WO2004066953A3 - Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing - Google Patents

Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing Download PDF

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Publication number
WO2004066953A3
WO2004066953A3 PCT/US2004/002512 US2004002512W WO2004066953A3 WO 2004066953 A3 WO2004066953 A3 WO 2004066953A3 US 2004002512 W US2004002512 W US 2004002512W WO 2004066953 A3 WO2004066953 A3 WO 2004066953A3
Authority
WO
WIPO (PCT)
Prior art keywords
tetramer
preparing
reduced amount
polymerized hemoglobin
hemoglobin solutions
Prior art date
Application number
PCT/US2004/002512
Other languages
French (fr)
Other versions
WO2004066953A2 (en
Inventor
Anthony Avella
Richard E Dewoskin
Marc D Doubleday
Original Assignee
Northfield Lab
Anthony Avella
Richard E Dewoskin
Marc D Doubleday
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northfield Lab, Anthony Avella, Richard E Dewoskin, Marc D Doubleday filed Critical Northfield Lab
Priority to AU2004207595A priority Critical patent/AU2004207595B2/en
Priority to EP04706483A priority patent/EP1592437A4/en
Priority to BR0407106-9A priority patent/BRPI0407106A/en
Priority to MXPA05007885A priority patent/MXPA05007885A/en
Priority to JP2006503142A priority patent/JP2006516994A/en
Priority to CA002512169A priority patent/CA2512169A1/en
Priority to NZ541340A priority patent/NZ541340A/en
Publication of WO2004066953A2 publication Critical patent/WO2004066953A2/en
Publication of WO2004066953A3 publication Critical patent/WO2004066953A3/en
Priority to NO20053745A priority patent/NO20053745L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood

Abstract

A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.
PCT/US2004/002512 2003-01-29 2004-01-29 Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing WO2004066953A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2004207595A AU2004207595B2 (en) 2003-01-29 2004-01-29 Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing
EP04706483A EP1592437A4 (en) 2003-01-29 2004-01-29 Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing
BR0407106-9A BRPI0407106A (en) 2003-01-29 2004-01-29 Reduced Tetramer Cured Hemoglobin Solutions and Method for Preparation
MXPA05007885A MXPA05007885A (en) 2003-01-29 2004-01-29 Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing.
JP2006503142A JP2006516994A (en) 2003-01-29 2004-01-29 Polymerized hemoglobin solution with reduced tetramer content and method for preparation
CA002512169A CA2512169A1 (en) 2003-01-29 2004-01-29 Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing
NZ541340A NZ541340A (en) 2003-01-29 2004-01-29 Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing
NO20053745A NO20053745L (en) 2003-01-29 2005-08-04 Polymerized hemoglobin solutions with reduced amount of tetramer and methods of preparation thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44343603P 2003-01-29 2003-01-29
US60/443,436 2003-01-29

Publications (2)

Publication Number Publication Date
WO2004066953A2 WO2004066953A2 (en) 2004-08-12
WO2004066953A3 true WO2004066953A3 (en) 2005-04-07

Family

ID=32825331

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/002512 WO2004066953A2 (en) 2003-01-29 2004-01-29 Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing

Country Status (14)

Country Link
US (2) US7135553B2 (en)
EP (1) EP1592437A4 (en)
JP (1) JP2006516994A (en)
KR (1) KR20050095636A (en)
CN (1) CN100431602C (en)
AU (1) AU2004207595B2 (en)
BR (1) BRPI0407106A (en)
CA (1) CA2512169A1 (en)
MX (1) MXPA05007885A (en)
NO (1) NO20053745L (en)
NZ (1) NZ541340A (en)
RU (1) RU2337705C2 (en)
WO (1) WO2004066953A2 (en)
ZA (1) ZA200505814B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0407106A (en) * 2003-01-29 2006-01-24 Northfield Lab Reduced Tetramer Cured Hemoglobin Solutions and Method for Preparation
EP1978802A2 (en) * 2006-01-24 2008-10-15 Northfield Laboratories, Inc. Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
RU2361608C1 (en) * 2008-03-18 2009-07-20 Общество С Ограниченной Ответственностью "Научно-Производственная Компания "Медбиофарм" Blood substitute with function of oxygen transfer, pharmaceutical composition (versions)
US8273857B2 (en) 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
US7989593B1 (en) 2010-05-27 2011-08-02 Bing Lou Wong Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
US7932356B1 (en) 2010-06-23 2011-04-26 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition
US8048856B1 (en) 2010-06-23 2011-11-01 Billion King, Ltd. Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
EP2682407B1 (en) 2011-03-01 2016-09-14 Chuo University Hemoglobin-albumin complex, and artificial plasma expander and artificial oxygen carrier, each containing same
US8084581B1 (en) 2011-04-29 2011-12-27 Bing Lou Wong Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus
US20130052232A1 (en) 2011-08-31 2013-02-28 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
CN103690978B (en) * 2013-12-19 2017-01-25 陕西佰美基因股份有限公司 Method for inactivating viruses of hemoglobin and hemoglobin-based oxygen carriers
JP7016124B2 (en) 2016-07-06 2022-02-04 学校法人 中央大学 Therapeutic agent for ischemic disease
US11504417B2 (en) 2017-07-18 2022-11-22 VirTech Bio, Inc. Blood substitutes comprising hemoglobin and methods of making

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WO1997035883A1 (en) * 1996-03-28 1997-10-02 Northfield Laboratories, Inc. Method and apparatus for preparing an acellular red blood cell substitute

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US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
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JPS5329908A (en) * 1976-08-27 1978-03-20 Green Cross Corp:The Immobilized haptoglobin preparation
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Also Published As

Publication number Publication date
KR20050095636A (en) 2005-09-29
AU2004207595B2 (en) 2009-02-05
US7135553B2 (en) 2006-11-14
EP1592437A4 (en) 2007-12-26
JP2006516994A (en) 2006-07-13
US7411044B2 (en) 2008-08-12
NO20053745L (en) 2005-10-03
CN1741813A (en) 2006-03-01
NZ541340A (en) 2008-04-30
RU2005127050A (en) 2006-01-20
US20040186047A1 (en) 2004-09-23
BRPI0407106A (en) 2006-01-24
EP1592437A2 (en) 2005-11-09
CA2512169A1 (en) 2004-08-12
NO20053745D0 (en) 2005-08-04
US20060287222A1 (en) 2006-12-21
WO2004066953A2 (en) 2004-08-12
AU2004207595A1 (en) 2004-08-12
ZA200505814B (en) 2006-05-31
MXPA05007885A (en) 2005-09-21
CN100431602C (en) 2008-11-12
RU2337705C2 (en) 2008-11-10

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