WO2004046328A3 - Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them - Google Patents

Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them Download PDF

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Publication number
WO2004046328A3
WO2004046328A3 PCT/US2003/036616 US0336616W WO2004046328A3 WO 2004046328 A3 WO2004046328 A3 WO 2004046328A3 US 0336616 W US0336616 W US 0336616W WO 2004046328 A3 WO2004046328 A3 WO 2004046328A3
Authority
WO
WIPO (PCT)
Prior art keywords
block copolymers
ortho esters
dioxane
bioerodible
ketene acetals
Prior art date
Application number
PCT/US2003/036616
Other languages
French (fr)
Other versions
WO2004046328A2 (en
Inventor
Jorge Heller
Steven Y Ng
Original Assignee
A P Pharma Inc
Jorge Heller
Steven Y Ng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A P Pharma Inc, Jorge Heller, Steven Y Ng filed Critical A P Pharma Inc
Priority to DE60319128T priority Critical patent/DE60319128T2/en
Priority to AU2003295563A priority patent/AU2003295563B2/en
Priority to JP2004553783A priority patent/JP2006506514A/en
Priority to CA002506241A priority patent/CA2506241A1/en
Priority to EP03786759A priority patent/EP1569664B1/en
Publication of WO2004046328A2 publication Critical patent/WO2004046328A2/en
Publication of WO2004046328A3 publication Critical patent/WO2004046328A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2/00—Addition polymers of aldehydes or cyclic oligomers thereof or of ketones; Addition copolymers thereof with less than 50 molar percent of other substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2/00—Addition polymers of aldehydes or cyclic oligomers thereof or of ketones; Addition copolymers thereof with less than 50 molar percent of other substances
    • C08G2/18—Copolymerisation of aldehydes or ketones
    • C08G2/24—Copolymerisation of aldehydes or ketones with acetals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group
    • C08G2650/42—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group containing orthoester groups

Abstract

Bioerodible poly(ortho esters) useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents from dioxane-based di(ketene acetals). Block copolymers contain these bioerodible poly(ortho esters). These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents.
PCT/US2003/036616 2002-11-15 2003-11-13 Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them WO2004046328A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE60319128T DE60319128T2 (en) 2002-11-15 2003-11-13 BIODEGRADABLE POLY (ORTHO ESTERS) OF DI (KETENACETALES) BASED ON DIOXIDE, AND BLOCK COPOLYMERS CONTAINING THEM
AU2003295563A AU2003295563B2 (en) 2002-11-15 2003-11-13 Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
JP2004553783A JP2006506514A (en) 2002-11-15 2003-11-13 Dioxane-based di (ketene acetal) derived bioerodible poly (orthoesters) and block copolymers containing them
CA002506241A CA2506241A1 (en) 2002-11-15 2003-11-13 Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
EP03786759A EP1569664B1 (en) 2002-11-15 2003-11-13 Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/298,151 US7045589B2 (en) 2002-11-15 2002-11-15 Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
US10/298,151 2002-11-15

Publications (2)

Publication Number Publication Date
WO2004046328A2 WO2004046328A2 (en) 2004-06-03
WO2004046328A3 true WO2004046328A3 (en) 2004-08-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/036616 WO2004046328A2 (en) 2002-11-15 2003-11-13 Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them

Country Status (11)

