WO2004066934A3 - Spermicidal and/or antifungal composition and methods of using the same - Google Patents

Spermicidal and/or antifungal composition and methods of using the same Download PDF

Info

Publication number
WO2004066934A3
WO2004066934A3 PCT/US2004/000206 US2004000206W WO2004066934A3 WO 2004066934 A3 WO2004066934 A3 WO 2004066934A3 US 2004000206 W US2004000206 W US 2004000206W WO 2004066934 A3 WO2004066934 A3 WO 2004066934A3
Authority
WO
WIPO (PCT)
Prior art keywords
spermicidal
methods
same
antifungal composition
compounds
Prior art date
Application number
PCT/US2004/000206
Other languages
French (fr)
Other versions
WO2004066934A2 (en
Inventor
Clarence Edgar Cook
Carol Delta Sloan
Brian Frazier Thomas
Hernan A Navarro
Original Assignee
Res Triangle Inst
Clarence Edgar Cook
Carol Delta Sloan
Brian Frazier Thomas
Hernan A Navarro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR0406572-7A priority Critical patent/BRPI0406572A/en
Priority to AU2004207436A priority patent/AU2004207436B2/en
Priority to DE602004031588T priority patent/DE602004031588D1/en
Priority to CA002514047A priority patent/CA2514047A1/en
Priority to EP04704789A priority patent/EP1585732B1/en
Priority to UAA200508141A priority patent/UA82864C2/en
Priority to JP2006536504A priority patent/JP4597136B2/en
Priority to MXPA05007892A priority patent/MXPA05007892A/en
Application filed by Res Triangle Inst, Clarence Edgar Cook, Carol Delta Sloan, Brian Frazier Thomas, Hernan A Navarro filed Critical Res Triangle Inst
Priority to AT04704789T priority patent/ATE499914T1/en
Priority to US10/895,959 priority patent/US7294259B2/en
Publication of WO2004066934A2 publication Critical patent/WO2004066934A2/en
Publication of WO2004066934A3 publication Critical patent/WO2004066934A3/en
Priority to IL169784A priority patent/IL169784A0/en
Priority to NO20053913A priority patent/NO20053913L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Hexahydroindenopyridine compounds are provided which act as spermicides and/or fungicides, spermicidal and/or fungicidal compositions containing the same, and methods for killing motile sperm and/or fungi using the compounds and compositions.
PCT/US2004/000206 2003-01-24 2004-01-23 Spermicidal and/or antifungal composition and methods of using the same WO2004066934A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP2006536504A JP4597136B2 (en) 2003-01-24 2004-01-23 Speritizing and / or bactericidal composition and method of use thereof
DE602004031588T DE602004031588D1 (en) 2003-01-24 2004-01-23 COMPOSITION WITH SPERMICIDAL EFFECT AND METHOD FOR ITS APPLICATION
CA002514047A CA2514047A1 (en) 2003-01-24 2004-01-23 Spermicidal and/or antifungal composition and methods of using the same
EP04704789A EP1585732B1 (en) 2003-01-24 2004-01-23 Spermicidal composition and methods of using the same
UAA200508141A UA82864C2 (en) 2003-01-24 2004-01-23 Spermicidal and/or antifungal composition and methods of using the same
BR0406572-7A BRPI0406572A (en) 2003-01-24 2004-01-23 Spermicidal and / or antifungal composition and methods of employing same
MXPA05007892A MXPA05007892A (en) 2003-01-24 2004-01-23 Spermicidal and/or antifungal composition and methods of using the same.
AU2004207436A AU2004207436B2 (en) 2003-01-24 2004-01-23 Spermicidal and/or antifungal composition and methods of using the same
AT04704789T ATE499914T1 (en) 2003-01-24 2004-01-23 COMPOSITION HAVING SPERMICIDAL EFFECT AND METHOD FOR USE THEREOF
US10/895,959 US7294259B2 (en) 2003-02-13 2004-07-22 Membrane module for gas transfer
IL169784A IL169784A0 (en) 2003-01-24 2005-07-20 Spermicidal and fungicidal compositions containing hexahydroindenopyridine derivatives and methods utilizing the same
NO20053913A NO20053913L (en) 2003-01-24 2005-08-22 Spermicidal and / or antifungal composition and methods for using the same.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/350,232 US7544696B2 (en) 2003-01-24 2003-01-24 Spermicidal and/or antifungal composition and methods of using the same
US10/350,232 2003-01-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/801,660 Continuation-In-Part US7169295B2 (en) 2003-02-13 2004-03-17 Supported biofilm apparatus and process

Publications (2)

Publication Number Publication Date
WO2004066934A2 WO2004066934A2 (en) 2004-08-12
WO2004066934A3 true WO2004066934A3 (en) 2005-05-19

Family

ID=32735516

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/000206 WO2004066934A2 (en) 2003-01-24 2004-01-23 Spermicidal and/or antifungal composition and methods of using the same

Country Status (20)

