ratchet lever (40) until blister medicament units in second concentric ring are exhausted (see Figures 8 A and 9B).
- the ratchet lever means is optional and may not be necessary in all designs. In embodiments where the inhaler has a robust design, the ratchet lever is not essential. In such embodiments the slider puncture pin assembly registered with the blister medicament units in the second ring of the annular blister pack cannot be easily moved back to the first ring of the blister pack due to lesser degree of freedom of movement of the slider puncture pin assembly due to such a design of the slider puncture pin assembly as well as due to the operational friction forces.
- first concentric ring is the outer ring and the second concentric ring is the inner ring of the blister pack.
- outer and inner refer to direction when moving from the boundary to the center, of the blister pack.
- FIG 7A illustrates the direction of indexing (38) for blister pack having numbered blister medicament units (39).
- the bottom unit (10) comprises a mouthpiece (21) and a mouthpiece cap (08).
- the rotatable support (11) is mounted on the tray of the bottom unit, which comprises an air inlet hole (13) and a ratchet (24) (see Figures 3, 10A and 10C) for the unidirectional rotation of the mounted blister pack support.
- the bottom unit also contains the medicament hole (22 and 23) through which medicament from the ruptured blister medicament unit in the first ring or second ring in the blister pack empties into the passageway connecting the air inlet hole to the air outlet hole in the mouthpiece. When not in use, the mouthpiece is covered by the mouthpiece cap.
- the air inlet hole is connected to a passageway (27) and the air flow (28) generated by the inhalation by the patient carries the medicament (29) via the air outlet means in the mouthpiece into the respiratory tract of the patient.
- the angle of the air inlet hole passage may be from 45° to 135°. It is preferred that the angle is greater than 90°. Angle used in the more preferred embodiment is 106.5°.
- the blister medicament units are located between the air inlet hole and the mouthpiece, hi alternate embodiments, the air inlet hole(s) are located between the two rings of the blister medicament units or between the blister medicament unit and the mouthpiece opening or outlet.
- the wall of the passageway leading into the air outlet hole can have various configurations of the scored formations of the turbulence elements.
- the scored formation acts to add turbulence to the medicament entrained in the air stream.
- the formation may be in the form of protrusions or projections of various shapes, for example, spiral, single or multiple ribs, linear, helical, circular, cone, wedge, rectangular and the like.
- the formation can also be in the form of depressions or dimples of various shapes, for example, spiral, linear, helical, circular, cone, wedge, rectangular and the like.
- Figures 5 A to 5D show different configurations of the scored formations of the turbulence elements on the wall of the passageway connecting the air inlet hole to the air outlet hole on the mouthpiece.
- the rotatable support (11) comprises a plurality of circular holes or depressions along the circumference of the disk arranged in two concentric rings, corresponding to the blister medicament units of the blister pack in order to receive the blister medicament units of the annular blister pack.
- the rotatable support may have elevations/projections called as alignment pins, which can fit into the corresponding holes in the blister pack such that the blister pack gets aligned with the rotatable support in precise manner and register the blister precisely with the puncture pin.
- the alignment pins may be circular (25) or rectangular (26) in shape.
- the rotatable support is provided with a means for unidirectional movement, which comprises a ratchet lever (43) for associating with the ratchet (24) of the bottom unit as can be seen from Figures 10A to IOC.
- Cavity (44) in the rotatable support allows ratchet lever (43) to flex outwards to enable unlocking from ratchet (24) upon rotation and then flex back into the next available ratchet (24) for locking into the next position.
- the proper registering of the ratchet lever of the support with ratchet (24) of the bottom unit allows locking of the rotatable support into its position and the shape of the ratchet and the ratchet lever allows only unidirectional movement of the support in the anti clockwise direction.
- the direction for movement of the rotatable support is in anti clockwise direction (12), as can be seen from Figures 2A and 10A.
- a click sound indicates that the next blister of the blister pack is in proper registration with the puncture pin.
- a spring mechanism can be used for the rotational movement of the rotatable support.
- the top cover On the top of the blister pack is the top cover (09).
