WO2004058041A2 - Immobilizable in vivo sensing device - Google Patents

Immobilizable in vivo sensing device Download PDF

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Publication number
WO2004058041A2
WO2004058041A2 PCT/IL2003/001104 IL0301104W WO2004058041A2 WO 2004058041 A2 WO2004058041 A2 WO 2004058041A2 IL 0301104 W IL0301104 W IL 0301104W WO 2004058041 A2 WO2004058041 A2 WO 2004058041A2
Authority
WO
WIPO (PCT)
Prior art keywords
vivo
immobilizer
signal
immobilizing
response
Prior art date
Application number
PCT/IL2003/001104
Other languages
French (fr)
Other versions
WO2004058041A3 (en
Inventor
Zvika Gilad
Gavriel J. Iddan
Original Assignee
Given Imaging Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Given Imaging Ltd. filed Critical Given Imaging Ltd.
Priority to JP2004563550A priority Critical patent/JP2006512130A/en
Priority to AU2003288516A priority patent/AU2003288516A1/en
Priority to AT03780591T priority patent/ATE547976T1/en
Priority to EP03780591A priority patent/EP1587407B1/en
Priority to US10/540,890 priority patent/US7946979B2/en
Publication of WO2004058041A2 publication Critical patent/WO2004058041A2/en
Publication of WO2004058041A3 publication Critical patent/WO2004058041A3/en
Priority to IL169401A priority patent/IL169401A/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041Capsule endoscopes for imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064Constructional details of the endoscope body
    • A61B1/00071Insertion part of the endoscope body
    • A61B1/0008Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00087Tools
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00147Holding or positioning arrangements
    • A61B1/00148Holding or positioning arrangements using anchoring means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/07Endoradiosondes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/07Endoradiosondes
    • A61B5/073Intestinal transmitters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683Means for maintaining contact with the body
    • A61B5/6835Supports or holders, e.g., articulated arms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6879Means for maintaining contact with the body
    • A61B5/6882Anchoring means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002Operational features of endoscopes
    • A61B1/00011Operational features of endoscopes characterised by signal transmission
    • A61B1/00016Operational features of endoscopes characterised by signal transmission using wireless means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/06Biopsy forceps, e.g. with cup-shaped jaws

Definitions

  • the present invention relates to in vivo sensing devices generally and to their immobilization in vivo, in particular.
  • In vivo sensing devices such as thermometers, pH meters, optical scanners, image sensors and so on, may be used for example to unobtrusively monitor bodily systems and in vivo sites.
  • Some in vivo sensors move through body lumens and may be remotely controlled. However, it may sometimes be desirable to immobilize a sensing device in vivo for continuous sensing of an in vivo site, for example, for post surgery monitoring.
  • Other in vivo sensors may perform treatment functions and may be immobilized to perform such treatment.
  • Still other in vivo sensors may be immobilized to monitor an area for a period of time in order to make a diagnosis, such as an in vivo pH sensor which may be immobilized to detect, record and analyze gastroesophageal pH. Immobilization of a device may also provide an opportunity for the device to release a compound such as a drug at a specific location or for taking a biopsy at such location.
  • an in vivo sensing device may include an immobilizer or immobilization unit that may be activated in response to a signal from for example a processor or controller.
  • the immobilizer may immobilize the device in an in vivo area that is to be monitored over a period of time.
  • the in vivo sensing device may be or include an autonomous in vivo sensing capsule.
  • a signal may be generated to activate an immobilizer that is included in an in vivo device so that the in vivo device is immobilized in an in vivo area to be monitored.
  • the immobilized in vivo device may continue to monitor or collect images or other sensing data from the area that is proximate to the device.
  • a housing may include or be attached to an in vivo sensor and an immobilizing unit, and may also include a processor that may activate the immobilization unit.
  • FIG. 1A is a schematic illustration of an in vivo device having an immobilization unit, constructed and operative in accordance with an embodiment of the present invention
  • Fig. IB is a schematic illustration of the in vivo device of Fig. 1A in an immobilized state, in accordance with an embodiment of the present invention
  • Fig. 1C is a schematic illustration of the in vivo device of Fig. 1A freed from an immobilized state, in accordance with an embodiment of the present invention
  • Fig. 2A is a schematic illustration of an in vivo device with a gripping unit, constructed and operative in accordance with an embodiment of the present invention
  • Fig. 2B is a cross-sectional illustration of the gripping unit of Fig. 2A, in accordance with an embodiment of the present invention
  • Fig. 2C is a cross-sectional illustration of the gripping unit of Fig. 2A in an extended state, in accordance with an embodiment of the present invention.
  • Fig 3 is a schematic flow chart diagram presentation of a method in accordance with certain embodiments of the present invention.
  • a device, system and method for immobilizing or otherwise controlling the movement of or holding a sensing device in an in vivo site for example in response to a signal that activates an immobilization unit or in response to another condition or event such as for example the passage of time.
  • Some embodiments may enable for example a doctor or other operator to indicate to an in vivo device such as for example an autonomous in vivo capsule, to stop the movement of the device in vivo or to direct that the device assume an immobilized state or position.
  • Immobilizing an in vivo device may be desirable for example, if something of concern, such as blood, a high temperature, a polyp or other protrusion, is detected while the sensor moves for example through a body lumen, and the operator wants to monitor the item of concern or particular in vivo site more carefully or for a longer period of time.
  • monitoring may include for example capturing images of the in vivo site or performing other sensing functions in the area proximate to where the device is immobilized.
  • a sensing device may be stopped or held at one or more known locations in the body lumen to recalibrate sensors in the device to those locations.
  • a device of the invention may include a sensing device, a transmitter that transmits the output of the sensing device, a reception system for receiving the transmitted output and a power source, which provides power to the elements of the device.
  • the sensing device may be connected to, or disposed within, a housing or shell, which may be configured for being transiently immobilized or held proximate to or in the vicinity of the site to be monitored.
  • the device may be permanently immobilized in vivo.
  • the sensing device may be a sensor that is adapted for being placed in vivo, for example, along the gastro-intestinal (GI) tract, and that is configured for sensing in vivo environmental conditions such as for example the presence of blood, pH, temperature, electrical impedance of tissues etc.
  • the sensing device may transmit (such as for example by radio waves) output relating to for example changes in in vivo environmental conditions.
  • Other sensors may be used and other conditions may be detected or monitored.
  • a system for monitoring, such as for example by way of an imager, a site in the GI tract over an extended period of time.
  • the imaging system may include at least one illumination source such as one or more light emitting diodes (LED), which may be for example monochromatic or a white LED, and an imaging device such as for example a charge coupled device (CCD) or complementary metal oxide semiconductor (CMOS) image sensor. Other light sources and other suitable imaging devices may be used.
  • the imaging system may further include an optical system for imaging an area of interest onto the imaging system.
  • the optical system may include mirrors and/or lenses for collimating the light from the illumination source.
  • a reception system receives the transmitted image output.
  • Such reception system may include an antenna array capable of surrounding a body for receiving the transmitted image output and for producing a plurality of received signals and a demodulator capable of transforming the pluralit ⁇ ' of received image signals into a single video data stream.
  • the reception system may include for example a display, such as for example an LCD or a monitor, for displaying the data transmitted to it.
  • Embodiments of the invention may be included in an autonomous device such as for example a self-contained in-vivo capsule capable of passing through a body lumen such as for example a GI tract, the reproductive tract, the urinary tract or a blood vessel, and where some or all of the operative components are substantially contained within a container, and where the device does not require wires or cables to for example receive power or transmit information.
  • a body lumen such as for example a GI tract, the reproductive tract, the urinary tract or a blood vessel
  • the device does not require wires or cables to for example receive power or transmit information.
  • power may be supplied by an internal battery or wireless receiving system.
  • Other embodiments may have other configurations and capabilities.
  • components may be distributed over multiple sites or units. Control information may be received from an external source.
  • a device or system in accordance with an embodiment of the invention may include an imager such as for example a camera system, a transmitter, a receiving system and a display system such as described in some embodiments of US 5,604,531 to Iddan and/or in International Application publication number WO 01/65995 entitled “A Device And System For In Vivo Imaging", published on 13 September, 2001. US 5,604,531 and WO 01/65995 are assigned to the common assignee of the present invention and are hereby incorporated herein by reference.
  • An imaging system in accordance with an embodiment of the invention may for example provide direct visual information of an in vivo site such that visibly detectable changes at the site, such as bleeding, swelling etc. can be seen by an operator.
  • the imaging system may further include a detector coupled to the sensor or imaging device that is optically changed in response to changes in environmental conditions. The optical change in the detector may be imaged and transmitted to a receiving system and shown on a display of the receiving unit to alert an external operator of the changed conditions.
  • the imaging system may include a pH meter that undergoes a color change in response to pH changes in its vicinity.
  • the imaging system may include a detector of chemical substances, such as blood components, which may undergo a change in color in response to the presence of the chemical substances.
  • a change in color may be detected by for example an imaging device or other sensor and an indication of such detection may be transmitted and received by the reception system for inspection by for example an operator.
  • a processor in an external receiving system may analyze a detected condition a may issue signals or instructions in response to said detected conditions.
  • a sensor such as an imager may signal a processor in the in vivo device as to the presence of a detected condition.
  • a processor or controller may generate a signal that may activate an immobilization unit that may be included in or attached to the device. As described herein, such signal may result in the immobilization of the device in a specific location where further sensing of in vivo conditions may be desired.
  • Device 10 may include a housing or body 12, which may include for example an optical window 14, behind or adjacent to which may be positioned illumination sources 16, an imaging device 18, and a controller or processor 20.
  • the body 12 may house additional elements of the system, such as a transceiver 13 for receiving instructions or commands from an external operator or processor and/or for transmitting data such as sensing data to an external receiver/transmitter 42, and a power source 15, such as a battery.
  • Transceiver 13 may include one or more antennas 48 or arrays of antennas 48.
  • a system in accordance with some embodiments of the invention may include outside a patient's body a receiver/transmitter 42, which may include an antenna or antenna array, a data storage unit 44, a processor 46 and a display system or monitor 47.
  • Receiver/transmitter 42 may receive signals in the form of for example radio waves that may be transmitted from device 10 and that may for example contain image data, location data and or other sensing data collected by or about device 10.
  • a transmitter such as for example receiver/transmitter 42 may also transmit signals or instructions to device 10 such as for example instructions to immobilize device 10 in a body lumen or to change a state of activation of a component of device 10.
  • Monitor 47 may include for example one or more screens, monitors or suitable display units. Monitor 47 may for example display images or other data captured or transmitted by device 10. In some embodiments, images and position or location information of such device 10 may be displayed on one or more monitors 47.
  • processor 20 may be or include for example one or more circuits such as for example an integrated circuit or circuit board suitable for processing, transmitting or delivering signals from for example a sensing device such as an in vivo imager or from an external transmitter, and for transmitting a signal to an immobilization unit 22.
  • controller or processor 20 may be or include an electronic, electrical, physical or mechanical controller such as for example a conductive element that may control directly or indirectly the operation of immobilization unit 22. Other controllers or processors 20 may be used.
  • Device 10 may include an immobilizer or an immobilization unit 22 or other suitable holding system. According to some embodiments, immobilization unit 22 may immobilize, hold or otherwise arrest the motion of the device 10 in response to instructions or signals of processor 20.
  • an instruction may be or include an electronic or electrical signal such as for example a signal to activate a heating element.
  • an instruction may include a physical signal such as the opening of latch to release an anchor 30 from a body 12.
  • the device 10 may be immobilized or held temporarily or transiently such that its movement may resume after a period of time or in response to certain conditions or triggers.
  • instructions to immobilize device 10 in an in vivo site may come from an external operator, when for example the operator sees or receives an indication of a condition, such as for example a protrusion 24 from an endo-luminal wall, that s/he might want to view for more than the few seconds or minutes typically available during the device's 10 regular traverse of the current region.
  • instructions or signals to immobilize may be issued by processor 20, or by an external operator for example providing input to a processor 20, in response to an analysis of sensed data that may indicate that there is a condition that may be of concern, such as for example blood in a region of the GI tract. Upon detection of such a condition, processor 20 may instruct or signal immobilization unit 22 to activate, stopping the progress of device 10 through a body lumen.
  • immobilizer or immobilization unit 22 may include a set of anchors 30 such as pointed anchors, a spring 32 between anchors 30 and a fuse 34. Other number of anchors 30 such as one anchor may be used. Anchors 30 may have other configurations such as for example a wheel or sphere with talons, points, hooks or other shapes that may be brought into contact with an endo-luminal tissue to immobilize device 10. According to an embodiment of the invention, immobilizer or immobilization unit 22 may be covered, retracted or located within a chamber 36 formed within body 12 and generally sealed from the other chambers of body 12 and from contact with a body lumen until activated.
  • chamber 36 may have holes to the outside through which anchors 30 may move.
  • the holes may be covered with a film cover 38 that anchors 30 may break or puncture as they move or are activated.
  • Spring 32 may be formed of any suitable spring-like material whose ends may be soldered or otherwise releaseably attached to the ends of fuse 34 with soldering or other adhesive material 35, as is depicted in Fig. 1 A.
  • Fuse 34 may be formed of a material, such as for example ferrite, which heats up in the presence of a radiofrequency. Such a fuse is discussed for example in US 5,723,844 to Dow filed on March 3, 1998 and entitled "Heating System using Ferrite to Convert RF Energy to Heat Energy ' ', which is incorporated herein by reference.
  • fuse 34 may be activated in response to a signal from for example receiver/transmitter 42, that may be received for example by transceiver 13, and processed by processor 20.
  • an external transmitter 37 may for example transmit radio waves of the frequency or frequencies which may heat up fuse 34. In such example, when fuse 34 heats up, fuse 34 may break material 35, thereby releasing spring 32 from its contracted state as is depicted in Fig. 1A, and pushing anchors 30 into walls 40 of the GI tract as is shown in Fig. IB. Fig.
  • IB shows device 10 stopped at a distance from protrusion 24 such that protrusion 24 might be viewed or sensed in more detail.
  • transmitter 37 may be included in or connected to receiver /transmitter 42.
  • An anchor 30 may have a pointed head 41 capable of piercing endo-luminal walls 40.
  • spring 32 may force head 41 most or all of the way into walls 40.
  • Pointed head 41 may be configured to a suitable size and shape which may hold device 10 in place.
  • head 41 may have a diameter at its point of 0.5 - 2mm which may in some embodiments be suitable for immobilizing a device with dimensions of approximately 11mm by 25mm. Other suitable dimensions may be used.
  • Anchors 30 may be formed of any suitable material such as for example a biodegradable material 43 strong enough to hold device 10 in place but which may degrade or be soluble upon exposure to for example the moist conditions of an in vivo environment such as the GI tract. Suitable materials may include, for example, caramel, biodegradable plastic resins or starches, such as gelatin, or wax. After a period of time, at least biodegradable material 43 of head 41 may dissolve, thereby releasing device 10, and device 10 may continue moving through a body lumen. The latter phase is shown in Fig. 1C where spring 32 is in an expanded state but where anchors 30 have degraded. In Fig. 1C, device 10 is depicted as passing protrusion 24.
  • the biodegradable material 43 of anchors 30 may include a pharmacological compound or composition.
  • the compound or composition might be or include an anti-biotic, for example to counter possible injury caused by anchors 30 when pushed into walls 40.
  • the compound might be a drug needed at a specific location.
  • the location, of device 10 as proximate to protrusion 24, may be known and processor 20 may instruct or signal for example fuse 34 or some other mechanism to activate immobilization unit 22 at the appropriate moment to cause anchors 30 to jab walls 40 at the desired location.
  • immobilization unit 22 may act as a drug delivery unit.
  • the biodegradable material 43 of anchors 30 may include in it a marker or any other compound needed to be delivered, preferably in a site-specific manner, to a body lumen, such as the GI tract.
  • anchors 30 may be replaced by one or more sets of grippers 50, which may extend for example longitudinally along a side 52 of body 12.
  • grippers 50 may be located within a chamber 54 which may be external to the main chamber of device 10.
  • grippers 50 may be connected to an actuator 56A and 56B, that may be formed for example of a piezoelectric material, such as for example poly vinylidene fluoride (PVDF), commercially available from PIEZOTECH S.A. of St. Louis, France. Other activating processes may be used to move, close or open grippers 50, and other materials may be used.
  • actuators 56 may change shape or otherwise pull on grippers 50, causing grippers 50 to extend outside of chamber 54 (see Fig. 2C) and, if walls 40 are close by, to grasp or pinch a portion of an endo-luminal wall 40 (not shown).
  • grippers 50 may arrest the motion of device 10.
  • Other mechanisms or processes of activating grippers 50 may be used.
  • Grippers 50 may be formed of a metal, plastic or other material suitable for use in a body lumen and may be formed of for example a plurality of double scissors mechanisms 58 with rods 60 rotatably joined by a pivot 62 and a gripping end 64.
  • Other configurations for grippers 50 are possible.
  • Figs. 2B and 2C show, for example, a double scissors mechanism 58, though other closing mechanisms to engage grippers 50 may be utilized.
  • Ends 66 of rods 60 may be rotatably connected, via pivots 68, to ends 70 of gripping end 64.
  • Gripping end 64 may be formed of two halves 64A and 64B, rotatably connected via pivot 72 and ending in opposing gripping shapes 74A and 74B.
  • Actuators 56 may be formed in a tweezers shape having two pinching halves 56A and 56B, each rotatably connected, via pivots 76. to ends 78 of crossed rod 60.
  • actuator 56 When actuator 56 may be in the open state (Fig. 2B), rods 60 and gripping end 64 may be in their open state and gripping shapes 74A and 74B may remain within chamber 54.
  • actuators 56 when actuators 56 may be in a closed state (Fig. 2B), rods 60 and gripping end 64 may extend into their closed states and gripping shapes 74A and 74B may extend outside of chamber 54 in an attempt to pinch walls 40.
  • processor 20 may provide instructions to actuators 56 to open, thereby retracting grippers 50, freeing device 10 from the in vivo site to which it was immobilized, and enabling device 10 to continue its traverse of a body lumen.
  • such instructions may be provided for example in response to a signal from receiver/transmitter 42 to transceiver 13.
  • grippers 50 may be used to pinch off a piece of tissue, such as while taking a biopsy. While grippers 50 are retracting, the piece of tissue may be collected into a sample container (not shown) that is placed within chamber 54.
  • a signal may be generated to activate an immobilizer included in an in vivo device.
  • such signal may originate from outside of the in vivo device and may be issued by for example a receiving system or a processor or controller connected with such receiving system, or by for example an operator or doctor who may view an image of an in vivo site or may otherwise receive information about an in vivo site that he wished to monitor for an extended period of time.
  • an operator may transmit a signal to for example a receiver in an in vivo device.
  • a receiver and for example a processor or controller with which such receiver is in contact may generate a signal to activate an immobilizer in such in vivo device to immobilize the in vivo device.
  • a signal may be generated in response to for example in vivo conditions detected by an in vivo sensor, and without input from an external operator.
  • a sensor may detect the presence of for example blood in the GI tract. The sensor's detection of blood may trigger a controller to activate an immobilization unit connected to the in vivo device.
  • a signal may include a burn of a fuse that holds a spring to which is connected an anchor or pointed head that may be included in an immobilization unit. Other signals and other methods or sources of generating signals are possible.
  • an in vivo device may be immobilized in an area that is near, proximate to or in the vicinity of an in vivo site to be monitored.
  • an immobilizing unit of an in vivo device that detected blood in a GI tract may immobilize the in vivo device in the area where the blood was detected.
  • the in vivo device may continue to monitor the site or area for continued bleeding.
  • an operator may view an image of an in vivo area that is generated by an in vivo device. If the image reveals an object, condition or area that the operator wishes to continue monitoring, the immobilizer may be activated and the device may be immobilized in the area proximate to the object or condition to be monitored.
  • the immobilizer may bring anchors with, for example, pointed heads into contact with, or may puncture, an endo-luminal tissue or wall to immobilize the in vivo device.
  • One or more springs may propel the anchors to contact, grasp or puncture an endo-luminal tissue.
  • Other methods of immobilizing an in vivo device are possible.
  • a signal may include a bu of a fuse that holds a spring to which may be connected an anchor or pointed head.
  • the in vivo site, area or object may be monitored by the immobilized in vivo device. For example, an in vivo imaging device may capture images
  • an anchor or pointed head may include or contain a compound such as for example a drug that may be injected into or brought into contact with an endo-luminal tissue in the area where the in vivo device is 5 immobilized.
  • anchors or grippers of the immobilization unit may remove a sample of tissue as part of for example a biopsy of an in vivo area.
  • anchors or pointed heads may be constructed of a material that degrades over time once exposed to in vivo conditions. Once the pointed heads degrade or melt, the in vivo device may be freed to continue moving through the body lumen.

