WO2005009291A3 - System and method for conditioning a diaphragm of a patient - Google Patents

System and method for conditioning a diaphragm of a patient Download PDF

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Publication number
WO2005009291A3
WO2005009291A3 PCT/US2004/023753 US2004023753W WO2005009291A3 WO 2005009291 A3 WO2005009291 A3 WO 2005009291A3 US 2004023753 W US2004023753 W US 2004023753W WO 2005009291 A3 WO2005009291 A3 WO 2005009291A3
Authority
WO
WIPO (PCT)
Prior art keywords
diaphragm
patient
conditioning
target site
electrode
Prior art date
Application number
PCT/US2004/023753
Other languages
French (fr)
Other versions
WO2005009291A2 (en
Inventor
Anthony R Ignagni
Raymond P Onders
Original Assignee
Synapse Biomedical Inc
Anthony R Ignagni
Raymond P Onders
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synapse Biomedical Inc, Anthony R Ignagni, Raymond P Onders filed Critical Synapse Biomedical Inc
Publication of WO2005009291A2 publication Critical patent/WO2005009291A2/en
Publication of WO2005009291A3 publication Critical patent/WO2005009291A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0558—Anchoring or fixation means therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/3611—Respiration control

Abstract

A method of conditioning a diaphragm of a patient is provided. The method can include the steps of implanting an electrode adjacent a target site in the diaphragm of the patient and operating the electrode to deliver a sufficient amount of electrical stimulation to the target site in the diaphragm of the patient to cause the diaphragm to contract.
PCT/US2004/023753 2003-07-23 2004-07-23 System and method for conditioning a diaphragm of a patient WO2005009291A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48112403P 2003-07-23 2003-07-23
US60/481,124 2003-07-23

Publications (2)

Publication Number Publication Date
WO2005009291A2 WO2005009291A2 (en) 2005-02-03
WO2005009291A3 true WO2005009291A3 (en) 2006-02-02

Family

ID=34102639

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/023753 WO2005009291A2 (en) 2003-07-23 2004-07-23 System and method for conditioning a diaphragm of a patient

Country Status (2)