- a numerical indexing means in the form of a counter window (16) in the top cover to show the numerical on the annular blister pack in order to see the number of the medicament unit being consumed.
- FIG. 7 A shows the number one when the puncture pin assembly is registered with the first blister of the first ring of the blister pack.
- Figures 7b and 7C show the advancement of the number in the counter window with advancement of the rotatable support.
- Figure 7D shows the counter window showing the number thirty-one corresponding to the first blister medicament unit of the second ring of the blister pack.
- the counter window may show only the number of the blister medicament unit which is registered with the slider and puncture pin assembly or it may show the numbers of the blister medicament units in both the first and second ring of the blister pack with which the slider and puncture pin assembly is registered with.
- the counter window and the numbering means are designed for the easy visibility to the patient of the number of the blister medicament unit on the blister pack being consumed.
- the further advancement of the counter window number along with the puncture pin assembly can be seen in Figure 7E.
- a slider (15) having a position marker (35) on it, in order to shift the position of the puncture pin from the first ring of the blister pack to the second ring.
- the slider can be moved in one direction (17) only and can be positioned such that the puncture pin is in a position (18) to puncture the first ring of the blister pack initially and later in a position (19) to puncture the second ring of the blister pack.
- the slider contains a slider lock pin (32), a ratchet lever (40) for non-return delivery and a puncture pin (31) set at an angle so as to puncture the blister at the center and a cover (41) for the slot.
- the slider is moved in unidirectional way (30) after 1 to 30 numbered blister medicament units in the first ring of the blister pack have been consumed to take it into a position to puncture 31 to 60 numbered blister medicament units in the second ring of the blister pack.
- Figures 6 A and 6B illustrate the puncture pin slider assembly position (33) ready to puncture 1 to 30 numbered blister medicament units in the first ring of the blister pack, starting with blister medicament unit 1. After puncture of the blister unit, the medicament falls (36) into the passageway from the first ring of the blister pack.
- Figures 6C and 6D illustrate the puncture pin slider assembly position (34) ready to puncture 31 to 60 numbered blister medicament units in the second ring of the blister pack, starting with blister medicament unit 31.
- the movable slider pin assembly is moved to the second ring position, it is in a non-return position (34) due to the locking of the ratchet lever (40) provided on the movable slider puncture pin assembly with a ratchet lock (42) provided in the top cover of the dry powder inhaler as can be seen from Figure 9B.
- the medicament falls (37) into the passageway from the second ring of the blister pack.
- the patient loads the blister pack in the dry powder inhaler.
- the slider pin counter window (16) will show the blister number 1 of the first ring to be in position with the puncture pin as illustrated in Figure 7A. He removes the mouth cap, holds the mouthpiece in his mouth, presses the cut in top cover (14) in order to depress the puncture pin and puncture the blister and inhales. The pressing of the top cover depresses the angled puncture pin in the blister so as to puncture the associated blister in the center of the bottom. This makes available the full dose of the medicament in a reproducible manner in the passageway and passes into the mouthpiece of the dry powder inhaler.
- the air inlet hole (13) When the patient inhales, the air enters through the air inlet hole (13) and passes out through the mouthpiece having entrained medicament therein.
- the rotatable support (11) In order to shift to the next blister, he moves the rotatable support (11) in an anti clock wise direction till a click sound is heard. This operation is continued till the 30 th blister is reached and punctured.
- the slider lock pin (32) moves inwards and upwards along an inclined plane on the top cover and gets engaged with the notch (5) in the blister pack.
- the patient In order to go to the second ring of blister medicament units, the patient has to slide the slider in the direction (30) permitted so that the slider lock pin moves inwards and upwards on an inclined plane along the notch.
- the puncture pin is registered with the first medicament blister unit of the second ring of blister medicament units of the annular blister pack and the ratchet lever (40) in the movable slider puncture pin assembly becomes firmly locked against the ratchet lock (42) in the top cover of the inhaler to prevent any further movement.
- the slider is now non retractable due to the locking of the ratchet lever and ratchet lock, so as to prevent any non-return movement of the slider back to the first ring.
