WO2004098698A3 - Methods and apparatus for the regulation of hormone release - Google Patents

Methods and apparatus for the regulation of hormone release Download PDF

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Publication number
WO2004098698A3
WO2004098698A3 PCT/US2004/011736 US2004011736W WO2004098698A3 WO 2004098698 A3 WO2004098698 A3 WO 2004098698A3 US 2004011736 W US2004011736 W US 2004011736W WO 2004098698 A3 WO2004098698 A3 WO 2004098698A3
Authority
WO
WIPO (PCT)
Prior art keywords
hormones
levels
spinal cord
regulation
sympathetic
Prior art date
Application number
PCT/US2004/011736
Other languages
French (fr)
Other versions
WO2004098698A2 (en
Inventor
Xiaohong Zhou
Gary W King
Thomas J Mullen
Michael R S Hill
Original Assignee
Medtronic Inc
Xiaohong Zhou
Gary W King
Thomas J Mullen
Michael R S Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc, Xiaohong Zhou, Gary W King, Thomas J Mullen, Michael R S Hill filed Critical Medtronic Inc
Priority to EP04750191A priority Critical patent/EP1622676A2/en
Publication of WO2004098698A2 publication Critical patent/WO2004098698A2/en
Publication of WO2004098698A3 publication Critical patent/WO2004098698A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071—Pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process

Abstract

A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7-L2 and the associated neural fibers within a region of the T7-L2 dermatomes.
PCT/US2004/011736 2003-04-30 2004-04-16 Methods and apparatus for the regulation of hormone release WO2004098698A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04750191A EP1622676A2 (en) 2003-04-30 2004-04-16 Methods and apparatus for the regulation of hormone release

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/426,610 US7221979B2 (en) 2003-04-30 2003-04-30 Methods and apparatus for the regulation of hormone release
US10/426,610 2003-04-30

Publications (2)

Publication Number Publication Date
WO2004098698A2 WO2004098698A2 (en) 2004-11-18
WO2004098698A3 true WO2004098698A3 (en) 2005-01-27

Family

ID=33309913

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/011736 WO2004098698A2 (en) 2003-04-30 2004-04-16 Methods and apparatus for the regulation of hormone release

Country Status (3)

Country Link
US (2) US7221979B2 (en)
EP (1) EP1622676A2 (en)
WO (1) WO2004098698A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
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US9517344B1 (en) 2015-03-13 2016-12-13 Nevro Corporation Systems and methods for selecting low-power, effective signal delivery parameters for an implanted pulse generator

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