Abstract

An in vivo sensing device (10) including an immobilizer (30) that may immobilize the device in an in vivo location. The immobilizer may be activated by for example a processor (20) or in response to an in vivo condition or in response to a signal (42) from an outside operator.

Description

HvIMOBILIZABLE IN VIVO SENSING DEVICE
FIELD OF THE INVENTION
The present invention relates to in vivo sensing devices generally and to their immobilization in vivo, in particular. BACKGROUND OF THE INVENTION
In vivo sensing devices, such as thermometers, pH meters, optical scanners, image sensors and so on, may be used for example to unobtrusively monitor bodily systems and in vivo sites. Some in vivo sensors move through body lumens and may be remotely controlled. However, it may sometimes be desirable to immobilize a sensing device in vivo for continuous sensing of an in vivo site, for example, for post surgery monitoring. Other in vivo sensors may perform treatment functions and may be immobilized to perform such treatment. Still other in vivo sensors may be immobilized to monitor an area for a period of time in order to make a diagnosis, such as an in vivo pH sensor which may be immobilized to detect, record and analyze gastroesophageal pH. Immobilization of a device may also provide an opportunity for the device to release a compound such as a drug at a specific location or for taking a biopsy at such location.
SUMMARY OF THE INVENTION
In embodiments of the invention an in vivo sensing device may include an immobilizer or immobilization unit that may be activated in response to a signal from for example a processor or controller. According to one embodiment, the immobilizer may immobilize the device in an in vivo area that is to be monitored over a period of time. In some embodiments, the in vivo sensing device may be or include an autonomous in vivo sensing capsule. In accordance with embodiments of a method of the invention a signal may be generated to activate an immobilizer that is included in an in vivo device so that the in vivo device is immobilized in an in vivo area to be monitored. The immobilized in vivo device may continue to monitor or collect images or other sensing data from the area that is proximate to the device. In accordance with a system of the invention, a housing may include or be attached to an in vivo sensor and an immobilizing unit, and may also include a processor that may activate the immobilization unit.
BRIEF DESCRIPTION OF THE DRAWINGS The subject matter regarded as the invention is particularly pointed out and distinctly claimed in the concluding portion of the specification. The invention, however, both as to organization and method of operation, together with objects, features, and advantages thereof, may best be understood by reference to the following detailed description when read with the accompanying drawings in which: Fig. 1A is a schematic illustration of an in vivo device having an immobilization unit, constructed and operative in accordance with an embodiment of the present invention;
Fig. IB is a schematic illustration of the in vivo device of Fig. 1A in an immobilized state, in accordance with an embodiment of the present invention;
Fig. 1C is a schematic illustration of the in vivo device of Fig. 1A freed from an immobilized state, in accordance with an embodiment of the present invention;
Fig. 2A is a schematic illustration of an in vivo device with a gripping unit, constructed and operative in accordance with an embodiment of the present invention;
Fig. 2B is a cross-sectional illustration of the gripping unit of Fig. 2A, in accordance with an embodiment of the present invention; Fig. 2C is a cross-sectional illustration of the gripping unit of Fig. 2A in an extended state, in accordance with an embodiment of the present invention; and
Fig 3 is a schematic flow chart diagram presentation of a method in accordance with certain embodiments of the present invention.
It will be appreciated that for simplicity and clarity of illustration, elements shown in the figures have not necessarily been drawn to scale. For example, the dimensions of some of the elements may be exaggerated relative to other elements for purposes of clarity. Further, where considered appropriate, reference numerals may be repeated among the figures to indicate corresponding or analogous elements. DETAILED DESCRIPTION OF THE INVENTION
In the following detailed description, numerous specific details are set forth in order to provide a thorough understanding of the invention. However, it will be understood by those skilled in the art that the present invention may be practiced without these specific details. In other instances, well-known methods, procedures, and components have not been described in detail so as not to obscure the present invention.
According to an embodiment of the present invention there is provided a device, system and method for immobilizing or otherwise controlling the movement of or holding a sensing device in an in vivo site for example in response to a signal that activates an immobilization unit or in response to another condition or event such as for example the passage of time. Some embodiments may enable for example a doctor or other operator to indicate to an in vivo device such as for example an autonomous in vivo capsule, to stop the movement of the device in vivo or to direct that the device assume an immobilized state or position. Immobilizing an in vivo device may be desirable for example, if something of concern, such as blood, a high temperature, a polyp or other protrusion, is detected while the sensor moves for example through a body lumen, and the operator wants to monitor the item of concern or particular in vivo site more carefully or for a longer period of time. In some embodiments, monitoring may include for example capturing images of the in vivo site or performing other sensing functions in the area proximate to where the device is immobilized. In some embodiments, a sensing device may be stopped or held at one or more known locations in the body lumen to recalibrate sensors in the device to those locations.
According to one embodiment, a device of the invention may include a sensing device, a transmitter that transmits the output of the sensing device, a reception system for receiving the transmitted output and a power source, which provides power to the elements of the device. The sensing device may be connected to, or disposed within, a housing or shell, which may be configured for being transiently immobilized or held proximate to or in the vicinity of the site to be monitored. According to other embodiments, the device may be permanently immobilized in vivo. The sensing device may be a sensor that is adapted for being placed in vivo, for example, along the gastro-intestinal (GI) tract, and that is configured for sensing in vivo environmental conditions such as for example the presence of blood, pH, temperature, electrical impedance of tissues etc. The sensing device may transmit (such as for example by radio waves) output relating to for example changes in in vivo environmental conditions. Other sensors may be used and other conditions may be detected or monitored.
In some embodiments, a system is provided for monitoring, such as for example by way of an imager, a site in the GI tract over an extended period of time. The imaging system may include at least one illumination source such as one or more light emitting diodes (LED), which may be for example monochromatic or a white LED, and an imaging device such as for example a charge coupled device (CCD) or complementary metal oxide semiconductor (CMOS) image sensor. Other light sources and other suitable imaging devices may be used. The imaging system may further include an optical system for imaging an area of interest onto the imaging system. The optical system may include mirrors and/or lenses for collimating the light from the illumination source. In some embodiments of the invention, a reception system receives the transmitted image output. Such reception system may include an antenna array capable of surrounding a body for receiving the transmitted image output and for producing a plurality of received signals and a demodulator capable of transforming the pluralit}' of received image signals into a single video data stream. The reception system may include for example a display, such as for example an LCD or a monitor, for displaying the data transmitted to it.
Embodiments of the invention may be included in an autonomous device such as for example a self-contained in-vivo capsule capable of passing through a body lumen such as for example a GI tract, the reproductive tract, the urinary tract or a blood vessel, and where some or all of the operative components are substantially contained within a container, and where the device does not require wires or cables to for example receive power or transmit information. For example, power may be supplied by an internal battery or wireless receiving system. Other embodiments may have other configurations and capabilities. For example, components may be distributed over multiple sites or units. Control information may be received from an external source. A device or system in accordance with an embodiment of the invention may include an imager such as for example a camera system, a transmitter, a receiving system and a display system such as described in some embodiments of US 5,604,531 to Iddan and/or in International Application publication number WO 01/65995 entitled "A Device And System For In Vivo Imaging", published on 13 September, 2001. US 5,604,531 and WO 01/65995 are assigned to the common assignee of the present invention and are hereby incorporated herein by reference.
An imaging system in accordance with an embodiment of the invention may for example provide direct visual information of an in vivo site such that visibly detectable changes at the site, such as bleeding, swelling etc. can be seen by an operator. In some embodiments, the imaging system may further include a detector coupled to the sensor or imaging device that is optically changed in response to changes in environmental conditions. The optical change in the detector may be imaged and transmitted to a receiving system and shown on a display of the receiving unit to alert an external operator of the changed conditions. For example, the imaging system may include a pH meter that undergoes a color change in response to pH changes in its vicinity. In some embodiments, the imaging system may include a detector of chemical substances, such as blood components, which may undergo a change in color in response to the presence of the chemical substances. In both cases, a change in color may be detected by for example an imaging device or other sensor and an indication of such detection may be transmitted and received by the reception system for inspection by for example an operator. In some embodiments, a processor in an external receiving system may analyze a detected condition a may issue signals or instructions in response to said detected conditions. In some embodiments, a sensor such as an imager may signal a processor in the in vivo device as to the presence of a detected condition. In response, a processor or controller may generate a signal that may activate an immobilization unit that may be included in or attached to the device. As described herein, such signal may result in the immobilization of the device in a specific location where further sensing of in vivo conditions may be desired. Reference is now made to Figs. 1A, IB and 1C which illustrate an in vivo device 10, designed, according to one embodiment, to passively traverse the GI tract. Device 10 may include a housing or body 12, which may include for example an optical window 14, behind or adjacent to which may be positioned illumination sources 16, an imaging device 18, and a controller or processor 20. According to an embodiment of the invention, the body 12 may house additional elements of the system, such as a transceiver 13 for receiving instructions or commands from an external operator or processor and/or for transmitting data such as sensing data to an external receiver/transmitter 42, and a power source 15, such as a battery. Transceiver 13 may include one or more antennas 48 or arrays of antennas 48.
A system in accordance with some embodiments of the invention may include outside a patient's body a receiver/transmitter 42, which may include an antenna or antenna array, a data storage unit 44, a processor 46 and a display system or monitor 47. Receiver/transmitter 42 may receive signals in the form of for example radio waves that may be transmitted from device 10 and that may for example contain image data, location data and or other sensing data collected by or about device 10. A transmitter such as for example receiver/transmitter 42 may also transmit signals or instructions to device 10 such as for example instructions to immobilize device 10 in a body lumen or to change a state of activation of a component of device 10.
Monitor 47 may include for example one or more screens, monitors or suitable display units. Monitor 47 may for example display images or other data captured or transmitted by device 10. In some embodiments, images and position or location information of such device 10 may be displayed on one or more monitors 47.
