WO2004080533B1 - Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue - Google Patents

Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue

Info

Publication number
WO2004080533B1
WO2004080533B1 PCT/US2004/007589 US2004007589W WO2004080533B1 WO 2004080533 B1 WO2004080533 B1 WO 2004080533B1 US 2004007589 W US2004007589 W US 2004007589W WO 2004080533 B1 WO2004080533 B1 WO 2004080533B1
Authority
WO
WIPO (PCT)
Prior art keywords
heart
gene expression
excitatory
cardiac
expression
Prior art date
Application number
PCT/US2004/007589
Other languages
French (fr)
Other versions
WO2004080533A1 (en
WO2004080533A8 (en
Inventor
Yuval Mika
Hani Sabbah
Walid Haddad
Benny Rousso
Original Assignee
Impulse Dynamics Nv
Yuval Mika
Hani Sabbah
Walid Haddad
Benny Rousso
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2006507121A priority Critical patent/JP2006519663A/en
Priority to EP04719312.3A priority patent/EP1606011B1/en
Priority to US10/549,216 priority patent/US7840262B2/en
Priority to CN200480012687.5A priority patent/CN1787850B/en
Application filed by Impulse Dynamics Nv, Yuval Mika, Hani Sabbah, Walid Haddad, Benny Rousso filed Critical Impulse Dynamics Nv
Publication of WO2004080533A1 publication Critical patent/WO2004080533A1/en
Publication of WO2004080533A8 publication Critical patent/WO2004080533A8/en
Publication of WO2004080533B1 publication Critical patent/WO2004080533B1/en
Priority to US11/792,811 priority patent/US9931503B2/en
Priority to US11/919,491 priority patent/US8548583B2/en
Priority to US11/802,685 priority patent/US8352031B2/en
Priority to US12/910,943 priority patent/US8326416B2/en
Priority to US13/970,647 priority patent/US8977353B2/en
Priority to US14/641,480 priority patent/US9440080B2/en
Priority to US15/249,506 priority patent/US10352948B2/en
Priority to US15/942,637 priority patent/US11439815B2/en
Priority to US16/232,088 priority patent/US20190137513A1/en
Priority to US17/524,015 priority patent/US11779768B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0587—Epicardial electrode systems; Endocardial electrodes piercing the pericardium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3627—Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
    • A61N1/36557—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by chemical substances in blood

Abstract

Method and apparatus (120) for modifying gene expression in cardiac muscle cells (110), by the application of electric fields.

Claims

AMENDED CLAIMS[Received by the International Bureau on 19 October 2004 (19.10.04): original claims 1-16 replaced by amended claims claims 1-20]
1. A device configured to deliver non-excitatory or non-excitatory and excitatory signals to heart tissue that will modify gene expression of muscle cells in the heart tissue in a way to improve the cardiac function of the cells.
2. A device configured to deliver cardiac contractility modulation signals including a non-excitatory contractility modulating component to heart tissue that will modify the expression of BNP and ANP in the heart tissue for treatment of heart failure.
3. A device configured to deliver cardiac contractility modulation signals including a non-excitatory contractility modulating component to heart tissue that will normalize the expression of alfa myosin heavy chain aMHC in the heart tissue for treatment of heart failure.
4. A device configured to deliver cardiac contractility modulation signals including a non-excitatory contractility modulating component that will modify the expression of basic fibroblast growth factor (bFGF) in the heart tissue for treatment of heart failure.
5. A method for improving heart function by electrically modifying the expression in heart tissue of genes that effect cardiovascular system function using an electric field that both modifies the expression and accurately modifies a cardiac function.
6. A method for treating heart failure by electrically modifying the expression in heart tissue of genes that effect cardiovascular system function using an electric field that both modifies the expression and accurately modifies a cardiac function.
29
7. The method of claim 6, wherein the heart failure is congestive heart failure.
8. The method of claim 5 or 6, wherein the electric field includes an excitatory component.
9. The method of Claim 8, wherein the signal or signals reduce RNA gene expression of BNP, ANP, or both BNP and ANP.
10. The method of Claim 8, wherein the signal or signals modify mRNA gene expression for bFGF to above normal level.
11. The method of Claim 8, wherein the signal or signals normalize nRNA gene expression for aMHC.
12. A method of treating a patient with a cardiac related disease, comprising:
determining a desired target gene expression profile in cardiac tissue; and
applying a non-excitatory signal to the cardiac tissue to modify the gene expression in accordance with the desired target gene expression profile.
13. A method according to claim 12, comprising stopping said applying when said target is reached.
14. A method according to claim 12, wherein said applying comprises applying for at least four hours.
15. A device adapted to apply a non-excitatory field to a heart in a manner which acutely affects a functioning of said heart, characterized in that the device is adapted to take an effect on gene expression into account in its j-unctioning.
30
16. A device according to claim 15, wherein said device is implantable.
17. A device according to claim 15, wherein said device includes a feedback control loop which modifies an application of non-excitatory field in response to an indication of a gene expression effect of a previous application of a non-excitatory field.
18. A device according to claim 17, including a watchdog which stops or modifies application of an electrical signal to a heart responsive to an effect of such application on gene expression in the heart.
19. A method for improving heart function by electrically modifying the expression in heart tissue of genes that effect cardiovascular system function using an electric field that both modifies the expression over a long term and acutely improves cell function of said heart.
20. A method of treating a patient with a cardiac related disease, comprising:
determining a desired target gene expression profile in cardiac tissue; and
applying a non-excitatory signal to the cardiac tissue to modify the gene expression in accordance with the desired target gene expression profile.
PCT/US2004/007589 2003-03-10 2004-03-10 Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue WO2004080533A1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP2006507121A JP2006519663A (en) 2003-03-10 2004-03-10 Apparatus and method for delivering electrical signals for regulating gene expression in heart tissue
EP04719312.3A EP1606011B1 (en) 2003-03-10 2004-03-10 Apparatus for delivering electrical signals to modify gene expression in cardiac tissue
US10/549,216 US7840262B2 (en) 2003-03-10 2004-03-10 Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue
CN200480012687.5A CN1787850B (en) 2003-03-10 2004-03-10 For transmitting the signal of telecommunication to revise the apparatus and method of gene expression in heart tissue
US11/792,811 US9931503B2 (en) 2003-03-10 2005-12-09 Protein activity modification
US11/919,491 US8548583B2 (en) 2004-03-10 2006-05-04 Protein activity modification
US11/802,685 US8352031B2 (en) 2004-03-10 2007-05-24 Protein activity modification
US12/910,943 US8326416B2 (en) 2003-03-10 2010-10-25 Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue
US13/970,647 US8977353B2 (en) 2004-03-10 2013-08-20 Protein activity modification
US14/641,480 US9440080B2 (en) 2004-03-10 2015-03-09 Protein activity modification
US15/249,506 US10352948B2 (en) 2004-03-10 2016-08-29 Protein activity modification
US15/942,637 US11439815B2 (en) 2003-03-10 2018-04-02 Protein activity modification
US16/232,088 US20190137513A1 (en) 2004-03-10 2018-12-26 Protein activity modification
US17/524,015 US11779768B2 (en) 2004-03-10 2021-11-11 Protein activity modification

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45334903P 2003-03-10 2003-03-10
US60/453,349 2003-03-10
US50307503P 2003-09-15 2003-09-15
US60/503,075 2003-09-15

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US10/549,216 A-371-Of-International US7840262B2 (en) 2003-03-10 2004-03-10 Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue
PCT/US2005/044557 Continuation-In-Part WO2006073671A1 (en) 1999-03-05 2005-12-09 Protein activity modification
US11/792,811 Continuation-In-Part US9931503B2 (en) 2003-03-10 2005-12-09 Protein activity modification
US12/910,943 Division US8326416B2 (en) 2003-03-10 2010-10-25 Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue

Publications (3)

Publication Number Publication Date
WO2004080533A1 WO2004080533A1 (en) 2004-09-23
WO2004080533A8 WO2004080533A8 (en) 2004-10-28
WO2004080533B1 true WO2004080533B1 (en) 2004-12-16

Family

ID=32994492

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/007589 WO2004080533A1 (en) 2003-03-10 2004-03-10 Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue

Country Status (5)

Country Link
US (2) US7840262B2 (en)
EP (1) EP1606011B1 (en)
JP (1) JP2006519663A (en)
CN (1) CN1787850B (en)
WO (1) WO2004080533A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8934975B2 (en) 2010-02-01 2015-01-13 Metacure Limited Gastrointestinal electrical therapy
US8958872B2 (en) 1996-01-08 2015-02-17 Impulse Dynamics, N.V. Electrical muscle controller
US8977353B2 (en) 2004-03-10 2015-03-10 Impulse Dynamics Nv Protein activity modification
US9265930B2 (en) 1997-07-16 2016-02-23 Metacure Limited Methods and devices for modifying vascular parameters
US9289618B1 (en) 1996-01-08 2016-03-22 Impulse Dynamics Nv Electrical muscle controller

