WO2004089334A3 - Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems - Google Patents

Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems Download PDF

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Publication number
WO2004089334A3
WO2004089334A3 PCT/US2004/010107 US2004010107W WO2004089334A3 WO 2004089334 A3 WO2004089334 A3 WO 2004089334A3 US 2004010107 W US2004010107 W US 2004010107W WO 2004089334 A3 WO2004089334 A3 WO 2004089334A3
Authority
WO
WIPO (PCT)
Prior art keywords
preloaded
present
osmotic delivery
osmotic pumps
delivery systems
Prior art date
Application number
PCT/US2004/010107
Other languages
French (fr)
Other versions
WO2004089334A2 (en
Inventor
Pamela J Fereira
Scott Lautenbach
Stephen Berry
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33159656&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2004089334(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp filed Critical Alza Corp
Priority to JP2006509604A priority Critical patent/JP2006521898A/en
Priority to CA002520766A priority patent/CA2520766A1/en
Priority to BRPI0408921-9A priority patent/BRPI0408921A/en
Priority to AU2004227986A priority patent/AU2004227986A1/en
Priority to MXPA05010604A priority patent/MXPA05010604A/en
Priority to EP04758752A priority patent/EP1610761A2/en
Publication of WO2004089334A2 publication Critical patent/WO2004089334A2/en
Publication of WO2004089334A3 publication Critical patent/WO2004089334A3/en
Priority to NO20055024A priority patent/NO20055024L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Abstract

The present invention includes devices and methods for reducing the start-up time of osmotically driven drug delivery systems capable of delivering a desired drug at a controlled rate over time. In particular, the present invention includes osmotic pumps that have a preloaded membrane, which includes a semipermeable material that has been preloaded with a nonaqueous, incompressible liquid filler that is miscible with water. The present invention further includes methods for making such osmotic pumps. The preloaded membranes included in the osmotic pumps according to the present invention have proven to provide significant decreases in average start-up times relative to osmotic pumps that include semipermeable membranes that are not preloaded.
PCT/US2004/010107 2003-03-31 2004-03-31 Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems WO2004089334A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2006509604A JP2006521898A (en) 2003-03-31 2004-03-31 Osmotic delivery system and method for reducing start-up time of an osmotic delivery system
CA002520766A CA2520766A1 (en) 2003-03-31 2004-03-31 Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems
BRPI0408921-9A BRPI0408921A (en) 2003-03-31 2004-03-31 osmotic distribution system and method for decreasing start times for osmotic distribution systems
AU2004227986A AU2004227986A1 (en) 2003-03-31 2004-03-31 Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems
MXPA05010604A MXPA05010604A (en) 2003-03-31 2004-03-31 Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems.
EP04758752A EP1610761A2 (en) 2003-03-31 2004-03-31 Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems
NO20055024A NO20055024L (en) 2003-03-31 2005-10-28 Osmotic delivery system and method for minimum start times for osmotic delivery systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45947303P 2003-03-31 2003-03-31
US60/459,473 2003-03-31

Publications (2)

Publication Number Publication Date
WO2004089334A2 WO2004089334A2 (en) 2004-10-21
WO2004089334A3 true WO2004089334A3 (en) 2004-12-29

Family

ID=33159656

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/010107 WO2004089334A2 (en) 2003-03-31 2004-03-31 Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems

Country Status (15)

Country Link
US (1) US20050010196A1 (en)
EP (1) EP1610761A2 (en)
JP (1) JP2006521898A (en)
KR (1) KR20050120767A (en)
CN (1) CN1767812A (en)
AR (1) AR043810A1 (en)
AU (1) AU2004227986A1 (en)
BR (1) BRPI0408921A (en)
CA (1) CA2520766A1 (en)
CL (1) CL2004000697A1 (en)
MX (1) MXPA05010604A (en)
NO (1) NO20055024L (en)
TW (1) TW200509999A (en)
WO (1) WO2004089334A2 (en)
ZA (1) ZA200508781B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
CN101453982B (en) 2006-05-30 2011-05-04 精达制药公司 Two-piece, internal-channel osmotic delivery system flow modulator
ES2422864T3 (en) 2006-08-09 2013-09-16 Intarcia Therapeutics, Inc Osmotic release systems and piston units
RU2440097C2 (en) 2007-04-23 2012-01-20 Интарсия Терапьютикс, Инк. Method of treating insulin-independent diabetes and obesity, osmotic delivery system and method for making it
EP2240155B1 (en) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
NZ592113A (en) * 2008-10-15 2012-04-27 Intarcia Therapeutics Inc Highly concentrated drug particles, formulations, suspensions and uses thereof
US8852155B2 (en) * 2009-08-12 2014-10-07 Medimetrics Personalized Drug Delivery Medicine reservoir for drug delivery device
EP3323423B1 (en) * 2009-09-28 2020-06-17 Intarcia Therapeutics, Inc Rapid establishment and/or termination of substantial steady-state drug delivery
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
EP3302354B1 (en) 2015-06-03 2023-10-04 i2o Therapeutics, Inc. Implant placement systems
WO2017200943A1 (en) 2016-05-16 2017-11-23 Intarcia Therapeutics, Inc. Glucagon-receptor selective polypeptides and methods of use thereof
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
KR20190104039A (en) 2017-01-03 2019-09-05 인타르시아 세라퓨틱스 인코포레이티드 Methods Including Continuous Administration of GLP-1 Receptor Agonists and Co-administration of Drugs
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4305927A (en) * 1979-02-05 1981-12-15 Alza Corporation Method for the management of intraocular pressure
WO1999033446A1 (en) * 1997-12-29 1999-07-08 Alza Corporation Osmotic delivery system with membrane plug retention mechanism
US6132420A (en) * 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
WO2001051041A1 (en) * 2000-01-13 2001-07-19 Osmotica Corp. Osmotic device containing venlafaxine and an anti-psychotic agent