In some embodiments, processor 20 may be or include for example one or more circuits such as for example an integrated circuit or circuit board suitable for processing, transmitting or delivering signals from for example a sensing device such as an in vivo imager or from an external transmitter, and for transmitting a signal to an immobilization unit 22. In some embodiments, controller or processor 20 may be or include an electronic, electrical, physical or mechanical controller such as for example a conductive element that may control directly or indirectly the operation of immobilization unit 22. Other controllers or processors 20 may be used. Device 10 may include an immobilizer or an immobilization unit 22 or other suitable holding system. According to some embodiments, immobilization unit 22 may immobilize, hold or otherwise arrest the motion of the device 10 in response to instructions or signals of processor 20. In some embodiments, an instruction may be or include an electronic or electrical signal such as for example a signal to activate a heating element. In some embodiments an instruction may include a physical signal such as the opening of latch to release an anchor 30 from a body 12.
In some embodiments the device 10 may be immobilized or held temporarily or transiently such that its movement may resume after a period of time or in response to certain conditions or triggers. In accordance with an embodiment of the present invention, instructions to immobilize device 10 in an in vivo site may come from an external operator, when for example the operator sees or receives an indication of a condition, such as for example a protrusion 24 from an endo-luminal wall, that s/he might want to view for more than the few seconds or minutes typically available during the device's 10 regular traverse of the current region. In some embodiments, instructions or signals to immobilize may be issued by processor 20, or by an external operator for example providing input to a processor 20, in response to an analysis of sensed data that may indicate that there is a condition that may be of concern, such as for example blood in a region of the GI tract. Upon detection of such a condition, processor 20 may instruct or signal immobilization unit 22 to activate, stopping the progress of device 10 through a body lumen.
In the example of Figs. 1A - 1C, immobilizer or immobilization unit 22 may include a set of anchors 30 such as pointed anchors, a spring 32 between anchors 30 and a fuse 34. Other number of anchors 30 such as one anchor may be used. Anchors 30 may have other configurations such as for example a wheel or sphere with talons, points, hooks or other shapes that may be brought into contact with an endo-luminal tissue to immobilize device 10. According to an embodiment of the invention, immobilizer or immobilization unit 22 may be covered, retracted or located within a chamber 36 formed within body 12 and generally sealed from the other chambers of body 12 and from contact with a body lumen until activated. In some embodiments, chamber 36 may have holes to the outside through which anchors 30 may move. In some embodiments, the holes may be covered with a film cover 38 that anchors 30 may break or puncture as they move or are activated. Spring 32 may be formed of any suitable spring-like material whose ends may be soldered or otherwise releaseably attached to the ends of fuse 34 with soldering or other adhesive material 35, as is depicted in Fig. 1 A. Fuse 34 may be formed of a material, such as for example ferrite, which heats up in the presence of a radiofrequency. Such a fuse is discussed for example in US 5,723,844 to Dow filed on March 3, 1998 and entitled "Heating System using Ferrite to Convert RF Energy to Heat Energy'', which is incorporated herein by reference. Other releasable adhesives or materials may be used to hold spring 32 and other means of releasing spring 32, such as for example with an electrical charge applied to spring 32 or to adhesive material 35. may be used. In one embodiment, fuse 34 may be activated in response to a signal from for example receiver/transmitter 42, that may be received for example by transceiver 13, and processed by processor 20. In another embodiment, an external transmitter 37 may for example transmit radio waves of the frequency or frequencies which may heat up fuse 34. In such example, when fuse 34 heats up, fuse 34 may break material 35, thereby releasing spring 32 from its contracted state as is depicted in Fig. 1A, and pushing anchors 30 into walls 40 of the GI tract as is shown in Fig. IB. Fig. IB shows device 10 stopped at a distance from protrusion 24 such that protrusion 24 might be viewed or sensed in more detail. In some embodiments, transmitter 37 may be included in or connected to receiver /transmitter 42. An anchor 30 may have a pointed head 41 capable of piercing endo-luminal walls 40. In some embodiments, spring 32 may force head 41 most or all of the way into walls 40. Pointed head 41 may be configured to a suitable size and shape which may hold device 10 in place. For example, head 41 may have a diameter at its point of 0.5 - 2mm which may in some embodiments be suitable for immobilizing a device with dimensions of approximately 11mm by 25mm. Other suitable dimensions may be used. Anchors 30 may be formed of any suitable material such as for example a biodegradable material 43 strong enough to hold device 10 in place but which may degrade or be soluble upon exposure to for example the moist conditions of an in vivo environment such as the GI tract. Suitable materials may include, for example, caramel, biodegradable plastic resins or starches, such as gelatin, or wax. After a period of time, at least biodegradable material 43 of head 41 may dissolve, thereby releasing device 10, and device 10 may continue moving through a body lumen. The latter phase is shown in Fig. 1C where spring 32 is in an expanded state but where anchors 30 have degraded. In Fig. 1C, device 10 is depicted as passing protrusion 24.
In accordance with an embodiment of the present invention, the biodegradable material 43 of anchors 30 may include a pharmacological compound or composition. For example, the compound or composition might be or include an anti-biotic, for example to counter possible injury caused by anchors 30 when pushed into walls 40.
In accordance with an alternative embodiment of the present invention, the compound might be a drug needed at a specific location. In such embodiment, the location, of device 10 as proximate to protrusion 24, may be known and processor 20 may instruct or signal for example fuse 34 or some other mechanism to activate immobilization unit 22 at the appropriate moment to cause anchors 30 to jab walls 40 at the desired location. In this embodiment, immobilization unit 22 may act as a drug delivery unit.
According to further embodiments, the biodegradable material 43 of anchors 30 may include in it a marker or any other compound needed to be delivered, preferably in a site-specific manner, to a body lumen, such as the GI tract.
Reference is now made to Figs. 2A, 2B and 2C which illustrate an alternative embodiment of the present invention. In such embodiment, anchors 30 may be replaced by one or more sets of grippers 50, which may extend for example longitudinally along a side 52 of body 12. As in the previous embodiment, grippers 50 may be located within a chamber 54 which may be external to the main chamber of device 10.
As can be seen in Fig. 2B, grippers 50 may be connected to an actuator 56A and 56B, that may be formed for example of a piezoelectric material, such as for example poly vinylidene fluoride (PVDF), commercially available from PIEZOTECH S.A. of St. Louis, France. Other activating processes may be used to move, close or open grippers 50, and other materials may be used. When instructed by processor 20 (not shown in Figs. 2A - C), actuators 56 may change shape or otherwise pull on grippers 50, causing grippers 50 to extend outside of chamber 54 (see Fig. 2C) and, if walls 40 are close by, to grasp or pinch a portion of an endo-luminal wall 40 (not shown). In the latter state, grippers 50 may arrest the motion of device 10. Other mechanisms or processes of activating grippers 50 may be used. Grippers 50 may be formed of a metal, plastic or other material suitable for use in a body lumen and may be formed of for example a plurality of double scissors mechanisms 58 with rods 60 rotatably joined by a pivot 62 and a gripping end 64. Other configurations for grippers 50 are possible. Figs. 2B and 2C show, for example, a double scissors mechanism 58, though other closing mechanisms to engage grippers 50 may be utilized. Ends 66 of rods 60 may be rotatably connected, via pivots 68, to ends 70 of gripping end 64. Gripping end 64 may be formed of two halves 64A and 64B, rotatably connected via pivot 72 and ending in opposing gripping shapes 74A and 74B.
Actuators 56 may be formed in a tweezers shape having two pinching halves 56A and 56B, each rotatably connected, via pivots 76. to ends 78 of crossed rod 60. When actuator 56 may be in the open state (Fig. 2B), rods 60 and gripping end 64 may be in their open state and gripping shapes 74A and 74B may remain within chamber 54. However, when actuators 56 may be in a closed state (Fig. 2B), rods 60 and gripping end 64 may extend into their closed states and gripping shapes 74A and 74B may extend outside of chamber 54 in an attempt to pinch walls 40.
When desired, and in response to for example a signal or instructions from a processor 20 or an operator, after a predetermined period of time, or after an expected action has occurred or condition has been sensed, processor 20 may provide instructions to actuators 56 to open, thereby retracting grippers 50, freeing device 10 from the in vivo site to which it was immobilized, and enabling device 10 to continue its traverse of a body lumen. In some embodiments, such instructions may be provided for example in response to a signal from receiver/transmitter 42 to transceiver 13.
According to another embodiment of the invention grippers 50 may be used to pinch off a piece of tissue, such as while taking a biopsy. While grippers 50 are retracting, the piece of tissue may be collected into a sample container (not shown) that is placed within chamber 54.
Reference is made to Fig 3, a schematic flow chart diagram presentation of a method in accordance with certain embodiments of the present invention. In block 300, a signal may be generated to activate an immobilizer included in an in vivo device. In some embodiments, such signal may originate from outside of the in vivo device and may be issued by for example a receiving system or a processor or controller connected with such receiving system, or by for example an operator or doctor who may view an image of an in vivo site or may otherwise receive information about an in vivo site that he wished to monitor for an extended period of time. In some embodiments, an operator may transmit a signal to for example a receiver in an in vivo device. A receiver and for example a processor or controller with which such receiver is in contact, may generate a signal to activate an immobilizer in such in vivo device to immobilize the in vivo device. In some embodiments a signal may be generated in response to for example in vivo conditions detected by an in vivo sensor, and without input from an external operator. For example, a sensor may detect the presence of for example blood in the GI tract. The sensor's detection of blood may trigger a controller to activate an immobilization unit connected to the in vivo device. In some embodiments, a signal may include a burn of a fuse that holds a spring to which is connected an anchor or pointed head that may be included in an immobilization unit. Other signals and other methods or sources of generating signals are possible. In block 302, an in vivo device may be immobilized in an area that is near, proximate to or in the vicinity of an in vivo site to be monitored. For example, an immobilizing unit of an in vivo device that detected blood in a GI tract may immobilize the in vivo device in the area where the blood was detected. The in vivo device may continue to monitor the site or area for continued bleeding. In another example, an operator may view an image of an in vivo area that is generated by an in vivo device. If the image reveals an object, condition or area that the operator wishes to continue monitoring, the immobilizer may be activated and the device may be immobilized in the area proximate to the object or condition to be monitored. In some embodiments, the immobilizer may bring anchors with, for example, pointed heads into contact with, or may puncture, an endo-luminal tissue or wall to immobilize the in vivo device. One or more springs may propel the anchors to contact, grasp or puncture an endo-luminal tissue. Other methods of immobilizing an in vivo device are possible. In some embodiments, a signal may include a bu of a fuse that holds a spring to which may be connected an anchor or pointed head. In block 304, the in vivo site, area or object may be monitored by the immobilized in vivo device. For example, an in vivo imaging device may capture images
π of an area or object over the period of time during which the in vivo device remains immobilized at a particular site. In some embodiments, an anchor or pointed head may include or contain a compound such as for example a drug that may be injected into or brought into contact with an endo-luminal tissue in the area where the in vivo device is 5 immobilized. In some embodiments, anchors or grippers of the immobilization unit may remove a sample of tissue as part of for example a biopsy of an in vivo area. In some embodiments, anchors or pointed heads may be constructed of a material that degrades over time once exposed to in vivo conditions. Once the pointed heads degrade or melt, the in vivo device may be freed to continue moving through the body lumen. l o While certain features of the invention have been illustrated and described herein, many modifications, substitutions, changes, and equivalents will now occur to those of ordinary skill in the art. It is, therefore, to be understood that the appended claims are intended to cover all such modifications and changes as fall within the true spirit of the invention.
15