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7167748B2 (en) * 1996-01-08 2007-01-23 Impulse Dynamics Nv Electrical muscle controller
US8321013B2 (en) * 1996-01-08 2012-11-27 Impulse Dynamics, N.V. Electrical muscle controller and pacing with hemodynamic enhancement
US8825152B2 (en) * 1996-01-08 2014-09-02 Impulse Dynamics, N.V. Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue
US9713723B2 (en) 1996-01-11 2017-07-25 Impulse Dynamics Nv Signal delivery through the right ventricular septum
US8700161B2 (en) * 1999-03-05 2014-04-15 Metacure Limited Blood glucose level control
US20040249421A1 (en) * 2000-09-13 2004-12-09 Impulse Dynamics Nv Blood glucose level control
US8019421B2 (en) * 1999-03-05 2011-09-13 Metacure Limited Blood glucose level control
US8666495B2 (en) * 1999-03-05 2014-03-04 Metacure Limited Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar
US7904176B2 (en) * 2006-09-07 2011-03-08 Bio Control Medical (B.C.M.) Ltd. Techniques for reducing pain associated with nerve stimulation
US8571653B2 (en) * 2001-08-31 2013-10-29 Bio Control Medical (B.C.M.) Ltd. Nerve stimulation techniques
US20080119898A1 (en) * 2005-09-22 2008-05-22 Biocontrol Medical Ltd. Nitric oxide synthase-affecting parasympathetic stimulation
US8615294B2 (en) * 2008-08-13 2013-12-24 Bio Control Medical (B.C.M.) Ltd. Electrode devices for nerve stimulation and cardiac sensing
US20090005845A1 (en) * 2007-06-26 2009-01-01 Tamir Ben David Intra-Atrial parasympathetic stimulation
WO2004110550A2 (en) * 2003-06-13 2004-12-23 Biocontrol Medical Ltd. Vagal stimulation for anti-embolic therapy
US7627373B2 (en) * 2002-11-30 2009-12-01 Cardiac Pacemakers, Inc. Method and apparatus for cell and electrical therapy of living tissue
US8880192B2 (en) 2012-04-02 2014-11-04 Bio Control Medical (B.C.M.) Ltd. Electrode cuffs
EP1606011B1 (en) * 2003-03-10 2015-08-19 Impulse Dynamics N.V. Apparatus for delivering electrical signals to modify gene expression in cardiac tissue
US11439815B2 (en) 2003-03-10 2022-09-13 Impulse Dynamics Nv Protein activity modification
US8792985B2 (en) * 2003-07-21 2014-07-29 Metacure Limited Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar
US7840263B2 (en) * 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US11779768B2 (en) 2004-03-10 2023-10-10 Impulse Dynamics Nv Protein activity modification
US8352031B2 (en) 2004-03-10 2013-01-08 Impulse Dynamics Nv Protein activity modification
US7764995B2 (en) * 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US7729761B2 (en) * 2004-07-14 2010-06-01 Cardiac Pacemakers, Inc. Method and apparatus for controlled gene or protein delivery
US7387610B2 (en) 2004-08-19 2008-06-17 Cardiac Pacemakers, Inc. Thoracic impedance detection with blood resistivity compensation
EP1827571B1 (en) * 2004-12-09 2016-09-07 Impulse Dynamics NV Protein activity modification
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US8874204B2 (en) * 2004-12-20 2014-10-28 Cardiac Pacemakers, Inc. Implantable medical devices comprising isolated extracellular matrix
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US8609082B2 (en) * 2005-01-25 2013-12-17 Bio Control Medical Ltd. Administering bone marrow progenitor cells or myoblasts followed by application of an electrical current for cardiac repair, increasing blood supply or enhancing angiogenesis
US8244371B2 (en) * 2005-03-18 2012-08-14 Metacure Limited Pancreas lead
US20070060962A1 (en) * 2005-07-26 2007-03-15 Carlo Pappone Apparatus and methods for cardiac resynchronization therapy and cardiac contractility modulation
US7774057B2 (en) 2005-09-06 2010-08-10 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression for cardiac protection
US20070190028A1 (en) * 2006-02-13 2007-08-16 Jihong Qu Method and apparatus for heat or electromagnetic control of gene expression
US8478406B2 (en) * 2006-04-24 2013-07-02 Medtronic, Inc. Apparatus and methods of delivering an enhanced refractory period stimulation therapy
US7835789B2 (en) * 2006-04-24 2010-11-16 Medtronic, Inc. Refractory period stimulation to increase ventricular performance
WO2008030581A1 (en) * 2006-09-08 2008-03-13 Symphony Medical, Inc. Intramyocardial patterning for treating localized anomalies of the heart
US20090012413A1 (en) * 2006-09-08 2009-01-08 Sabbah Hani N Cardiac patterning for improving diastolic function
EP2094352A4 (en) 2006-12-06 2010-05-19 Cleveland Clinic Foundation Method and system for treating acute heart failure by neuromodulation
EP2146667A2 (en) * 2007-04-11 2010-01-27 Henry Ford Health System Cardiac repair, resizing and reshaping using the venous system of the heart
US20080280341A1 (en) * 2007-05-08 2008-11-13 Kenknight Bruce System And Method For Local Field Stimulation
US9150832B2 (en) * 2007-05-08 2015-10-06 Cardiac Pacemakers, Inc. Cell training for local field stimulation
WO2010008597A2 (en) * 2008-07-16 2010-01-21 Cardiac Pacemakers, Inc. Intermittent pacing therapy for angina and disease prevention
US8326422B2 (en) * 2008-12-22 2012-12-04 Pacesetter, Inc. Implantable systems and methods for monitoring BNP levels, HF and MI
JP6580068B2 (en) 2014-05-22 2019-09-25 カーディオノミック，インク． Catheter and catheter system for electrical neuromodulation
WO2016040037A1 (en) 2014-09-08 2016-03-17 CARDIONOMIC, Inc. Catheter and electrode systems for electrical neuromodulation
AU2015315570B2 (en) 2014-09-08 2020-05-14 CARDIONOMIC, Inc. Methods for electrical neuromodulation of the heart
CN109568786A (en) 2015-01-05 2019-04-05 卡迪诺米克公司 Heart, which is adjusted, promotes method and system
JP2019513032A (en) 2016-03-09 2019-05-23 カーディオノミック，インク． Cardiac contraction stimulation system and method
EP3664703A4 (en) 2017-09-13 2021-05-12 Cardionomic, Inc. Neurostimulation systems and methods for affecting cardiac contractility
EP3836859A4 (en) 2018-08-13 2022-05-11 Cardionomic, Inc. Systems and methods for affecting cardiac contractility and/or relaxation
WO2020227234A1 (en) 2019-05-06 2020-11-12 CARDIONOMIC, Inc. Systems and methods for denoising physiological signals during electrical neuromodulation
WO2024018361A1 (en) * 2022-07-18 2024-01-25 Impulse Dynamics Nv Acute non-excitatory electrical heart failure therapy

