WO2005007796A3 - Improved multiwell plate - Google Patents

Improved multiwell plate Download PDF

Info

Publication number
WO2005007796A3
WO2005007796A3 PCT/IL2004/000661 IL2004000661W WO2005007796A3 WO 2005007796 A3 WO2005007796 A3 WO 2005007796A3 IL 2004000661 W IL2004000661 W IL 2004000661W WO 2005007796 A3 WO2005007796 A3 WO 2005007796A3
Authority
WO
WIPO (PCT)
Prior art keywords
multiwell plate
living cells
stimulus
producing
plate
Prior art date
Application number
PCT/IL2004/000661
Other languages
French (fr)
Other versions
WO2005007796A2 (en
Inventor
Mordechai Deutsch
Max Herzberg
Reuven Tirosh
Assaf Deutsch
Original Assignee
Molecular Cytomics Ltd
Mordechai Deutsch
Max Herzberg
Reuven Tirosh
Assaf Deutsch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IL2004/000571 external-priority patent/WO2004113492A1/en
Application filed by Molecular Cytomics Ltd, Mordechai Deutsch, Max Herzberg, Reuven Tirosh, Assaf Deutsch filed Critical Molecular Cytomics Ltd
Priority to US10/565,240 priority Critical patent/US9200245B2/en
Priority to EP04745001A priority patent/EP1664265A4/en
Publication of WO2005007796A2 publication Critical patent/WO2005007796A2/en
Publication of WO2005007796A3 publication Critical patent/WO2005007796A3/en
Priority to IL173170A priority patent/IL173170A0/en
Priority to US14/883,659 priority patent/US10190082B2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

Abstract

A multiwell plate (52) having a plurality of picowells (46) on the bottom of the wells of the plate as well as methods of producing the multiwell plate are provided. Provided is also a method of handling living cells (48) by providing an ordered array of living cells immobilized in a non-fluid matrix, contacting the living cells with a stimulus; and detecting a response to the stimulus. The present invention is also of a method of producing an ordered array of living cells.
PCT/IL2004/000661 2003-06-26 2004-07-20 Improved multiwell plate WO2005007796A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/565,240 US9200245B2 (en) 2003-06-26 2004-07-20 Multiwell plate
EP04745001A EP1664265A4 (en) 2003-07-21 2004-07-20 Improved multiwell plate
IL173170A IL173170A0 (en) 2003-07-21 2006-01-16 Improved multiwell plate
US14/883,659 US10190082B2 (en) 2003-06-26 2015-10-15 Multiwell plate

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US48840803P 2003-07-21 2003-07-21
US48840903P 2003-07-21 2003-07-21
US60/488,409 2003-07-21
US60/488,408 2003-07-21
US51707303P 2003-11-05 2003-11-05
US51708403P 2003-11-05 2003-11-05
US60/517,084 2003-11-05
US60/517,073 2003-11-05
US54435604P 2004-02-17 2004-02-17
US54435704P 2004-02-17 2004-02-17
US60/544,356 2004-02-17
US60/544,357 2004-02-17
PCT/IL2004/000571 WO2004113492A1 (en) 2003-06-26 2004-06-27 Improved materials for constructing cell-chips, cell-chip covers, cell-chip coats, processed cell-chips and uses thereof
ILPCT/IL04/000571 2004-06-27

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
PCT/IL2004/000571 Continuation-In-Part WO2004113492A1 (en) 2003-06-26 2004-06-27 Improved materials for constructing cell-chips, cell-chip covers, cell-chip coats, processed cell-chips and uses thereof
US10/561,839 Continuation-In-Part US20060240548A1 (en) 2003-06-26 2004-06-27 Materials for constructing cell-chips, cell-chip covers, cell-chips coats, processed cell-chips and uses thereof
US11/561,839 Continuation-In-Part US20080296437A1 (en) 2005-11-22 2006-11-20 Method and Device to Generate a Transverse Casimir Force for Propulsion, Guidance and Maneuvering of a Space Vehicle

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/565,240 A-371-Of-International US9200245B2 (en) 2003-06-26 2004-07-20 Multiwell plate
US14/883,659 Division US10190082B2 (en) 2003-06-26 2015-10-15 Multiwell plate

Publications (2)

Publication Number Publication Date
WO2005007796A2 WO2005007796A2 (en) 2005-01-27
WO2005007796A3 true WO2005007796A3 (en) 2005-04-14

Family

ID=42331773

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2004/000661 WO2005007796A2 (en) 2003-06-26 2004-07-20 Improved multiwell plate

Country Status (3)