Country Link
US (3) US7840270B2 (en)
WO (1) WO2005009291A2 (en)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050261747A1 (en) * 2003-05-16 2005-11-24 Schuler Eleanor L Method and system to control respiration by means of neuro-electrical coded signals
WO2005009291A2 (en) 2003-07-23 2005-02-03 Synapse Biomedical, Inc. System and method for conditioning a diaphragm of a patient
US8265759B2 (en) 2003-10-15 2012-09-11 Rmx, Llc Device and method for treating disorders of the cardiovascular system or heart
US8160711B2 (en) 2003-10-15 2012-04-17 Rmx, Llc Multimode device and method for controlling breathing
US20080215106A1 (en) * 2003-10-15 2008-09-04 Chang Lee Thoracoscopically implantable diaphragm stimulator
US20080161878A1 (en) * 2003-10-15 2008-07-03 Tehrani Amir J Device and method to for independently stimulating hemidiaphragms
US7970475B2 (en) 2003-10-15 2011-06-28 Rmx, Llc Device and method for biasing lung volume
US8244358B2 (en) * 2003-10-15 2012-08-14 Rmx, Llc Device and method for treating obstructive sleep apnea
US9259573B2 (en) 2003-10-15 2016-02-16 Rmx, Llc Device and method for manipulating exhalation
US7979128B2 (en) 2003-10-15 2011-07-12 Rmx, Llc Device and method for gradually controlling breathing
US8140164B2 (en) * 2003-10-15 2012-03-20 Rmx, Llc Therapeutic diaphragm stimulation device and method
US8467876B2 (en) * 2003-10-15 2013-06-18 Rmx, Llc Breathing disorder detection and therapy delivery device and method
CA2455287A1 (en) * 2004-01-16 2005-07-16 Francois Bellemare Catheter for transdiaphragmatic pressure and diaphragm electromyogram recording using helicoidal electrodes
EP1750799A2 (en) 2004-05-04 2007-02-14 The Cleveland Clinic Foundation Methods of treating medical conditions by neuromodulation of the sympathetic nervous system
US20060122661A1 (en) * 2004-12-03 2006-06-08 Mandell Lee J Diaphragmatic pacing with activity monitor adjustment
US7966072B2 (en) * 2005-02-18 2011-06-21 Palo Alto Investors Methods and compositions for treating obesity-hypoventilation syndrome
US20070044669A1 (en) * 2005-08-24 2007-03-01 Geise Gregory D Aluminum can compacting mechanism with improved actuation handle assembly
US9050005B2 (en) * 2005-08-25 2015-06-09 Synapse Biomedical, Inc. Method and apparatus for transgastric neurostimulation
CA2630211C (en) * 2005-11-18 2016-11-01 Cardiac Concepts, Inc. System and method to modulate phrenic nerve to prevent sleep apnea
CN101495177A (en) * 2005-12-02 2009-07-29 突触生物医学有限公司 Transvisceral neurostimulation mapping device and method
US8868172B2 (en) * 2005-12-28 2014-10-21 Cyberonics, Inc. Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders
WO2007103585A2 (en) * 2006-03-09 2007-09-13 Synapse Biomedical, Inc. Ventilator assist system and method to improve respiratory function
US8280513B2 (en) 2006-12-22 2012-10-02 Rmx, Llc Device and method to treat flow limitations
US20080183248A1 (en) * 2007-01-17 2008-07-31 The Cleveland Clinic Foundation Apparatus and methods for treating pulmonary conditions
CA2877177C (en) 2007-01-29 2018-05-22 Simon Fraser University Transvascular nerve stimulation apparatus and methods
US9079016B2 (en) * 2007-02-05 2015-07-14 Synapse Biomedical, Inc. Removable intramuscular electrode
US9820671B2 (en) * 2007-05-17 2017-11-21 Synapse Biomedical, Inc. Devices and methods for assessing motor point electromyogram as a biomarker
US8983609B2 (en) 2007-05-30 2015-03-17 The Cleveland Clinic Foundation Apparatus and method for treating pulmonary conditions
US8478412B2 (en) * 2007-10-30 2013-07-02 Synapse Biomedical, Inc. Method of improving sleep disordered breathing
US8428726B2 (en) 2007-10-30 2013-04-23 Synapse Biomedical, Inc. Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system
US8155744B2 (en) * 2007-12-13 2012-04-10 The Cleveland Clinic Foundation Neuromodulatory methods for treating pulmonary disorders
US8352036B2 (en) * 2009-01-19 2013-01-08 Anthony DiMarco Respiratory muscle activation by spinal cord stimulation
WO2011084325A1 (en) 2009-12-17 2011-07-14 Cardiac Pacemakers, Inc. Electrical inhibition of the phrenic nerve during cardiac pacing
EP4070850A1 (en) 2012-03-05 2022-10-12 Lungpacer Medical Inc. Transvascular nerve stimulation apparatus and methods