Family Cites Families (436)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB304587A (en) 1928-01-21 1930-03-13 Abraham Esau Improvements in apparatus for treatment by diathermy
US3211154A (en) 1962-06-25 1965-10-12 Mine Safety Appliances Co Sequence switch for ventricular defibrillator
FR94491E (en) * 1965-10-13 1969-08-22 Philips Massiot Mat Medic Pacemaker.
US6141587A (en) 1996-08-19 2000-10-31 Mower Family Chf Treatment Irrevocable Trust Augmentation of muscle contractility by biphasic stimulation
US6136019A (en) 1996-08-19 2000-10-24 Mower Family Chf Treatment Irrevocable Trust Augmentation of electrical conduction and contractility by biphasic cardiac pacing administered via the cardiac blood pool
US6343232B1 (en) * 1966-08-19 2002-01-29 Mower Chf Treatment Irrevocable Trust Augmentation of muscle contractility by biphasic stimulation
DE1679493B1 (en) 1967-05-02 1970-06-04 Berckheim Graf Von Arrangement for the electrical air conditioning of rooms in buildings and vehicles
US3587567A (en) 1968-12-20 1971-06-28 Peter Paul Schiff Mechanical ventricular assistance assembly
DE1924227C3 (en) 1969-05-12 1974-12-05 Draegerwerk Ag, 2400 Luebeck Anesthetic vaporizer
US3651806A (en) 1969-10-24 1972-03-28 Philip I Hirshberg Method and apparatus for administering digitalizing medications
US3933147A (en) * 1970-04-02 1976-01-20 Vall Wilbur E Du Apparatus and method for treating disorders in the region of the pubococcygeous muscle
US3942536A (en) * 1971-03-15 1976-03-09 Mieczyslaw Mirowski Cardioverting device having single intravascular catheter electrode system and method for its use
US3796221A (en) * 1971-07-07 1974-03-12 N Hagfors Apparatus for delivering electrical stimulation energy to body-implanted apparatus with signal-receiving means
GB1394171A (en) 1973-05-16 1975-05-14 Whittaker Corp Blood glucose level monitoring-alarm system and method therefor
NL7409823A (en) * 1973-07-31 1975-02-04 Fujitsu Ltd OUTPUT DEVICE FOR COORDINATE POSITIONS INFORMATION.
US3911930A (en) 1974-03-01 1975-10-14 Stimulation Tech Method and structure of preventing and treating ileus, and reducing acute pain by electrical pulse stimulation
US4572191B1 (en) * 1974-04-25 2000-10-24 Mirowski Miecyslaw Command atrial cardioverter
US4316472C1 (en) * 1974-04-25 2001-08-14 Mieczyslaw Mirowski Cardioverting device with stored energy selecting means and discharge initiating means and related method
US3952750A (en) * 1974-04-25 1976-04-27 Mieczyslaw Mirowski Command atrial cardioverting device
US3924641A (en) 1974-08-19 1975-12-09 Axotronics Inc Bi-phasic current stimulation system
US4055190A (en) 1974-12-19 1977-10-25 Michio Tany Electrical therapeutic apparatus
SU553977A1 (en) 1975-03-12 1977-04-15 Свердловский научно-исследовательский институт охраны материнства и младенчества Electric Stimulator
US4184493A (en) * 1975-09-30 1980-01-22 Mieczyslaw Mirowski Circuit for monitoring a heart and for effecting cardioversion of a needy heart
US4030509A (en) 1975-09-30 1977-06-21 Mieczyslaw Mirowski Implantable electrodes for accomplishing ventricular defibrillation and pacing and method of electrode implantation and utilization
US4202340A (en) * 1975-09-30 1980-05-13 Mieczyslaw Mirowski Method and apparatus for monitoring heart activity, detecting abnormalities, and cardioverting a malfunctioning heart
US4137021A (en) * 1976-02-19 1979-01-30 Lassota Marek J Rotary compressor and process of compressing compressible fluids
US4315503A (en) * 1976-11-17 1982-02-16 Electro-Biology, Inc. Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment
US4106494A (en) 1977-08-29 1978-08-15 American Optical Corporation Heart defibrillating and monitoring system
US4164216A (en) 1978-01-26 1979-08-14 Person Orville W Throat obstruction expulsion device
US4223678A (en) 1978-05-03 1980-09-23 Mieczyslaw Mirowski Arrhythmia recorder for use with an implantable defibrillator
US4168711A (en) 1978-06-08 1979-09-25 American Optical Corporation Reversal protection for RLC defibrillator
US4273114A (en) 1978-10-19 1981-06-16 Michigan Instruments, Inc. Cardiopulmonary resuscitator, defibrillator and monitor
US4293734A (en) 1979-02-23 1981-10-06 Peptek, Incorporated Touch panel system and method
SU831131A1 (en) 1979-04-19 1981-05-23 Всесоюзный Научно-Исследовательскийинститут Акушерства И Гинекологии Method of curing pregnancy preinterruption
US4237895A (en) 1979-04-20 1980-12-09 Medcor, Inc. Control signal transmitter and monitor for implanted pacer
US4403614A (en) 1979-07-19 1983-09-13 Medtronic, Inc. Implantable cardioverter
US4686332A (en) 1986-06-26 1987-08-11 International Business Machines Corporation Combined finger touch and stylus detection system for use on the viewing surface of a visual display device
US4369791A (en) * 1979-10-01 1983-01-25 Medtronic, Inc. Body implantable electrode
US4312354A (en) * 1980-02-04 1982-01-26 Arco Medical Products Company Pacemaker with circuit for pulse width modulating stimulus pulses in accordance with programmed parameter control states
US4337776A (en) 1980-08-29 1982-07-06 Telectronics Pty. Ltd. Impedance measuring pacer
US4440172A (en) * 1980-10-02 1984-04-03 Mieczyslaw Mirowski Apparatus for combining pacing and cardioverting functions in a single implanted device
US4387717A (en) 1980-10-03 1983-06-14 Research Corporation Pacer internal cardiac electrogram sensing system
JPS5772627A (en) 1980-10-21 1982-05-07 Tokyo Shibaura Electric Co Apparatus for detecting abnormal cell
WO1982001656A1 (en) 1980-11-20 1982-05-27 Roy E Mcdonnell Electrical control of body discharges and headaches
US4639720A (en) * 1981-01-12 1987-01-27 Harris Corporation Electronic sketch pad
US4407288B1 (en) 1981-02-18 2000-09-19 Mieczyslaw Mirowski Implantable heart stimulator and stimulation method
US4384585A (en) * 1981-03-06 1983-05-24 Medtronic, Inc. Synchronous intracardiac cardioverter
US4693253A (en) 1981-03-23 1987-09-15 Medtronic, Inc. Automatic implantable defibrillator and pacer
US4406288A (en) 1981-04-06 1983-09-27 Hugh P. Cash Bladder control device and method
US4428366A (en) * 1981-05-06 1984-01-31 Alfred B. Kurtz Electromagnetic apparatus and method for the reduction of serum glucose levels
US4765341A (en) 1981-06-22 1988-08-23 Mieczyslaw Mirowski Cardiac electrode with attachment fin
US4411268A (en) 1982-02-10 1983-10-25 Medtronic, Inc. Muscle stimulator
US4543738A (en) 1982-03-30 1985-10-01 Mower Morton M Ski boot for concentrating a skier's weight on a ski edge
US4708145A (en) 1982-06-01 1987-11-24 Medtronic, Inc. Sequential-pulse, multiple pathway defibrillation method
US4559946A (en) 1982-06-18 1985-12-24 Mieczyslaw Mirowski Method and apparatus for correcting abnormal cardiac activity by low energy shocks
US4554922A (en) 1982-09-30 1985-11-26 Prystowsky Eric N Method of inhibiting cardiac arrhythmias
CA1199371A (en) * 1982-12-03 1986-01-14 Orest Z. Roy Ultrasonic enhancement of cardiac contractility synchronised with ecg event or defibrillation pulse
US4506680A (en) * 1983-03-17 1985-03-26 Medtronic, Inc. Drug dispensing body implantable lead
CA1247960A (en) 1983-03-24 1989-01-03 Hideki Aoki Transcutaneously implantable element
US4554992A (en) 1983-09-09 1985-11-26 Fmc Corporation Hydraulically operated four wheel sweeper
US4550221A (en) 1983-10-07 1985-10-29 Scott Mabusth Touch sensitive control device
FR2557371B1 (en) 1983-12-27 1987-01-16 Thomson Csf PHOTOSENSITIVE DEVICE COMPRISING BETWEEN THE DETECTORS OF THE RADIATION OPAQUE AREAS TO BE DETECTED, AND MANUFACTURING METHOD
US4559947A (en) 1984-01-27 1985-12-24 Renger Herman L Cardiac tissue stimulator providing P-wave verification, telemetry, marker channels, and antitachycardia capabilities
EP0156593A3 (en) 1984-03-22 1985-12-27 AMP INCORPORATED (a New Jersey corporation) Method and apparatus for mode changes and/or touch mouse control
US4543956A (en) 1984-05-24 1985-10-01 Cordis Corporation Biphasic cardiac pacer
US4628934A (en) 1984-08-07 1986-12-16 Cordis Corporation Method and means of electrode selection for pacemaker with multielectrode leads
US4566456A (en) * 1984-10-18 1986-01-28 Cordis Corporation Apparatus and method for adjusting heart/pacer rate relative to right ventricular systolic pressure to obtain a required cardiac output
US4674508A (en) 1985-05-28 1987-06-23 Cordis Corporation Low-power consumption cardiac pacer based on automatic verification of evoked contractions
US4637397A (en) * 1985-05-30 1987-01-20 Case Western Reserve University Triphasic wave defibrillation
US4690155A (en) 1985-07-03 1987-09-01 Cordis Corporation Monophasic action potential recording lead
GB8526417D0 (en) 1985-10-25 1985-11-27 Davies D W Recognition of ventricular tachycardia
US4726379A (en) * 1985-11-14 1988-02-23 Cardiac Control Systems, Inc. Cardiac pacer with switching circuit for isolation
US4717581A (en) * 1986-02-06 1988-01-05 Eic Laboratories, Inc. Iridium oxide coated electrodes for neural stimulation
US4679572A (en) 1986-03-11 1987-07-14 Intermedics, Inc. Low threshold cardiac pacing electrodes
US4834100A (en) * 1986-05-12 1989-05-30 Charms Bernard L Apparatus and method of defibrillation
DE3772450D1 (en) * 1986-05-22 1991-10-02 Siemens Ag MEASURING DEVICE FOR INTRA-CARDIAL DETECTION OF BLOOD OXYGEN SATURATION.
US4998532A (en) * 1986-05-23 1991-03-12 Lti Biomedical, Inc. Portable electro-therapy system
US4830006B1 (en) * 1986-06-17 1997-10-28 Intermedics Inc Implantable cardiac stimulator for detection and treatment of ventricular arrhythmias
JPS6370326A (en) 1986-09-12 1988-03-30 Wacom Co Ltd Position detector
US4726279A (en) * 1986-11-12 1988-02-23 United Technologies Corporation Wake stabilized supersonic combustion ram cannon
DE3732640C1 (en) * 1987-09-28 1989-05-18 Alt Eckhard Medical device for determining physiological functional parameters
US4870974A (en) 1987-09-30 1989-10-03 Chinese Pla General Hospital Apparatus and method for detecting heart characteristics by way of electrical stimulation
US4967749A (en) 1987-10-06 1990-11-06 Leonard Bloom Hemodynamically responsive system for and method of treating a malfunctioning heart
US5018522A (en) 1987-10-26 1991-05-28 Medtronic, Inc. Ramped waveform non-invasive pacemaker
KR0122737B1 (en) * 1987-12-25 1997-11-20 후루다 모또오 Position detecting device
US5387419A (en) * 1988-03-31 1995-02-07 The University Of Michigan System for controlled release of antiarrhythmic agents