Claims

CLAIMSWe claim:
1. An in vivo sensing device comprising an immobilizer, said immobilizer capable of being activated in response to a signal.
2. The device as in claim 1, including a processor capable of issuing said signal.
3. The device as in claim 2, wherein said processor issues said signal in response to an instruction received from outside a body lumen.
4. The device as in claim 1, wherein said immobilizer is degradable.
5. The device as in claim 4, wherein said immobilizer is capable of degrading upon exposure to in vivo conditions.
6. The device as in claim 1, wherein said signal is issued in response to a detected environmental condition.
7. The device as in claim 1, wherein said sensing device comprises an imager.
8. The device as in claim 1, wherein said immobilizer comprises an anchor.
9. The device as in claim 8, wherein said anchor is a pointed anchor.
10. The device as in claim 1, wherein said immobilizer comprises a spring.
11. The device as in claim 10, wherein said spring is releasably attached to a fuse.
12. The device as in claim 1, wherein said immobilizer comprises a composition delivery unit.
13. The device as in claim 12, wherein said composition comprises a drug.
14. The device as in claim 1, wherein said immobilizer comprises a gripper and an actuator.
15. The device as in claim 14, wherein said gripper is to remove a sample of said tissue.
16. The device as in claim 1, comprising a power source.
17. An autonomous in vivo capsule comprising an immobilization unit, said immobilization unit capable of being activated in response to a signal.
18. The capsule as in claim 17, wherein said signal is sent from outside of a body lumen.
19. The capsule as in claim 17, comprising an anchor.
20. The capsule as in claim 17, comprising an imager.
21. The capsule as in claim 17, wherein said immobilizer is degradable.
22. A method of monitoring an in vivo site, the method comprising: generating a signal to activate an immobilizer attached to an in vivo device; immobilizing said device proximate to an in vivo site to be monitored: and monitoring said in vivo site with said device.
23. The method as in claim 22, wherein said immobilizing comprises bringing an immobilizer into contact with an endo-luminal tissue.
24. The method as in claim 22, wherein said immobilizing comprises releasing a spring holding said immobilizer.
25. The method as in claim 24, wherein said releasing a spring comprises burning a fuse holding said spring.
26. The method as in claim 22, comprising releasing a composition into said in vivo site.
27. The method as in claim 22, wherein said immobilizing comprises gripping an endo-luminal tissue.
28. The method of claim 27, comprising removing a sample of said endo-luminal tissue with a gripper.
29. The method as in claim 22, comprising freeing said device from said in vivo site.
30. The method as in claim 29, wherein said freeing comprises degrading an immobilizer.
31. The method as in claim 22, wherein said immobilizing said device comprises transiently immobilizing said device.
32. The method as in claim 22, wherein said monitoring comprises capturing images of said in vivo site.
33. A method for immobilizing an autonomous in vivo device comprising generating a signal to activate an immobilizer attached to said in vivo device.
34. The method as in claim 33. comprising immobilizing said device proximate to an in vivo site to be monitored;
35. An in vivo sensing system comprising: an immobilizable housing; a sensor attached to said housing; and a controller to activate an immobilization unit of said housing.
36. The system as in claim 35, wherein said sensor is an imager.
37. The system as in claim 35, wherein said immobilizable unit comprises a pointed anchor.
38. The system as in claim 35, comprising a transmitter.
PCT/IL2003/001104 2002-12-26 2003-12-25 Immobilizable in vivo sensing device WO2004058041A2 (en)

