WO2004089335A3 - Non-aqueous single phase vehicles and formulations utilizing such vehicles - Google Patents

Non-aqueous single phase vehicles and formulations utilizing such vehicles Download PDF

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Publication number
WO2004089335A3
WO2004089335A3 PCT/US2004/009755 US2004009755W WO2004089335A3 WO 2004089335 A3 WO2004089335 A3 WO 2004089335A3 US 2004009755 W US2004009755 W US 2004009755W WO 2004089335 A3 WO2004089335 A3 WO 2004089335A3
Authority
WO
WIPO (PCT)
Prior art keywords
vehicles
drug formulations
present
formulations
nonaqueous
Prior art date
Application number
PCT/US2004/009755
Other languages
French (fr)
Other versions
WO2004089335A2 (en
Inventor
Pamela Fereira
Michael Desjardin
Catherine Rohloff
Stephen Berry
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33159638&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2004089335(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to NZ542867A priority Critical patent/NZ542867A/en
Priority to DE602004015755T priority patent/DE602004015755D1/en
Priority to AU2004227837A priority patent/AU2004227837A1/en
Priority to JP2006509491A priority patent/JP2006522133A/en
Priority to CA002520775A priority patent/CA2520775A1/en
Application filed by Alza Corp filed Critical Alza Corp
Priority to BRPI0408925-1A priority patent/BRPI0408925A/en
Priority to MXPA05010602A priority patent/MXPA05010602A/en
Priority to EP04749544A priority patent/EP1610765B1/en
Publication of WO2004089335A2 publication Critical patent/WO2004089335A2/en
Publication of WO2004089335A3 publication Critical patent/WO2004089335A3/en
Priority to NO20054904A priority patent/NO20054904L/en
Priority to HK06107533.3A priority patent/HK1090834A1/en
Priority to AU2010212478A priority patent/AU2010212478B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

Abstract

The present invention includes materials and methods for providing vehicles useful for providing drug formulations that address the potential drawbacks of known nonaqueous formulations. In particular, the present invention includes nonaqueous vehicles that are formed using a combination of polymer and solvent that results in a vehicle that is miscible in water. The nonaqueous vehicles facilitate the formulation of drug formulations that are stable over time, even when stored at, or exposed to, elevated temperatures. Moreover, the miscible vehicles of the present invention allow the preparation of drug formulations that work to reduce the occurrence of partial or complete occlusions of the delivery conduits included in delivery devices used to administer the drug formulations.
PCT/US2004/009755 2003-03-31 2004-03-31 Non-aqueous single phase vehicles and formulations utilizing such vehicles WO2004089335A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP04749544A EP1610765B1 (en) 2003-03-31 2004-03-31 Non-aqueous single phase vehicles and formulations utilizing such vehicles
MXPA05010602A MXPA05010602A (en) 2003-03-31 2004-03-31 Non-aqueous single phase vehicles and formulations utilizing such vehicles.
AU2004227837A AU2004227837A1 (en) 2003-03-31 2004-03-31 Non-aqueous single phase vehicles and formulations utilizing such vehicles
JP2006509491A JP2006522133A (en) 2003-03-31 2004-03-31 Non-aqueous single phase media and formulations utilizing such media
CA002520775A CA2520775A1 (en) 2003-03-31 2004-03-31 Non-aqueous single phase vehicles and formulations utilizing such vehicles
NZ542867A NZ542867A (en) 2003-03-31 2004-03-31 Non-aqueous single phase vehicles and formulations utilizing such vehicles involving a polymer
BRPI0408925-1A BRPI0408925A (en) 2003-03-31 2004-03-31 non-aqueous single phase vehicles and formulations using such vehicles
DE602004015755T DE602004015755D1 (en) 2003-03-31 2004-03-31 NON-AQUEOUS SINGLE-PHASE VEGETABLE VEHICLES AND FORMULATIONS THAT USE THESE VEHICLES
NO20054904A NO20054904L (en) 2003-03-31 2005-10-24 Non-aqueous single-phase carriers and formulations expressing such carriers
HK06107533.3A HK1090834A1 (en) 2003-03-31 2006-07-04 Non-aqueous single phase vehicles and formulations utilizing such vehicles
AU2010212478A AU2010212478B2 (en) 2003-03-31 2010-08-20 Non-aqueous single phase vehicles and formulations utilizing such vehicles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45930003P 2003-03-31 2003-03-31
US60/459,300 2003-03-31

Publications (2)