US4914624A (en) * 1988-05-06 1990-04-03 Dunthorn David I Virtual button for touch screen
DE3816042A1 (en) 1988-05-10 1989-11-23 Alt Eckhard ENERGY SAVING HEART PACEMAKER
CA1327838C (en) * 1988-06-13 1994-03-15 Fred Zacouto Implantable device to prevent blood clotting disorders
US4850959A (en) 1988-08-02 1989-07-25 Bioresearch, Inc. Bioelectrochemical modulation of biological functions using resonant/non-resonant fields synergistically
US5002052A (en) 1988-08-29 1991-03-26 Intermedics, Inc. System and method for detection and treatment of ventricular arrhythmias
JPH0538723Y2 (en) 1988-12-19 1993-09-30
USRE38119E1 (en) 1989-01-23 2003-05-20 Mirowski Family Ventures, LLC Method and apparatus for treating hemodynamic disfunction
US4928688A (en) * 1989-01-23 1990-05-29 Mieczyslaw Mirowski Method and apparatus for treating hemodynamic disfunction
US5144554A (en) 1989-03-04 1992-09-01 Xueshan Zhang Apparatus for diagnosing and providing therapy for gastrointestinal diseases without causing patient discomfort and injury
US5031617A (en) 1989-03-13 1991-07-16 Klettner Harold L Method of altering human blood glucose levels by the application of electric charge
US5433730A (en) 1989-05-03 1995-07-18 Intermedics, Inc. Conductive pouch electrode for defibrillation
US4971058A (en) 1989-07-06 1990-11-20 Ventritex, Inc. Cardiac therapy method with duration timer
US5190041A (en) * 1989-08-11 1993-03-02 Palti Yoram Prof System for monitoring and controlling blood glucose
US5101814A (en) * 1989-08-11 1992-04-07 Palti Yoram Prof System for monitoring and controlling blood glucose
US5063929A (en) 1989-08-25 1991-11-12 Staodyn, Inc. Electronic stimulating device having timed treatment of varying intensity and method therefor
US5050612A (en) 1989-09-12 1991-09-24 Matsumura Kenneth N Device for computer-assisted monitoring of the body
US5097833A (en) * 1989-09-19 1992-03-24 Campos James M Transcutaneous electrical nerve and/or muscle stimulator
US4996984A (en) * 1989-09-26 1991-03-05 Eli Lilly And Company Defibrillation method
DE68928987T2 (en) 1989-10-02 1999-11-11 Koninkl Philips Electronics Nv Data processing system with a touch display and a digitizing tablet, both integrated in an input device
US5402151A (en) * 1989-10-02 1995-03-28 U.S. Philips Corporation Data processing system with a touch screen and a digitizing tablet, both integrated in an input device
US5041107A (en) 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
US5020544A (en) 1989-11-01 1991-06-04 Cardiac Pacemakers, Inc. Low energy defibrillation electrode
US5044375A (en) 1989-12-08 1991-09-03 Cardiac Pacemakers, Inc. Unitary intravascular defibrillating catheter with separate bipolar sensing
US5097832A (en) 1990-03-09 1992-03-24 Siemens-Pacesetter, Inc. System and method for preventing false pacemaker pvc response
US4998531A (en) * 1990-03-28 1991-03-12 Cardiac Pacemakers, Inc. Implantable N-phasic defibrillator output bridge circuit
US5386835A (en) * 1990-03-30 1995-02-07 Elphick; Kevin J. Barrier means
US5097843A (en) * 1990-04-10 1992-03-24 Siemens-Pacesetter, Inc. Porous electrode for a pacemaker
US5048522A (en) 1990-04-13 1991-09-17 Therapeutic Technologies, Inc. Power muscle stimulator
JP2631902B2 (en) * 1990-04-20 1997-07-16 日本航空電子工業 株式会社 Optical integrated circuit
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5083564A (en) * 1990-06-01 1992-01-28 Board Of Regents Of The University Of Oklahoma Method for alleviating and diagnosing symptoms of heart block
US5320642A (en) 1990-06-01 1994-06-14 Board Of Regents For The University Of Ok Method for alleviating and diagnosing symptoms of heart block
US5431688A (en) 1990-06-12 1995-07-11 Zmd Corporation Method and apparatus for transcutaneous electrical cardiac pacing
US5205284A (en) * 1990-06-12 1993-04-27 Zoll Medical Corporation Method and apparatus for transcutaneous electrical cardiac pacing with background stimulation
AU8074591A (en) * 1990-06-15 1992-01-07 Cortrak Medical, Inc. Drug delivery apparatus and method
US5499971A (en) * 1990-06-15 1996-03-19 Cortrak Medical, Inc. Method for iontophoretically delivering drug adjacent to a heart
US5087243A (en) * 1990-06-18 1992-02-11 Boaz Avitall Myocardial iontophoresis
US5111814A (en) 1990-07-06 1992-05-12 Thomas Jefferson University Laryngeal pacemaker
US5233985A (en) 1990-08-10 1993-08-10 Medtronic, Inc. Cardiac pacemaker with operational amplifier output circuit
US5370665A (en) 1990-08-10 1994-12-06 Medtronic, Inc. Medical stimulator with multiple operational amplifier output stimulation circuits
US5156149A (en) 1990-08-10 1992-10-20 Medtronic, Inc. Sensor for detecting cardiac depolarizations particularly adapted for use in a cardiac pacemaker
US5085218A (en) 1990-08-31 1992-02-04 Cardiac Pacemakers, Inc. Bipolar myocardial positive fixation lead with improved sensing capability
US5267560A (en) 1990-09-07 1993-12-07 Cohen Fred M Methods for control of the ventricular activation sequence
US5584804A (en) 1990-10-10 1996-12-17 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5163428A (en) 1990-10-11 1992-11-17 Ventritex, Inc. Implantable cardiac defibrillator with current leakage detecting means
US5111815A (en) 1990-10-15 1992-05-12 Cardiac Pacemakers, Inc. Method and apparatus for cardioverter/pacer utilizing neurosensing
US5172699A (en) 1990-10-19 1992-12-22 Angelase, Inc. Process of identification of a ventricular tachycardia (VT) active site and an ablation catheter system
EP0481684A3 (en) 1990-10-19 1993-03-03 Angelase, Inc. Location and ablation of an active site of ventricular tachycardia
US5154501A (en) 1990-10-19 1992-10-13 Angelase, Inc. Process for identification of an active site of ventricular tachycardia and for electrode attachment of an endocardial defibrilator
US5172690A (en) 1990-10-26 1992-12-22 Telectronics Pacing Systems, Inc. Automatic stimulus artifact reduction for accurate analysis of the heart's stimulated response
US5133354A (en) 1990-11-08 1992-07-28 Medtronic, Inc. Method and apparatus for improving muscle tone
US5163427A (en) 1990-11-14 1992-11-17 Medtronic, Inc. Apparatus for delivering single and multiple cardioversion and defibrillation pulses
US5281219A (en) * 1990-11-23 1994-01-25 Medtronic, Inc. Multiple stimulation electrodes
US5137021A (en) 1990-11-29 1992-08-11 Medtronic, Inc. Lead current measurement circuit
US5174286A (en) 1990-12-07 1992-12-29 Raul Chirife Sensor for right ventricular and thoracic volumes using the trailing edge value of a generated pulse
US5129394A (en) 1991-01-07 1992-07-14 Medtronic, Inc. Method and apparatus for controlling heart rate in proportion to left ventricular pressure
US5476497A (en) 1991-01-09 1995-12-19 Ann Mirowski Oval electrode lead body
IT1246631B (en) * 1991-01-25 1994-11-24 Gd Spa STABILIZATION CONVEYOR OF CIGARETTES PACKAGES OUT OF A PACKAGING MACHINE.
US5107834A (en) 1991-01-30 1992-04-28 Cardiac Pacemakers, Inc. Low energy multiple shock defibrillation/cardioversion discharge technique and electrode configuration
US5188104A (en) * 1991-02-01 1993-02-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5156147A (en) 1991-02-05 1992-10-20 Cardiac Pacemakers, Inc. Variable rate pacemaker having upper rate limit governor based on hemodynamic performance
US5161527A (en) 1991-02-13 1992-11-10 Telectronics Pacing Systems, Inc. Apparatus and method for detecting abnormal cardiac rhythms in dual chamber arrhythmia control system
US5190036A (en) * 1991-02-28 1993-03-02 Linder Steven H Abdominal binder for effectuating cough stimulation
US5188106A (en) 1991-03-08 1993-02-23 Telectronics Pacing Systems, Inc. Method and apparatus for chronically monitoring the hemodynamic state of a patient using doppler ultrasound
US5199428A (en) * 1991-03-22 1993-04-06 Medtronic, Inc. Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workload
US5464020A (en) 1991-03-25 1995-11-07 Lerner; Albert M. Diagnosing and treating subacute cardiac dysfunction
US5482052A (en) * 1991-04-29 1996-01-09 Lerner; Eduard N. Method and apparatus for determining sensory functions
US5674259A (en) 1992-10-20 1997-10-07 Gray; Noel Desmond Multi-focal leadless apical cardiac pacemaker
WO1992021285A1 (en) * 1991-05-24 1992-12-10 Ep Technologies, Inc. Combination monophasic action potential/ablation catheter and high-performance filter system
US5458568A (en) 1991-05-24 1995-10-17 Cortrak Medical, Inc. Porous balloon for selective dilatation and drug delivery
US5584803A (en) 1991-07-16 1996-12-17 Heartport, Inc. System for cardiac procedures
US5213098A (en) * 1991-07-26 1993-05-25 Medtronic, Inc. Post-extrasystolic potentiation stimulation with physiologic sensor feedback
US5231988A (en) 1991-08-09 1993-08-03 Cyberonics, Inc. Treatment of endocrine disorders by nerve stimulation
US5230336A (en) 1991-08-16 1993-07-27 Ventritex, Inc. Method and apparatus for impedance based automatic pulse duration adjustment for defibrillation shock delivery
US5185620A (en) * 1991-08-22 1993-02-09 Cooper George F Eyeglass system
US5381160A (en) * 1991-09-27 1995-01-10 Calcomp Inc. See-through digitizer with clear conductive grid
US5184616A (en) * 1991-10-21 1993-02-09 Telectronics Pacing Systems, Inc. Apparatus and method for generation of varying waveforms in arrhythmia control system
US5314448A (en) 1991-10-28 1994-05-24 Angeion Corporation Process for defibrillation pretreatment of a heart
DE69213657T2 (en) 1991-11-04 1997-01-23 Cardiac Pacemakers Inc Implantable device for monitoring and stimulating the heart for diagnosis and therapy
US5324327A (en) 1991-12-17 1994-06-28 Cohen Donald M Low threshold cardiac pacing lead
US5184620A (en) * 1991-12-26 1993-02-09 Marquette Electronics, Inc. Method of using a multiple electrode pad assembly
FR2685624B1 (en) 1991-12-31 1994-03-11 Ela Medical CARDIAC ACTIVITY ANALYSIS SYSTEM FOR AN IMPLANTABLE DEVICE FOR TREATING TACHYCARDIAS.
US5534015A (en) 1992-02-18 1996-07-09 Angeion Corporation Method and apparatus for generating biphasic waveforms in an implantable defibrillator
US5284491A (en) * 1992-02-27 1994-02-08 Medtronic, Inc. Cardiac pacemaker with hysteresis behavior
US5531764A (en) 1992-03-24 1996-07-02 Angeion Corporation Implantable defibrillator system and method having successive changeable defibrillation waveforms
US5342404A (en) 1992-04-03 1994-08-30 Intermedics, Inc. Implantable medical interventional device