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AT03780591T ATE547976T1 (en) 2002-12-26 2003-12-25 IMMOBILIZABLE IN-VIVO MEASUREMENT DEVICE
EP03780591A EP1587407B1 (en) 2002-12-26 2003-12-25 Immobilizable in vivo sensing device
US10/540,890 US7946979B2 (en) 2002-12-26 2003-12-25 Immobilizable in vivo sensing device
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Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005032290A1 (en) * 2005-07-11 2007-01-18 Siemens Ag Capsule and method to be used for magnetic wireless diagnosis and treatment of gastrointestinal tract, comprises substance releasing facility and anchor
WO2007007648A1 (en) 2005-07-08 2007-01-18 Olympus Medical Systems Corp. Apparatus for placing capsule type medical device, apparatus for placing capsule endoscope in the body and capsule type medical device for placement
WO2007010997A1 (en) * 2005-07-20 2007-01-25 Olympus Medical Systems Corp. Apparatus and system for detaining a device for introduction into body cavity
EP1769729A3 (en) * 2005-09-30 2007-05-02 Given Imaging Limited System and method for in-vivo feature detection
EP1875858A2 (en) 2006-07-03 2008-01-09 Novineon Healthcare Technology Partners Gmbh Device for detecting bleeding
WO2008017967A1 (en) * 2006-08-07 2008-02-14 Koninklijke Philips Electronics N.V. Device, system and method for interacting with a cell or tissue in a body
EP1959830A2 (en) * 2005-12-02 2008-08-27 Given Imaging Ltd. System and device for in vivo procedures
US7678043B2 (en) 2005-12-29 2010-03-16 Given Imaging, Ltd. Device, system and method for in-vivo sensing of a body lumen
GB2453676B (en) * 2004-04-19 2010-11-10 Searete Llc Lumen-traveling biological interface device and method of use
US7850676B2 (en) 2004-04-19 2010-12-14 The Invention Science Fund I, Llc System with a reservoir for perfusion management
US7857767B2 (en) 2004-04-19 2010-12-28 Invention Science Fund I, Llc Lumen-traveling device
US7879023B2 (en) 2004-04-19 2011-02-01 The Invention Science Fund I, Llc System for perfusion management
US7998060B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
US8019413B2 (en) 2007-03-19 2011-09-13 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US8092549B2 (en) 2004-09-24 2012-01-10 The Invention Science Fund I, Llc Ciliated stent-like-system
US8353896B2 (en) 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
US8361014B2 (en) 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US8512241B2 (en) 2006-09-06 2013-08-20 Innurvation, Inc. Methods and systems for acoustic data transmission
US8588887B2 (en) 2006-09-06 2013-11-19 Innurvation, Inc. Ingestible low power sensor device and system for communicating with same
US8617058B2 (en) 2008-07-09 2013-12-31 Innurvation, Inc. Displaying image data from a scanner capsule
US8647259B2 (en) 2010-03-26 2014-02-11 Innurvation, Inc. Ultrasound scanning capsule endoscope (USCE)
US8840551B2 (en) 2009-12-21 2014-09-23 Given Imaging, Inc. Tethering capsule system
US9011329B2 (en) 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US9197470B2 (en) 2007-10-05 2015-11-24 Innurvation, Inc. Data transmission via multi-path channels using orthogonal multi-frequency signals with differential phase shift keying modulation
US9192353B2 (en) 2009-10-27 2015-11-24 Innurvation, Inc. Data transmission via wide band acoustic channels
US9198563B2 (en) 2006-04-12 2015-12-01 The Invention Science Fund I, Llc Temporal control of a lumen traveling device in a body tube tree
US9232884B2 (en) 2008-04-07 2016-01-12 Olympus Corporation Capsule medical apparatus and medical system
US9342881B1 (en) 2013-12-31 2016-05-17 Given Imaging Ltd. System and method for automatic detection of in vivo polyps in video sequences
EP3461478A1 (en) * 2009-12-24 2019-04-03 Rani Therapeutics, LLC Swallowable drug delivery device
US10478396B2 (en) 2010-12-23 2019-11-19 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10487145B2 (en) 2010-12-23 2019-11-26 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10548850B2 (en) 2010-12-23 2020-02-04 Rani Therapeutics, Llc Therapeutic composition comprising insulin prepared for delivery into an intestinal tract
US10596359B2 (en) 2009-12-24 2020-03-24 Rani Therapeutics, Llc Therapeutic agent preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US10632251B2 (en) 2010-12-23 2020-04-28 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US10752681B2 (en) 2010-12-23 2020-08-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10864254B2 (en) 2010-12-23 2020-12-15 Rani Therapeutics, Llc Method of delivering gonadotropin releasing hormone or an analogue thereof into a lumen of the intestinal tract using a swallowable drug delivery device
US10874840B2 (en) 2010-12-23 2020-12-29 Rani Therapeutics, Llc Preparation comprising exanatide for delivery into a lumen of the intestinal tract
US10926073B2 (en) 2010-12-23 2021-02-23 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10953077B2 (en) 2010-12-23 2021-03-23 Rani Therapeutics, Llc Method of delivering a somatostatin compound into a lumen of the intestinal tract using a swallowable drug delivery device
US10967050B2 (en) 2010-12-23 2021-04-06 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11229684B2 (en) 2010-12-23 2022-01-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11304895B2 (en) 2010-12-23 2022-04-19 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11439817B2 (en) 2009-08-03 2022-09-13 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4663230B2 (en) 2001-06-28 2011-04-06 ギブン イメージング リミテッド In vivo imaging device having a small cross-sectional area and method for constructing the same
US20030216622A1 (en) * 2002-04-25 2003-11-20 Gavriel Meron Device and method for orienting a device in vivo
US20080045788A1 (en) * 2002-11-27 2008-02-21 Zvika Gilad Method and device of imaging with an in vivo imager
US8702597B2 (en) * 2003-12-31 2014-04-22 Given Imaging Ltd. Immobilizable in-vivo imager with moveable focusing mechanism
ITPI20040008A1 (en) * 2004-02-17 2004-05-17 Dino Accoto ROBOTIC CAPSULE FOR INTRA-BODY BIOMEDICAL APPLICATIONS
US7654985B2 (en) * 2004-03-30 2010-02-02 Given Imaging Ltd. Controlled detachment of intra-luminal medical device
US20050288555A1 (en) * 2004-06-28 2005-12-29 Binmoeller Kenneth E Methods and devices for illuminating, vievwing and monitoring a body cavity
DE102005015522A1 (en) * 2005-04-04 2006-10-05 Karl Storz Gmbh & Co. Kg Intracorporal probe for human or animal body, has image acquisition unit designed for optical admission of area outside probe, and movably held within housing in order to change movement of admission area
JP4695432B2 (en) * 2005-04-12 2011-06-08 オリンパスメディカルシステムズ株式会社 In-subject introduction apparatus, in-subject information display apparatus, and in-subject information acquisition system
JP4981316B2 (en) * 2005-12-16 2012-07-18 オリンパスメディカルシステムズ株式会社 Intra-subject introduction device
US20070239827A1 (en) * 2006-02-13 2007-10-11 Scott Deboy Global chat system
US20080058786A1 (en) * 2006-04-12 2008-03-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Autofluorescent imaging and target ablation
US20080058785A1 (en) * 2006-04-12 2008-03-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Autofluorescent imaging and target ablation
US20070270651A1 (en) * 2006-05-19 2007-11-22 Zvika Gilad Device and method for illuminating an in vivo site
US20080172073A1 (en) * 2006-06-16 2008-07-17 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Active blood vessel sleeve
US8163003B2 (en) * 2006-06-16 2012-04-24 The Invention Science Fund I, Llc Active blood vessel sleeve methods and systems
ATE474496T1 (en) * 2007-04-04 2010-08-15 Scuola Superiore Di Studi Universitari E Di Perfezionamento Sant Anna REMOTE CONTROLLED ENDOSCOPIC CAPSULE
CN101808567B (en) * 2007-09-26 2012-09-05 奥林巴斯医疗株式会社 Introduction-into-subject system
US8707964B2 (en) * 2007-10-31 2014-04-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090105561A1 (en) * 2007-10-17 2009-04-23 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US8789536B2 (en) * 2007-10-17 2014-07-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8808276B2 (en) * 2007-10-23 2014-08-19 The Invention Science Fund I, Llc Adaptive dispensation in a digestive tract
US8808271B2 (en) 2007-10-31 2014-08-19 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8333754B2 (en) 2007-10-31 2012-12-18 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090163894A1 (en) * 2007-10-31 2009-06-25 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US20090137866A1 (en) * 2007-11-28 2009-05-28 Searete Llc, A Limited Liability Corporation Of The State Delaware Medical or veterinary digestive tract utilization systems and methods
JP5314913B2 (en) * 2008-04-03 2013-10-16 オリンパスメディカルシステムズ株式会社 Capsule medical system
US20090275824A1 (en) * 2008-04-30 2009-11-05 Pacesetter, Inc. System and Method for Sensing Gastric Contractions
US8494623B2 (en) * 2008-06-09 2013-07-23 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus for in-vivo physiological monitoring
WO2010004752A1 (en) * 2008-07-10 2010-01-14 学校法人自治医科大学 Medical-instrument indwelling device
WO2010087368A1 (en) * 2009-01-28 2010-08-05 オリンパスメディカルシステムズ株式会社 Capsule medical device system
DE102009047405A1 (en) * 2009-12-02 2011-06-09 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Device for determining a process variable of a liquid in a process plant
JP4734475B2 (en) * 2009-02-16 2011-07-27 オリンパスメディカルシステムズ株式会社 Capsule medical device
WO2010137705A1 (en) * 2009-05-29 2010-12-02 オリンパスメディカルシステムズ株式会社 Capsule type medical device
US9615745B2 (en) * 2009-11-25 2017-04-11 The Brigham And Women's Hospital System and method for wireless biosensor monitoring
EP2377574A3 (en) * 2010-04-13 2011-11-30 BIOTRONIK SE & Co. KG Implant and applicator
US9638177B2 (en) * 2010-10-05 2017-05-02 Kyusun Choi Device having a vibration based propulsion system
US8846040B2 (en) 2010-12-23 2014-09-30 Rani Therapeutics, Llc Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809271B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US20120296163A1 (en) * 2011-05-19 2012-11-22 Tyco Healthcare Group Lp Integrated visualization apparatus, systems and methods thereof
US20150150544A1 (en) * 2011-06-29 2015-06-04 Uti Limited Partnership Apparatuses and Methods for Endoscope and/or With Tool Actuated by Shape Memory Alloy Element
ES2773115T3 (en) * 2011-06-29 2020-07-09 Rani Therapeutics Llc Therapeutic agent preparations for administration into the lumen of the intestinal tube using a swallowable drug delivery device
EP2726141B1 (en) * 2011-06-29 2019-12-25 Rani Therapeutics, LLC Device for the oral delivery of therapeutic compounds
ITFI20110185A1 (en) * 2011-08-23 2013-02-24 Fond Istituto Italiano Di Tecnologia CAPSULE FOR LOCALIZED THERAPY THROUGH ENDOLUMINAL PATCHES IN THE GASTROINTESTINAL SYSTEM
US9149172B2 (en) 2011-12-29 2015-10-06 Given Imaging Ltd. System and apparatus for anchoring and operation of in-vivo medical devices
WO2013120184A1 (en) 2012-02-17 2013-08-22 Micropharma Limited Ingestible medical device
US20150051589A1 (en) * 2012-03-27 2015-02-19 Sony Corporation Capsule type medical device and medical system
US20130282173A1 (en) * 2012-04-20 2013-10-24 Erhan H. Gunday Remotely Controlled Surgical Robots
US9375202B2 (en) 2012-05-04 2016-06-28 Given Imaging Ltd. Device and method for in vivo cytology acquisition
JP6265630B2 (en) * 2013-06-13 2018-01-24 オリンパス株式会社 Endoscope apparatus and method for operating endoscope apparatus
WO2015112575A1 (en) * 2014-01-22 2015-07-30 The Board Of Regents Of The University Of Nebraska Gastrointestinal sensor implantation system
WO2016167102A1 (en) * 2015-04-15 2016-10-20 オリンパス株式会社 Capsule-type medical device
JP6526519B2 (en) * 2015-08-18 2019-06-05 英敏 太田 Gastrointestinal tract observation device
EP3509469A1 (en) 2016-09-09 2019-07-17 Progenity, Inc. Electromechanical ingestible device for delivery of a dispensable substance
IL270450B2 (en) 2017-05-17 2023-09-01 Massachusetts Inst Technology Self-righting systems and related components and methods
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
CN108095806B (en) * 2017-12-16 2023-04-28 重庆金山科技(集团)有限公司 Adsorption puncture fixing device with self-locking function
US11202903B2 (en) 2018-05-17 2021-12-21 Massachusetts Institute Of Technology Systems for electrical stimulation
CN116726361A (en) 2018-11-19 2023-09-12 比奥拉治疗股份有限公司 Methods and devices for treating diseases with biologic therapeutic agents
WO2020160399A1 (en) 2019-02-01 2020-08-06 Massachusetts Institute Of Technology Systems and methods for liquid injection
CN113660899A (en) * 2019-04-01 2021-11-16 吉温成象有限公司 In vivo immunoassay system
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
CN115666704A (en) 2019-12-13 2023-01-31 比奥拉治疗股份有限公司 Ingestible device for delivery of therapeutic agents to the gastrointestinal tract
CN112075916B (en) * 2020-09-14 2021-08-10 青岛大学附属医院 Capsule gastroscope

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6240312B1 (en) * 1997-10-23 2001-05-29 Robert R. Alfano Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment
US20020042562A1 (en) * 2000-09-27 2002-04-11 Gavriel Meron Immobilizable in vivo sensing device