Publication Number Publication Date
WO2004089335A2 WO2004089335A2 (en) 2004-10-21
WO2004089335A3 true WO2004089335A3 (en) 2005-02-10

Family

ID=33159638

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/009755 WO2004089335A2 (en) 2003-03-31 2004-03-31 Non-aqueous single phase vehicles and formulations utilizing such vehicles

Country Status (20)

Country Link
US (3) US20050008661A1 (en)
EP (1) EP1610765B1 (en)
JP (1) JP2006522133A (en)
KR (1) KR20060002922A (en)
CN (1) CN1767815A (en)
AR (1) AR043811A1 (en)
AT (1) ATE404175T1 (en)
AU (2) AU2004227837A1 (en)
BR (1) BRPI0408925A (en)
CA (1) CA2520775A1 (en)
CL (1) CL2004000698A1 (en)
DE (1) DE602004015755D1 (en)
HK (1) HK1090834A1 (en)
MX (1) MXPA05010602A (en)
NO (1) NO20054904L (en)
NZ (1) NZ542867A (en)
RU (1) RU2005133427A (en)
TW (1) TW200505500A (en)
WO (1) WO2004089335A2 (en)
ZA (1) ZA200508782B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9526763B2 (en) 2005-02-03 2016-12-27 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US9539200B2 (en) 2005-02-03 2017-01-10 Intarcia Therapeutics Inc. Two-piece, internal-channel osmotic delivery system flow modulator
US9572889B2 (en) 2008-02-13 2017-02-21 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US7635463B2 (en) * 2002-02-27 2009-12-22 Pharmain Corporation Compositions for delivery of therapeutics and other materials
US20050260259A1 (en) * 2004-04-23 2005-11-24 Bolotin Elijah M Compositions for treatment with glucagon-like peptide, and methods of making and using the same
JP2005524657A (en) * 2002-02-27 2005-08-18 ファーメイン， エルティーディー． Compositions for delivering therapeutic agents and other substances, and methods of making and using said compositions
MXPA04012976A (en) * 2002-06-17 2005-05-16 Alza Corp Osmotic delivery system with early zero order push power engine comprising an osmotic agent dispersed in the fluid vehicle.
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
KR20060017749A (en) * 2003-03-31 2006-02-27 알자 코포레이션 Osmotic pump with means for dissipating internal pressure
BRPI0408921A (en) * 2003-03-31 2006-03-28 Alza Corp osmotic distribution system and method for decreasing start times for osmotic distribution systems
CN1767815A (en) 2003-03-31 2006-05-03 阿尔萨公司 Non-aqueous single phase vehicles and formulations utilizing such vehicles
AU2004232858B2 (en) 2003-04-23 2009-07-09 Mannkind Corporation Hydraulically actuated pump for long duration medicament administration
BRPI0416094A (en) * 2003-10-31 2007-01-02 Alza Corp self-retaining quick start membrane plug osmotic pump
AU2004289218A1 (en) * 2003-11-06 2005-05-26 Alza Corporation Modular imbibition rate reducer for use with implantable osmotic pump
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
WO2006014425A1 (en) 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
US7772182B2 (en) * 2004-08-05 2010-08-10 Alza Corporation Stable suspension formulations of erythropoietin receptor agonists
US20060045891A1 (en) * 2004-08-24 2006-03-02 Lovalenti Phillip M Density-matched suspension vehicles and pharmaceutical suspensions
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US20060216242A1 (en) * 2005-02-03 2006-09-28 Rohloff Catherine M Suspending vehicles and pharmaceutical suspensions for drug dosage forms