US5365461A (en) 1992-04-30 1994-11-15 Microtouch Systems, Inc. Position sensing computer input device
RU2014844C1 (en) 1992-05-06 1994-06-30 Московский областной научно-исследовательский клинический институт Method for treating viral diarrhea
US5501662A (en) * 1992-05-22 1996-03-26 Genetronics, Inc. Implantable electroporation method and apparatus for drug and gene delivery
IT1260485B (en) 1992-05-29 1996-04-09 PROCEDURE AND DEVICE FOR THE TREATMENT OF THE OBESITY OF A PATIENT
US5914465A (en) 1992-06-08 1999-06-22 Synaptics, Inc. Object position detector
DE69324067T2 (en) 1992-06-08 1999-07-15 Synaptics Inc Object position detector
US5543588A (en) 1992-06-08 1996-08-06 Synaptics, Incorporated Touch pad driven handheld computing device
US6239389B1 (en) 1992-06-08 2001-05-29 Synaptics, Inc. Object position detection system and method
US5861583A (en) * 1992-06-08 1999-01-19 Synaptics, Incorporated Object position detector
RU2055606C1 (en) 1992-06-15 1996-03-10 Научно-исследовательский институт полупроводниковых приборов Electric stimulator for stomach-guts section
US5350403A (en) 1992-06-17 1994-09-27 Siemens Aktiengesellschaft Apparatus for charging living tissue with electrical pulses
US5366486A (en) 1992-06-25 1994-11-22 Indiana University Foundation Automatic fibrillation detector and defibrillator apparatus and method
US5243980A (en) 1992-06-30 1993-09-14 Medtronic, Inc. Method and apparatus for discrimination of ventricular and supraventricular tachycardia
US5292344A (en) * 1992-07-10 1994-03-08 Douglas Donald D Percutaneously placed electrical gastrointestinal pacemaker stimulatory system, sensing system, and pH monitoring system, with optional delivery port
US5342401A (en) 1992-08-19 1994-08-30 The Regents Of The University Of California Real time cardiac arrhythmia stabilizing system
SE9202662D0 (en) 1992-09-16 1992-09-16 Siemens Elema Ab DEVICE FOR CREATING STIMULATION PULSES AND DEFIBRILLATION SHOCKS CREATED HEART DEFIBRILLATION SEQUENCES
SE9202663D0 (en) 1992-09-16 1992-09-16 Siemens Elema Ab IMPLANTABLE HEART DEFIBRILLATOR
US5662687A (en) 1992-09-16 1997-09-02 Pacesetter Ab Implantable heart defibrillator
US5634899A (en) 1993-08-20 1997-06-03 Cortrak Medical, Inc. Simultaneous cardiac pacing and local drug delivery method
US5320643A (en) 1992-10-06 1994-06-14 Medtronic, Inc. Automatic cardiac capture restoration and threshold-seeking method and apparatus
US5522853A (en) 1992-10-27 1996-06-04 Angeion Corporation Method and apparatus for progressive recruitment of cardiac fibrillation
US5334222A (en) 1992-11-03 1994-08-02 Cardiac Pacemakers, Inc. Cardiac stimulating apparatus and method for heart failure therapy
SE9203284D0 (en) 1992-11-04 1992-11-04 Siemens Elema Ab HJAERTSTIMULATOR
US5807306A (en) 1992-11-09 1998-09-15 Cortrak Medical, Inc. Polymer matrix drug delivery apparatus
US5346506A (en) 1992-11-10 1994-09-13 Mower Morton M Method for establishing defibrillation threshold for a cardiac defibrillator
US5318591A (en) 1992-11-23 1994-06-07 Siemens Pacesetter, Inc. Implantable cardioverter-defibrillator having early charging capability
US5353800A (en) 1992-12-11 1994-10-11 Medtronic, Inc. Implantable pressure sensor lead
US5397344A (en) * 1992-12-22 1995-03-14 Schering Aktiengesellschaft Methods of and apparatus for measuring uterine electrical and mechanical activity
US5991649A (en) 1992-12-22 1999-11-23 University Of Texas Methods for activating the muscle cells or nerves of the uterus or cervix
US5447526A (en) 1992-12-24 1995-09-05 Karsdon; Jeffrey Transcutaneous electric muscle/nerve controller/feedback unit
US5327887A (en) 1993-01-25 1994-07-12 Ludwik Nowakowski Cardiopulmonary resuscitation device
US5386837A (en) * 1993-02-01 1995-02-07 Mmtc, Inc. Method for enhancing delivery of chemotherapy employing high-frequency force fields
US5320543A (en) 1993-02-04 1994-06-14 Barton Craig S Flexible plug protector
US5697953A (en) 1993-03-13 1997-12-16 Angeion Corporation Implantable cardioverter defibrillator having a smaller displacement volume
US6133906A (en) 1993-03-15 2000-10-17 Microtouch Systems, Inc. Display-integrated stylus detection system
US5702359A (en) 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
JP2986047B2 (en) 1993-04-29 1999-12-06 インターナショナル・ビジネス・マシーンズ・コーポレイション Digital input display device and input processing device and method
US5445609A (en) 1993-05-28 1995-08-29 Alza Corporation Electrotransport agent delivery device having a disposable component and a removable liner
US5528002A (en) 1993-07-15 1996-06-18 Pentel Kabushiki Kaisha Noiseproof digitizing apparatus with low power cordless pen
US5391199A (en) 1993-07-20 1995-02-21 Biosense, Inc. Apparatus and method for treating cardiac arrhythmias
US5738096A (en) * 1993-07-20 1998-04-14 Biosense, Inc. Cardiac electromechanics
US5468254A (en) 1993-07-26 1995-11-21 Cardiac Pacemakers, Inc. Method and apparatus for defibrillation using a multiphasic truncated exponential waveform
US5368040A (en) 1993-08-02 1994-11-29 Medtronic, Inc. Apparatus and method for determining a plurality of hemodynamic variables from a single, chroniclaly implanted absolute pressure sensor
US5571997A (en) 1993-08-02 1996-11-05 Kurta Corporation Pressure sensitive pointing device for transmitting signals to a tablet
BE1007462A3 (en) * 1993-08-26 1995-07-04 Philips Electronics Nv Data processing device with touch sensor and power.
US5489293A (en) * 1993-08-31 1996-02-06 Ventritex, Inc. Method and apparatus for treating cardiac tachyarrhythmia
US5443485A (en) 1993-09-08 1995-08-22 Intermedics, Inc. Apparatus and method for capture detection in a cardiac stimulator
US5447525A (en) 1993-09-15 1995-09-05 Medtronic, Inc. Pacemaker which adapts to minimize current drain and provide desired capture safety margin
US5415629A (en) 1993-09-15 1995-05-16 Henley; Julian L. Programmable apparatus for the transdermal delivery of drugs and method
AU7729094A (en) * 1993-09-15 1995-04-03 Pacesetter, Inc. Synchronized cardioverter shock therapy for preemptive depolarization
US5476485A (en) 1993-09-21 1995-12-19 Pacesetter, Inc. Automatic implantable pulse generator
US5411531A (en) 1993-09-23 1995-05-02 Medtronic, Inc. Method and apparatus for control of A-V interval
SE9303736D0 (en) 1993-11-12 1993-11-12 Siemens Elema Ab Apparatus intended to sense the physical state of a living being
GB9302462D0 (en) 1993-12-01 1993-12-01 Semple Keith Motor cycle centre-stand lock
US5431693A (en) 1993-12-10 1995-07-11 Intermedics, Inc. Method of verifying capture of the heart by a pacemaker
US5425363A (en) 1993-12-17 1995-06-20 Wang; Yong G. Plunge electrode for recording multiple intramyocardial monophasic action potential
US5419763B1 (en) 1994-01-04 1997-07-15 Cor Trak Medical Inc Prostatic drug-delivery catheter
RU2077273C1 (en) 1994-02-08 1997-04-20 Вениамин Иванович Шапошников Method to apply intestinal and gastric fistulas
US5391192A (en) * 1994-03-04 1995-02-21 Telectronics Pacing Systems, Inc. Automatic ventricular pacing pulse threshold determination utilizing an external programmer and a surface electrocardiogram
EP0672427A1 (en) 1994-03-17 1995-09-20 Siemens-Elema AB System for infusion of medicine into the body of a patient
IT233201Y1 (en) 1994-03-24 2000-01-26 Bracco Spa TWO-COMPONENT DEVICE FOR THE ADMINISTRATION OF DRUGS
GB9406702D0 (en) 1994-04-05 1994-05-25 Binstead Ronald P Multiple input proximity detector and touchpad system
EP0756507B1 (en) 1994-04-21 1999-05-12 Medtronic, Inc. Treatment of atrial fibrillation
US5562708A (en) 1994-04-21 1996-10-08 Medtronic, Inc. Method and apparatus for treatment of atrial fibrillation
KR100300397B1 (en) 1994-04-21 2001-10-22 김순택 System having touch panel and digitizer function and driving method
US5540722A (en) 1994-05-16 1996-07-30 Physiometrix, Inc. Switch apparatus and method for switching between multiple electrodes for diagnostic and therapeutic procedures
US5527345A (en) 1994-05-17 1996-06-18 Infinger; Kenneth R. Implantable atrial defibrillator having an intermittenly activated pacing modality
US5543589A (en) 1994-05-23 1996-08-06 International Business Machines Corporation Touchpad with dual sensor that simplifies scanning
US5735876A (en) * 1994-05-31 1998-04-07 Galvani Ltd. Electrical cardiac output forcing method and apparatus for an atrial defibrillator
JP3186946B2 (en) 1994-05-31 2001-07-11 シャープ株式会社 Coordinate detection device
JP2691510B2 (en) 1994-06-02 1997-12-17 株式会社バイオセンサー研究所 Enzyme measuring device
US5514162A (en) 1994-06-07 1996-05-07 Pacesetter, Inc. System and method for automatically determining the slope of a transfer function for a rate-responsive cardiac pacemaker
US5505700A (en) 1994-06-14 1996-04-09 Cordis Corporation Electro-osmotic infusion catheter
US5681278A (en) 1994-06-23 1997-10-28 Cormedics Corp. Coronary vasculature treatment method
US5771890A (en) 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
EP0688579B1 (en) 1994-06-24 2001-08-22 St. Jude Medical AB Device for heart therapy
US5601611A (en) * 1994-08-05 1997-02-11 Ventritex, Inc. Optical blood flow measurement apparatus and method and implantable defibrillator incorporating same
SE9402865D0 (en) 1994-08-29 1994-08-29 Siemens Elema Ab Implantable cardiac defibrillator
US5626622A (en) 1994-09-21 1997-05-06 Telectronics Pacing Systems, Inc. Dual sensor rate responsive pacemaker
US5540734A (en) 1994-09-28 1996-07-30 Zabara; Jacob Cranial nerve stimulation treatments using neurocybernetic prosthesis
US5687734A (en) 1994-10-20 1997-11-18 Hewlett-Packard Company Flexible patient monitoring system featuring a multiport transmitter
DE4440386A1 (en) 1994-11-11 1996-05-15 Pacesetter Ab Electrodes for medical applications
US5736580A (en) 1994-11-14 1998-04-07 Alza Croporation Composition, device, and method for electrotransport agent delivery
TW274598B (en) 1994-11-15 1996-04-21 Alps Electric Co Ltd Coordinate input device for pen of finger tip
US5622687A (en) * 1994-11-15 1997-04-22 Molecular Biosystems, Inc. Calixarene conjugates useful as MRI and CT diagnostic imaging agents
US5549646A (en) 1994-12-06 1996-08-27 Pacesetter, Inc. Periodic electrical lead intergrity testing system and method for implantable cardiac stimulating devices
US5476487A (en) 1994-12-28 1995-12-19 Pacesetter, Inc. Autothreshold assessment in an implantable pacemaker
