WO2004056354A1 - Controlled release pharmaceutical compositions of tamsulosin - Google Patents
Controlled release pharmaceutical compositions of tamsulosin Download PDFInfo
- Publication number
- WO2004056354A1 WO2004056354A1 PCT/IB2003/006072 IB0306072W WO2004056354A1 WO 2004056354 A1 WO2004056354 A1 WO 2004056354A1 IB 0306072 W IB0306072 W IB 0306072W WO 2004056354 A1 WO2004056354 A1 WO 2004056354A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tamsulosin
- composition
- cellulose
- mixtures
- enteric
- Prior art date
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- DRHKJLXJIQTDTD-OAHLLOKOSA-N Tamsulosine Chemical compound CCOC1=CC=CC=C1OCCN[C@H](C)CC1=CC=C(OC)C(S(N)(=O)=O)=C1 DRHKJLXJIQTDTD-OAHLLOKOSA-N 0.000 title claims abstract description 67
- 229960002613 tamsulosin Drugs 0.000 title claims abstract description 66
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 27
- 238000013270 controlled release Methods 0.000 title claims abstract description 23
- 239000000203 mixture Substances 0.000 claims abstract description 96
- 150000003839 salts Chemical class 0.000 claims abstract description 42
- 238000000034 method Methods 0.000 claims description 74
- 230000008569 process Effects 0.000 claims description 62
- 229920000642 polymer Polymers 0.000 claims description 55
- 239000003795 chemical substances by application Substances 0.000 claims description 36
- 239000002702 enteric coating Substances 0.000 claims description 28
- 238000009505 enteric coating Methods 0.000 claims description 28
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 28
- 229920001577 copolymer Polymers 0.000 claims description 24
- 239000001993 wax Substances 0.000 claims description 23
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 20
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- 150000004665 fatty acids Chemical class 0.000 claims description 20
- 229910052751 metal Inorganic materials 0.000 claims description 20
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- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 19
- 239000002775 capsule Substances 0.000 claims description 15
- 238000000576 coating method Methods 0.000 claims description 15
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- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical group CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 14
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- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229960003198 tamsulosin hydrochloride Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002511208A CA2511208A1 (en) | 2002-12-20 | 2003-12-18 | Controlled release pharmaceutical compositions of tamsulosin |
BR0317567-7A BR0317567A (en) | 2002-12-20 | 2003-12-18 | Controlled release pharmaceutical composition of tamsulosin and process for its preparation |
JP2004561893A JP2006512358A (en) | 2002-12-20 | 2003-12-18 | Tamsulosin controlled release pharmaceutical composition |
AU2003288604A AU2003288604A1 (en) | 2002-12-20 | 2003-12-18 | Controlled release pharmaceutical compositions of tamsulosin |
EP03780445A EP1596849A1 (en) | 2002-12-20 | 2003-12-18 | Controlled release pharmaceutical compositions of tamsulosin |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1292DE2002 IN192381B (en) | 2002-12-20 | 2002-12-20 | |
IN1292/DEL/2002 | 2002-12-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004056354A1 true WO2004056354A1 (en) | 2004-07-08 |
Family
ID=32676755
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2003/006072 WO2004056354A1 (en) | 2002-12-20 | 2003-12-18 | Controlled release pharmaceutical compositions of tamsulosin |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1596849A1 (en) |
JP (1) | JP2006512358A (en) |
CN (1) | CN1744889A (en) |
AU (1) | AU2003288604A1 (en) |
BR (1) | BR0317567A (en) |
CA (1) | CA2511208A1 (en) |
IN (1) | IN192381B (en) |
RU (1) | RU2005121999A (en) |
WO (1) | WO2004056354A1 (en) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1600157A1 (en) * | 2003-01-27 | 2005-11-30 | Astellas Pharma Inc. | Enteric sustained-release fine particles for tamsulosin or its salt and process for producing the same |
