WO2004047714A1 - Multiple-chamber medical container and method for producing the same - Google Patents

Multiple-chamber medical container and method for producing the same Download PDF

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Publication number
WO2004047714A1
WO2004047714A1 PCT/JP2003/014869 JP0314869W WO2004047714A1 WO 2004047714 A1 WO2004047714 A1 WO 2004047714A1 JP 0314869 W JP0314869 W JP 0314869W WO 2004047714 A1 WO2004047714 A1 WO 2004047714A1
Authority
WO
WIPO (PCT)
Prior art keywords
discharge
chamber
seal
medicament
container body
Prior art date
Application number
PCT/JP2003/014869
Other languages
English (en)
French (fr)
Other versions
WO2004047714A8 (en
Inventor
Katsuyoshi Nagao
Koichi Kume
Original Assignee
Otsuka Pharmaceutical Factory, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Factory, Inc. filed Critical Otsuka Pharmaceutical Factory, Inc.
Priority to JP2005510283A priority Critical patent/JP4463205B2/ja
Priority to AU2003282391A priority patent/AU2003282391A1/en
Publication of WO2004047714A1 publication Critical patent/WO2004047714A1/en
Publication of WO2004047714A8 publication Critical patent/WO2004047714A8/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093Containers having several compartments for products to be mixed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202Separating means
    • A61J1/2024Separating means having peelable seals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10Bag-type containers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/18Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using heated tools
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/76Making non-permanent or releasable joints
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/01General aspects dealing with the joint area or with the area to be joined
    • B29C66/05Particular design of joint configurations
    • B29C66/10Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112Single lapped joints
    • B29C66/1122Single lap to lap joints, i.e. overlap joints
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/01General aspects dealing with the joint area or with the area to be joined
    • B29C66/05Particular design of joint configurations
    • B29C66/20Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/21Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being formed by a single dot or dash or by several dots or dashes, i.e. spot joining or spot welding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/01General aspects dealing with the joint area or with the area to be joined
    • B29C66/05Particular design of joint configurations
    • B29C66/20Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/24Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight
    • B29C66/244Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being non-straight, e.g. forming non-closed contours
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/01General aspects dealing with the joint area or with the area to be joined
    • B29C66/05Particular design of joint configurations
    • B29C66/20Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/24Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight
    • B29C66/244Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being non-straight, e.g. forming non-closed contours
    • B29C66/2442Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being non-straight, e.g. forming non-closed contours in the form of a single arc of circle
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/01General aspects dealing with the joint area or with the area to be joined
    • B29C66/345Progressively making the joint, e.g. starting from the middle
    • B29C66/3452Making complete joints by combining partial joints
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/01General aspects dealing with the joint area or with the area to be joined
    • B29C66/346Making joints having variable thicknesses in the joint area, e.g. by using jaws having an adapted configuration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/01General aspects dealing with the joint area or with the area to be joined
    • B29C66/346Making joints having variable thicknesses in the joint area, e.g. by using jaws having an adapted configuration
    • B29C66/3462Making joints having variable thicknesses in the joint area, e.g. by using jaws having an adapted configuration by differentially heating the zones of different thickness
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/01General aspects dealing with the joint area or with the area to be joined
    • B29C66/347General aspects dealing with the joint area or with the area to be joined using particular temperature distributions or gradients; using particular heat distributions or gradients
    • B29C66/3472General aspects dealing with the joint area or with the area to be joined using particular temperature distributions or gradients; using particular heat distributions or gradients in the plane of the joint, e.g. along the joint line in the plane of the joint or perpendicular to the joint line in the plane of the joint
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/40General aspects of joining substantially flat articles, e.g. plates, sheets or web-like materials; Making flat seams in tubular or hollow articles; Joining single elements to substantially flat surfaces
    • B29C66/41Joining substantially flat articles ; Making flat seams in tubular or hollow articles
    • B29C66/43Joining a relatively small portion of the surface of said articles
    • B29C66/431Joining the articles to themselves
    • B29C66/4312Joining the articles to themselves for making flat seams in tubular or hollow articles, e.g. transversal seams
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/50General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/53Joining single elements to tubular articles, hollow articles or bars
    • B29C66/532Joining single elements to the wall of tubular articles, hollow articles or bars
    • B29C66/5326Joining single elements to the wall of tubular articles, hollow articles or bars said single elements being substantially flat
    • B29C66/53261Enclosing tubular articles between substantially flat elements
    • B29C66/53262Enclosing spouts between the walls of bags, e.g. of medical bags
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/70General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/70General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/739General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/7392General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of at least one of the parts being a thermoplastic
    • B29C66/73921General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of at least one of the parts being a thermoplastic characterised by the materials of both parts being thermoplastics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/90Measuring or controlling the joining process
    • B29C66/91Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux
    • B29C66/914Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux
    • B29C66/9141Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux by controlling or regulating the temperature
    • B29C66/91411Measuring or controlling the joining process by measuring or controlling the temperature, the heat or the thermal flux by controlling or regulating the temperature, the heat or the thermal flux by controlling or regulating the temperature of the parts to be joined, e.g. the joining process taking the temperature of the parts to be joined into account
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00General aspects of processes or apparatus for joining preformed parts
    • B29C66/90Measuring or controlling the joining process
    • B29C66/92Measuring or controlling the joining process by measuring or controlling the pressure, the force, the mechanical power or the displacement of the joining tools
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2009/00Layered products
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00Other particular articles
    • B29L2031/712Containers; Packaging elements or accessories, Packages
    • B29L2031/7148Blood bags, medical bags

