WO2004065551A3 - Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (mgat3), and uses thereof - Google Patents

Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (mgat3), and uses thereof Download PDF

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Publication number
WO2004065551A3
WO2004065551A3 PCT/US2004/001431 US2004001431W WO2004065551A3 WO 2004065551 A3 WO2004065551 A3 WO 2004065551A3 US 2004001431 W US2004001431 W US 2004001431W WO 2004065551 A3 WO2004065551 A3 WO 2004065551A3
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WO
WIPO (PCT)
Prior art keywords
polypeptides
mgat3
polynucleotide encoding
acyl coenzyme
monoacylglycerol acyltransferase
Prior art date
Application number
PCT/US2004/001431
Other languages
French (fr)
Other versions
WO2004065551A2 (en
Inventor
John N Feder
Thomas C Nelson
Jian Chen
Rupalie Meegalla
Michael Ramaker
Dong Cheng
Original Assignee
Bristol Myers Squibb Co
John N Feder
Thomas C Nelson
Jian Chen
Rupalie Meegalla
Michael Ramaker
Dong Cheng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, John N Feder, Thomas C Nelson, Jian Chen, Rupalie Meegalla, Michael Ramaker, Dong Cheng filed Critical Bristol Myers Squibb Co
Priority to MXPA05007615A priority Critical patent/MXPA05007615A/en
Priority to EP04704009A priority patent/EP1585815A4/en
Priority to AU2004206250A priority patent/AU2004206250B8/en
Priority to JP2006501048A priority patent/JP2006518997A/en
Publication of WO2004065551A2 publication Critical patent/WO2004065551A2/en
Publication of WO2004065551A3 publication Critical patent/WO2004065551A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

The present invention provides novel polynucleotides encoding MGAT3 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MGAT3 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as obesity. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
PCT/US2004/001431 2003-01-21 2004-01-21 Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (mgat3), and uses thereof WO2004065551A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
MXPA05007615A MXPA05007615A (en) 2003-01-21 2004-01-21 Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (mgat3), and uses thereof.
EP04704009A EP1585815A4 (en) 2003-01-21 2004-01-21 Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (mgat3), and uses thereof
AU2004206250A AU2004206250B8 (en) 2003-01-21 2004-01-21 Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof
JP2006501048A JP2006518997A (en) 2003-01-21 2004-01-21 Novel acyl coenzyme A: polynucleotide encoding monoacylglycerol acyltransferase-3 (MGAT3) and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44156703P 2003-01-21 2003-01-21
US60/441,567 2003-01-21

Publications (2)

Publication Number Publication Date
WO2004065551A2 WO2004065551A2 (en) 2004-08-05
WO2004065551A3 true WO2004065551A3 (en) 2005-02-03

Family

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Family Applications (1)

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PCT/US2004/001431 WO2004065551A2 (en) 2003-01-21 2004-01-21 Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (mgat3), and uses thereof

Country Status (6)

Country Link
US (2) US7259002B2 (en)
EP (1) EP1585815A4 (en)
JP (1) JP2006518997A (en)
AU (1) AU2004206250B8 (en)
MX (1) MXPA05007615A (en)
WO (1) WO2004065551A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113481185B (en) * 2021-08-05 2022-12-02 云南师范大学 Salt-tolerant beta-galactosidase GalNC2-13 and preparation method and application thereof

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Also Published As

Publication number Publication date
US20080019958A1 (en) 2008-01-24
US20040223959A1 (en) 2004-11-11
EP1585815A4 (en) 2006-02-22
MXPA05007615A (en) 2005-09-30
JP2006518997A (en) 2006-08-24
AU2004206250B9 (en) 2009-08-13
AU2004206250A1 (en) 2004-08-05
EP1585815A2 (en) 2005-10-19
WO2004065551A2 (en) 2004-08-05
AU2004206250B2 (en) 2009-07-16
US7259002B2 (en) 2007-08-21
AU2004206250B8 (en) 2009-09-17

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