WO2006005512A1 (en) * | 2004-07-14 | 2006-01-19 | Siegfried Generics International Ag | Granules for controlled release of tamsulosin |
WO2007112579A1 (en) * | 2006-04-03 | 2007-10-11 | Isa Odidi | Drug delivery composition |
EP2308483A1 (en) * | 2008-07-01 | 2011-04-13 | Sawai Pharmaceutical Co., Ltd. | Process for production of spherical microparticles comprising tamsulosin hydrochloride |
US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
US8603520B2 (en) | 2003-06-26 | 2013-12-10 | Intellipharmaceutics Corp. | Oral multi-functional pharmaceutical capsule preparations of proton pump inhibitors |
KR101423237B1 (en) | 2010-05-04 | 2014-07-30 | 주식회사 삼양바이오팜 | Release controlled pharmaceutical composition comprising tamsulosin or pharmaceutically acceptable salts thereof, and oral dosage form comprising the composition |
US9078827B2 (en) | 2006-05-12 | 2015-07-14 | Isa Odidi | Pharmaceutical composition having reduced abuse potential |
EP2949319A1 (en) | 2014-05-26 | 2015-12-02 | Galenicum Health S.L. | Pharmaceutical compositions comprising an active agent |
US9561188B2 (en) | 2006-04-03 | 2017-02-07 | Intellipharmaceutics Corporation | Controlled release delivery device comprising an organosol coat |
WO2017192808A1 (en) * | 2016-05-04 | 2017-11-09 | Aspen Park Pharmaceuticals, Inc. | Delayed release oral tamsulosin hydrochloride |
US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
EP3473245A1 (en) | 2017-10-20 | 2019-04-24 | Veru Inc. | Controlled release oral tamsulosin hydrochloride |
EP3473244A1 (en) | 2017-10-20 | 2019-04-24 | Veru Inc. | Controlled release oral tamsulosin hydrochloride |
US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
EP3881832A4 (en) * | 2018-12-21 | 2022-08-31 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition containing tamsulosin hydrochloride with excellent acid resistance and preparation method therefor |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008089593A1 (en) * | 2007-01-18 | 2008-07-31 | Standard Chem. & Pharm. Co., Ltd. | Sustained release tamsulosin formulation and producing method |
CN101695478B (en) * | 2009-10-23 | 2012-01-18 | 江苏大学 | Tamsulosin hydrochloride sustained-release pellets and preparation method thereof |
CN103315962A (en) * | 2013-02-01 | 2013-09-25 | 北京科信必成医药科技发展有限公司 | Tamsulosin sustained-release pellet preparation and preparation method thereof |
CN103142492A (en) * | 2013-02-01 | 2013-06-12 | 北京科信必成医药科技发展有限公司 | Controlled release pellet preparation and its preparation method |
CN103919735B (en) * | 2014-05-04 | 2018-04-17 | 翰宇药业(武汉)有限公司 | A kind of tamsulosin hydrochloride sustained release pellet and preparation method thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5158777A (en) * | 1990-02-16 | 1992-10-27 | E. R. Squibb & Sons, Inc. | Captopril formulation providing increased duration of activity |
EP1064938A1 (en) * | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Pharmaceutical dosage forms for controlled release producing at least a timed pulse |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
WO2003039530A1 (en) * | 2001-11-07 | 2003-05-15 | Synthon B.V. | Tamsulosin tablets |
-
2002
- 2002-12-20 IN IN1292DE2002 patent/IN192381B/en unknown
-
2003
- 2003-12-18 RU RU2005121999/15A patent/RU2005121999A/en not_active Application Discontinuation
- 2003-12-18 CA CA002511208A patent/CA2511208A1/en not_active Abandoned
- 2003-12-18 EP EP03780445A patent/EP1596849A1/en not_active Withdrawn
- 2003-12-18 AU AU2003288604A patent/AU2003288604A1/en not_active Abandoned
- 2003-12-18 CN CNA2003801094133A patent/CN1744889A/en active Pending
- 2003-12-18 WO PCT/IB2003/006072 patent/WO2004056354A1/en not_active Application Discontinuation
- 2003-12-18 JP JP2004561893A patent/JP2006512358A/en not_active Withdrawn
- 2003-12-18 BR BR0317567-7A patent/BR0317567A/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5158777A (en) * | 1990-02-16 | 1992-10-27 | E. R. Squibb & Sons, Inc. | Captopril formulation providing increased duration of activity |
EP1064938A1 (en) * | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Pharmaceutical dosage forms for controlled release producing at least a timed pulse |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
