WO2004050683A8 - Antibodies directed to tumor necrosis factor and uses thereof - Google Patents
Antibodies directed to tumor necrosis factor and uses thereofInfo
- Publication number
- WO2004050683A8 WO2004050683A8 PCT/US2003/038281 US0338281W WO2004050683A8 WO 2004050683 A8 WO2004050683 A8 WO 2004050683A8 US 0338281 W US0338281 W US 0338281W WO 2004050683 A8 WO2004050683 A8 WO 2004050683A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antibodies directed
- necrosis factor
- tumor necrosis
- light chain
- immunoglobulin molecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03796574A EP1578799B8 (en) | 2002-12-02 | 2003-12-02 | Antibodies directed to tumor necrosis factor and uses thereof |
DE60333228T DE60333228D1 (en) | 2002-12-02 | 2003-12-02 | AGAINST THE TUMOR NEKROSE FACTOR TARGETED ANTIBODIES AND THEIR USES |
AT03796574T ATE472556T1 (en) | 2002-12-02 | 2003-12-02 | ANTIBODIES DIRECTED AGAINST THE TUMOR NECROSIS FACTOR AND THEIR USES |
CA2508375A CA2508375C (en) | 2002-12-02 | 2003-12-02 | Antibodies directed to tumor necrosis factor and uses thereof |
MXPA05005921A MXPA05005921A (en) | 2002-12-02 | 2003-12-02 | Antibodies directed to tumor necrosis factor and uses thereof. |
AU2003298816A AU2003298816C1 (en) | 2002-12-02 | 2003-12-02 | Antibodies directed to Tumor Necrosis Factor and uses thereof |
JP2004557489A JP4754219B2 (en) | 2002-12-02 | 2003-12-02 | Antibodies directed against tumor necrosis factor and their use |
HK06103052.3A HK1083023A1 (en) | 2002-12-02 | 2006-03-09 | Antibodies directed to tumor necrosis factor and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43072902P | 2002-12-02 | 2002-12-02 | |
US60/430,729 | 2002-12-02 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2004050683A2 WO2004050683A2 (en) | 2004-06-17 |
WO2004050683A3 WO2004050683A3 (en) | 2005-04-14 |
WO2004050683A8 true WO2004050683A8 (en) | 2005-07-28 |
Family
ID=32469516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/038281 WO2004050683A2 (en) | 2002-12-02 | 2003-12-02 | Antibodies directed to tumor necrosis factor and uses thereof |
Country Status (13)
Country | Link |
---|---|
US (2) | US7285269B2 (en) |
EP (1) | EP1578799B8 (en) |
JP (1) | JP4754219B2 (en) |
CN (1) | CN100434440C (en) |
AT (1) | ATE472556T1 (en) |
AU (1) | AU2003298816C1 (en) |
CA (1) | CA2508375C (en) |
DE (1) | DE60333228D1 (en) |
ES (1) | ES2347239T3 (en) |
HK (1) | HK1083023A1 (en) |
MX (1) | MXPA05005921A (en) |
RU (1) | RU2377253C2 (en) |
WO (1) | WO2004050683A2 (en) |
Cited By (2)
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US7943342B2 (en) | 2004-06-17 | 2011-05-17 | Wyeth Llc | Nucleic acids encoding IL-13 binding agents |
US8221752B2 (en) | 2004-06-09 | 2012-07-17 | Wyeth Llc | Antibodies against human interleukin-13 and uses therefor |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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US8221752B2 (en) | 2004-06-09 | 2012-07-17 | Wyeth Llc | Antibodies against human interleukin-13 and uses therefor |
US7943342B2 (en) | 2004-06-17 | 2011-05-17 | Wyeth Llc | Nucleic acids encoding IL-13 binding agents |
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CA2508375C (en) | 2014-05-27 |
US20080187531A1 (en) | 2008-08-07 |
AU2003298816B2 (en) | 2010-06-17 |
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US8101178B2 (en) | 2012-01-24 |
EP1578799B1 (en) | 2010-06-30 |
HK1083023A1 (en) | 2006-06-23 |
CN100434440C (en) | 2008-11-19 |
EP1578799B8 (en) | 2011-03-23 |
RU2005116225A (en) | 2006-02-27 |
ES2347239T3 (en) | 2010-10-27 |
US20050049402A1 (en) | 2005-03-03 |
CN1745101A (en) | 2006-03-08 |
EP1578799A2 (en) | 2005-09-28 |
CA2508375A1 (en) | 2004-06-17 |
AU2003298816A1 (en) | 2004-06-23 |
ATE472556T1 (en) | 2010-07-15 |
AU2003298816C1 (en) | 2010-12-16 |
MXPA05005921A (en) | 2005-10-19 |
JP4754219B2 (en) | 2011-08-24 |
EP1578799A4 (en) | 2007-04-04 |
US7285269B2 (en) | 2007-10-23 |
RU2377253C2 (en) | 2009-12-27 |
WO2004050683A2 (en) | 2004-06-17 |
JP2006508167A (en) | 2006-03-09 |
WO2004050683A3 (en) | 2005-04-14 |
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