JP2008528699A (en) * 2005-02-03 2008-07-31 アルザ・コーポレーシヨン Method for reducing peroxide levels in BOP compatible polymer preparations
JP2008528698A (en) * 2005-02-03 2008-07-31 インターシア セラピューティクス，インコーポレイティド Implantable interferon-containing devices
WO2006083950A2 (en) * 2005-02-03 2006-08-10 Alza Corporation Method for reducing the level of peroxides in bopcompatible polymer preparations
US7959938B2 (en) * 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
US20070027105A1 (en) * 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
AU2006330610B2 (en) 2005-12-19 2012-08-16 Pharmain Corporation Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same
JP2009532117A (en) 2006-03-30 2009-09-10 ヴァレリタス，エルエルシー Multi-cartridge fluid dispensing device
ES2422864T3 (en) * 2006-08-09 2013-09-16 Intarcia Therapeutics, Inc Osmotic release systems and piston units
JP5018307B2 (en) * 2006-09-26 2012-09-05 富士通株式会社 Resist pattern thickening material, resist pattern forming method, semiconductor device and manufacturing method thereof
WO2008133908A2 (en) 2007-04-23 2008-11-06 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
US7960336B2 (en) 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
US8563527B2 (en) * 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
WO2009033800A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
US20090176892A1 (en) * 2008-01-09 2009-07-09 Pharmain Corporation Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same
US20100092566A1 (en) * 2008-10-15 2010-04-15 Alessi Thomas R Highly concentrated drug particles, formulations, suspensions and uses thereof
WO2011037623A1 (en) * 2009-09-28 2011-03-31 Intarcia Therapeutics, Inc. Rapid establishment and/or termination of substantial steady-state drug delivery
US9072668B2 (en) 2010-03-09 2015-07-07 Janssen Biotech, Inc. Non-aqueous high concentration reduced viscosity suspension formulations of antibodies
US20110223208A1 (en) 2010-03-09 2011-09-15 Beth Hill Non-Aqueous High Concentration Reduced Viscosity Suspension Formulations
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9956287B2 (en) * 2013-02-06 2018-05-01 Perosphere Inc. Stable glucagon formulations
EP3808338A1 (en) 2013-09-11 2021-04-21 Eagle Biologics, Inc. Liquid protein formulations containing ionic liquids
CN106456704A (en) 2014-04-16 2017-02-22 Veyx-药物有限公司 Veterinary pharmaceutical composition and use thereof
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
SG10201902915VA (en) 2014-10-01 2019-04-29 Eagle Biologics Inc Polysaccharide and nucleic acid formulations containing viscosity-lowering agents
CN113598842A (en) 2015-06-03 2021-11-05 因塔西亚制药公司 Implant placement and removal system
EP3458084B1 (en) 2016-05-16 2020-04-01 Intarcia Therapeutics, Inc Glucagon-receptor selective polypeptides and methods of use thereof
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
EP3565580B1 (en) 2017-01-03 2024-03-06 i2o Therapeutics, Inc. Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel
US10646569B2 (en) 2017-05-16 2020-05-12 Bhami's Research Laboratory, Pvt. Ltd. High concentration protein formulations with reduced viscosity
CN115666621A (en) 2020-01-13 2023-01-31 度勒科特公司 Sustained release drug delivery systems with reduced impurities and related methods