Country Link
EP (1) EP1664265A4 (en)
IL (1) IL173170A0 (en)
WO (1) WO2005007796A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL154677A0 (en) 2003-02-27 2003-09-17 Univ Bar Ilan A method and apparatus for manipulating an individual cell
US7888110B2 (en) 2003-06-26 2011-02-15 Seng Enterprises Ltd. Pico liter well holding device and method of making the same
BRPI0506610A (en) 2004-02-03 2007-05-02 Chemagis Ltd amorphous montelukast sodium, amorphous sodium montelukast preparation process, pharmaceutical composition, treatment method using the administration of amorphous montelukast sodium, amorphous montelukast amorphous co-precipitate and amorphous montelukast amorphous co-precipitate preparation process
US7403647B2 (en) 2004-09-13 2008-07-22 Seng Enterprises Ltd. Method for identifying an image of a well in an image of a well-bearing component
EP1781404A2 (en) * 2004-08-25 2007-05-09 Seng Enterprises Limited Method and device for isolating cells
ES2352344T3 (en) * 2005-01-25 2011-02-17 Seng Enterprises Limited MICROFLUID DEVICE FOR CELL STUDY.
WO2007052245A1 (en) * 2005-11-03 2007-05-10 Seng Enterprises Ltd. Method and device for studying floating, living cells
US20080220169A1 (en) * 2006-10-16 2008-09-11 The Brigham And Women's Hospital, Inc. Parylene-C Stencils
EP1990638A1 (en) * 2007-05-11 2008-11-12 Koninklijke Philips Electronics N.V. Flow-through biosensor
CA2702118A1 (en) * 2007-08-30 2009-03-12 President And Fellows Of Harvard College Compliant surface multi-well culture plate
WO2009081409A2 (en) 2007-12-26 2009-07-02 Seng Enterprises Ltd. Device for the study of living cells
EP2222832A4 (en) * 2007-11-15 2012-08-29 Seng Entpr Ltd Pico liter well holding device and method of making the same
EP2230014A1 (en) 2009-03-20 2010-09-22 Mark Ungrin Devices and methods for production of cell aggregates
US9309557B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
US9334531B2 (en) 2010-12-17 2016-05-10 Life Technologies Corporation Nucleic acid amplification
US9309566B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Methods, compositions, systems, apparatuses and kits for nucleic acid amplification
EP3564392B1 (en) 2010-12-17 2021-11-24 Life Technologies Corporation Methods for nucleic acid amplification
CA2861387A1 (en) 2012-02-02 2013-08-08 Invenra, Inc. High throughput screen for biologically active polypeptides
WO2014134716A1 (en) * 2013-03-08 2014-09-12 The University Of British Columbia Substituted organofluoroborates as imaging agents
US10066260B2 (en) 2013-03-14 2018-09-04 Life Technologies Corporation Matrix arrays and methods for making same
DK3237597T3 (en) * 2014-12-22 2021-03-15 Ecole Polytechnique Fed Lausanne Epfl FACILITIES FOR HIGH FLOW AGGREGATION AND MANIPULATION OF MAMMAL CELLS
KR20180085783A (en) 2015-11-23 2018-07-27 버클리 라잇츠, 인크. In situ-generated microfluidic isolation structures, kits, and methods of use thereof
CA3005077C (en) 2015-12-08 2023-02-28 Berkeley Lights, Inc. In situ-generated microfluidic assay structures, related kits, and methods of use thereof
CN107372236B (en) * 2017-08-25 2022-10-25 中国水产科学研究院南海水产研究所 Attachment plate for artificial breeding of holothuria scabra and breeding method

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US5627045A (en) * 1995-04-12 1997-05-06 Biolog, Inc. Multi-test format with gel-forming matrix for characterization of microorganisms
US20020173033A1 (en) * 2001-05-17 2002-11-21 Kyle Hammerick Device and method or three-dimensional spatial localization and functional interconnection of different types of cells
WO2003035824A1 (en) * 2001-10-25 2003-05-01 Bar-Ilan University Interactive transparent individual cells biochip processor

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US20030096232A1 (en) * 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US6699665B1 (en) 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
ATE509272T1 (en) * 2001-11-09 2011-05-15 3Dbiosurfaces Technologies Llc SUBSTRATES WITH HIGH SURFACE AREA FOR MICROARRAYS AND METHOD FOR PRODUCING SAME
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Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US4308351A (en) * 1980-04-18 1981-12-29 Joseph Leighton System for growing tissue cultures
US5627045A (en) * 1995-04-12 1997-05-06 Biolog, Inc. Multi-test format with gel-forming matrix for characterization of microorganisms
US20020173033A1 (en) * 2001-05-17 2002-11-21 Kyle Hammerick Device and method or three-dimensional spatial localization and functional interconnection of different types of cells
WO2003035824A1 (en) * 2001-10-25 2003-05-01 Bar-Ilan University Interactive transparent individual cells biochip processor

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells

Also Published As

Publication number Publication date
EP1664265A2 (en) 2006-06-07
IL173170A0 (en) 2006-06-11
EP1664265A4 (en) 2009-11-25
WO2005007796A2 (en) 2005-01-27

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