- the slider puncture pin assembly does not return to the first ring due to the less freedom of movement of the slider assembly unit as well as due to the frictional forces.
- FIG. 11, 12 and 13 illustrate a preferred embodiment of the dry powder inhaler of the present invention.
- a stopper ring (45) in the rotatable support. This stopper ring acts as a means to prevent the slider puncture pin assembly from moving from the first ring of blister medicament units to the second ring of the blister medicament units on the blister pack till all the blister medicament units on the first ring of the blister pack are consumed.
- the slider puncture pin assembly In addition to the stopper ring (45) present on the rotatable support as shown in figure 12 A, there is also a provided a projection on the slider puncture pin assembly which projects on to the rotatable support and just touches the stopper ring, when the slider puncture pin assembly is in the first ring of the annular blister pack (not shown).
- the slider puncture pin assembly can only be moved along the first ring to consume the blister medicament units along the first ring of the blister pack, but cannot be moved to the second ring as the projection provided on the slider puncture pin assembly is obstructed by the stopper ring.
- the movable slider puncture pin assembly can only be moved from the first ring of the blister medicament units to the second ring of the blister medicament units, when all the blister medicament units in the first ring are consumed, and the projection provided on the slider puncture pin assembly encounters a break provided in the stopper ring which coincides with the notch provided in the blister pack, so as to allow the projection provided on the movable slider pin assembly to move inwards and upwards on an inclined plane on the top cover, beyond the stopper ring while simultaneously the slider lock pin of the slider pin assembly also moves inwards and upwards on the inclined plane on the top cover to engage with the notch, so that the puncture pin is now registered with the first blister medicament unit of the second ring of the annular blister pack.
- FIG 12 A Two of the pins are seen in figure 12 A.
- One pin (not shown) engages with the holes in the rotatable support from beneath.
- Another pin is activated by the serrations on the periphery of the roiatable support.
- the third pin is activated by the top cover when the puncture pin assembly is pressed to consume a blister unit.
- a pin of the interlock engages with the rotatable support from beneath and prevents it from moving ahead.
- the interlock is activated, by which the lower pin releases itself from the rotatable support and now it can be moved ahead.
- the inhaler of this embodiment has the preferred spiral configuration (48) of scored formation of the turbulence elements on the passageway connecting the air inlet hole to air outlet hole in the mouthpiece as seen in figures 13A and 13B.
- a spring assembly is used in combination with the stopper ring and the projection provided on the slider puncture pin assembly which projects on to the rotatable support.
- the blister pack has 30 blister medicament units in the first ring and 30 blister medicament units in the second ring of the annular blister pack, in line with each other (denoted as 30+30 inline) and the outer diameter of the blister pack is 67.5 mm.
- Different configurations of the two rings of the blister pack and different number of the blister medicament units on the blister pack are also possible and may be encompassed in the scope of the invention.
- the thirty blister medicament units in the first ring and thirty blister medicament units in the second ring may be staggered or out of line with each other (denoted as 30+30 staggered).
- Some other configurations of the blister pack which may be used in the present invention include 16 blister medicament units in each of the first and second concentric rings of the blister pack which are either in line with each other (denoted as 16+16 inline) or which are staggered or not in line with each other (denoted as 16+16 staggered); or 32 blister medicament units in each of the first and second concentric rings of the blister pack which are either in line with each other (denoted as 32+32 inline) or which are staggered or not in line with each other (denoted as 32+32 staggered).
- Figure 14 illustrates an embodiment of a blister pack having 16 blister medicament units in each of the first and second concentric rings of the blister pack, which are in line with each other.
- Figure 15 illustrates another embodiment of a blister pack having 16 blister medicament units in each of the first and second concentric rings of the blister pack, which are staggered or out of line with each other.
- Figure 16 illustrates another embodiment of a blister pack having 32 blister medicament units in each of the first and second concentric rings of the blister pack, which are in line with each other.