Country Link
US (2) US7045589B2 (en)
EP (1) EP1569664B1 (en)
JP (1) JP2006506514A (en)
KR (1) KR20050075414A (en)
CN (1) CN1726043A (en)
AT (1) ATE385801T1 (en)
AU (1) AU2003295563B2 (en)
CA (1) CA2506241A1 (en)
DE (1) DE60319128T2 (en)
ES (1) ES2299746T3 (en)
WO (1) WO2004046328A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050042194A1 (en) * 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
GB0329654D0 (en) * 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
US7350479B2 (en) * 2004-09-10 2008-04-01 United States Of America As Represented By The Secretary Of The Army System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp
CN101155844A (en) * 2005-03-31 2008-04-02 阿帕医药有限公司 Peg-polyacetal and peg-polyacetal-poe graft copolymers and pharmaceutical compositions
US20070264339A1 (en) * 2006-05-12 2007-11-15 Ap Pharma, Inc. Base-stabilized polyorthoester formulations
US20070264338A1 (en) * 2006-05-12 2007-11-15 Shah Devang T Base-stabilized polyorthoester formulations
US20070281870A1 (en) * 2006-06-02 2007-12-06 Halliburton Energy Services, Inc. Stimuli-degradable gels
US7306040B1 (en) * 2006-06-02 2007-12-11 Halliburton Energy Services, Inc. Stimuli-degradable gels
WO2008005371A2 (en) * 2006-06-29 2008-01-10 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
EP2042538A1 (en) * 2007-09-18 2009-04-01 Nirvana's Tree House Amphiphilic copolymers and compositions containing such polymers
US8475823B2 (en) * 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
AU2009270695A1 (en) 2008-07-17 2010-01-21 Ap Pharma Methods for enhancing the stability of polyorthoesters and their formulations
CN102292076A (en) * 2008-12-11 2011-12-21 阿帕医药有限公司 Methods for enhancing stability of polyorthoesters and their formulations
US10179173B2 (en) 2012-03-23 2019-01-15 Regents Of The University Of Minnesota Semi-solid delivery systems
CN111956598A (en) 2013-03-15 2020-11-20 赫伦治疗有限公司 Composition of polyorthoester and aprotic solvent
KR102063027B1 (en) 2013-10-31 2020-01-07 (주)아모레퍼시픽 Composition comprising encapsulated fragrances
JP6232280B2 (en) * 2013-12-25 2017-11-15 株式会社ダイセル Polymer having oxygen-containing saturated heterocycle and process for producing the same
KR20220140711A (en) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 Reduced Impurity Sustained Release Drug Delivery Systems and Related Methods
CN114886840B (en) * 2020-07-10 2023-08-25 南京海鲸药业股份有限公司 Serial polymers with acid sensitive degradation and temperature sensitive properties and medicine carrying composition thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
US6590059B2 (en) * 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
US6613355B2 (en) * 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US138474A (en) * 1873-05-06 Improvement in wave-powers
US176844A (en) * 1876-05-02 Improvement in beer-taps
US130472A (en) * 1872-08-13 Improvement in hinges for sewing-machine tables
US82362A (en) * 1868-09-22 Samuel swes
US37300A (en) * 1863-01-06 Improvement in window-blind fastenings
US168336A (en) * 1875-10-05 Improvement in horseshoe-machines
US152630A (en) * 1874-06-30 Improvement in cars for transporting coal
US3268550A (en) 1963-08-26 1966-08-23 Ibm Nu-butenyl carbazoles
US4180064A (en) 1972-12-27 1979-12-25 Alza Corporation System for delivering agent to environment of use over prolonged time
US4014987A (en) 1974-06-04 1977-03-29 Alza Corporation Device for delivery of useful agent
US4131648A (en) 1975-01-28 1978-12-26 Alza Corporation Structured orthoester and orthocarbonate drug delivery devices
US4180646A (en) 1975-01-28 1979-12-25 Alza Corporation Novel orthoester polymers and orthocarbonate polymers
US4093709A (en) 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
DE2601681A1 (en) * 1976-01-17 1977-07-21 Degussa PROCESS FOR THE PRODUCTION OF 4,4'-ISOPROPYLIDEN-BIS (2,6-DIBROMPHENOL)
US4079038A (en) 1976-03-05 1978-03-14 Alza Corporation Poly(carbonates)
US4131848A (en) * 1976-12-03 1978-12-26 Gulf & Western Industries, Inc. Digital loop detector with automatic tuning
US4131662A (en) 1978-01-03 1978-12-26 Mobay Chemical Corporation Talc-based external mold release agent for polyurethane foams
US4261969A (en) 1979-05-03 1981-04-14 World Health Organization Controlled drug release composition
US4249531A (en) 1979-07-05 1981-02-10 Alza Corporation Bioerodible system for delivering drug manufactured from poly(carboxylic acid)
US4304767A (en) 1980-05-15 1981-12-08 Sri International Polymers of di- (and higher functionality) ketene acetals and polyols
US4502976A (en) 1982-10-25 1985-03-05 Bend Research, Inc. Water soluble polyesters
US4513143A (en) 1982-12-01 1985-04-23 Sri International Preparation of ketene acetals
US4532335A (en) 1983-03-07 1985-07-30 Sri International Preparation of ketene acetals by rearrangement of allyl and substituted allyl acetals
IT1205640B (en) * 1983-04-06 1989-03-23 Yason Srl NEW COMPOUNDS WITH ANTI-INFLAMMATORY ACTIVITY, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
US4710497A (en) 1983-05-20 1987-12-01 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering physiologically active agents