Definitions

  • multiple-chamber containers as described above have thus far been proposed.
  • a typical example of these is a multiple-chamber container made of plastic film and formed in the shape of a bag. Making use of the plastic film, a weak partition seal to separate the chambers from each other is formed in such a container by heat-sealing the facing surfaces of the film.
  • the narrowest part of the pathway preferably has a width or diameter of 1 to 5 mm, thereby a free inflow of the liquid medicament from the storage compartment to the middle chamber can be reliably suppressed. Consequently, even if the pathway is formed, quick leakage of the medicament from the storage chamber to the medicament outlet before use can be reliably prevented.
  • a weak discharge-control seal (discharge-control seal) 21 is formed between the second storage chamber 11 and the medicament outlet 7 to interrupt the passage of medicament therebetween.
  • the weak discharge-control .seal 21 is formed arcwise around the medicament outlet 7 and both ends thereof are connected to the circumference 3 of the container body 5 in proximity to the medicament outlet 7.
  • a middle chamber 23 is formed in the shape of semi-circle between the weak partition seal 21 and the medicament outlet 7.
  • a pathway 25 having narrow width is arranged at the top part of the arc of weak discharge-control seal 21, and the second storage chamber 11 and the middle chamber 23 communicate with each other via the pathway 25.
  • the width of the pathway 25 is preferably 1 to 5 mm so that the gas passage can be allowed between the storage chamber 11 and the middle chamber 23 and the inflow of liquid medicament from the second storage chamber 11 into the middle chamber 23 can be inhibited by the inner pressure of the middle chamber 23.
  • the weak discharge-control seal 21 is formed in a similar way to the weak partition seal 13 by heat- sealing the inner surfaces of two facing films of container body 5.
  • the weak discharge-control seal 21 is provided in such a manner as to be openable by increasing the inner pressures of the storage chambers 9 and 11, and the opening strength thereof is adjusted to be smaller than that of the weak partition seal 13.
  • the weak discharge-control seal 23 is arranged arcwise in the above embodiment, the shape is not particularly limited.
  • the weak discharge- control seal may be shaped semi-ellipse, substantially arcwise having squared corners, or linear to link both sides of the container body 5 as shown in FIG. 4.
  • the pathway 25 does not necessarily have a uniform width and has only to prevent a passage of liquid. Especially, when the width of the narrowest part is 1 to 5 mm, such effect can be fully achieved.
  • the pathway 25 may be provided not only in one position but in two or more positions, as long as a passage of medicament is inhibited. (Second embodiment)
  • one of the ends 21a of the weak discharge- control seal 21 may be connected to the lower edge 3a where the medicament outlet 7 is provided, and the other end to the side edge 3b.
  • both ends 21a of each weak discharge-control seal 21 have a narrower width in the above, only one of the two ends may also have a narrow width. However, in order to avoid an unopened part reliably, it is preferred to narrow the both ends.
  • the width of the weak discharge-control seal 21 is adjusted so that the both ends thereof are easily opened.
  • easier opening of the both ends can also be achieved by changing the sealing conditions of the center part and both ends with their width kept same.
  • the heat sealing can be carried out with a mold to form the weak discharge-control seal 21, at the sealing temperature of both ends 21a lower than that of the center part 21b.
  • the center part 21b can be referred to as a high-temperature sealed part while the both end parts 21a as a low- temperature sealed part.
  • the difference in the sealing temperature is preferably 0.3 to 10 °C, and thereby the sealing release strength of both ends 21a can be set smaller than that of the center part 21b.
  • “Sealing release strength” denotes the strength that can release the sealed state per unit length in the longitudinal direction of the weak discharge-control seal 21, i.e. the strength at the time the surfaces of two sealed films separate from each other.
  • the sealing release strength can be expressed, for example as a peeling strength shown in JIS-Z0238.
  • the peeling strength denotes the strength required for separating two film surfaces that are heat-sealed by a weak seal having a width of 15 mm. In this case, it is preferred that the peeling strength of the center part 21b of the weak discharge-control seal 21 is 1 to 7 N/15mm and the peeling strength of its both ends 21a is 25 to 90% of that of the center part.
  • the sealing release strength can be adjusted by varying the thickness of the mold. That is, a pair of molds 41 for forming the weak discharge-control seal 21 is provided in such a manner as to consist of the first molds 41a for forming both end parts 21a and the second molds 41b for forming the center part 21b and the second mold 41b is provided thicker than the first mold 41a. Accordingly the distance between the molds is different between the end parts and the center part, and the sealing strength of both end parts 21a having a further distance between the molds becomes smaller when the heat-sealing is carried out. Therefore, the sealing release strength of the both ends 21a can be adjusted smaller than that of the center part 21b.
  • the difference in thickness between the first mold 41a and the second mold 41b is preferably 20 to 80 ⁇ m.
  • the above-described constitution of the weak discharge-control seal 21 is applicable to the multiple- chamber container of the first embodiment.
  • a pathway is provided at the center part of the weak discharge-control seal and the both end parts 21a can be provided as to have a narrower width than that of the center part 21b.
  • the pathway shown in the first embodiment can be formed at the weak discharge- control seal shown in FIGs. 6 to 9, where the both end parts 21a are opened more easily than the center part 21b.
PCT/JP2003/014869 2002-11-28 2003-11-21 Multiple-chamber medical container and method for producing the same WO2004047714A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2005510283A JP4463205B2 (ja) 2002-11-28 2003-11-21 医療用複室容器及びその製造方法
AU2003282391A AU2003282391A1 (en) 2002-11-28 2003-11-21 Multiple-chamber medical container and method for producing the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2002346056 2002-11-28
JP2002-346056 2002-11-28
JP2003003418 2003-01-09
JP2003-003418 2003-01-09