Country Link
US (2) US7544696B2 (en)
EP (1) EP1585732B1 (en)
JP (2) JP4597136B2 (en)
KR (1) KR20050103282A (en)
CN (1) CN1751027A (en)
AT (1) ATE499914T1 (en)
AU (1) AU2004207436B2 (en)
BR (1) BRPI0406572A (en)
CA (1) CA2514047A1 (en)
CO (1) CO5670353A2 (en)
DE (1) DE602004031588D1 (en)
EC (1) ECSP055992A (en)
ES (1) ES2359814T3 (en)
IL (1) IL169784A0 (en)
MX (1) MXPA05007892A (en)
NO (1) NO20053913L (en)
RU (1) RU2346687C2 (en)
UA (1) UA82864C2 (en)
WO (1) WO2004066934A2 (en)
ZA (1) ZA200505870B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7795436B2 (en) 2005-08-24 2010-09-14 Bristol-Myers Squibb Company Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists
EP2007374A4 (en) * 2006-04-19 2010-12-15 Res Triangle Inst Antispermatogenic, spermicidal and/or antifungal composition and methods of using the same
WO2009026375A2 (en) * 2007-08-21 2009-02-26 Lehigh University Spermicidal and microbicidal compositions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5314917A (en) * 1991-03-22 1994-05-24 E. B. Michaels Research Associates, Inc. Method for inactivating enveloped viruses and sperm
US5319084A (en) * 1993-08-16 1994-06-07 Research Triangle Institute Hexahydroindenopyridine compounds having antispermatogenic activity
US5952336A (en) * 1997-01-31 1999-09-14 Research Triangle Institute Hexahydroindenopyridine compounds having antispermatogenic activity

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2470109A (en) 1949-05-17 Heterocyclic amines
US2470108A (en) 1949-05-17 Heterocyclic amines
US2546652A (en) 1949-07-30 1951-03-27 Hoffmann La Roche Pyridindenes and process for their manufacture
CH432518A (en) 1964-01-17 1967-03-31 Sandoz Ag Process for the preparation of new heterocyclic compounds
CH498120A (en) 1968-03-28 1970-10-31 Sandoz Ag Process for the preparation of new indenopyridine derivatives
US3462443A (en) 1967-04-19 1969-08-19 Mcneilab Inc Indeno(1,2-c)pyridine derivatives
DE77720C (en) 1968-05-21 FARBWERKE VORM. MEISTER LUCIUS & BRÜNING, Höchst a. M Process for the preparation of a green to black staining dye of the anthracene series
CY819A (en) 1969-05-07 1976-12-01 Sandoz Ltd Indenopyridine derivatives
US3627773A (en) 1969-06-09 1971-12-14 Sandoz Ltd 1,3,4,4A,5,9B-HEXAHYDRO-5-PHENYL-2H-INDENO{8 1,2-c{9 -PYRIDINES
US3678057A (en) 1970-03-26 1972-07-18 Sandoz Ltd 1,3,4,4A,5,9B-HEXAHYDRO-5-PHENYL-2H-INDENO{8 1,2-c{9 -PYRIDINES
US3991066A (en) 1971-01-26 1976-11-09 Sandoz Ltd. 1,3,4,9B-Tetrahydro-5-methyl-2H-indeno[1,2-c]pyridines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5314917A (en) * 1991-03-22 1994-05-24 E. B. Michaels Research Associates, Inc. Method for inactivating enveloped viruses and sperm
US6297278B1 (en) * 1991-03-22 2001-10-02 Biosyn Inc. (A Pennsylvania Corporation) Method for inactivating sexually transmitted enveloped viruses
US5319084A (en) * 1993-08-16 1994-06-07 Research Triangle Institute Hexahydroindenopyridine compounds having antispermatogenic activity
US5952336A (en) * 1997-01-31 1999-09-14 Research Triangle Institute Hexahydroindenopyridine compounds having antispermatogenic activity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
COOK ET AL.: "Structure-activity studies of 2,3,4,a,5,9b-hexahydroindeno[1,2-c]pyridines as antispermatogenic agents for male contraception", J. MED. CHEM., vol. 38, 1995, pages 753 - 763, XP002985552 *
MATTER ET AL.: "Actions of an antispermatogenic, but non-mutagenic, indenopyridine derivative in mice and Salmonelly typhimurium", MUTATION RESEARCH, vol. 66, 1979, pages 113 - 127, XP002985553 *

Also Published As

Publication number Publication date
RU2346687C2 (en) 2009-02-20
IL169784A0 (en) 2007-07-04
US20090149490A1 (en) 2009-06-11
EP1585732A4 (en) 2009-01-28
AU2004207436B2 (en) 2009-08-06
JP2010202671A (en) 2010-09-16
ES2359814T3 (en) 2011-05-27
RU2005126720A (en) 2006-02-10
CN1751027A (en) 2006-03-22
NO20053913L (en) 2005-08-22
ZA200505870B (en) 2006-10-25
US8193213B2 (en) 2012-06-05
JP2007506806A (en) 2007-03-22
WO2004066934A2 (en) 2004-08-12
US7544696B2 (en) 2009-06-09
EP1585732A2 (en) 2005-10-19
KR20050103282A (en) 2005-10-28
US20040147539A1 (en) 2004-07-29
AU2004207436A1 (en) 2004-08-12
CO5670353A2 (en) 2006-08-31
BRPI0406572A (en) 2005-12-20
EP1585732B1 (en) 2011-03-02
JP4597136B2 (en) 2010-12-15
DE602004031588D1 (en) 2011-04-14
UA82864C2 (en) 2008-05-26
MXPA05007892A (en) 2005-11-17
ATE499914T1 (en) 2011-03-15
CA2514047A1 (en) 2004-08-12
ECSP055992A (en) 2006-01-16

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