WO2003039530A1 (en) * | 2001-11-07 | 2003-05-15 | Synthon B.V. | Tamsulosin tablets |
Non-Patent Citations (2)
Title |
---|
DEBUNNE A ET AL: "Development and in vitro evaluation of an enteric-coated multiparticulate drug delivery system for the administration of piroxicam to dogs", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 54, no. 3, November 2002 (2002-11-01), pages 343 - 348, XP004394053, ISSN: 0939-6411 * |
WILLIAMS III R O ET AL: "Influence of processing and curing conditions on beads coated with an aqueous dispersion of cellulose acetate phthalate", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 49, no. 3, 2 May 2000 (2000-05-02), pages 243 - 252, XP004257164, ISSN: 0939-6411 * |
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1600157A1 (en) * | 2003-01-27 | 2005-11-30 | Astellas Pharma Inc. | Enteric sustained-release fine particles for tamsulosin or its salt and process for producing the same |
EP1600157A4 (en) * | 2003-01-27 | 2006-02-08 | Astellas Pharma Inc | Enteric sustained-release fine particles for tamsulosin or its salt and process for producing the same |
US8603520B2 (en) | 2003-06-26 | 2013-12-10 | Intellipharmaceutics Corp. | Oral multi-functional pharmaceutical capsule preparations of proton pump inhibitors |
US9636306B2 (en) | 2003-06-26 | 2017-05-02 | Intellipharmaceutics Corp. | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
US8802139B2 (en) | 2003-06-26 | 2014-08-12 | Intellipharmaceutics Corp. | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
WO2006005512A1 (en) * | 2004-07-14 | 2006-01-19 | Siegfried Generics International Ag | Granules for controlled release of tamsulosin |
EP1618873A1 (en) * | 2004-07-14 | 2006-01-25 | Siegfried Generics International AG | Granule for the control release of tamsulosin, containing alginate |
US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
WO2007112579A1 (en) * | 2006-04-03 | 2007-10-11 | Isa Odidi | Drug delivery composition |
US9561188B2 (en) | 2006-04-03 | 2017-02-07 | Intellipharmaceutics Corporation | Controlled release delivery device comprising an organosol coat |
US9078827B2 (en) | 2006-05-12 | 2015-07-14 | Isa Odidi | Pharmaceutical composition having reduced abuse potential |
US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
US10632205B2 (en) | 2006-05-12 | 2020-04-28 | Intellipharmaceutics Corp | Pharmaceutical composition having reduced abuse potential |
EP2308483A4 (en) * | 2008-07-01 | 2014-09-10 | Sawai Seiyaku Kk | Process for production of spherical microparticles comprising tamsulosin hydrochloride |
EP2308483A1 (en) * | 2008-07-01 | 2011-04-13 | Sawai Pharmaceutical Co., Ltd. | Process for production of spherical microparticles comprising tamsulosin hydrochloride |
KR101423237B1 (en) | 2010-05-04 | 2014-07-30 | 주식회사 삼양바이오팜 | Release controlled pharmaceutical composition comprising tamsulosin or pharmaceutically acceptable salts thereof, and oral dosage form comprising the composition |
EP2949319A1 (en) | 2014-05-26 | 2015-12-02 | Galenicum Health S.L. | Pharmaceutical compositions comprising an active agent |
CN109562071A (en) * | 2016-05-04 | 2019-04-02 | 艾森潘帕克制药股份有限公司 | Sustained release oral hydrochloride Tamsulosin |
WO2017192808A1 (en) * | 2016-05-04 | 2017-11-09 | Aspen Park Pharmaceuticals, Inc. | Delayed release oral tamsulosin hydrochloride |
EP3473244A1 (en) | 2017-10-20 | 2019-04-24 | Veru Inc. | Controlled release oral tamsulosin hydrochloride |
EP3473245A1 (en) | 2017-10-20 | 2019-04-24 | Veru Inc. | Controlled release oral tamsulosin hydrochloride |
EP3881832A4 (en) * | 2018-12-21 | 2022-08-31 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition containing tamsulosin hydrochloride with excellent acid resistance and preparation method therefor |
Also Published As
Publication number | Publication date |
---|---|
BR0317567A (en) | 2005-11-22 |
CN1744889A (en) | 2006-03-08 |
CA2511208A1 (en) | 2004-07-08 |
RU2005121999A (en) | 2006-01-20 |
AU2003288604A1 (en) | 2004-07-14 |
IN192381B (en) | 2004-04-10 |
EP1596849A1 (en) | 2005-11-23 |
JP2006512358A (en) | 2006-04-13 |
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