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797492A (en) * 1972-12-27 1974-03-19 Alza Corp Device for dispensing product with directional guidance member
US3987790A (en) * 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US4008719A (en) * 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
JPH0772799B2 (en) * 1986-08-13 1995-08-02 ソニー株式会社 Resist material
US4874388A (en) * 1987-06-25 1989-10-17 Alza Corporation Multi-layer delivery system
US5110596A (en) * 1988-12-13 1992-05-05 Alza Corporation Delivery system comprising means for delivering agent to livestock
US5059423A (en) * 1988-12-13 1991-10-22 Alza Corporation Delivery system comprising biocompatible beneficial agent formulation
US5057318A (en) * 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5034229A (en) * 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US5219572A (en) * 1989-03-17 1993-06-15 Pitman-Moore, Inc. Controlled release delivery device for macromolecular proteins
US5112614A (en) * 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5234693A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5234692A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5151093A (en) * 1990-10-29 1992-09-29 Alza Corporation Osmotically driven syringe with programmable agent delivery
GB9027422D0 (en) * 1990-12-18 1991-02-06 Scras Osmotically driven infusion device
US5137727A (en) * 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5288214A (en) * 1991-09-30 1994-02-22 Toshio Fukuda Micropump
DE4137649C2 (en) * 1991-11-15 1997-11-20 Gerhard Dingler Component
US5308348A (en) * 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
US5368588A (en) * 1993-02-26 1994-11-29 Bettinger; David S. Parenteral fluid medication reservoir pump
US5639477A (en) * 1993-06-23 1997-06-17 Alza Corporation Ruminal drug delivery device
US5697975A (en) * 1994-02-09 1997-12-16 The University Of Iowa Research Foundation Human cerebral cortex neural prosthetic for tinnitus
NL9401150A (en) * 1994-07-12 1996-02-01 Nederland Ptt Method for presenting on a receiving side a first number of video signals originating from a transmitting side, as well as a system, as well as a transmitter, as well as a network, and also a receiver.
DE69529572T2 (en) * 1994-11-10 2003-06-18 Univ Kentucky Res Foundation L IMPLANTABLE REFILLABLE DEVICE WITH CONTROLLED RELEASE FOR ADMINISTERING MEDICINAL SUBSTANCES DIRECTLY ON AN INNER PART OF THE BODY
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US6156331A (en) * 1996-02-02 2000-12-05 Alza Corporation Sustained delivery of an active agent using an implantable system
RU2189221C2 (en) * 1996-02-02 2002-09-20 Элзэ Копэрейшн Method and device for administering active substance and method for treating prostate carcinoma patients
US6395292B2 (en) * 1996-02-02 2002-05-28 Alza Corporation Sustained delivery of an active agent using an implantable system
US6261584B1 (en) * 1996-02-02 2001-07-17 Alza Corporation Sustained delivery of an active agent using an implantable system
US5976109A (en) * 1996-04-30 1999-11-02 Medtronic, Inc. Apparatus for drug infusion implanted within a living body
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations
ES2158611T3 (en) * 1996-12-20 2001-09-01 Alza Corp COMPOSITION IN INJECTABLE GEL WITH RETARD EFFECT AND PROCEDURE FOR THE PREPARATION OF SUCH COMPOSITION.
ZA981610B (en) * 1997-03-24 1999-08-26 Alza Corp Self adjustable exit port.
US5874388A (en) * 1997-04-02 1999-02-23 Dow Corning Corporation Lubricant composition for disc brake caliper pin and a disc brake asembly containing the lubricant
MY125849A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
DK1041975T3 (en) * 1997-12-22 2002-11-04 Alza Corp Speed-controlling membranes for controlled drug delivery devices
JP4494629B2 (en) * 1997-12-30 2010-06-30 インターシア セラピューティクス，インコーポレイティド Beneficial agent supply system with membrane plug
