WO2004056348A3 - Natural vitamin e compositions with superior antioxidant potency - Google Patents

Natural vitamin e compositions with superior antioxidant potency Download PDF

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Publication number
WO2004056348A3
WO2004056348A3 PCT/US2003/040398 US0340398W WO2004056348A3 WO 2004056348 A3 WO2004056348 A3 WO 2004056348A3 US 0340398 W US0340398 W US 0340398W WO 2004056348 A3 WO2004056348 A3 WO 2004056348A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
alpha
tocopherol
natural vitamin
antioxidant potency
Prior art date
Application number
PCT/US2003/040398
Other languages
French (fr)
Other versions
WO2004056348A2 (en
Inventor
Yousry Naguib
Ronald Udell
Richard Passwater Jr
Melvin Rich
Original Assignee
Soft Gel Technologies Inc
Yousry Naguib
Ronald Udell
Richard Passwater Jr
Melvin Rich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Soft Gel Technologies Inc, Yousry Naguib, Ronald Udell, Richard Passwater Jr, Melvin Rich filed Critical Soft Gel Technologies Inc
Priority to DE60316024T priority Critical patent/DE60316024D1/en
Priority to AU2003301069A priority patent/AU2003301069B2/en
Priority to EP03813747A priority patent/EP1572195B1/en
Publication of WO2004056348A2 publication Critical patent/WO2004056348A2/en
Publication of WO2004056348A3 publication Critical patent/WO2004056348A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Compositions for increased antioxidant potency of natural vitamin E (d-alpha-tocopherol), comprising alpha-, beta-, delta-, and gamma-forms of tocopherols and tocotrienols are disclosed. All of these compositions provide 400 International Units (IU), based on one mg of d-alpha-tocopherol providing 1.49 IU. These compositions showed antioxidant activities superior to natural d-alpha-tocopherol. These compositions are designed to provide protection of the cell membrane lipid layer, and protection against hear disease, cancer, and eye disease.
PCT/US2003/040398 2002-12-17 2003-12-17 Natural vitamin e compositions with superior antioxidant potency WO2004056348A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE60316024T DE60316024D1 (en) 2002-12-17 2003-12-17 NATURAL VITAMIN E COMPOSITIONS WITH EXCELLENT ANTIOXIDATION EFFECTIVENESS
AU2003301069A AU2003301069B2 (en) 2002-12-17 2003-12-17 Natural vitamin E compositions with superior antioxidant potency
EP03813747A EP1572195B1 (en) 2002-12-17 2003-12-17 Natural vitamin e compositions with superior antioxidant potency

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/321,318 2002-12-17
US10/321,318 US7329688B2 (en) 2002-12-17 2002-12-17 Natural vitamin E compositions with superior antioxidant potency

Publications (2)

Publication Number Publication Date
WO2004056348A2 WO2004056348A2 (en) 2004-07-08
WO2004056348A3 true WO2004056348A3 (en) 2004-09-10

Family

ID=32507093

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/040398 WO2004056348A2 (en) 2002-12-17 2003-12-17 Natural vitamin e compositions with superior antioxidant potency

Country Status (6)