US5654030A (en) 1995-02-07 1997-08-05 Intermedics, Inc. Method of making implantable stimulation electrodes
SE9500620D0 (en) 1995-02-20 1995-02-20 Pacesetter Ab Cardiac stimulation device
JPH08227336A (en) 1995-02-20 1996-09-03 Wacom Co Ltd Pressure sensing mechanism and stylus pen
US5626620A (en) 1995-02-21 1997-05-06 Medtronic, Inc. Dual chamber pacing system and method with continual adjustment of the AV escape interval so as to maintain optimized ventricular pacing for treating cardiomyopathy
US5556421A (en) 1995-02-22 1996-09-17 Intermedics, Inc. Implantable medical device with enclosed physiological parameter sensors or telemetry link
KR100392723B1 (en) 1995-02-22 2003-11-28 코닌클리케 필립스 일렉트로닉스 엔.브이. Data processing system with input device capable of data input by touch and stylus and input device
US5540730A (en) 1995-06-06 1996-07-30 Cyberonics, Inc. Treatment of motility disorders by nerve stimulation
US5790107A (en) 1995-06-07 1998-08-04 Logitech, Inc. Touch sensing method and apparatus
US6041252A (en) * 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
US5713924A (en) * 1995-06-27 1998-02-03 Medtronic, Inc. Defibrillation threshold reduction system
US5995860A (en) 1995-07-06 1999-11-30 Thomas Jefferson University Implantable sensor and system for measurement and control of blood constituent levels
US5956020A (en) 1995-07-27 1999-09-21 Microtouch Systems, Inc. Touchscreen controller with pen and/or finger inputs
US5836311A (en) 1995-09-20 1998-11-17 Medtronic, Inc. Method and apparatus for temporarily immobilizing a local area of tissue
US5782873A (en) * 1995-10-11 1998-07-21 Trustees Of Boston University Method and apparatus for improving the function of sensory cells
JP3171373B2 (en) 1995-10-12 2001-05-28 アルプス電気株式会社 Microcurrent detection circuit and coordinate input device using the same
US5738105A (en) * 1995-10-24 1998-04-14 Angeion Corporation Method and apparatus for sensing R-waves using both near field and far field sensing simultaneously
US5741211A (en) 1995-10-26 1998-04-21 Medtronic, Inc. System and method for continuous monitoring of diabetes-related blood constituents
US6473069B1 (en) 1995-11-13 2002-10-29 Cirque Corporation Apparatus and method for tactile feedback from input device
RU2078547C1 (en) 1995-11-28 1997-05-10 Центральный научно-исследовательский рентгено-радиологический институт МЗМП РФ Method for treating polyposis of stomach and duodenum
US5779661A (en) 1995-12-11 1998-07-14 Physion, S.R.L. Method of treating dysfunctional bladder syndromes by electromotive drug administration
AU704825B2 (en) * 1995-12-15 1999-05-06 Novo Nordisk A/S Novel method
US5920309A (en) 1996-01-04 1999-07-06 Logitech, Inc. Touch sensing method and apparatus
US5825352A (en) 1996-01-04 1998-10-20 Logitech, Inc. Multiple fingers contact sensing method for emulating mouse buttons and mouse operations on a touch sensor pad
US8825152B2 (en) * 1996-01-08 2014-09-02 Impulse Dynamics, N.V. Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue
IL119261A0 (en) 1996-09-17 1996-12-05 New Technologies Sa Ysy Ltd Electrical muscle controller
US8321013B2 (en) 1996-01-08 2012-11-27 Impulse Dynamics, N.V. Electrical muscle controller and pacing with hemodynamic enhancement
US7167748B2 (en) * 1996-01-08 2007-01-23 Impulse Dynamics Nv Electrical muscle controller
US6363279B1 (en) * 1996-01-08 2002-03-26 Impulse Dynamics N.V. Electrical muscle controller
IL125136A (en) 1996-01-08 2003-07-31 Impulse Dynamics Nv Electrical cardiac muscle controller method and apparatus
IL125424A0 (en) 1998-07-20 1999-03-12 New Technologies Sa Ysy Ltd Pacing with hemodynamic enhancement
US20020032467A1 (en) 2000-05-04 2002-03-14 Itsik Shemer Signal delivery through the right ventricular septum
US9713723B2 (en) 1996-01-11 2017-07-25 Impulse Dynamics Nv Signal delivery through the right ventricular septum
US6415178B1 (en) * 1996-09-16 2002-07-02 Impulse Dynamics N.V. Fencing of cardiac muscles
JPH09190268A (en) 1996-01-11 1997-07-22 Canon Inc Information processor and method for processing information
RU2075980C1 (en) 1996-01-18 1997-03-27 Акционерное общество открытого типа "Завод "Компонент" Electrostimulator of gastrointestinal tract
US6066163A (en) 1996-02-02 2000-05-23 John; Michael Sasha Adaptive brain stimulation method and system
SE9600389D0 (en) 1996-02-02 1996-02-02 Pacesetter Ab Medical device used to stimulate tissue
US5913876A (en) 1996-02-20 1999-06-22 Cardiothoracic Systems, Inc. Method and apparatus for using vagus nerve stimulation in surgery
US5651378A (en) 1996-02-20 1997-07-29 Cardiothoracic Systems, Inc. Method of using vagal nerve stimulation in surgery
US5727569A (en) * 1996-02-20 1998-03-17 Cardiothoracic Systems, Inc. Surgical devices for imposing a negative pressure to fix the position of cardiac tissue during surgery
US20030167476A1 (en) 1996-03-26 2003-09-04 Conklin Bruce R. Selective target cell activation by expression of a G protein-coupled receptor activated superiorly by synthetic ligand
US5683431A (en) 1996-03-27 1997-11-04 Medtronic, Inc. Verification of capture by sensing evoked response across cardioversion electrodes
WO1997036916A1 (en) 1996-03-29 1997-10-09 The University Of Medicine And Dentistry Of New Jersey dUTPASE, ITS ISOFORMS, AND DIAGNOSTIC AND OTHER USES
WO1997036646A1 (en) 1996-04-01 1997-10-09 Valery Ivanovich Kobozev Electrical gastro-intestinal tract stimulator
US5782876A (en) 1996-04-15 1998-07-21 Medtronic, Inc. Method and apparatus using windows and an index value for identifying cardic arrhythmias
US5683429A (en) 1996-04-30 1997-11-04 Medtronic, Inc. Method and apparatus for cardiac pacing to prevent atrial fibrillation
US6006134A (en) 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US5792198A (en) 1996-04-30 1998-08-11 Nappholz; Tibor A. Auto adaptation of RR interval in implantable pacemaker
US5713929A (en) * 1996-05-03 1998-02-03 Medtronic, Inc. Arrhythmia and fibrillation prevention pacemaker using ratchet up and decay modes of operation
US5690691A (en) 1996-05-08 1997-11-25 The Center For Innovative Technology Gastro-intestinal pacemaker having phased multi-point stimulation
US5720768A (en) * 1996-05-22 1998-02-24 Sulzer Intermedics Inc. Dual chamber pacing with interchamber delay
US6128007A (en) 1996-07-29 2000-10-03 Motorola, Inc. Method and apparatus for multi-mode handwritten input and hand directed control of a computing device
US5911223A (en) 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
US5871506A (en) * 1996-08-19 1999-02-16 Mower; Morton M. Augmentation of electrical conduction and contractility by biphasic cardiac pacing
US6411847B1 (en) 1996-08-19 2002-06-25 Morton M. Mower Apparatus for applying cyclic pacing at an average rate just above the intrinsic heart rate
US6141586A (en) 1996-08-19 2000-10-31 Mower Family Chf Treatment Irrevocable Trust Method and apparatus to allow cyclic pacing at an average rate just above the intrinsic heart rate so as to maximize inotropic pacing effects at minimal heart rates
US6341235B1 (en) * 1996-08-19 2002-01-22 Mower Chf Treatment Irrevocable Trust Augmentation of electrical conduction and contractility by biphasic cardiac pacing administered via the cardiac blood pool
US6178351B1 (en) * 1996-08-19 2001-01-23 The Mower Family Chf Treatment Irrevocable Trust Atrial sensing and multiple site stimulation as intervention means for atrial fibrillation
US6337995B1 (en) * 1996-08-19 2002-01-08 Mower Chf Treatment Irrevocable Trust Atrial sensing and multiple site stimulation as intervention for atrial fibrillation
US6295470B1 (en) 1996-08-19 2001-09-25 The Mower Family Chf Treatment Irrevocable Trust Antitachycardial pacing
US5755740A (en) 1996-08-22 1998-05-26 Nappholz; Tibor Pacemaker with automatic calibration of the response of multiple sensors
US5713935A (en) * 1996-08-23 1998-02-03 Sulzer Intermedics Inc. Method and apparatus for monitored biphasic cardiac impedance sensing
AU4107297A (en) 1996-09-05 1998-03-26 Governors Of The University Of Alberta, The Gastro-intestinal electrical pacemaker
ZA976114B (en) 1996-09-16 1998-03-19 New Technologies Sa Ysy Ltd Fencing of cardiac muscles.
US6463324B1 (en) 1996-09-16 2002-10-08 Impulse Dynamics N. V. Cardiac output enhanced pacemaker
EP1011793A1 (en) 1996-09-16 2000-06-28 Impulse Dynamics N.V. Apparatus and method for controlling the contractility of muscles
US5782881A (en) 1996-09-20 1998-07-21 Lu; Richard Pacemaker with safety pacing
US5797967A (en) 1996-09-27 1998-08-25 Cardiac Pacemakers, Inc. System and method to reduce defibrillation requirements
US5800464A (en) 1996-10-03 1998-09-01 Medtronic, Inc. System for providing hyperpolarization of cardiac to enhance cardiac function
US5814079A (en) 1996-10-04 1998-09-29 Medtronic, Inc. Cardiac arrhythmia management by application of adnodal stimulation for hyperpolarization of myocardial cells
TW408277B (en) 1996-11-15 2000-10-11 Alps Electric Co Ltd Small current detector circuit and locator device using the same
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
WO1998030967A2 (en) 1996-12-20 1998-07-16 Logitech, Inc. Flexible touchpad circuit with mounted circuit board
US6151586A (en) 1996-12-23 2000-11-21 Health Hero Network, Inc. Computerized reward system for encouraging participation in a health management program
US6026326A (en) * 1997-01-13 2000-02-15 Medtronic, Inc. Apparatus and method for treating chronic constipation
EP1666087A3 (en) * 1997-02-26 2009-04-29 The Alfred E Mann Foundation for Scientific Research Battery-powered patient implantable device
US6086582A (en) 1997-03-13 2000-07-11 Altman; Peter A. Cardiac drug delivery system
US5954761A (en) 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
US5792189A (en) 1997-04-04 1998-08-11 The Research Foundation Of State University Of New York Defibrillation utilizing the dominant frequency of fibrillation
US5861014A (en) 1997-04-30 1999-01-19 Medtronic, Inc. Method and apparatus for sensing a stimulating gastrointestinal tract on-demand
US5836994A (en) 1997-04-30 1998-11-17 Medtronic, Inc. Method and apparatus for electrical stimulation of the gastrointestinal tract
US6381495B1 (en) * 1997-05-28 2002-04-30 Transneuronix, Inc. Medical device for use in laparoscopic surgery
US5919216A (en) 1997-06-16 1999-07-06 Medtronic, Inc. System and method for enhancement of glucose production by stimulation of pancreatic beta cells