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998027962A2 (en) * 1996-12-20 1998-07-02 Alza Corporation Injectable depot gel composition and method of preparing the composition
WO2000045790A2 (en) * 1999-02-08 2000-08-10 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
WO2003041684A2 (en) * 2001-11-14 2003-05-22 Alza Corporation Injectable depot compositions and uses thereof
WO2003072113A1 (en) * 2002-02-28 2003-09-04 Norbrook Laboratories Limited Long acting parasiticidal composition containing a salicylanilide compound, a polymeric species and at least one other anti-parasitic compound

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069251A (en) * 1969-02-08 1978-01-17 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler Continuous process for the manufacture of methionine
US3797492A (en) * 1972-12-27 1974-03-19 Alza Corp Device for dispensing product with directional guidance member
US3987790A (en) * 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US4008719A (en) * 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4305927A (en) * 1979-02-05 1981-12-15 Alza Corporation Method for the management of intraocular pressure
US4304767A (en) * 1980-05-15 1981-12-08 Sri International Polymers of di- (and higher functionality) ketene acetals and polyols
US4562024A (en) * 1982-07-06 1985-12-31 Sterling Drug Inc. Process for preparing granulate containing poorly compressible medicinally active matter
US4865845A (en) * 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
JPS62267326A (en) * 1986-05-15 1987-11-20 Sanyo Chem Ind Ltd Purification of polyether
JPH0657722B2 (en) * 1986-05-27 1994-08-03 三菱化成株式会社 Water-soluble polymer composition
US4874388A (en) * 1987-06-25 1989-10-17 Alza Corporation Multi-layer delivery system
US5110596A (en) * 1988-12-13 1992-05-05 Alza Corporation Delivery system comprising means for delivering agent to livestock
US5034229A (en) * 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US5059423A (en) * 1988-12-13 1991-10-22 Alza Corporation Delivery system comprising biocompatible beneficial agent formulation
US5057318A (en) * 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5219572A (en) * 1989-03-17 1993-06-15 Pitman-Moore, Inc. Controlled release delivery device for macromolecular proteins
US5112614A (en) * 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
DE69129110T2 (en) * 1990-05-10 1998-12-10 Bechgaard Int Res PHARMACEUTICAL PREPARATION CONTAINING N-GLYCOFUROLE AND N-ETHYLENE GLYCOL
US5234692A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5234693A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5151093A (en) * 1990-10-29 1992-09-29 Alza Corporation Osmotically driven syringe with programmable agent delivery
GB9027422D0 (en) * 1990-12-18 1991-02-06 Scras Osmotically driven infusion device
US5137727A (en) * 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5221698A (en) * 1991-06-27 1993-06-22 The Regents Of The University Of Michigan Bioactive composition
US5288214A (en) * 1991-09-30 1994-02-22 Toshio Fukuda Micropump
DE4137649C2 (en) * 1991-11-15 1997-11-20 Gerhard Dingler Component
US5308348A (en) * 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
US5456679A (en) * 1992-02-18 1995-10-10 Alza Corporation Delivery devices with pulsatile effect
US5368588A (en) * 1993-02-26 1994-11-29 Bettinger; David S. Parenteral fluid medication reservoir pump
US5639477A (en) * 1993-06-23 1997-06-17 Alza Corporation Ruminal drug delivery device
DE4403567A1 (en) * 1994-02-07 1995-08-10 Storz Karl Gmbh & Co Device for performing endoscopic operations using an intra- and / or extracorporeal sheath
US5697975A (en) * 1994-02-09 1997-12-16 The University Of Iowa Research Foundation Human cerebral cortex neural prosthetic for tinnitus
NL9401150A (en) * 1994-07-12 1996-02-01 Nederland Ptt Method for presenting on a receiving side a first number of video signals originating from a transmitting side, as well as a system, as well as a transmitter, as well as a network, and also a receiver.
WO1996014834A1 (en) 1994-11-10 1996-05-23 University Of Kentucky Research Foundation Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body
SE9501189D0 (en) * 1995-03-31 1995-03-31 Pharmacia Ab Protein formulation
US7833543B2 (en) 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
DE69734168T2 (en) * 1996-02-02 2006-01-19 Alza Corp., Mountain View Implantable system with delayed release of active ingredient
US6156331A (en) * 1996-02-02 2000-12-05 Alza Corporation Sustained delivery of an active agent using an implantable system
US6132420A (en) * 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
US6261584B1 (en) * 1996-02-02 2001-07-17 Alza Corporation Sustained delivery of an active agent using an implantable system
US6395292B2 (en) * 1996-02-02 2002-05-28 Alza Corporation Sustained delivery of an active agent using an implantable system
US5976109A (en) * 1996-04-30 1999-11-02 Medtronic, Inc. Apparatus for drug infusion implanted within a living body
WO1998001117A1 (en) * 1996-07-08 1998-01-15 Edward Mendell Co., Inc. Sustained release matrix for high-dose insoluble drugs
US5780431A (en) * 1996-09-20 1998-07-14 Neurobiological Technologies, Inc. Pharmaceutical formulations of corticotropin releasing factor having improved stability in liquid form
ZA981610B (en) * 1997-03-24 1999-08-26 Alza Corp Self adjustable exit port.
