WO2005005668A3 - Diagnosis and treatment methods related to aging (8a) - Google Patents

Diagnosis and treatment methods related to aging (8a) Download PDF

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Publication number
WO2005005668A3
WO2005005668A3 PCT/US2004/021944 US2004021944W WO2005005668A3 WO 2005005668 A3 WO2005005668 A3 WO 2005005668A3 US 2004021944 W US2004021944 W US 2004021944W WO 2005005668 A3 WO2005005668 A3 WO 2005005668A3
Authority
WO
WIPO (PCT)
Prior art keywords
aging
biological aging
normal
diagnosis
treatment methods
Prior art date
Application number
PCT/US2004/021944
Other languages
French (fr)
Other versions
WO2005005668A2 (en
Inventor
John J Kopchick
Markus Riders
Karen T Coschigano
Elahu S Gosney
Original Assignee
Univ Ohio
John J Kopchick
Markus Riders
Karen T Coschigano
Elahu S Gosney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ohio, John J Kopchick, Markus Riders, Karen T Coschigano, Elahu S Gosney filed Critical Univ Ohio
Priority to CA002531420A priority Critical patent/CA2531420A1/en
Priority to EP04777802A priority patent/EP1649063A2/en
Publication of WO2005005668A2 publication Critical patent/WO2005005668A2/en
Publication of WO2005005668A3 publication Critical patent/WO2005005668A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Abstract

Mouse genes differentially expressed in comparisons of gene expression in growth hormone receptor/binding protein gene-disrupted mouse livers and normal mouse livers have been identified, as have corresponding human genes and proteins. The human molecules, or antagonists thereof, may be used for protection against faster-than-normal biological aging, or to achieve slower-than-normal biological aging. The human molecules may also be used as markers of biological aging, to retard biological aging, or to treat age-related diseases.
PCT/US2004/021944 2003-07-08 2004-07-08 Diagnosis and treatment methods related to aging (8a) WO2005005668A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002531420A CA2531420A1 (en) 2003-07-08 2004-07-08 Diagnosis and treatment methods related to aging (8a)
EP04777802A EP1649063A2 (en) 2003-07-08 2004-07-08 Diagnosis and treatment methods related to aging (8a)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48522203P 2003-07-08 2003-07-08
US60/485,222 2003-07-08

Publications (2)

Publication Number Publication Date
WO2005005668A2 WO2005005668A2 (en) 2005-01-20
WO2005005668A3 true WO2005005668A3 (en) 2005-09-09

Family

ID=34062070

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/021944 WO2005005668A2 (en) 2003-07-08 2004-07-08 Diagnosis and treatment methods related to aging (8a)

Country Status (3)

Country Link
EP (1) EP1649063A2 (en)
CA (1) CA2531420A1 (en)
WO (1) WO2005005668A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025194A (en) * 1997-11-19 2000-02-15 Geron Corporation Nucleic acid sequence of senescence asssociated gene
WO2003000861A2 (en) * 2001-06-22 2003-01-03 The Regents Of The University Of California Eukaryotic genes involved in adult lifespan regulation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025194A (en) * 1997-11-19 2000-02-15 Geron Corporation Nucleic acid sequence of senescence asssociated gene
WO2003000861A2 (en) * 2001-06-22 2003-01-03 The Regents Of The University Of California Eukaryotic genes involved in adult lifespan regulation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
LIO D ET AL: "Gender-specific association between -1082 IL-10 promoter polymorphism and longevity", GENES AND IMMUNITY, vol. 3, no. 1, February 2002 (2002-02-01), pages 30 - 33, XP008039832, ISSN: 1466-4879 *
MERCHED A ET AL: "APOLIPOPROTEIN AIV CODON 360 MUTATION INCREASES WITH HUMAN AGING AND IS NOT ASSOCIATED WITH ALZHEIMER'S DISEASE", NEUROSCIENCE LETTERS, LIMERICK, IE, vol. 242, no. 2, 13 February 1998 (1998-02-13), pages 117 - 119, XP000863724, ISSN: 0304-3940 *
MICHIKAWA Y ET AL: "Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 286, 22 October 1999 (1999-10-22), pages 774 - 779, XP002179334, ISSN: 0036-8075 *
MOCCHEGIANI EUGENIO ET AL: "MTmRNA gene expression, via IL-6 and glucocorticoids, as potential genetic marker of immunosenescence: Lessons from very old mice and humans", EXPERIMENTAL GERONTOLOGY, vol. 37, no. 2-3, January 2002 (2002-01-01), pages 349 - 357, XP002312292, ISSN: 0531-5565 *
ZHOU YIHUA ET AL: "A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 94, no. 24, 25 November 1997 (1997-11-25), pages 13215 - 13220, XP002312293, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
CA2531420A1 (en) 2005-01-20
WO2005005668A2 (en) 2005-01-20
EP1649063A2 (en) 2006-04-26

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