US6093167A (en) 1997-06-16 2000-07-25 Medtronic, Inc. System for pancreatic stimulation and glucose measurement
US5807234A (en) 1997-06-27 1998-09-15 Pacesetter, Inc. Myostimulator control using metabolic demand and muscle performance
EP1779890B8 (en) 1997-07-16 2009-07-08 Metacure Limited Smooth muscle controller
US7006871B1 (en) * 1997-07-16 2006-02-28 Metacure N.V. Blood glucose level control
US20050095227A1 (en) 1997-07-22 2005-05-05 The General Hospital Corporation Treating heart failure
US6037882A (en) * 1997-09-30 2000-03-14 Levy; David H. Method and apparatus for inputting data to an electronic system
EP1025178B1 (en) 1997-10-23 2002-12-18 H.B. Fuller Licensing & Financing, Inc. Hot melt pressure sensitive adhesive which exhibits minimal staining
US6180082B1 (en) 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
ID27614A (en) 1997-11-28 2001-04-12 Masayuki Matsuura METHOD AND RADAS FOR WAVE THERAPY
US6392636B1 (en) 1998-01-22 2002-05-21 Stmicroelectronics, Inc. Touchpad providing screen cursor/pointer movement control
US7663607B2 (en) 2004-05-06 2010-02-16 Apple Inc. Multipoint touchscreen
US6067470A (en) 1998-03-05 2000-05-23 Mower Family Chf Treatment Irrevocable Trust System and method for multiple site biphasic stimulation to revert ventricular arrhythmias
US6278443B1 (en) 1998-04-30 2001-08-21 International Business Machines Corporation Touch screen with random finger placement and rolling on screen to control the movement of information on-screen
US7599736B2 (en) * 2001-07-23 2009-10-06 Dilorenzo Biomedical, Llc Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease
US6949081B1 (en) 1998-08-26 2005-09-27 Non-Invasive Technology, Inc. Sensing and interactive drug delivery
JP4142175B2 (en) 1998-10-20 2008-08-27 松下電器産業株式会社 Graphical user interface device
US6292693B1 (en) 1998-11-06 2001-09-18 Impulse Dynamics N.V. Contractility enhancement using excitable tissue control and multi-site pacing
WO2000027472A1 (en) 1998-11-06 2000-05-18 Impulse Dynamics Nv Trigger-based regulation of excitable tissue control in the heart
US6463323B1 (en) 1998-11-12 2002-10-08 Em Vascular, Inc. Electrically mediated angiogenesis
MXPA01005267A (en) 1998-11-27 2002-04-24 Synaptics Uk Ltd Position sensor.
JP4275865B2 (en) 1999-01-26 2009-06-10 キューアールジー リミテッド Capacitive sensors and arrays
US20020081732A1 (en) 2000-10-18 2002-06-27 Bowlin Gary L. Electroprocessing in drug delivery and cell encapsulation
US8700161B2 (en) 1999-03-05 2014-04-15 Metacure Limited Blood glucose level control
US8346363B2 (en) 1999-03-05 2013-01-01 Metacure Limited Blood glucose level control
US20040249421A1 (en) 2000-09-13 2004-12-09 Impulse Dynamics Nv Blood glucose level control
US8019421B2 (en) * 1999-03-05 2011-09-13 Metacure Limited Blood glucose level control
US9101765B2 (en) 1999-03-05 2015-08-11 Metacure Limited Non-immediate effects of therapy
US6261280B1 (en) 1999-03-22 2001-07-17 Medtronic, Inc Method of obtaining a measure of blood glucose
US6023640A (en) * 1999-03-29 2000-02-08 Ross; Jesse Method contributing to obviating male impotency
AU3931300A (en) 1999-03-31 2000-10-16 Rosetta Inpharmatics, Inc. Methods for identifying pathway-specific reporters and target genes, and uses thereof
US6684104B2 (en) * 1999-04-14 2004-01-27 Transneuronix, Inc. Gastric stimulator apparatus and method for installing
US6292704B1 (en) 1999-05-25 2001-09-18 Impulse Dynamics N. V. High capacitance myocardial electrodes
US6285906B1 (en) 1999-05-26 2001-09-04 Impulse Dynamics N. V. Muscle contraction assist device
US7171263B2 (en) * 1999-06-04 2007-01-30 Impulse Dynamics Nv Drug delivery device
US7190997B1 (en) 1999-06-04 2007-03-13 Impulse Dynamics Nv Drug delivery device
US7092753B2 (en) 1999-06-04 2006-08-15 Impulse Dynamics Nv Drug delivery device
US6233487B1 (en) 1999-06-08 2001-05-15 Impulse Dynamics N.V. Apparatus and method for setting the parameters of an alert window used for timing the delivery of ETC signals to a heart under varying cardiac conditions
US6504530B1 (en) * 1999-09-07 2003-01-07 Elo Touchsystems, Inc. Touch confirming touchscreen utilizing plural touch sensors
US6296693B1 (en) 1999-09-17 2001-10-02 Mccarthy Walton W. Life cell
US7027863B1 (en) 1999-10-25 2006-04-11 Impulse Dynamics N.V. Device for cardiac therapy
JP4365493B2 (en) 1999-10-25 2009-11-18 東北リコー株式会社 Printing device
US6587093B1 (en) 1999-11-04 2003-07-01 Synaptics Incorporated Capacitive mouse
US20020026141A1 (en) * 1999-11-04 2002-02-28 Medtronic, Inc. System for pancreatic stimulation and glucose measurement
JP2001142639A (en) 1999-11-15 2001-05-25 Pioneer Electronic Corp Touch panel device
US6853862B1 (en) * 1999-12-03 2005-02-08 Medtronic, Inc. Gastroelectric stimulation for influencing pancreatic secretions
US6600953B2 (en) 2000-12-11 2003-07-29 Impulse Dynamics N.V. Acute and chronic electrical signal therapy for obesity
US6417846B1 (en) 2000-02-02 2002-07-09 Lee Si-Ken Multifunction input device
US6919205B2 (en) 2000-02-23 2005-07-19 The Trustees Of The University Of Pennsylvania Regulation of type II collagen gene expression using specific and selective electrical and electromagnetic signals
US6572542B1 (en) 2000-03-03 2003-06-03 Medtronic, Inc. System and method for monitoring and controlling the glycemic state of a patient
DE60024144T2 (en) 2000-03-05 2006-08-03 Impulse Dynamics N.V. CONTROL OF THE BLOOD SUGAR MIRROR
US6810286B2 (en) 2000-03-06 2004-10-26 Medtronic, Inc Stimulation for delivery of molecular therapy
US6612983B1 (en) 2000-03-28 2003-09-02 Medtronic, Inc. Pancreatic secretion response to stimulation test protocol
US6826428B1 (en) * 2000-04-11 2004-11-30 The Board Of Regents Of The University Of Texas System Gastrointestinal electrical stimulation
JP2001308247A (en) * 2000-04-19 2001-11-02 Nec Kansai Ltd Lead frame and surface mounting type semiconductor device
CN1277589C (en) 2000-05-31 2006-10-04 超治疗股份有限公司 Electropancreatography
JP3910019B2 (en) 2000-07-04 2007-04-25 アルプス電気株式会社 Input device
US6555235B1 (en) * 2000-07-06 2003-04-29 3M Innovative Properties Co. Touch screen system
US6605039B2 (en) 2000-07-24 2003-08-12 Medtronic, Inc. Cell-based biosensors suitable for implantable medical device applications
US6634895B2 (en) 2000-07-28 2003-10-21 Cooper Technologies Company Adapter for track lighting systems
US6690156B1 (en) * 2000-07-28 2004-02-10 N-Trig Ltd. Physical object location apparatus and method and a graphic display device using the same
US6505745B1 (en) * 2000-08-01 2003-01-14 Richard E Anderson Holder for articles such as napkins
WO2002020086A1 (en) 2000-09-07 2002-03-14 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Method and apparatus for control of bowel function
US20020072780A1 (en) 2000-09-26 2002-06-13 Transneuronix, Inc. Method and apparatus for intentional impairment of gastric motility and /or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity
US6567700B1 (en) 2000-10-19 2003-05-20 Robert Turcott Implantable cardiac stimulation device and method which optimizes pacing effectiveness
US7440806B1 (en) 2000-11-21 2008-10-21 Boston Scientific Neuromodulation Corp. Systems and methods for treatment of diabetes by electrical brain stimulation and/or drug infusion
US6484057B2 (en) 2000-12-21 2002-11-19 Uab Research Foundation Pacing methods and devices for treating cardiac arrhythmias and fibrillation
EP1357971B1 (en) * 2001-01-05 2015-05-20 Metacure Limited Regulation of eating habits
US6570557B1 (en) 2001-02-10 2003-05-27 Finger Works, Inc. Multi-touch system and method for emulating modifier keys via fingertip chords
US6583676B2 (en) 2001-06-20 2003-06-24 Apple Computer, Inc. Proximity/touch detector and calibration circuit
US20030100889A1 (en) 2001-07-05 2003-05-29 Nicolas Duverger Method of administration of a gene of interest to a vascular tissue
US7191000B2 (en) * 2001-07-31 2007-03-13 Cardiac Pacemakers, Inc. Cardiac rhythm management system for edema
US6762752B2 (en) 2001-11-29 2004-07-13 N-Trig Ltd. Dual function input device and method
US20070060812A1 (en) 2001-11-29 2007-03-15 Metacure N.V. Sensing of pancreatic electrical activity
US7239912B2 (en) 2002-03-22 2007-07-03 Leptos Biomedical, Inc. Electric modulation of sympathetic nervous system
US20030188899A1 (en) 2002-04-09 2003-10-09 Ching-Chuan Chao Prepositive electro-magnetic tablet with transparent antenna
US20050065553A1 (en) 2003-06-13 2005-03-24 Omry Ben Ezra Applications of vagal stimulation
US6652444B1 (en) 2002-08-13 2003-11-25 Jesse Ross Supplemental diabetic treatment method
US6875605B1 (en) 2002-08-21 2005-04-05 Florida State University Research Foundation, Inc. Modular cell culture bioreactor and associated methods
WO2004021328A2 (en) 2002-08-29 2004-03-11 N-Trig Ltd. Transparent digitiser
KR100459230B1 (en) 2002-11-14 2004-12-03 엘지.필립스 엘시디 주식회사 touch panel for display device
US20040106954A1 (en) 2002-11-15 2004-06-03 Whitehurst Todd K. Treatment of congestive heart failure
US20040158289A1 (en) * 2002-11-30 2004-08-12 Girouard Steven D. Method and apparatus for cell and electrical therapy of living tissue
US7372455B2 (en) 2003-02-10 2008-05-13 N-Trig Ltd. Touch detection for a digitizer
EP1606011B1 (en) * 2003-03-10 2015-08-19 Impulse Dynamics N.V. Apparatus for delivering electrical signals to modify gene expression in cardiac tissue
DE10316177B4 (en) * 2003-04-10 2007-05-31 Cardiac Pacemakers, Inc., St. Paul Pacemaker electrode arrangement
US7529592B2 (en) 2003-04-11 2009-05-05 Cardiac Pacemakers, Inc. Subcutaneous electrode and lead with temporary pharmacological agents
US8352031B2 (en) 2004-03-10 2013-01-08 Impulse Dynamics Nv Protein activity modification
WO2006119467A2 (en) * 2005-05-04 2006-11-09 Impulse Dynamics Nv Protein activity modification
AU2005233583B2 (en) 2004-04-08 2011-02-03 Sangamo Therapeutics, Inc. Methods and compositions for modulating cardiac contractility
US7828711B2 (en) * 2004-08-16 2010-11-09 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular growth and regeneration using ventricular assist device
EP1796529B1 (en) 2004-09-08 2016-02-03 Olympus Corporation Capsule type medical device
EP1827571B1 (en) 2004-12-09 2016-09-07 Impulse Dynamics NV Protein activity modification
US8244371B2 (en) 2005-03-18 2012-08-14 Metacure Limited Pancreas lead
US20070016262A1 (en) * 2005-07-13 2007-01-18 Betastim, Ltd. Gi and pancreatic device for treating obesity and diabetes