Family Cites Families (201)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL85911C (en) 1951-02-09
US3190286A (en) 1961-10-31 1965-06-22 Bausch & Lomb Flexible viewing probe for endoscopic use
US3528429A (en) 1968-10-21 1970-09-15 Charles B Beal Method and device for orally admitting an elongated flexible element in the alimentary canal
JPS4831554B1 (en) 1968-12-24 1973-09-29
US3719183A (en) 1970-03-05 1973-03-06 H Schwartz Method for detecting blockage or insufficiency of pancreatic exocrine function
US3683890A (en) 1970-10-02 1972-08-15 Charles B Beal Carrier system for delivery of an end of an elongated member to the upper gastrointestinal tract
US3683389A (en) 1971-01-20 1972-08-08 Corning Glass Works Omnidirectional loop antenna array
US3971362A (en) 1972-10-27 1976-07-27 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Miniature ingestible telemeter devices to measure deep-body temperature
US3888237A (en) 1973-10-15 1975-06-10 Olympus Optical Co Ph-measuring device used in an endoscope
US4262632A (en) 1974-01-03 1981-04-21 Hanton John P Electronic livestock identification system
US4040413A (en) 1974-07-18 1977-08-09 Fuji Photo Optical Co. Ltd. Endoscope
US4148307A (en) 1975-12-26 1979-04-10 Olympus Optical Company Limited Tubular medical instrument having a flexible sheath driven by a plurality of cuffs
US4083369A (en) 1976-07-02 1978-04-11 Manfred Sinnreich Surgical instruments
US4239040A (en) 1976-10-19 1980-12-16 Kabushiki Kaisha Daini Seikosha Capsule for medical use
US4176662A (en) 1977-06-17 1979-12-04 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Apparatus for endoscopic examination
US4178735A (en) 1977-07-13 1979-12-18 The Kendall Company Method of sheathing catheter
JPS5519124A (en) 1978-07-27 1980-02-09 Olympus Optical Co Camera system for medical treatment
US4217045A (en) 1978-12-29 1980-08-12 Ziskind Stanley H Capsule for photographic use in a walled organ of the living body
DE2928477C3 (en) * 1979-07-14 1982-04-15 Battelle-Institut E.V., 6000 Frankfurt Device for the release of substances at defined locations in the digestive tract
US5993378A (en) 1980-10-28 1999-11-30 Lemelson; Jerome H. Electro-optical instruments and methods for treating disease
US4803992A (en) 1980-10-28 1989-02-14 Lemelson Jerome H Electro-optical instruments and methods for producing same
US4389208A (en) 1980-11-06 1983-06-21 Leveen Robert F Catheter advancer
US4456011A (en) 1980-12-22 1984-06-26 Irene Warnecke Balloon-catheter
JPS57156736A (en) 1981-03-23 1982-09-28 Olympus Optical Co Therapeutic capsule apparatus
JPS5819233A (en) * 1981-07-29 1983-02-04 オリンパス光学工業株式会社 Medical capsule
US6010453A (en) 1982-03-22 2000-01-04 Instrumentarium Corporation Tonometric catheter combination
DE3337455A1 (en) 1982-10-15 1984-04-19 Olympus Optical Co., Ltd., Tokio/Tokyo ENDOSCOPIC PHOTOGRAPHER
DE3440177A1 (en) 1984-11-02 1986-05-15 Friedrich Dipl.-Ing. 8031 Eichenau Hilliges Television recording and replay device for endoscopy on human and animal bodies
US4689621A (en) 1986-03-31 1987-08-25 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Temperature responsive transmitter
JPH0664243B2 (en) 1986-04-30 1994-08-22 オリンパス光学工業株式会社 Endoscope
JPS6349125A (en) 1986-08-16 1988-03-01 奥津 一郎 Guide pipe for endoscope
US4878898A (en) 1987-08-17 1989-11-07 Nova Medical Specialties Thermodilution and pressure transducer balloon catheter
US4929214A (en) 1987-11-02 1990-05-29 Liebermann Ron B Inflatable enclosure and means to inflate same
US4936823A (en) 1988-05-04 1990-06-26 Triangle Research And Development Corp. Transendoscopic implant capsule
US4844076A (en) 1988-08-26 1989-07-04 The Johns Hopkins University Ingestible size continuously transmitting temperature monitoring pill
DE3836349A1 (en) 1988-10-25 1990-05-03 Forschungsgesellschaft Fuer Bi CATHETER FOR MEASURING MOTILITY AND PERISTALTICS IN HOSE-SHAPED ORGANS WHICH CONTAIN THEIR CONTENT BY SIMULTANEOUS MULTIPLE IMPEDANCE MEASUREMENT
US4915113A (en) 1988-12-16 1990-04-10 Bio-Vascular, Inc. Method and apparatus for monitoring the patency of vascular grafts
US5421337A (en) 1989-04-14 1995-06-06 Massachusetts Institute Of Technology Spectral diagnosis of diseased tissue
US4940997A (en) 1989-08-08 1990-07-10 Hewlett-Packard Company Out-of-ink sensing method
EP0419729A1 (en) 1989-09-29 1991-04-03 Siemens Aktiengesellschaft Position finding of a catheter by means of non-ionising fields
US5195955A (en) 1989-11-14 1993-03-23 Don Michael T Anthony Device for removal of embolic debris
US5081041A (en) 1990-04-03 1992-01-14 Minnesota Mining And Manufacturing Company Ionic component sensor and method for making and using same
US5108407A (en) * 1990-06-08 1992-04-28 Rush-Presbyterian St. Luke's Medical Center Method and apparatus for placement of an embolic coil
GB9018660D0 (en) 1990-08-24 1990-10-10 Imperial College Probe system
JP3164609B2 (en) 1990-10-31 2001-05-08 オリンパス光学工業株式会社 Endoscope device
JPH04176443A (en) * 1990-11-09 1992-06-24 Olympus Optical Co Ltd Medical capsule
US5267033A (en) 1990-11-28 1993-11-30 Dai Nippon Printing Co., Ltd. Hollow body inspection system, hollow body inspection apparatus and signal transmission apparatus
CA2060067A1 (en) 1991-01-28 1992-07-29 Lilip Lau Stent delivery system
JPH04347138A (en) * 1991-05-24 1992-12-02 Olympus Optical Co Ltd Medical capsule
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
US5395366A (en) 1991-05-30 1995-03-07 The State University Of New York Sampling capsule and process
US5330427A (en) 1991-07-02 1994-07-19 Ortho Pharmaceutical Corporation Prefilled suppository applicator
US5795325A (en) 1991-07-16 1998-08-18 Heartport, Inc. Methods and apparatus for anchoring an occluding member
US5191879A (en) 1991-07-24 1993-03-09 Welch Allyn, Inc. Variable focus camera for borescope or endoscope
US5211165A (en) 1991-09-03 1993-05-18 General Electric Company Tracking system to follow the position and orientation of a device with radiofrequency field gradients
FR2688997A1 (en) 1992-03-26 1993-10-01 Lambert Alain Autonomous telemetric capsule for exploring small bowel - contains sampler for carrying out mucous biopsies, radio transmitter and position detector
US5318589A (en) 1992-04-15 1994-06-07 Microsurge, Inc. Surgical instrument for endoscopic surgery
AT399229B (en) 1992-04-23 1995-04-25 Avl Verbrennungskraft Messtech SENSOR ARRANGEMENT FOR DIRECT OR INDIRECT OPTICAL DETERMINATION OF PHYSICAL OR CHEMICAL PARAMETERS
US5913820A (en) 1992-08-14 1999-06-22 British Telecommunications Public Limited Company Position location system
JPH0663030A (en) * 1992-08-24 1994-03-08 Olympus Optical Co Ltd Medical capsule
US5337732A (en) 1992-09-16 1994-08-16 Cedars-Sinai Medical Center Robotic endoscopy
US5495114A (en) 1992-09-30 1996-02-27 Adair; Edwin L. Miniaturized electronic imaging chip
JPH06114036A (en) * 1992-10-05 1994-04-26 Olympus Optical Co Ltd Capsule for medical treatment
JP3285235B2 (en) * 1992-11-05 2002-05-27 オリンパス光学工業株式会社 Capsule device for in vivo observation
JP3020376B2 (en) 1993-03-26 2000-03-15 サージミヤワキ株式会社 Internal body identification device for animals
US5398851A (en) 1993-08-06 1995-03-21 River Medical, Inc. Liquid delivery device
US5398670A (en) 1993-08-31 1995-03-21 Ethicon, Inc. Lumen traversing device
WO1995009561A1 (en) 1993-10-01 1995-04-13 Target Therapeutics, Inc. Sheathed multipolar catheter and multipolar guidewire for sensing cardiac electrical activity
US5479935A (en) 1993-10-21 1996-01-02 Synectics Medical, Inc. Ambulatory reflux monitoring system
ZA948393B (en) 1993-11-01 1995-06-26 Polartechnics Ltd Method and apparatus for tissue type recognition
IL108352A (en) 1994-01-17 2000-02-29 Given Imaging Ltd In vivo video camera system
EP0672427A1 (en) 1994-03-17 1995-09-20 Siemens-Elema AB System for infusion of medicine into the body of a patient
CA2145232A1 (en) 1994-03-24 1995-09-25 Arie Avny Viewing method and apparatus particularly useful for viewing the interior of the large intestine
US5595565A (en) 1994-06-30 1997-01-21 The Trustees Of Columbia University In The City Of New York Self-propelled endoscope using pressure driven linear actuators
US5723844A (en) 1994-08-08 1998-03-03 Dow; Robert L. Heating system using ferrite to convert RF energy into heat energy
EP0794732A4 (en) 1994-11-30 1999-11-24 Boston Scient Corp Acoustic imaging and doppler catheters and guidewires
JP3487944B2 (en) 1995-02-24 2004-01-19 オリンパス株式会社 Endoscope device
US5782771A (en) * 1995-04-17 1998-07-21 Hussman; Karl L. Dual, fused, and grooved optical localization fibers
US5837196A (en) 1996-01-26 1998-11-17 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
AU733341B2 (en) * 1996-02-02 2001-05-10 Transvascular, Inc. A device, system and method for interstitial transvascular intervention
US5833603A (en) 1996-03-13 1998-11-10 Lipomatrix, Inc. Implantable biosensing transponder
US5853005A (en) 1996-05-02 1998-12-29 The United States Of America As Represented By The Secretary Of The Army Acoustic monitoring system
US5879289A (en) 1996-07-15 1999-03-09 Universal Technologies International, Inc. Hand-held portable endoscopic camera
US5830217A (en) 1996-08-09 1998-11-03 Thomas J. Fogarty Soluble fixation device and method for stent delivery catheters
US5947924A (en) 1996-09-13 1999-09-07 Angiorad, L.L.C. Dilatation/centering catheter used for the treatment of stenosis or other constriction in a bodily passageway and method thereof
US5904647A (en) 1996-10-08 1999-05-18 Asahi Kogyo Kabushiki Kaisha Treatment accessories for an endoscope
US6007482A (en) 1996-12-20 1999-12-28 Madni; Asad M. Endoscope with stretchable flexible sheath covering
US6149581A (en) 1997-06-12 2000-11-21 Klingenstein; Ralph James Device and method for access to the colon and small bowel of a patient
US6324418B1 (en) 1997-09-29 2001-11-27 Boston Scientific Corporation Portable tissue spectroscopy apparatus and method
US5984875A (en) 1997-08-22 1999-11-16 Innotek Pet Products, Inc. Ingestible animal temperature sensor
US6043839A (en) 1997-10-06 2000-03-28 Adair; Edwin L. Reduced area imaging devices
US5929901A (en) 1997-10-06 1999-07-27 Adair; Edwin L. Reduced area imaging devices incorporated within surgical instruments
US5986693A (en) 1997-10-06 1999-11-16 Adair; Edwin L. Reduced area imaging devices incorporated within surgical instruments
EP0908137A1 (en) 1997-10-06 1999-04-14 Technologiestichting STW A method and apparatus for making an image of a lumen or other body cavity and its surrounding tissue
US6409674B1 (en) * 1998-09-24 2002-06-25 Data Sciences International, Inc. Implantable sensor with wireless communication
US6369812B1 (en) 1997-11-26 2002-04-09 Philips Medical Systems, (Cleveland), Inc. Inter-active viewing system for generating virtual endoscopy studies of medical diagnostic data with a continuous sequence of spherical panoramic views and viewing the studies over networks
