WO2005000868A1 - Process for the synthesis of high purity d-(17alpha)-13-ethyl-17hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime - Google Patents
Process for the synthesis of high purity d-(17alpha)-13-ethyl-17hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime Download PDFInfo
- Publication number
- WO2005000868A1 WO2005000868A1 PCT/HU2004/000031 HU2004000031W WO2005000868A1 WO 2005000868 A1 WO2005000868 A1 WO 2005000868A1 HU 2004000031 W HU2004000031 W HU 2004000031W WO 2005000868 A1 WO2005000868 A1 WO 2005000868A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ene
- yne
- ethyl
- water
- acetoxy
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 13
- 230000015572 biosynthetic process Effects 0.000 title claims abstract description 9
- 238000003786 synthesis reaction Methods 0.000 title claims abstract description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 51
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 39
- 239000000047 product Substances 0.000 claims abstract description 26
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000725 suspension Substances 0.000 claims abstract description 18
- 238000003756 stirring Methods 0.000 claims abstract description 17
- 239000011541 reaction mixture Substances 0.000 claims abstract description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000006243 chemical reaction Methods 0.000 claims abstract description 14
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 238000001914 filtration Methods 0.000 claims abstract description 11
- 229960004400 levonorgestrel Drugs 0.000 claims abstract description 11
- 239000003610 charcoal Substances 0.000 claims abstract description 10
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 claims abstract description 8
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims abstract description 8
- 239000012043 crude product Substances 0.000 claims abstract description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000012299 nitrogen atmosphere Substances 0.000 claims abstract description 6
- 239000007858 starting material Substances 0.000 claims abstract description 6
- 230000021736 acetylation Effects 0.000 claims abstract description 5
- 238000006640 acetylation reaction Methods 0.000 claims abstract description 5
- 230000003301 hydrolyzing effect Effects 0.000 claims abstract description 5
- WTDHULULXKLSOZ-UHFFFAOYSA-N hydroxylamine hydrochloride Substances Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000005457 ice water Substances 0.000 claims abstract description 5
- 239000000741 silica gel Substances 0.000 claims abstract description 5
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 5
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims abstract description 4
- -1 enol acetate Chemical class 0.000 claims abstract description 4
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims abstract description 4
- WCYJQVALWQMJGE-UHFFFAOYSA-M hydroxylammonium chloride Chemical compound [Cl-].O[NH3+] WCYJQVALWQMJGE-UHFFFAOYSA-M 0.000 claims abstract description 4
- 238000006146 oximation reaction Methods 0.000 claims abstract description 4
- 125000004043 oxo group Chemical group O=* 0.000 claims abstract description 4
- 239000011592 zinc chloride Substances 0.000 claims abstract description 4
- 235000005074 zinc chloride Nutrition 0.000 claims abstract description 4
- HMNQNULAYXDEEQ-UHFFFAOYSA-N acetic acid;hydroxylamine Chemical compound ON.CC(O)=O HMNQNULAYXDEEQ-UHFFFAOYSA-N 0.000 claims abstract description 3
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims abstract description 3
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims abstract description 3
- 239000012298 atmosphere Substances 0.000 claims abstract description 3
- 239000006227 byproduct Substances 0.000 claims abstract description 3