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8958872B2 (en) 1996-01-08 2015-02-17 Impulse Dynamics, N.V. Electrical muscle controller
US9186514B2 (en) 1996-01-08 2015-11-17 Impulse Dynamics Nv Electrical muscle controller
US9289618B1 (en) 1996-01-08 2016-03-22 Impulse Dynamics Nv Electrical muscle controller
US9265930B2 (en) 1997-07-16 2016-02-23 Metacure Limited Methods and devices for modifying vascular parameters
US8977353B2 (en) 2004-03-10 2015-03-10 Impulse Dynamics Nv Protein activity modification
US9440080B2 (en) 2004-03-10 2016-09-13 Impulse Dynamics Nv Protein activity modification
US8934975B2 (en) 2010-02-01 2015-01-13 Metacure Limited Gastrointestinal electrical therapy

Also Published As

Publication number Publication date
CN1787850A (en) 2006-06-14
EP1606011B1 (en) 2015-08-19
WO2004080533A1 (en) 2004-09-23
EP1606011A1 (en) 2005-12-21
US20070027487A1 (en) 2007-02-01
US8326416B2 (en) 2012-12-04
US7840262B2 (en) 2010-11-23
CN1787850B (en) 2015-12-16
US20110093028A1 (en) 2011-04-21
EP1606011A4 (en) 2010-12-01
WO2004080533A8 (en) 2004-10-28
JP2006519663A (en) 2006-08-31

Similar Documents

Publication Publication Date Title
WO2004080533B1 (en) Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue
US20210154470A1 (en) Methods and systems for treating acute heart failure by neuromodulation
US8825152B2 (en) Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue
US7869867B2 (en) Implantable neurostimulator with refractory stimulation
AU2008216902B2 (en) Systems for electrical stimulation of blood vessels
US7949400B2 (en) Devices and methods for cardiovascular reflex control via coupled electrodes
EP2914192B1 (en) Controlled tissue ablation
JP4413626B2 (en) Device and method for controlling circulatory system reflection by connecting electrodes
US20080077184A1 (en) Intravascular Stimulation System With Wireless Power Supply
US20030060857A1 (en) Electrode designs and methods of use for cardiovascular reflex control devices
US9782592B2 (en) Energy efficient high frequency nerve blocking technique
JP2008018252A (en) Cardiac output controller
US20180021583A1 (en) Methods and systems for managing synchronous conducted communication for an implantable medical device
CN101244314A (en) Electrostimulation platform system, method for setting therapy mode and storage medium
US7310555B2 (en) Regulation of excitable tissue control of the heart based on physiological input
US7621906B2 (en) Method and apparatus to deliver drug and pacing therapy for treatment of cardiac disorders
US20230271016A1 (en) Treatment of congestive heart failure with electrical stimulation, and associated systems and methods
WO2001024871A2 (en) Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue
US10918871B2 (en) Systems and methods for peripheral nervous stimulation for metabolic and endocrine function
US20230191128A1 (en) Modulation of fabp4
WO2017146660A1 (en) A system for decreasing the internal organ blood flow to alleviate hypotension, hypoglisemia and myocardial infarction with segmental non-invasive stimulation of sympathetic innervation to specific internal organs and their arterial smooth muscles
Charles et al. Agata, J., Zhang, JJ, Chao, J. and Chao, L., Adrenomedullin gene delivery inhibits neointima formation in rat artery after balloon angioplasty, 115 Akimoto, K., see Tadokoro, K., 71 Allaker, RP and Kapas, S., Adrenomedullin and mucosal defence: interaction between host and microorganism, 147

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WR Later publication of a revised version of an international search report
121 Ep: the epo has been informed by wipo that ep was designated in this application
B Later publication of amended claims

Effective date: 20041019

WWE Wipo information: entry into national phase

Ref document number: 2006507121

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2004719312

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2589/CHENP/2005

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 20048126875

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2004719312

Country of ref document: EP

DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2007027487

Country of ref document: US

Ref document number: 10549216

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 10549216

Country of ref document: US