- Figure 17 illustrates yet another embodiment of a blister pack having 32 blister medicament units in each of the first and second concentric rings of the blister pack, which are staggered or out of line with each other. h all the figures 14 to 17, the 0 symbol indicates the diameter in mm while the rest of the numbers are the lengths in mm.
- the dry powder inhaler of the invention is disposable and has to be replaced with a new device when all the blister medicament units of the annular blister pack are exhausted.
- the dry powder inhaler of the invention is reusable and the exhausted annular blister pack with the two rings of blister medicament units can be replaced with a fresh annular blister pack with two rings of blister medicament units.
- the slider puncture pin assembly is pulled back to the outer first ring position in order to register with the first blister medicament unit of the first ring of the fresh annular blister pack.
- an additional air inlet hole located on the slider puncture pin assembly, leading into the punctured blister medicament unit.
- This hole is located around the puncture pin and leads into the punctured blister medicament unit and into the medicament hole.
- the main air inlet hole (13) located on the top cover is absent and only the air inlet hole on the slider puncture pin assembly is present. The air inlet hole on the slider puncture pin assembly serves to directly entrain the medicament still remaining in the punctured blister medicament unit and making available more of the medicament to the patient.
- any one or all the components of the dry powder inhaler can be made photo luminescent to enable the patient to access the inhaler even in darkness.
- the various components of the dry powder inhaler can be made transparent or translucent in order to make easy the visualization of the blister medicament units used or unused.
- a "soft feel" material can be incorporated in any of the components of the dry powder inhaler preferably the sides of the device where the patient grips the dry powder inhaler in order to administer a dose.
- the "soft feel” material used may be a TPE (Thermoplastic elastomer) with a shore hardness of about 30 to about 50.
- the medicament dose number on the blister pack of doses 50 to about 60 may be in red color to remind the patient of the near exhaustion of the doses in the blister pack.
- the annular blister pack used in the dry powder inhaler of the invention can be made of any suitable material known in the art.
- the forming film of the blister may be made from polyvinyl chloride (PVC), polyvinylidene chloride (PVDC) coated PVC, PVC/chlorotrifluoroethylene (CTFE) films, polypropylene (PP), polystyrene (PS), oriented polyamide (OPA)/aluminum PVC laminates and the like.
- the lidding material used in the blister may be aluminum foil or its combination with paper and/or polyester (PET) and the like.
- the dry powder inhaler can be made of inert metal or reinforced plastics and synthetic polymeric material.
- the mouthpiece of the dry powder inhaler may be made of any moldable or formed plastic and may be of a suitable size and shape.
- the dry powder inhaler may optionally have secondary air inlet holes located on the top or bottom or the sides of the mouthpiece in order to achieve an optimum balance of fine particle fraction of the medicament available to the patient and the resistance of the device, in order to be therapeutically effective as well as convenient for use to the patient.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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CA002506866A CA2506866A1 (en) | 2002-11-20 | 2003-11-20 | Dry powder inhaler |
MXPA05005402A MXPA05005402A (en) | 2002-11-20 | 2003-11-20 | Dry powder inhaler. |
AU2003302078A AU2003302078A1 (en) | 2002-11-20 | 2003-11-20 | Dry powder inhaler |