- 239000011261 inert gas Substances 0.000 claims abstract description 3
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000001632 sodium acetate Substances 0.000 claims abstract description 3
- 235000017281 sodium acetate Nutrition 0.000 claims abstract description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 12
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- PQVSTLUFSYVLTO-UHFFFAOYSA-N ethyl n-ethoxycarbonylcarbamate Chemical compound CCOC(=O)NC(=O)OCC PQVSTLUFSYVLTO-UHFFFAOYSA-N 0.000 claims description 2
- GLXDVVHUTZTUQK-UHFFFAOYSA-M lithium hydroxide monohydrate Substances [Li+].O.[OH-] GLXDVVHUTZTUQK-UHFFFAOYSA-M 0.000 claims description 2
- 229940040692 lithium hydroxide monohydrate Drugs 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims 3
- 238000007865 diluting Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
- 239000012535 impurity Substances 0.000 description 11
- KIQQMECNKUGGKA-NMYWJIRASA-N norgestimate Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(OC(C)=O)C#C)[C@@H]4[C@@H]3CCC2=C\1 KIQQMECNKUGGKA-NMYWJIRASA-N 0.000 description 11
- 229960000417 norgestimate Drugs 0.000 description 11
- 229960004756 ethanol Drugs 0.000 description 10
- 235000019441 ethanol Nutrition 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- 238000004809 thin layer chromatography Methods 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- YDQDJLTYVZAOQX-GOMYTPFNSA-N [(8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(OC(C)=O)C#C)[C@@H]4[C@@H]3CCC2=C1 YDQDJLTYVZAOQX-GOMYTPFNSA-N 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000003480 eluent Substances 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 239000012086 standard solution Substances 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000012456 homogeneous solution Substances 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 1
- AWUFOBZBTGUADR-ZOFHRBRSSA-N (8r,9s,10r,13s,14s,17s)-13-ethyl-3-hydroxyimino-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-ol Chemical compound ON=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 AWUFOBZBTGUADR-ZOFHRBRSSA-N 0.000 description 1
- QTSYTSHBAAYKBP-ZBRFXRBCSA-N (8s,9s,13s,14s,17s)-3-methoxy-4,6,7,8,9,11,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-ol Chemical compound C1C[C@@H]2C(CC=C(C3)OC)=C3CC[C@H]2[C@@H]2CC[C@H](O)[C@H]21 QTSYTSHBAAYKBP-ZBRFXRBCSA-N 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940040526 anhydrous sodium acetate Drugs 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 230000002254 contraceptive effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- ROAYSRAUMPWBQX-UHFFFAOYSA-N ethanol;sulfuric acid Chemical compound CCO.OS(O)(=O)=O ROAYSRAUMPWBQX-UHFFFAOYSA-N 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- RBLWMQWAHONKNC-UHFFFAOYSA-N hydroxyazanium Chemical compound O[NH3+] RBLWMQWAHONKNC-UHFFFAOYSA-N 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- XYKIUTSFQGXHOW-UHFFFAOYSA-N propan-2-one;toluene Chemical compound CC(C)=O.CC1=CC=CC=C1 XYKIUTSFQGXHOW-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006518378A JP2007516946A (en) | 2003-06-30 | 2004-04-29 | Method for synthesizing high purity d- (17α) -13-ethyl-17-hydroxy-18,19-dinor-preg-4-en-20-in-3-one-oxime |
UAA200600812A UA80059C2 (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity d-(17alpha)-13-ethyl-17hydroxy-18,19-dinorpregn-4-ene-20-yne-3-one-oxime |
AU2004251118A AU2004251118A1 (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity d-(17alpha)-13-ethyl-17-hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime |
BRPI0412186-4A BRPI0412186A (en) | 2003-06-30 | 2004-04-29 | process for the synthesis of high purity d- (17alpha) -13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yne-3-one-oxime |