Publications (2)

Publication Number Publication Date
WO2004047714A1 true WO2004047714A1 (en) 2004-06-10
WO2004047714A8 WO2004047714A8 (en) 2004-08-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/014869 WO2004047714A1 (en) 2002-11-28 2003-11-21 Multiple-chamber medical container and method for producing the same

Country Status (4)

Country Link
JP (1) JP4463205B2 (es)
AU (1) AU2003282391A1 (es)
TW (1) TWI226234B (es)
WO (1) WO2004047714A1 (es)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005342174A (ja) * 2004-06-02 2005-12-15 Showa Denko Plastic Products Co Ltd 医療用薬液容器
JP2006006707A (ja) * 2004-06-28 2006-01-12 Otsuka Pharmaceut Factory Inc 医療用複室容器及びこれに取り付けられる排出規制部材
EP1621177A1 (en) * 2004-07-29 2006-02-01 Fresenius Kabi Deutschland GmbH Medical container with improved peelable seal
JP2006255406A (ja) * 2005-02-17 2006-09-28 Terumo Corp 医療用複室容器
JP2007014632A (ja) * 2005-07-08 2007-01-25 Otsuka Pharmaceut Factory Inc 複室容器
WO2007046744A1 (en) * 2005-10-17 2007-04-26 Gambro Lundia Ab Multicompartment container containing a medical solution
JP2007217044A (ja) * 2006-02-18 2007-08-30 Kusaka Rare Metal Products Co Ltd 電子レンジ調理用食品包装体
US7875016B2 (en) 2004-07-29 2011-01-25 Fresenius Kabi Deutschland Gmbh Flexible multi-chamber container for the preparation of medical mixed solutions
WO2011019347A1 (en) * 2009-08-12 2011-02-17 Baxter International Inc. Containers comprising peelable seals
JP2011131104A (ja) * 2005-02-17 2011-07-07 Terumo Corp 医療用複室容器
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JP2011131104A (ja) * 2005-02-17 2011-07-07 Terumo Corp 医療用複室容器
JP2006255406A (ja) * 2005-02-17 2006-09-28 Terumo Corp 医療用複室容器
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JP2007014632A (ja) * 2005-07-08 2007-01-25 Otsuka Pharmaceut Factory Inc 複室容器
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US8048055B2 (en) 2005-11-07 2011-11-01 Caridianbct Biotechnologies, Llc Clamp assembly for displacing fluid from portions of fluid containers
JP2007217044A (ja) * 2006-02-18 2007-08-30 Kusaka Rare Metal Products Co Ltd 電子レンジ調理用食品包装体
US8668681B2 (en) 2007-04-27 2014-03-11 Ajinomoto Co., Inc. Multi-chamber container
WO2011019347A1 (en) * 2009-08-12 2011-02-17 Baxter International Inc. Containers comprising peelable seals
US8940228B2 (en) 2012-01-11 2015-01-27 Terumo Bct, Inc. Slidable clamp for port isolation
CN112584814A (zh) * 2018-08-17 2021-03-30 美国圣戈班性能塑料公司 用于储存药物或生物介质的系统和方法
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TW200412926A (en) 2004-08-01
AU2003282391A1 (en) 2004-06-18

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