US4765973A (en) 1984-06-06 1988-08-23 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
US4639366A (en) 1984-06-06 1987-01-27 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
GB8416234D0 (en) 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US4549010A (en) 1984-06-27 1985-10-22 Merck & Co., Inc. Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal
US4855132A (en) 1986-02-25 1989-08-08 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4764364A (en) 1986-02-25 1988-08-16 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4801457A (en) 1986-08-01 1989-01-31 Sandoz Pharm. Corp. Polyacetal hydrogels formed from divinyl ethers and polyols
US4713441A (en) 1986-08-01 1987-12-15 Sandoz Pharmaceuticals Corp. Polyacetal hydrogels formed from divinyl ethers and polyols
US4898928A (en) 1988-03-07 1990-02-06 Sandoz Pharmaceuticals Corp. Polyacetal and polyketal hydrogels formed from acetals or ketals and polyols
US4957998A (en) 1988-08-22 1990-09-18 Pharmaceutical Delivery Systems, Inc. Polymers containing acetal, carboxy-acetal, ortho ester and carboxyortho ester linkages
JP2517760B2 (en) 1989-05-11 1996-07-24 新技術事業団 Water-soluble polymerized pharmaceutical preparation
US4946931A (en) 1989-06-14 1990-08-07 Pharmaceutical Delivery Systems, Inc. Polymers containing carboxy-ortho ester and ortho ester linkages
JPH05502465A (en) 1989-08-28 1993-04-28 ファーマスーティカル　デリバリー　システムズ Biodegradable polymers useful for controlled release of therapeutic agents
US5030457A (en) 1989-08-28 1991-07-09 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
US5047464A (en) 1989-09-20 1991-09-10 Merck & Co., Inc. Bioerodible thermoset elastomers
US5133739A (en) 1990-02-06 1992-07-28 Ethicon, Inc. Segmented copolymers of ε-caprolactone and glycolide
US5211951A (en) 1991-07-24 1993-05-18 Merck & Co., Inc. Process for the manufacture of bioerodible poly (orthoester)s and polyacetals
AU3941493A (en) 1992-03-30 1993-11-08 Alza Corporation Viscous suspensions of controlled-release drug particles
US5461140A (en) 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
KR940003548U (en) 1992-08-14 1994-02-21 김형술 Laundry dryer
MY113268A (en) 1992-12-29 2002-01-31 Insite Vision Incorporated Plasticized bioerodible controlled delivery system
GB2273874A (en) 1992-12-31 1994-07-06 Pertti Olavi Toermaelae Preparation of pharmaceuticals in a polymer matrix
JP4259610B2 (en) 1994-04-08 2009-04-30 キューエルティー・ユーエスエイ・インコーポレーテッド Liquid delivery composition
US6007845A (en) 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5607686A (en) 1994-11-22 1997-03-04 United States Surgical Corporation Polymeric composition
US5811510A (en) 1995-04-14 1998-09-22 General Hospital Corporation Biodegradable polyacetal polymers and methods for their formation and use
WO1997025366A1 (en) * 1996-01-05 1997-07-17 Advanced Polymer Systems, Inc. Polymers with controlled physical state and bioerodibility
US5968543A (en) 1996-01-05 1999-10-19 Advanced Polymer Systems, Inc. Polymers with controlled physical state and bioerodibility
EP0876142B1 (en) 1996-01-16 2001-09-26 Advanced Polymer Systems, Inc. Topical delivery of drugs to the lower gastrointestinal tract
US5993858A (en) * 1996-06-14 1999-11-30 Port Systems L.L.C. Method and formulation for increasing the bioavailability of poorly water-soluble drugs
US6046187A (en) 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
US5993856A (en) 1997-01-24 1999-11-30 Femmepharma Pharmaceutical preparations and methods for their administration
US5939453A (en) 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6143314A (en) 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
EP1142596A1 (en) 2000-04-03 2001-10-10 Universiteit Gent Compositions of crosslinkable prepolymers for use in therapeutically active biodegradable implants
DE60115631T2 (en) 2000-05-11 2006-08-10 AP Pharma, Inc., Redwood HALF-SENSITIVE ADMINISTRATIVE MEDICINAL PRODUCTS
CA2453050A1 (en) 2000-09-06 2002-03-14 A.P. Pharma, Inc. Degradable polyacetal polymers
EP1395626A1 (en) 2001-05-11 2004-03-10 AP Pharma, Inc. Peg-poe, peg-poe-peg, and poe-peg-poe block copolymers
US20020176844A1 (en) 2001-05-11 2002-11-28 Ng Steven Y. Bioerodible polyorthoesters containing hydrogen bonding groups
US20030152630A1 (en) 2001-05-11 2003-08-14 Ng Steven Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613355B2 (en) * 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
US6590059B2 (en) * 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups

Also Published As

Publication number Publication date
KR20050075414A (en) 2005-07-20
AU2003295563B2 (en) 2009-01-08
AU2003295563A1 (en) 2004-06-15
DE60319128D1 (en) 2008-03-27
EP1569664A4 (en) 2006-11-02
US20060155101A1 (en) 2006-07-13
JP2006506514A (en) 2006-02-23
CN1726043A (en) 2006-01-25
US20040096506A1 (en) 2004-05-20
EP1569664A2 (en) 2005-09-07
US7045589B2 (en) 2006-05-16
US7163694B2 (en) 2007-01-16
WO2004046328A2 (en) 2004-06-03
DE60319128T2 (en) 2009-02-05
ATE385801T1 (en) 2008-03-15
CA2506241A1 (en) 2004-06-03
EP1569664B1 (en) 2008-02-13
ES2299746T3 (en) 2008-06-01

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