NZ544378A NZ544378A (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity norgestrel 3-one-oxime |
CA002528952A CA2528952A1 (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity d-(17alpha)-13-ethyl-17hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime |
AT04730316T ATE462712T1 (en) | 2003-06-30 | 2004-04-29 | METHOD FOR PRODUCING HIGH PURITY D-(17ALPHA)-13-ETHYL-17-HYDROXY-18,19-DINOR-PREGN 4-ENE-20-YNE-3-ONE-OXIME |
EA200600119A EA008411B1 (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity d-(17alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yne-3-one |
DE602004026306T DE602004026306D1 (en) | 2003-06-30 | 2004-04-29 | PROCESS FOR PREPARING HIGH-PURITY D- (17ALPHA) -13-ETHYL-17-HYDROXY-18,19-DINOR-PREGN-4-ENE-20-YNE-3-ONE-OXIM |
MXPA05013948A MXPA05013948A (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity d-(17alpha)-13-ethyl-17 -hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime. |
YUP-2005/0897A RS20050897A (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity d-(17alpha)-13- ethyl- 17hydroxy-18,19-dinor-pregn-4-ene 20- yne-3-one-oxime |
EP04730316A EP1638988B1 (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity d-(17alpha)-13-ethyl-17hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime |
NO20060455A NO20060455L (en) | 2003-06-30 | 2006-01-27 | Process for the synthesis of highly pure D- (17alpha) -13-ethyl-17-hydroxy-18,19-dinor-pregn-4-en-20-yn-3-one oxime. |
HR20060038A HRP20060038A2 (en) | 2003-06-30 | 2006-01-27 | PROCESS FOR THE SYNTHESIS OF HIGH PURITY D-(17α)-13-ETHYL-17-HYDROXY-18,19-DINOPREGN-4-ENE-20-YNE-3-OXIME |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0301982A HUP0301982A2 (en) | 2003-06-30 | 2003-06-30 | Process for the preparation of high purity d-(17alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime |
HUP0301982 | 2003-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005000868A1 true WO2005000868A1 (en) | 2005-01-06 |
Family
ID=90001694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/HU2004/000031 WO2005000868A1 (en) | 2003-06-30 | 2004-04-29 | Process for the synthesis of high purity d-(17alpha)-13-ethyl-17hydroxy-18,19-dinorpre:gn-4-ene-20-yne-3-one-oxime |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1638988B1 (en) |
JP (1) | JP2007516946A (en) |
CN (1) | CN100355771C (en) |
AT (1) | ATE462712T1 (en) |
AU (1) | AU2004251118A1 (en) |
BR (1) | BRPI0412186A (en) |
CA (1) | CA2528952A1 (en) |
DE (1) | DE602004026306D1 (en) |
EA (1) | EA008411B1 (en) |
HR (1) | HRP20060038A2 (en) |
HU (1) | HUP0301982A2 (en) |
MX (1) | MXPA05013948A (en) |
NO (1) | NO20060455L (en) |
NZ (1) | NZ544378A (en) |
RS (1) | RS20050897A (en) |
UA (1) | UA80059C2 (en) |
WO (1) | WO2005000868A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1818338A1 (en) * | 2005-12-22 | 2007-08-15 | S.N.I.F.F. Italia S.P.A. | Process for the preparation of norelgestromin |
US7576226B2 (en) | 2003-06-30 | 2009-08-18 | Richter Gedeon Vegyeszeti Gyar Rt. | Process of making isomers of norelgestromin and methods using the same |
CN108827950A (en) * | 2018-05-31 | 2018-11-16 | 成都市科隆化学品有限公司 | The detection method of micro-acetic acid acid anhydride in acetic acid |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4027019A (en) * | 1975-07-24 | 1977-05-31 | Ortho Pharmaceutical Corporation | 3-Oximes of D-17α-ethynyl-19-nortestosterone esters and method |
AT348151B (en) * | 1972-05-26 | 1979-02-12 | Richter Gedeon Vegyeszet | PROCESS FOR THE MANUFACTURING OF RAZEMIC OR OPTICALLY ACTIVE 13BETA-AETHYL-17ALFA-AETHINYL-GON-4-EN-3-ON-17BETA-OL |
US5876746A (en) * | 1995-06-07 | 1999-03-02 | Cygnus, Inc. | Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen |
-
2003
- 2003-06-30 HU HU0301982A patent/HUP0301982A2/en unknown
-
2004
- 2004-04-29 CA CA002528952A patent/CA2528952A1/en not_active Abandoned