Country Link
US (4) US7329688B2 (en)
EP (1) EP1572195B1 (en)
AT (1) ATE371447T1 (en)
AU (1) AU2003301069B2 (en)
DE (1) DE60316024D1 (en)
WO (1) WO2004056348A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716451B1 (en) * 1999-11-30 2004-04-06 Soft Gel Technologies, Inc. Formulation and delivery method to enhance antioxidant potency of vitamin E
AU2002327517B2 (en) * 2001-08-21 2008-04-17 Johnson & Johnson Consumer Companies, Inc. Tocopherol enriched compositions and amelioration of inflammatory symptoms
US20030144219A1 (en) * 2001-11-15 2003-07-31 Phinney Stephen Dodge Formulations and methods for treatment or amelioration of inflammatory conditions
MXPA04012740A (en) * 2002-07-02 2005-03-23 Galileo Pharmaceuticals Inc Compositions and methods for reduction of inflammatory symptoms and/or biomarkers in female subjects.
US7329688B2 (en) 2002-12-17 2008-02-12 Soft Gel Technologies, Inc. Natural vitamin E compositions with superior antioxidant potency
CA2545788A1 (en) * 2003-11-13 2005-06-02 Galileo Pharmaceuticals, Inc. Plant-derived protein extract compositions and methods
US20080038316A1 (en) * 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
US20070021497A1 (en) * 2005-07-11 2007-01-25 The Fruitful Yield Vitamin e compositions
BRPI0613631A8 (en) * 2005-07-18 2017-12-26 Univ Massachusetts Lowell nanoemulsion and method,
HUP0500975A2 (en) * 2005-10-25 2008-02-28 Arpad Tosaki Process for producing of extract of sour cherry seed, use of extract for producing of medicament and medicaments consist extract
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
KR20150024888A (en) 2012-06-08 2015-03-09 더 오하이오 스테이트 유니버시티 Treating burn and scar injury using tocotrienol
US20190185864A1 (en) 2016-08-23 2019-06-20 Akouos, Inc. Compositions and methods for treating non-age-associated hearing impairment in a human subject
CN117731591A (en) 2016-11-21 2024-03-22 艾里奥治疗公司 Transdermal delivery of large agents
BR112022016596A2 (en) 2020-02-21 2022-11-16 Akouos Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF NON-AGE-ASSOCIATED HEARING IMPAIRMENT IN A HUMAN INDIVIDUAL

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH029939A (en) * 1988-02-25 1990-01-12 Robert Bosch Gmbh Device for improving mixture distribution
US5348974A (en) * 1989-10-04 1994-09-20 Bristol-Myers Squibb Company Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders
US5376361A (en) * 1993-01-13 1994-12-27 Perricone; Nicholas V. Method and compositions for topical application to the skin for prevention and/or treatment of radiation-induced skin damage
US6239171B1 (en) * 1991-11-22 2001-05-29 Lipogenics, Inc. Tocotrienols and tocotrienol-like compounds and methods for their use
US20010046548A1 (en) * 1998-10-14 2001-11-29 Berry Christopher J. Anticholesterolemic edible oil
US6358997B1 (en) * 1995-12-22 2002-03-19 Cognis Corporation Tocopherol and tocotrienol compositions