US6248112B1 (en) * 1998-09-30 2001-06-19 C. R. Bard, Inc. Implant delivery system
CA2356860C (en) * 1998-12-31 2006-11-07 Alza Corporation Osmotic delivery system having space efficient piston
US7258869B1 (en) * 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US20030059376A1 (en) * 1999-06-04 2003-03-27 Libbey Miles A. Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same
US6436091B1 (en) * 1999-11-16 2002-08-20 Microsolutions, Inc. Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
DE60023361T2 (en) * 1999-12-21 2006-04-27 Alza Corp., Mountain View VALVE FOR OSMOTIC DEVICES
US6283949B1 (en) * 1999-12-27 2001-09-04 Advanced Cardiovascular Systems, Inc. Refillable implantable drug delivery pump
US7163688B2 (en) * 2001-06-22 2007-01-16 Alza Corporation Osmotic implant with membrane and membrane retention means
CA2467239A1 (en) * 2001-11-14 2003-05-22 Alza Corporation Catheter injectable depot compositions and uses thereof
CA2484052C (en) * 2002-04-11 2011-06-14 Medimmune Vaccines, Inc. Preservation of bioactive materials by spray drying
CN1668279A (en) * 2002-06-17 2005-09-14 阿尔萨公司 Osmotic delivery system with early zero order push power engine comprising an osmotic agent dispersed in the fluid vehicle
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
ATE376854T1 (en) * 2002-06-26 2007-11-15 Alza Corp MINIMALLY FORGIVE VOLUME EFFICIENT PISTON FOR OSMOTIC DRUG DELIVERY SYSTEMS
IL166418A0 (en) * 2002-07-31 2006-01-15 Alza Corp Injectable depot compositions and uses thereof
MXPA05004927A (en) * 2002-11-06 2005-09-08 Alza Corp Controlled release depot formulations.
US7014636B2 (en) * 2002-11-21 2006-03-21 Alza Corporation Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
BR0317421A (en) * 2002-12-19 2005-11-08 Alza Corp Stable non-aqueous single phase gels and formulations for release from an implantable device
JP2006521897A (en) * 2003-03-31 2006-09-28 アルザ・コーポレーション Osmotic pump with means for dissipating internal pressure
KR20060002922A (en) * 2003-03-31 2006-01-09 알자 코포레이션 Non-aqueous single phase vehicles and formulations utilizing such vehicles
CA2537811A1 (en) * 2003-10-31 2005-05-19 Alza Corporation Osmotic pump with self-retaining, fast-start membrane plug
US20050175701A1 (en) * 2004-02-10 2005-08-11 Alza Corporation Capillary moderator for osmotic delivery system
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
US20060216242A1 (en) * 2005-02-03 2006-09-28 Rohloff Catherine M Suspending vehicles and pharmaceutical suspensions for drug dosage forms
WO2006083761A2 (en) * 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US7959938B2 (en) * 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
US20070027105A1 (en) * 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
CN101453982B (en) * 2006-05-30 2011-05-04 精达制药公司 Two-piece, internal-channel osmotic delivery system flow modulator

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4305927A (en) * 1979-02-05 1981-12-15 Alza Corporation Method for the management of intraocular pressure
US6132420A (en) * 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
WO1999033446A1 (en) * 1997-12-29 1999-07-08 Alza Corporation Osmotic delivery system with membrane plug retention mechanism
WO2001051041A1 (en) * 2000-01-13 2001-07-19 Osmotica Corp. Osmotic device containing venlafaxine and an anti-psychotic agent

Also Published As

Publication number Publication date
AR043810A1 (en) 2005-08-17
CN1767812A (en) 2006-05-03
CA2520766A1 (en) 2004-10-21
NO20055024L (en) 2005-12-16
KR20050120767A (en) 2005-12-23
CL2004000697A1 (en) 2005-05-20
TW200509999A (en) 2005-03-16
NO20055024D0 (en) 2005-10-28
WO2004089334A2 (en) 2004-10-21
BRPI0408921A (en) 2006-03-28
ZA200508781B (en) 2007-01-31
JP2006521898A (en) 2006-09-28
EP1610761A2 (en) 2006-01-04
MXPA05010604A (en) 2005-11-23
AU2004227986A1 (en) 2004-10-21
US20050010196A1 (en) 2005-01-13

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