- 2004-04-29 NZ NZ544378A patent/NZ544378A/en unknown
- 2004-04-29 MX MXPA05013948A patent/MXPA05013948A/en active IP Right Grant
- 2004-04-29 JP JP2006518378A patent/JP2007516946A/en active Pending
- 2004-04-29 EA EA200600119A patent/EA008411B1/en not_active IP Right Cessation
- 2004-04-29 DE DE602004026306T patent/DE602004026306D1/en not_active Expired - Fee Related
- 2004-04-29 RS YUP-2005/0897A patent/RS20050897A/en unknown
- 2004-04-29 CN CNB2004800165780A patent/CN100355771C/en not_active Expired - Fee Related
- 2004-04-29 AU AU2004251118A patent/AU2004251118A1/en not_active Abandoned
- 2004-04-29 BR BRPI0412186-4A patent/BRPI0412186A/en not_active IP Right Cessation
- 2004-04-29 UA UAA200600812A patent/UA80059C2/en unknown
- 2004-04-29 AT AT04730316T patent/ATE462712T1/en not_active IP Right Cessation
- 2004-04-29 WO PCT/HU2004/000031 patent/WO2005000868A1/en active Application Filing
- 2004-04-29 EP EP04730316A patent/EP1638988B1/en not_active Expired - Lifetime
-
2006
- 2006-01-27 HR HR20060038A patent/HRP20060038A2/en not_active Application Discontinuation
- 2006-01-27 NO NO20060455A patent/NO20060455L/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT348151B (en) * | 1972-05-26 | 1979-02-12 | Richter Gedeon Vegyeszet | PROCESS FOR THE MANUFACTURING OF RAZEMIC OR OPTICALLY ACTIVE 13BETA-AETHYL-17ALFA-AETHINYL-GON-4-EN-3-ON-17BETA-OL |
US4027019A (en) * | 1975-07-24 | 1977-05-31 | Ortho Pharmaceutical Corporation | 3-Oximes of D-17α-ethynyl-19-nortestosterone esters and method |
US5876746A (en) * | 1995-06-07 | 1999-03-02 | Cygnus, Inc. | Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen |
Non-Patent Citations (2)
Title |
---|
RUFER C ET AL: "[Total synthesis of optically active 13-ethyl-gonane derivatives]", JUSTUS LIEBIGS ANNALEN DER CHEMIE. 1967, vol. 702, 1967, pages 141 - 148, XP002297402, ISSN: 0075-4617 * |
SISENWINE, SAMUEL F. ET AL: "The conversion of d-norgestrel-3-oxime-17-acetate to d-norgestrel in female rhesus monkeys", CONTRACEPTION , 15(1), 25-37 CODEN: CCPTAY; ISSN: 0010-7824, 1977, XP008035682 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7576226B2 (en) | 2003-06-30 | 2009-08-18 | Richter Gedeon Vegyeszeti Gyar Rt. | Process of making isomers of norelgestromin and methods using the same |
US7816546B2 (en) | 2003-06-30 | 2010-10-19 | Richter Gedeon Vegyeszeti Gyar Rt. | Process for the synthesis of high purity d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime |
EP1818338A1 (en) * | 2005-12-22 | 2007-08-15 | S.N.I.F.F. Italia S.P.A. | Process for the preparation of norelgestromin |
US7393964B2 (en) | 2005-12-22 | 2008-07-01 | S.N.I.F.F. Italia S.P.A. | Process for the preparation of norelgestromin |
CN108827950A (en) * | 2018-05-31 | 2018-11-16 | 成都市科隆化学品有限公司 | The detection method of micro-acetic acid acid anhydride in acetic acid |
CN108827950B (en) * | 2018-05-31 | 2020-08-21 | 成都市科隆化学品有限公司 | Method for detecting trace acetic anhydride in acetic acid |
Also Published As
Publication number | Publication date |
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JP2007516946A (en) | 2007-06-28 |
EA008411B1 (en) | 2007-04-27 |
BRPI0412186A (en) | 2006-08-22 |
AU2004251118A1 (en) | 2005-01-06 |
HUP0301982D0 (en) | 2003-09-29 |
CA2528952A1 (en) | 2005-01-06 |
ATE462712T1 (en) | 2010-04-15 |
CN100355771C (en) | 2007-12-19 |
NO20060455L (en) | 2006-03-29 |
CN1805970A (en) | 2006-07-19 |
NZ544378A (en) | 2008-02-29 |
HUP0301982A2 (en) | 2005-04-28 |
DE602004026306D1 (en) | 2010-05-12 |
UA80059C2 (en) | 2007-08-10 |
HRP20060038A2 (en) | 2006-11-30 |
EA200600119A1 (en) | 2006-06-30 |
EP1638988A1 (en) | 2006-03-29 |
MXPA05013948A (en) | 2006-03-09 |
EP1638988B1 (en) | 2010-03-31 |
RS20050897A (en) | 2007-08-03 |
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