BR0316428-4A BR0316428A (en) | 2002-11-20 | 2003-11-20 | Dry Powder Inhaler |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1010MU2002 | 2002-11-20 | ||
IN1010/MUM/2002 | 2002-11-20 |
Publications (2)
Publication Number | Publication Date |
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WO2004045487A2 true WO2004045487A2 (en) | 2004-06-03 |
WO2004045487A3 WO2004045487A3 (en) | 2005-01-27 |
Family
ID=34074056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2003/000362 WO2004045487A2 (en) | 2002-11-20 | 2003-11-20 | Dry powder inhaler |
Country Status (5)
Country | Link |
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AU (1) | AU2003302078A1 (en) |
BR (1) | BR0316428A (en) |
CA (1) | CA2506866A1 (en) |
MX (1) | MXPA05005402A (en) |
WO (1) | WO2004045487A2 (en) |
Cited By (12)
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WO2007012861A1 (en) * | 2005-07-27 | 2007-02-01 | Cambridge Consultants Limited | Canister-supported gauge-type count readout assembly for a metered dose inhaler |
US7318436B2 (en) | 2000-05-10 | 2008-01-15 | Innovative Devices, Llc | Medicament container with same side airflow inlet and outlet and method of use |
US20090173345A1 (en) * | 2006-04-13 | 2009-07-09 | Boehringer Ingelheim International Gmbh | Medicine Dispensation Device |
EP2100634A3 (en) * | 2006-09-26 | 2009-09-23 | von Schuckmann, Alfred | Dispenser for powder compounds |
WO2010036836A1 (en) * | 2008-09-26 | 2010-04-01 | Oriel Therapeutics, Inc. | Dry powder inhalers with dual piercing members and related devices and methods |
WO2010039201A2 (en) * | 2008-09-30 | 2010-04-08 | Oriel Therapeutics, Inc. | Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods |
US7931022B2 (en) | 2001-10-19 | 2011-04-26 | Respirks, Inc. | Method and apparatus for dispensing inhalator medicament |
EP2328645A2 (en) * | 2008-10-01 | 2011-06-08 | Oriel Therapeutics, Inc. | Dry powder inhalers with rotating piercing mechanisms and related devices and methods |
EP2346554A2 (en) * | 2008-09-26 | 2011-07-27 | Oriel Therapeutics, Inc. | Inhaler mechanisms with radially biased piercers and related methods |
WO2013068579A1 (en) * | 2011-11-12 | 2013-05-16 | Markus Mezger | Inhaler |
EP2231240B1 (en) * | 2008-01-24 | 2017-11-08 | Boehringer Ingelheim International GmbH | Inhaler |
US10493222B2 (en) | 2008-09-26 | 2019-12-03 | Oriel Therapeutics, Inc. | Dry powder dose container assemblies and related inhalers |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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USD641076S1 (en) | 2010-03-26 | 2011-07-05 | Oriel Therapeutics, Inc. | Dry powder inhaler |
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GB2264237A (en) * | 1992-02-05 | 1993-08-25 | Robert Edward Newell | An inhaler |
EP1106196A2 (en) * | 1999-12-10 | 2001-06-13 | Unisia Jecs Corporation | Inhalant medicator |
US6328034B1 (en) * | 1996-07-22 | 2001-12-11 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
WO2002024263A2 (en) * | 2000-09-19 | 2002-03-28 | Glaxo Group Limited | Inhalation device |
-
2003
- 2003-11-20 CA CA002506866A patent/CA2506866A1/en not_active Abandoned
- 2003-11-20 WO PCT/IN2003/000362 patent/WO2004045487A2/en not_active Application Discontinuation
- 2003-11-20 AU AU2003302078A patent/AU2003302078A1/en not_active Abandoned
- 2003-11-20 MX MXPA05005402A patent/MXPA05005402A/en unknown
- 2003-11-20 BR BR0316428-4A patent/BR0316428A/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2264237A (en) * | 1992-02-05 | 1993-08-25 | Robert Edward Newell | An inhaler |
US6328034B1 (en) * | 1996-07-22 | 2001-12-11 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
EP1106196A2 (en) * | 1999-12-10 | 2001-06-13 | Unisia Jecs Corporation | Inhalant medicator |
WO2002024263A2 (en) * | 2000-09-19 | 2002-03-28 | Glaxo Group Limited | Inhalation device |
Cited By (26)