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2940900A (en) * 1957-09-25 1960-06-14 Eastman Kodak Co Dry vitamine e composition
US3102078A (en) * 1961-01-13 1963-08-27 Eastman Kodak Co Water-dispersible vitamin preparations
US3212901A (en) * 1961-06-07 1965-10-19 Eastman Kodak Co Stabilized tocopherol concentrates and process for preparing the same
US3564097A (en) * 1968-04-05 1971-02-16 Louis Magid Stable multivitamin tablets containing tricalcium phosphate
US4364945A (en) * 1979-12-13 1982-12-21 Whittle Barry J Nasal composition for relieving nasal distress
US4551332A (en) * 1981-08-05 1985-11-05 Theodore Stillman Vitamin E compositions and methods
US5948769A (en) * 1984-01-28 1999-09-07 Ismail; Roshdy Agent for treating heart diseases
US4612194A (en) * 1984-02-15 1986-09-16 Roshdy Ismail Anti-rheumatic agents and their use
US4711894A (en) * 1986-01-16 1987-12-08 Henkel Corporation Stabilized tocopherol in dry, particulate, free-flowing form
FR2657526B1 (en) * 1990-01-31 1994-10-28 Lvmh Rech USE OF AN ALPHA-TOCOPHEROL PHOSPHATE, OR ONE OF ITS DERIVATIVES, FOR THE PREPARATION OF COSMETIC, DERMATOLOGICAL, OR PHARMACEUTICAL COMPOSITIONS; COMPOSITIONS THUS OBTAINED.
US5114957A (en) * 1990-05-08 1992-05-19 Biodor U.S. Holding Tocopherol-based antiviral agents and method of using same
US5102659A (en) * 1990-07-12 1992-04-07 Shaklee Corporation Natural antioxidant compositions
US5179122A (en) * 1991-02-11 1993-01-12 Eastman Kodak Company Nutritional supplement containing vitamin e
US5545398A (en) * 1993-01-13 1996-08-13 Perricone; Nicholos V. Method and compositions for topical application to the skin of tocotrienol for prevention and/or treatment of skin damage
US5352696A (en) * 1993-01-22 1994-10-04 Pacific Corporation Quaternary nitrogen-containing vitamin E derivatives and uses thereof
JP3651915B2 (en) 1993-06-30 2005-05-25 財団法人神奈川科学技術アカデミー Method for searching DNA fragment encoding signal sequence peptide and vector therefor
WO1996019218A1 (en) * 1994-12-22 1996-06-27 Henkel Corporation Tocopherol and tocotrienol compositions
CN1114438C (en) * 1997-08-29 2003-07-16 里塞克斯股份有限公司 Method for treating diabetes, hyperglycemia and hypoglycemia
US5985344A (en) * 1997-09-02 1999-11-16 The Ricex Company Process for obtaining micronutrient enriched rice bran oil
US5997892A (en) * 1997-10-09 1999-12-07 Camp; Gary Don Topical therapeutic composition for and method of treating psoriasis
US6048891A (en) * 1998-12-17 2000-04-11 Loma Linda University Medical Center Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of natriuretic disease
US6716451B1 (en) * 1999-11-30 2004-04-06 Soft Gel Technologies, Inc. Formulation and delivery method to enhance antioxidant potency of vitamin E
US7329688B2 (en) 2002-12-17 2008-02-12 Soft Gel Technologies, Inc. Natural vitamin E compositions with superior antioxidant potency

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH029939A (en) * 1988-02-25 1990-01-12 Robert Bosch Gmbh Device for improving mixture distribution
US5348974A (en) * 1989-10-04 1994-09-20 Bristol-Myers Squibb Company Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders
US6239171B1 (en) * 1991-11-22 2001-05-29 Lipogenics, Inc. Tocotrienols and tocotrienol-like compounds and methods for their use
US5376361A (en) * 1993-01-13 1994-12-27 Perricone; Nicholas V. Method and compositions for topical application to the skin for prevention and/or treatment of radiation-induced skin damage
US6358997B1 (en) * 1995-12-22 2002-03-19 Cognis Corporation Tocopherol and tocotrienol compositions
US20010046548A1 (en) * 1998-10-14 2001-11-29 Berry Christopher J. Anticholesterolemic edible oil

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NG T K W ET AL: "EFFECTS OF TOCOTRIENOL-RICH AND TOCOPHEROL-RICH FRACTIONS FROM PALMOIL ON SERUM LIPIDS AND PLATELET AGGREGATION IN THE RAT", 1990, ASEAN FOOD JOURNAL, ASEAN FOOD HANDLING BURAEU, KUALA LUMPUR, MY, PAGE(S) 165-169, ISSN: 0127-7324, XP001038596 *
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 05 30 May 1997 (1997-05-30) *

Also Published As

Publication number Publication date
AU2003301069B2 (en) 2010-11-18
US7449491B2 (en) 2008-11-11
US20060093664A1 (en) 2006-05-04
DE60316024D1 (en) 2007-10-11
WO2004056348A2 (en) 2004-07-08
US7329688B2 (en) 2008-02-12
EP1572195A2 (en) 2005-09-14
EP1572195B1 (en) 2007-08-29
US20090156664A1 (en) 2009-06-18
US20110251274A1 (en) 2011-10-13
US7989493B2 (en) 2011-08-02
ATE371447T1 (en) 2007-09-15
AU2003301069A1 (en) 2004-07-14
US20040116512A1 (en) 2004-06-17

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