WO2004045772A3 - Reaction vessels and reaction apparatus for use with such vessels - Google Patents

Reaction vessels and reaction apparatus for use with such vessels Download PDF

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Publication number
WO2004045772A3
WO2004045772A3 PCT/GB2003/005041 GB0305041W WO2004045772A3 WO 2004045772 A3 WO2004045772 A3 WO 2004045772A3 GB 0305041 W GB0305041 W GB 0305041W WO 2004045772 A3 WO2004045772 A3 WO 2004045772A3
Authority
WO
WIPO (PCT)
Prior art keywords
reaction
vessels
vessel
window
heating means
Prior art date
Application number
PCT/GB2003/005041
Other languages
French (fr)
Other versions
WO2004045772A2 (en
Inventor
James Howell
Ben Webster
Roderic Fuerst
Original Assignee
Biogene Ltd
James Howell
Ben Webster
Roderic Fuerst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogene Ltd, James Howell, Ben Webster, Roderic Fuerst filed Critical Biogene Ltd
Priority to AU2003286253A priority Critical patent/AU2003286253A1/en
Publication of WO2004045772A2 publication Critical patent/WO2004045772A2/en
Publication of WO2004045772A3 publication Critical patent/WO2004045772A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0332—Cuvette constructions with temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/523—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/15—Preventing contamination of the components of the optical system or obstruction of the light path
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00961—Temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/54—Heating or cooling apparatus; Heat insulating devices using spatial temperature gradients
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/16—Making multilayered or multicoloured articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0003—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds having particular electrical or magnetic properties, e.g. piezoelectric
    • B29K2995/0005—Conductive
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0003—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds having particular electrical or magnetic properties, e.g. piezoelectric
    • B29K2995/0007—Insulating
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/15—Preventing contamination of the components of the optical system or obstruction of the light path
    • G01N2021/158—Eliminating condensation

Abstract

A reaction vessel (10), typically a microtitre vessel. incorporating heating means (13) for effecting the reaction and having a lid (20) with a window (22) for enabling interrogation of the contents of the vessel (10), the arrangement being such that the heating means (13) also operates to ensure that the window (22) is kept vapour-free. Apparatus within which such reaction vessels are stationed during the reaction has an array of thermopile sensors (52) for measuring vessel temperature.
PCT/GB2003/005041 2002-11-19 2003-11-19 Reaction vessels and reaction apparatus for use with such vessels WO2004045772A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003286253A AU2003286253A1 (en) 2002-11-19 2003-11-19 Reaction vessels and reaction apparatus for use with such vessels

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0226863A GB0226863D0 (en) 2002-11-19 2002-11-19 Improvements in and relating to reaction vessels and reaction apparatus for use with such vessels
GB0226863.9 2002-11-19

Publications (2)

Publication Number Publication Date
WO2004045772A2 WO2004045772A2 (en) 2004-06-03
WO2004045772A3 true WO2004045772A3 (en) 2004-09-16

Family

ID=9948041

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/005041 WO2004045772A2 (en) 2002-11-19 2003-11-19 Reaction vessels and reaction apparatus for use with such vessels

Country Status (3)

Country Link
AU (1) AU2003286253A1 (en)
GB (5) GB0226863D0 (en)
WO (1) WO2004045772A2 (en)