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US7318436B2 (en) | 2000-05-10 | 2008-01-15 | Innovative Devices, Llc | Medicament container with same side airflow inlet and outlet and method of use |
US7931022B2 (en) | 2001-10-19 | 2011-04-26 | Respirks, Inc. | Method and apparatus for dispensing inhalator medicament |
WO2007012861A1 (en) * | 2005-07-27 | 2007-02-01 | Cambridge Consultants Limited | Canister-supported gauge-type count readout assembly for a metered dose inhaler |
US20090173345A1 (en) * | 2006-04-13 | 2009-07-09 | Boehringer Ingelheim International Gmbh | Medicine Dispensation Device |
US8944054B2 (en) * | 2006-04-13 | 2015-02-03 | Boehringer Ingelheim International Gmbh | Medicine dispensation device |
EP2100634A3 (en) * | 2006-09-26 | 2009-09-23 | von Schuckmann, Alfred | Dispenser for powder compounds |
EP2231240B1 (en) * | 2008-01-24 | 2017-11-08 | Boehringer Ingelheim International GmbH | Inhaler |
WO2010036836A1 (en) * | 2008-09-26 | 2010-04-01 | Oriel Therapeutics, Inc. | Dry powder inhalers with dual piercing members and related devices and methods |
US10493222B2 (en) | 2008-09-26 | 2019-12-03 | Oriel Therapeutics, Inc. | Dry powder dose container assemblies and related inhalers |
KR20110063560A (en) * | 2008-09-26 | 2011-06-10 | 오리엘 테라퓨틱스, 인크. | Dry powder inhalers with dual piercing members and related devices and methods |
EP2346554A2 (en) * | 2008-09-26 | 2011-07-27 | Oriel Therapeutics, Inc. | Inhaler mechanisms with radially biased piercers and related methods |
JP2012503530A (en) * | 2008-09-26 | 2012-02-09 | オリエル・セラピューティクス,インコーポレイテッド | Dry powder inhaler with dual piercing members and associated apparatus and method |
US9795749B2 (en) | 2008-09-26 | 2017-10-24 | Oriel Therapeutics, Inc. | Dry powder inhalers with dual piercing members and methods of operating same |
EP2346554A4 (en) * | 2008-09-26 | 2012-02-29 | Oriel Therapeutics Inc | Inhaler mechanisms with radially biased piercers and related methods |
KR101650075B1 (en) * | 2008-09-26 | 2016-08-22 | 오리엘 테라퓨틱스, 인크. | Dry powder inhalers with dual piercing members and related devices and methods |
AU2009296535B2 (en) * | 2008-09-26 | 2013-04-18 | Oriel Therapeutics, Inc. | Dry powder inhalers with dual piercing members and related devices and methods |
US8985103B2 (en) | 2008-09-26 | 2015-03-24 | Oriel Therapeutics, Inc. | Dry powder inhalers with dual piercing members |
JP2014138861A (en) * | 2008-09-26 | 2014-07-31 | Oriel Therapeutics Inc | Dry powder inhaler with dual piercing members, and related device and method |
WO2010039201A3 (en) * | 2008-09-30 | 2010-07-01 | Oriel Therapeutics, Inc. | Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods |
US9050427B2 (en) | 2008-09-30 | 2015-06-09 | Oriel Therapeutics, Inc. | Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods |
WO2010039201A2 (en) * | 2008-09-30 | 2010-04-08 | Oriel Therapeutics, Inc. | Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods |
US8646446B2 (en) | 2008-10-01 | 2014-02-11 | Oriel Therapeutics, Inc. | Dry powder inhalers with rotating piercing mechanisms and related devices and methods |
EP2328645A4 (en) * | 2008-10-01 | 2012-04-18 | Oriel Therapeutics Inc | Dry powder inhalers with rotating piercing mechanisms and related devices and methods |
JP2012504456A (en) * | 2008-10-01 | 2012-02-23 | オリエル・セラピューティクス,インコーポレイテッド | Dry powder inhaler with rotating piercing mechanism and associated apparatus and method |
EP2328645A2 (en) * | 2008-10-01 | 2011-06-08 | Oriel Therapeutics, Inc. | Dry powder inhalers with rotating piercing mechanisms and related devices and methods |
WO2013068579A1 (en) * | 2011-11-12 | 2013-05-16 | Markus Mezger | Inhaler |
Also Published As
Publication number | Publication date |
---|---|
MXPA05005402A (en) | 2005-08-03 |
WO2004045487A3 (en) | 2005-01-27 |
BR0316428A (en) | 2005-10-11 |
AU2003302078A1 (en) | 2004-06-15 |
CA2506866A1 (en) | 2004-06-03 |
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