US5874388A (en) * 1997-04-02 1999-02-23 Dow Corning Corporation Lubricant composition for disc brake caliper pin and a disc brake asembly containing the lubricant
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
JP3703262B2 (en) * 1997-08-19 2005-10-05 三井化学株式会社 Polyoxyalkylene polyol, flexible polyurethane foam, and method for producing non-foamed polyurethane
CA2315890C (en) * 1997-12-22 2009-08-11 Alza Corporation Rate controlling membranes for controlled drug delivery devices
JP4173635B2 (en) 1997-12-29 2008-10-29 インターシア セラピューティクス，インコーポレイティド Permeation supply apparatus having membrane plug holding mechanism
EP1041974B1 (en) * 1997-12-30 2006-10-11 Alza Corporation Beneficial agent delivery system with membrane plug
US6241969B1 (en) * 1998-06-26 2001-06-05 Elan Corporation Plc Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
US6248112B1 (en) * 1998-09-30 2001-06-19 C. R. Bard, Inc. Implant delivery system
AU1574900A (en) * 1998-12-04 2000-06-26 Provalis (Uk) Limited Pharmaceutical compositions containing insulin
US7258869B1 (en) * 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
WO2002043800A2 (en) 2000-11-29 2002-06-06 Durect Corporation Devices and methods for controlled delivery from a drug delivery device
US6541021B1 (en) 1999-03-18 2003-04-01 Durect Corporation Devices and methods for pain management
US20030059376A1 (en) * 1999-06-04 2003-03-27 Libbey Miles A. Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same
IL149008A0 (en) * 1999-10-04 2002-11-10 Chiron Corp Stabilized liquid polypeptide-containing pharmaceutical compositions
US6436091B1 (en) * 1999-11-16 2002-08-20 Microsolutions, Inc. Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
WO2001043528A2 (en) 1999-12-17 2001-06-21 Durect Corporation Devices and methods in intracerebrospinal delivery of morphine-6-glucuronide
AU773354B2 (en) * 1999-12-21 2004-05-20 Intarcia Therapeutics, Inc. Valve for osmotic devices
US6283949B1 (en) * 1999-12-27 2001-09-04 Advanced Cardiovascular Systems, Inc. Refillable implantable drug delivery pump
AU2001900A (en) * 1999-12-29 2001-07-16 Progen S.R.L. Biocompatible hydrogel and method of its production
US6572890B2 (en) 2000-01-13 2003-06-03 Osmotica Corp. Osmotic device containing venlafaxine and an anti-psychotic agent
AU2001233315B2 (en) * 2000-02-08 2004-07-08 Allergan Sales, Inc. Botulinum toxin pharmaceutical compositions
US6495534B2 (en) * 2000-05-15 2002-12-17 Pharmacia & Upjohn Spa Stabilized aqueous suspensions for parenteral use
AU2001296770A1 (en) 2000-10-06 2002-04-15 Durect Corporation Devices and methods for management of inflammation
CA2429898C (en) 2000-11-16 2011-02-22 Durect Corporation Devices and methods for cholesterol management
JP4460892B2 (en) * 2001-06-21 2010-05-12 ジェネンテック インコーポレイテッド Sustained release composition
US20030021841A1 (en) * 2001-07-02 2003-01-30 Matharu Amol Singh Pharmaceutical composition
DE60239556D1 (en) * 2001-11-14 2011-05-05 Durect Corp CATHETERINJICIBLE DEPOT COMPOSITIONS AND THEIR USE
AU2003221888B2 (en) * 2002-04-11 2008-11-06 Medimmune, Llc Preservation of bioactive materials by spray drying
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
CA2494342A1 (en) * 2002-07-31 2004-02-12 Alza Corporation Injectable depot compositions and uses thereof
ATE418323T1 (en) * 2002-11-06 2009-01-15 Alza Corp DEPOSIT DELAYED RELEASE FORMULATIONS
JP2006512370A (en) * 2002-12-19 2006-04-13 アルザ・コーポレーション A stable non-aqueous single phase gel and its formulation for delivery from an implantable device
CN1767815A (en) * 2003-03-31 2006-05-03 阿尔萨公司 Non-aqueous single phase vehicles and formulations utilizing such vehicles
BRPI0416094A (en) * 2003-10-31 2007-01-02 Alza Corp self-retaining quick start membrane plug osmotic pump
US20050118206A1 (en) 2003-11-14 2005-06-02 Luk Andrew S. Surfactant-based gel as an injectable, sustained drug delivery vehicle

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998027962A2 (en) * 1996-12-20 1998-07-02 Alza Corporation Injectable depot gel composition and method of preparing the composition
WO2000045790A2 (en) * 1999-02-08 2000-08-10 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
WO2003041684A2 (en) * 2001-11-14 2003-05-22 Alza Corporation Injectable depot compositions and uses thereof
WO2003072113A1 (en) * 2002-02-28 2003-09-04 Norbrook Laboratories Limited Long acting parasiticidal composition containing a salicylanilide compound, a polymeric species and at least one other anti-parasitic compound

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9526763B2 (en) 2005-02-03 2016-12-27 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US9539200B2 (en) 2005-02-03 2017-01-10 Intarcia Therapeutics Inc. Two-piece, internal-channel osmotic delivery system flow modulator
US9572889B2 (en) 2008-02-13 2017-02-21 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents

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US20130251674A1 (en) 2013-09-26
CA2520775A1 (en) 2004-10-21
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KR20060002922A (en) 2006-01-09
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US20050276856A1 (en) 2005-12-15
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EP1610765A2 (en) 2006-01-04
AU2010212478B2 (en) 2011-06-23
AR043811A1 (en) 2005-08-17
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US20050008661A1 (en) 2005-01-13
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