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GB2404883B (en) * 2003-08-01 2008-02-27 Biogene Ltd Improvement in biological, chemical and biochemical processes and apparatus
US7754473B2 (en) 2004-06-04 2010-07-13 Abacus Diagnostica Oy Temperature control of reaction vessel, system with reaction vessel, software product for system and use of system
GB2431006A (en) * 2005-09-12 2007-04-11 Polylogic Ltd Data capture system for microtiter plates
GB2435624B (en) * 2006-03-01 2009-05-27 Vapourtec Ltd Chamber heater
GB0610432D0 (en) * 2006-05-26 2006-07-05 B G Res Ltd Performance issues in use of vessels for biological applications
US11827875B2 (en) 2006-08-02 2023-11-28 Finesse Solutions, Inc. Method for manufacturing a composite sensor
US10227555B2 (en) 2006-08-02 2019-03-12 Finesse Solutions, Inc. Composite sensor assemblies for single use bioreactors
GB0623910D0 (en) * 2006-11-30 2007-01-10 Enigma Diagnostics Ltd Thermal cycler
GB0715171D0 (en) 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Sample processor
GB0715170D0 (en) 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Reaction vessel
WO2009030908A2 (en) * 2007-09-06 2009-03-12 It-Is International Ltd Thermal control apparatus for chemical and biochemical reactions
GB2457094A (en) * 2008-02-04 2009-08-05 Univ Dublin City A cuvette assembly for holding milking samples
US8322918B2 (en) 2008-08-01 2012-12-04 Eppendorf Ag Tempering apparatus with testing device and method for testing a tempering apparatus
EP2153901A1 (en) * 2008-08-01 2010-02-17 Eppendorf Ag Tempering device with test capabilities and method for testing a tempering device
FI20095059A0 (en) * 2009-01-26 2009-01-26 Wallac Oy Apparatus and method for optical measurement of samples
WO2010146339A1 (en) 2009-06-15 2010-12-23 Bg Research Ltd Nucleic acid detection
CN102313594B (en) * 2011-05-18 2013-07-03 福建师范大学 Detection device with different diffraction angle light intensity distributions
CN105263627B (en) * 2013-01-18 2019-05-21 生米公司 Analytical equipment
US9289767B2 (en) * 2013-03-13 2016-03-22 Alphagem Bio Inc. Microtube cap
GB201401584D0 (en) * 2014-01-29 2014-03-19 Bg Res Ltd Intelligent detection of biological entities
DE102014018308A1 (en) * 2014-12-10 2016-06-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Temperature control body for a multiwell plate and method and apparatus for freezing and / or thawing biological samples
DE102014018535A1 (en) * 2014-12-12 2016-06-16 Nanotemper Technologies Gmbh System and method for a seal-free tempering of capillaries
EP3385720B1 (en) * 2017-04-05 2020-09-02 F. Hoffmann-La Roche AG Vessel carrier for an automated analysis system
US10260033B1 (en) * 2017-10-06 2019-04-16 Wyatt Technology Corporation Method and apparatus to mitigate evaporation in high throughput measurements
CN113874708A (en) 2019-03-21 2021-12-31 生米公司 Multifunctional analysis device
CA3192080A1 (en) 2020-09-18 2022-03-24 Marc DEJOHN Portable devices and methods for analyzing samples
WO2023274859A1 (en) * 2021-06-29 2023-01-05 Signify Holding B.V. Photoreactor assembly

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US5106540A (en) * 1986-01-14 1992-04-21 Raychem Corporation Conductive polymer composition
US5167929A (en) * 1988-07-07 1992-12-01 Walter Sarstedt Geraete Und Verbrauchsmaterial Fuer Medizin Und Wissenshaft Reaction vessel for receiving minimal quantities of fluid samples
US5710381A (en) * 1990-11-29 1998-01-20 The Perkin-Elmer Corporation Two piece holder for PCR sample tubes
GB2333250A (en) * 1998-01-16 1999-07-21 Secr Defence Reduced volume heated reaction vessel
WO2001066254A1 (en) * 2000-03-08 2001-09-13 The Secretary Of State For Defence Reaction system for thermal cycling
US20020028165A1 (en) * 1996-12-06 2002-03-07 Martin A Lee Reaction vessels
US20020055187A1 (en) * 2000-11-03 2002-05-09 Rainer Treptow Method and apparatus for tempering specimens

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US5106540A (en) * 1986-01-14 1992-04-21 Raychem Corporation Conductive polymer composition
US5167929A (en) * 1988-07-07 1992-12-01 Walter Sarstedt Geraete Und Verbrauchsmaterial Fuer Medizin Und Wissenshaft Reaction vessel for receiving minimal quantities of fluid samples
US5710381A (en) * 1990-11-29 1998-01-20 The Perkin-Elmer Corporation Two piece holder for PCR sample tubes
US20020028165A1 (en) * 1996-12-06 2002-03-07 Martin A Lee Reaction vessels
GB2333250A (en) * 1998-01-16 1999-07-21 Secr Defence Reduced volume heated reaction vessel
WO2001066254A1 (en) * 2000-03-08 2001-09-13 The Secretary Of State For Defence Reaction system for thermal cycling
US20020055187A1 (en) * 2000-11-03 2002-05-09 Rainer Treptow Method and apparatus for tempering specimens

Also Published As

Publication number Publication date
WO2004045772A2 (en) 2004-06-03
GB0326878D0 (en) 2003-12-24
AU2003286253A8 (en) 2004-06-15
GB2424199B (en) 2007-06-27
GB0226863D0 (en) 2002-12-24
AU2003286253A1 (en) 2004-06-15
GB0612553D0 (en) 2006-08-02
GB2424381A (en) 2006-09-27
GB2424381B (en) 2007-06-27
GB2424199A (en) 2006-09-20
GB0612554D0 (en) 2006-08-02
GB2424380A (en) 2006-09-27
GB0609750D0 (en) 2006-06-28
GB2424380B (en) 2007-06-27
GB2404882A (en) 2005-02-16

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