AU1927399A (en) 1998-01-16 1999-08-02 Lumend, Inc. Catheter apparatus for treating arterial occlusions
US6338709B1 (en) 1998-02-19 2002-01-15 Medtronic Percusurge, Inc. Intravascular radiation therapy device and method of use
US6174291B1 (en) 1998-03-09 2001-01-16 Spectrascience, Inc. Optical biopsy system and methods for tissue diagnosis
US5938585A (en) 1998-03-20 1999-08-17 Boston Scientific Corporation Anchoring and positioning device and method for an endoscope
US5984860A (en) 1998-03-25 1999-11-16 Shan; Yansong Pass-through duodenal enteroscopic device
US6395562B1 (en) 1998-04-22 2002-05-28 The Regents Of The University Of California Diagnostic microarray apparatus
US6019721A (en) 1998-06-09 2000-02-01 Integra Medical Camera with improved focus mechanism
IL126727A (en) 1998-10-22 2006-12-31 Given Imaging Ltd Method for delivering a device to a target location
US6228048B1 (en) 1998-10-23 2001-05-08 Cm Robbins Company Inc. Colonic irrigation apparatus and method
US6471631B1 (en) 1998-11-27 2002-10-29 Syntheon, Llc Implantable radiation therapy device having controllable radiation emission
US6162171A (en) 1998-12-07 2000-12-19 Wan Sing Ng Robotic endoscope and an autonomous pipe robot for performing endoscopic procedures
US7116352B2 (en) 1999-02-25 2006-10-03 Visionsense Ltd. Capsule
US8636648B2 (en) 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
US6285897B1 (en) * 1999-04-07 2001-09-04 Endonetics, Inc. Remote physiological monitoring system
US6233476B1 (en) 1999-05-18 2001-05-15 Mediguide Ltd. Medical positioning system
JP4180736B2 (en) 1999-05-28 2008-11-12 マスプロ電工株式会社 Joint reception equipment
JP3462795B2 (en) 1999-06-07 2003-11-05 ペンタックス株式会社 Swallowable endoscope device
JP3793368B2 (en) 1999-06-07 2006-07-05 ペンタックス株式会社 Swallowing endoscope device
JP3490932B2 (en) 1999-06-07 2004-01-26 ペンタックス株式会社 Swallowable endoscope device
IL143258A0 (en) 2001-05-20 2002-04-21 Given Imaging Ltd A method for in vivo imaging of the gastrointestinal tract in unmodified conditions
JP3289779B2 (en) 1999-07-30 2002-06-10 日本軽金属株式会社 Method for producing hollow panel structure and hollow extruded profile for the production
US20020015952A1 (en) 1999-07-30 2002-02-07 Anderson Norman G. Microarrays and their manufacture by slicing
JP2001091860A (en) 1999-09-22 2001-04-06 Asahi Optical Co Ltd Capsule endoscope
JP2001095756A (en) 1999-09-30 2001-04-10 Asahi Optical Co Ltd Capsule type endoscope
JP2001095755A (en) 1999-09-30 2001-04-10 Asahi Optical Co Ltd Capsule type endoscope
JP2001104243A (en) 1999-10-04 2001-04-17 Asahi Optical Co Ltd Capsule endoscope
JP2001104242A (en) 1999-10-04 2001-04-17 Asahi Optical Co Ltd Capsule endoscope
JP2001104244A (en) 1999-10-04 2001-04-17 Asahi Optical Co Ltd Capsule endoscope
JP2001104241A (en) 1999-10-04 2001-04-17 Asahi Optical Co Ltd Capsule endoscope
JP2001104287A (en) 1999-10-04 2001-04-17 Asahi Optical Co Ltd Capsule endoscope
JP2001112710A (en) 1999-10-20 2001-04-24 Asahi Optical Co Ltd Capsulated endoscope
JP2001112709A (en) 1999-10-20 2001-04-24 Asahi Optical Co Ltd Capsulated endscope
JP2001112740A (en) 1999-10-20 2001-04-24 Asahi Optical Co Ltd Capsulated endoscope
JP4472069B2 (en) 1999-11-10 2010-06-02 オリンパス株式会社 Medical capsule endoscope
US6364830B1 (en) 1999-11-30 2002-04-02 Durell & Gitelis, Inc. Variable view arthroscope
IL134017A (en) * 2000-01-13 2008-04-13 Capsule View Inc Camera for viewing inside intestines
AU2001227020A1 (en) 2000-01-19 2001-07-31 Given Imaging Ltd. A system for detecting substances
US6517477B1 (en) 2000-01-27 2003-02-11 Scimed Life Systems, Inc. Catheter introducer system for exploration of body cavities
JP3679674B2 (en) * 2000-02-03 2005-08-03 オリンパス株式会社 Endoscope
US7039453B2 (en) 2000-02-08 2006-05-02 Tarun Mullick Miniature ingestible capsule
JP4338280B2 (en) 2000-02-15 2009-10-07 Hoya株式会社 Capsule endoscope
JP2001224553A (en) 2000-02-17 2001-08-21 Asahi Optical Co Ltd Imaging instrument for capusle endoscope
JP4360730B2 (en) 2000-02-21 2009-11-11 Hoya株式会社 Capsule endoscope
US6527753B2 (en) * 2000-02-29 2003-03-04 Olympus Optical Co., Ltd. Endoscopic treatment system
JP2001245844A (en) 2000-03-03 2001-09-11 Asahi Optical Co Ltd Capsule endoscope
KR20030025222A (en) 2000-03-08 2003-03-28 기븐 이미징 리미티드 A device and system for in vivo imaging
JP3488170B2 (en) 2000-03-21 2004-01-19 オリンパス株式会社 Endoscope
AU2001249308A1 (en) * 2000-03-24 2001-10-15 Johns Hopkins University Peritoneal cavity device and method
US6692430B2 (en) 2000-04-10 2004-02-17 C2Cure Inc. Intra vascular imaging apparatus
JP4263336B2 (en) 2000-04-12 2009-05-13 パイオニア株式会社 Partition structure of plasma display panel
US6709387B1 (en) 2000-05-15 2004-03-23 Given Imaging Ltd. System and method for controlling in vivo camera capture and display rate
US6475145B1 (en) 2000-05-17 2002-11-05 Baymar, Inc. Method and apparatus for detection of acid reflux
IL163684A0 (en) 2000-05-31 2005-12-18 Given Imaging Ltd Measurement of electrical characteristics of tissue
US7175593B2 (en) 2000-08-30 2007-02-13 Durell & Gitelis, Inc. Variable view arthroscope with charge coupled device
US6929636B1 (en) 2000-11-08 2005-08-16 Hewlett-Packard Development Company, L.P. Internal drug dispenser capsule medical device
US6632175B1 (en) 2000-11-08 2003-10-14 Hewlett-Packard Development Company, L.P. Swallowable data recorder capsule medical device
US6783499B2 (en) 2000-12-18 2004-08-31 Biosense, Inc. Anchoring mechanism for implantable telemetric medical sensor
KR100870033B1 (en) 2001-01-16 2008-11-21 기븐 이미징 리미티드 System and method for wide field imaging of body lumens
KR100380181B1 (en) 2001-02-10 2003-04-11 한국과학기술연구원 Micro Robot for Test the Large Intestines
JP4067407B2 (en) 2001-03-14 2008-03-26 ギブン・イメージング・リミテツド Method and system for detecting colorimetric anomalies in vivo
WO2002080376A2 (en) 2001-03-29 2002-10-10 Given Imaging Ltd. A method for timing control
KR100413058B1 (en) * 2001-04-24 2003-12-31 한국과학기술연구원 Micro Robotic Colonoscope with Motor Locomotion
US6535764B2 (en) * 2001-05-01 2003-03-18 Intrapace, Inc. Gastric treatment and diagnosis device and method
IL143259A (en) 2001-05-20 2006-08-01 Given Imaging Ltd Method for moving an object through the colon
IL143260A (en) 2001-05-20 2006-09-05 Given Imaging Ltd Array system and method for locating an in vivo signal source
US6549796B2 (en) 2001-05-25 2003-04-15 Lifescan, Inc. Monitoring analyte concentration using minimally invasive devices
EP1420693A4 (en) * 2001-06-05 2007-05-30 Barnev Ltd Probe anchor
IL150167A (en) 2001-06-11 2010-05-17 Arkady Glukhovsky Device for in vivo imaging
US7160258B2 (en) 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
US7161164B2 (en) 2001-07-05 2007-01-09 Given Imaging Ltd. Device and method for attenuating radiation from in vivo electrical devices
US6934573B1 (en) 2001-07-23 2005-08-23 Given Imaging Ltd. System and method for changing transmission from an in vivo sensing device
US20030117491A1 (en) 2001-07-26 2003-06-26 Dov Avni Apparatus and method for controlling illumination in an in-vivo imaging device
US6951536B2 (en) 2001-07-30 2005-10-04 Olympus Corporation Capsule-type medical device and medical system
JP4744026B2 (en) 2001-07-30 2011-08-10 オリンパス株式会社 Capsule endoscope and capsule endoscope system
IL151049A0 (en) 2001-08-02 2003-04-10 Given Imaging Ltd In vivo imaging methods and devices
CN100354889C (en) 2001-09-05 2007-12-12 吉温成象有限公司 System and method for three dimensional display of body lumens
US7907986B2 (en) 2001-09-24 2011-03-15 Given Imaging Ltd. System and method for controlling a device in vivo
DE10150092C1 (en) * 2001-10-11 2003-04-03 Salzgitter Antriebstechnik Gmb Process for charging inner high pressure deforming presses with several parts comprises inserting all parts of the workpiece into the lower part of an assembly device, and controlling the position of the parts in the lower part
KR100417163B1 (en) 2001-11-12 2004-02-05 한국과학기술연구원 Micro capsule robot
US8423110B2 (en) 2002-01-09 2013-04-16 Boston Scientific Scimed, Inc. Imaging device and related methods
US6958034B2 (en) 2002-02-11 2005-10-25 Given Imaging Ltd. Self propelled device
US6939290B2 (en) 2002-02-11 2005-09-06 Given Imaging Ltd Self propelled device having a magnetohydrodynamic propulsion system
US20030195415A1 (en) 2002-02-14 2003-10-16 Iddan Gavriel J. Device, system and method for accoustic in-vivo measuring
JP3895618B2 (en) 2002-03-08 2007-03-22 オリンパス株式会社 Capsule endoscope
JP4009473B2 (en) 2002-03-08 2007-11-14 オリンパス株式会社 Capsule endoscope
JP4363843B2 (en) 2002-03-08 2009-11-11 オリンパス株式会社 Capsule endoscope
US7261728B2 (en) * 2002-03-15 2007-08-28 Ethicon Endo-Surgery, Inc. Biopsy forceps device and method
JP3917885B2 (en) 2002-04-08 2007-05-23 オリンパス株式会社 Capsule endoscope system
US20030216622A1 (en) * 2002-04-25 2003-11-20 Gavriel Meron Device and method for orienting a device in vivo
EP1513440A2 (en) 2002-05-30 2005-03-16 The Board of Trustees of The Leland Stanford Junior University Apparatus and method for coronary sinus access
US7001329B2 (en) 2002-07-23 2006-02-21 Pentax Corporation Capsule endoscope guidance system, capsule endoscope holder, and capsule endoscope
US7515953B2 (en) 2002-08-01 2009-04-07 The Johns Hopkins University Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence
US7473218B2 (en) 2002-08-06 2009-01-06 Olympus Corporation Assembling method of capsule medical apparatus
JP4109927B2 (en) 2002-08-20 2008-07-02 セイコークロック株式会社 Radio correction watch and method
US6776165B2 (en) 2002-09-12 2004-08-17 The Regents Of The University Of California Magnetic navigation system for diagnosis, biopsy and drug delivery vehicles
US8449452B2 (en) 2002-09-30 2013-05-28 Given Imaging Ltd. In-vivo sensing system
US6936003B2 (en) 2002-10-29 2005-08-30 Given Imaging Ltd In-vivo extendable element device and system, and method of use
US20040097791A1 (en) 2002-11-13 2004-05-20 Olympus Corporation Endoscope
US7118529B2 (en) 2002-11-29 2006-10-10 Given Imaging, Ltd. Method and apparatus for transmitting non-image information via an image sensor in an in vivo imaging system
US20040186349A1 (en) 2002-12-24 2004-09-23 Usgi Medical Corp. Apparatus and methods for achieving endoluminal access
KR100743332B1 (en) 2003-04-25 2007-07-26 올림푸스 가부시키가이샤 Capsule endoscope and capsule endoscope system
US7044908B1 (en) 2003-07-08 2006-05-16 National Semiconductor Corporation Method and system for dynamically adjusting field of view in a capsule endoscope
US7066879B2 (en) 2003-07-15 2006-06-27 The Trustees Of Columbia University In The City Of New York Insertable device and system for minimal access procedure
US8702597B2 (en) 2003-12-31 2014-04-22 Given Imaging Ltd. Immobilizable in-vivo imager with moveable focusing mechanism
US20070270651A1 (en) 2006-05-19 2007-11-22 Zvika Gilad Device and method for illuminating an in vivo site

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6240312B1 (en) * 1997-10-23 2001-05-29 Robert R. Alfano Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment
US20020042562A1 (en) * 2000-09-27 2002-04-11 Gavriel Meron Immobilizable in vivo sensing device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1587407A2 *

Cited By (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8361014B2 (en) 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US8361013B2 (en) 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US8000784B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling device
US7879023B2 (en) 2004-04-19 2011-02-01 The Invention Science Fund I, Llc System for perfusion management
US9011329B2 (en) 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US9173837B2 (en) 2004-04-19 2015-11-03 The Invention Science Fund I, Llc Controllable release nasal system
US8512219B2 (en) 2004-04-19 2013-08-20 The Invention Science Fund I, Llc Bioelectromagnetic interface system
US8372032B2 (en) 2004-04-19 2013-02-12 The Invention Science Fund I, Llc Telescoping perfusion management system
US8660642B2 (en) 2004-04-19 2014-02-25 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US8353896B2 (en) 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
US8337482B2 (en) 2004-04-19 2012-12-25 The Invention Science Fund I, Llc System for perfusion management
US8323263B2 (en) 2004-04-19 2012-12-04 The Invention Science Fund I, Llc System with a reservoir for perfusion management
US7998060B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
GB2453676B (en) * 2004-04-19 2010-11-10 Searete Llc Lumen-traveling biological interface device and method of use
US7850676B2 (en) 2004-04-19 2010-12-14 The Invention Science Fund I, Llc System with a reservoir for perfusion management
US7857767B2 (en) 2004-04-19 2010-12-28 Invention Science Fund I, Llc Lumen-traveling device
US7867217B2 (en) 2004-04-19 2011-01-11 The Invention Science Fund I, Llc System with a reservoir for perfusion management
US7871402B2 (en) 2004-04-19 2011-01-18 The Invention Science Fund I, Llc System with a reservoir for perfusion management
US9801527B2 (en) 2004-04-19 2017-10-31 Gearbox, Llc Lumen-traveling biological interface device
US8092549B2 (en) 2004-09-24 2012-01-10 The Invention Science Fund I, Llc Ciliated stent-like-system
EP1902663A1 (en) * 2005-07-08 2008-03-26 Olympus Medical Systems Corp. Apparatus for placing capsule type medical device, apparatus for placing capsule endoscope in the body and capsule type medical device for placement
EP1902663A4 (en) * 2005-07-08 2009-12-16 Olympus Medical Systems Corp Apparatus for placing capsule type medical device, apparatus for placing capsule endoscope in the body and capsule type medical device for placement
WO2007007648A1 (en) 2005-07-08 2007-01-18 Olympus Medical Systems Corp. Apparatus for placing capsule type medical device, apparatus for placing capsule endoscope in the body and capsule type medical device for placement
DE102005032290A1 (en) * 2005-07-11 2007-01-18 Siemens Ag Capsule and method to be used for magnetic wireless diagnosis and treatment of gastrointestinal tract, comprises substance releasing facility and anchor
WO2007010997A1 (en) * 2005-07-20 2007-01-25 Olympus Medical Systems Corp. Apparatus and system for detaining a device for introduction into body cavity
JP2007125373A (en) * 2005-09-30 2007-05-24 Given Imaging Ltd System and method for in vivo feature detection
EP1769729A3 (en) * 2005-09-30 2007-05-02 Given Imaging Limited System and method for in-vivo feature detection
US8423123B2 (en) 2005-09-30 2013-04-16 Given Imaging Ltd. System and method for in-vivo feature detection
EP1959830A2 (en) * 2005-12-02 2008-08-27 Given Imaging Ltd. System and device for in vivo procedures
EP1959830A4 (en) * 2005-12-02 2010-01-06 Given Imaging Ltd System and device for in vivo procedures
US7678043B2 (en) 2005-12-29 2010-03-16 Given Imaging, Ltd. Device, system and method for in-vivo sensing of a body lumen
US8694092B2 (en) 2006-04-12 2014-04-08 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US9408530B2 (en) 2006-04-12 2016-08-09 Gearbox, Llc Parameter-based navigation by a lumen traveling device
US9198563B2 (en) 2006-04-12 2015-12-01 The Invention Science Fund I, Llc Temporal control of a lumen traveling device in a body tube tree
EP1875858A2 (en) 2006-07-03 2008-01-09 Novineon Healthcare Technology Partners Gmbh Device for detecting bleeding
EP1875858A3 (en) * 2006-07-03 2008-02-27 Novineon Healthcare Technology Partners Gmbh Device for detecting bleeding
WO2008017967A1 (en) * 2006-08-07 2008-02-14 Koninklijke Philips Electronics N.V. Device, system and method for interacting with a cell or tissue in a body
US8588887B2 (en) 2006-09-06 2013-11-19 Innurvation, Inc. Ingestible low power sensor device and system for communicating with same
US9900109B2 (en) 2006-09-06 2018-02-20 Innurvation, Inc. Methods and systems for acoustic data transmission
US10320491B2 (en) 2006-09-06 2019-06-11 Innurvation Inc. Methods and systems for acoustic data transmission
US8615284B2 (en) 2006-09-06 2013-12-24 Innurvation, Inc. Method for acoustic information exchange involving an ingestible low power capsule
US8512241B2 (en) 2006-09-06 2013-08-20 Innurvation, Inc. Methods and systems for acoustic data transmission
US8024036B2 (en) 2007-03-19 2011-09-20 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US8019413B2 (en) 2007-03-19 2011-09-13 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US9197470B2 (en) 2007-10-05 2015-11-24 Innurvation, Inc. Data transmission via multi-path channels using orthogonal multi-frequency signals with differential phase shift keying modulation
US9769004B2 (en) 2007-10-05 2017-09-19 Innurvation, Inc. Data transmission via multi-path channels using orthogonal multi-frequency signals with differential phase shift keying modulation
US9232884B2 (en) 2008-04-07 2016-01-12 Olympus Corporation Capsule medical apparatus and medical system
US8617058B2 (en) 2008-07-09 2013-12-31 Innurvation, Inc. Displaying image data from a scanner capsule
US9788708B2 (en) 2008-07-09 2017-10-17 Innurvation, Inc. Displaying image data from a scanner capsule
US9351632B2 (en) 2008-07-09 2016-05-31 Innurvation, Inc. Displaying image data from a scanner capsule
US11872396B2 (en) 2009-08-03 2024-01-16 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
US11439817B2 (en) 2009-08-03 2022-09-13 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
US9192353B2 (en) 2009-10-27 2015-11-24 Innurvation, Inc. Data transmission via wide band acoustic channels
US8840551B2 (en) 2009-12-21 2014-09-23 Given Imaging, Inc. Tethering capsule system
US10603475B2 (en) 2009-12-24 2020-03-31 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
US10987499B2 (en) 2009-12-24 2021-04-27 Rani Therapeutics, Llc Swallowable drug delivery device and method of delivery
EP3461478A1 (en) * 2009-12-24 2019-04-03 Rani Therapeutics, LLC Swallowable drug delivery device
US10596359B2 (en) 2009-12-24 2020-03-24 Rani Therapeutics, Llc Therapeutic agent preparations into a lumen of the intestinal tract using a swallowable drug delivery device
EP4056173A3 (en) * 2009-12-24 2022-11-23 Rani Therapeutics, LLC Swallowable drug delivery device
US11376405B2 (en) 2009-12-24 2022-07-05 Rani Therapeutics, Llc Therapeutic agent preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US11338118B2 (en) 2009-12-24 2022-05-24 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
US11253686B2 (en) 2009-12-24 2022-02-22 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
EP3756657A1 (en) * 2009-12-24 2020-12-30 Rani Therapeutics, LLC Swallowable drug delivery device
US9480459B2 (en) 2010-03-26 2016-11-01 Innurvation, Inc. Ultrasound scanning capsule endoscope
US8647259B2 (en) 2010-03-26 2014-02-11 Innurvation, Inc. Ultrasound scanning capsule endoscope (USCE)
US10548850B2 (en) 2010-12-23 2020-02-04 Rani Therapeutics, Llc Therapeutic composition comprising insulin prepared for delivery into an intestinal tract
US11419812B2 (en) 2010-12-23 2022-08-23 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US10888517B2 (en) 2010-12-23 2021-01-12 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10926073B2 (en) 2010-12-23 2021-02-23 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10953077B2 (en) 2010-12-23 2021-03-23 Rani Therapeutics, Llc Method of delivering a somatostatin compound into a lumen of the intestinal tract using a swallowable drug delivery device
US10967050B2 (en) 2010-12-23 2021-04-06 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10980749B2 (en) 2010-12-23 2021-04-20 Rani Therapeutics, Llc Therapeutic preparation comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10864254B2 (en) 2010-12-23 2020-12-15 Rani Therapeutics, Llc Method of delivering gonadotropin releasing hormone or an analogue thereof into a lumen of the intestinal tract using a swallowable drug delivery device
US11229684B2 (en) 2010-12-23 2022-01-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10752681B2 (en) 2010-12-23 2020-08-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11304895B2 (en) 2010-12-23 2022-04-19 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US10632251B2 (en) 2010-12-23 2020-04-28 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US10874840B2 (en) 2010-12-23 2020-12-29 Rani Therapeutics, Llc Preparation comprising exanatide for delivery into a lumen of the intestinal tract
US10487145B2 (en) 2010-12-23 2019-11-26 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10478396B2 (en) 2010-12-23 2019-11-19 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11555068B2 (en) 2010-12-23 2023-01-17 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11638690B2 (en) 2010-12-23 2023-05-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11654182B2 (en) 2010-12-23 2023-05-23 Rani Therapeutics, Llc Method of delivering gonadotropin releasing hormone or an analogue thereof into a lumen of the intestinal tract using a swallowable drug delivery device
US11684761B2 (en) 2010-12-23 2023-06-27 Rani Therapeutics, Llc Preparation comprising exanatide for delivery into a lumen of the intestinal tract
US11771879B2 (en) 2010-12-23 2023-10-03 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11806504B2 (en) 2010-12-23 2023-11-07 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US11813314B2 (en) 2010-12-23 2023-11-14 Rani Therapeutics, Llc Method of delivering a somatostatin compound into a lumen of the intestinal tract using a swallowable drug delivery device
US11814427B2 (en) 2010-12-23 2023-11-14 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11844867B2 (en) 2010-12-23 2023-12-19 Rani Therapeutics, Llc Method of delivering insulin into a lumen of the intestinal tract using a swallowable drug delivery device
US9342881B1 (en) 2013-12-31 2016-05-17 Given Imaging Ltd. System and method for automatic detection of in vivo polyps in video sequences

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US7946979B2 (en) 2011-05-24
EP1587407A2 (en) 2005-10-26
JP2006512130A (en) 2006-04-13
AU2003288516A8 (en) 2004-07-22
US20060167339A1 (en) 2006-07-27
ATE547976T1 (en) 2012-03-15
EP1587407A4 (en) 2009-07-15
EP1587407B1 (en) 2012-03-07
AU2003288516A1 (en) 2004-07-22
WO2004058041A3 (en) 2004-11-11

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