AT512534B1 (en) 2012-04-26 2013-09-15 Univ Wien Med Nerve cuff electrode assembly
CA2877049C (en) * 2012-06-21 2022-08-16 Simon Fraser University Transvascular diaphragm pacing systems and methods of use
JP2015531628A (en) * 2012-08-20 2015-11-05 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． Synchronization of mechanical forced inspiration exhalation and diaphragmatic pacing
US8751004B2 (en) * 2012-08-27 2014-06-10 Anthony Fortunato DiMarco Bipolar spinal cord stimulation to activate the expiratory muscles to restore cough
EP2934668B1 (en) 2012-12-19 2018-08-22 VisCardia, Inc. Hemodynamic performance enhancement through asymptomatic diaphragm stimulation
US10335592B2 (en) 2012-12-19 2019-07-02 Viscardia, Inc. Systems, devices, and methods for improving hemodynamic performance through asymptomatic diaphragm stimulation
CN103142400B (en) * 2013-03-20 2014-12-31 张栋 Method for generating diaphragm rehabilitation stimulation signal and diaphragm functional rehabilitative apparatus
CN105873630B (en) 2013-11-22 2020-01-03 隆佩瑟尔医疗公司 Device and method for assisted respiration by transvascular nerve stimulation
CA2935454A1 (en) 2014-01-21 2015-07-30 Simon Fraser University Systems and related methods for optimization of multi-electrode nerve pacing
WO2016033245A1 (en) 2014-08-26 2016-03-03 Rmx, Llc Devices and methods for reducing intrathoracic pressure
CA2966197C (en) 2014-10-31 2023-04-11 Avent, Inc. Non-invasive nerve stimulation system and method
US9682235B1 (en) 2015-12-14 2017-06-20 Stimdia Medical, Inc. Electrical stimulation for preservation and restoration of diaphragm function
US10537735B2 (en) 2016-04-29 2020-01-21 Viscardia, Inc. Implantable medical devices and methods for real-time or near real-time adjustment of diaphragmatic stimulation parameters to affect pressures within the intrathoracic cavity
EP3481490B1 (en) 2016-07-08 2022-11-02 Anthony F. Dimarco System for activating inspiratory and expiratory muscle function
KR101806743B1 (en) * 2016-10-28 2017-12-07 영남대학교 산학협력단 Respiratory muscle strengthening device
US10293164B2 (en) 2017-05-26 2019-05-21 Lungpacer Medical Inc. Apparatus and methods for assisted breathing by transvascular nerve stimulation
EP4115942A1 (en) 2017-06-30 2023-01-11 Lungpacer Medical Inc. System for prevention, moderation, and/or treatment of cognitive injury
WO2019010396A1 (en) 2017-07-06 2019-01-10 Stimdia Medical Inc. Percutaneous electrical phrenic nerve stimulation system
US10195429B1 (en) 2017-08-02 2019-02-05 Lungpacer Medical Inc. Systems and methods for intravascular catheter positioning and/or nerve stimulation
US10940308B2 (en) 2017-08-04 2021-03-09 Lungpacer Medical Inc. Systems and methods for trans-esophageal sympathetic ganglion recruitment
US10722710B2 (en) 2018-03-24 2020-07-28 Moshe Hayik Secretion clearance and cough assist
US11058349B2 (en) 2018-03-24 2021-07-13 Ovadia Sagiv Non-invasive handling of sleep apnea, snoring and emergency situations
EP3877043A4 (en) 2018-11-08 2022-08-24 Lungpacer Medical Inc. Stimulation systems and related user interfaces
US11471683B2 (en) 2019-01-29 2022-10-18 Synapse Biomedical, Inc. Systems and methods for treating sleep apnea using neuromodulation
WO2020232333A1 (en) 2019-05-16 2020-11-19 Lungpacer Medical Inc. Systems and methods for sensing and stimulation
EP3983057A4 (en) 2019-06-12 2023-07-12 Lungpacer Medical Inc. Circuitry for medical stimulation systems
US11266838B1 (en) 2019-06-21 2022-03-08 Rmx, Llc Airway diagnostics utilizing phrenic nerve stimulation device and method
US11458312B2 (en) 2019-09-26 2022-10-04 Viscardia, Inc. Implantable medical systems, devices, and methods for affecting cardiac function through diaphragm stimulation, and for monitoring diaphragmatic health
CN111657940B (en) * 2020-06-22 2023-04-18 中国人民解放军陆军特色医学中心 Severe patient rehabilitation training auxiliary device and working method thereof
RU2750236C1 (en) * 2020-06-25 2021-06-24 Евгений Александрович Горемыкин System for maintaining respiratory function through neurostimulation of patients connected to arventural ventilation devices
CN116963847A (en) 2021-12-30 2023-10-27 米凯·亚历山大维奇·米山尼诺夫 Reactor of waste treatment device
EP4254771A1 (en) 2022-02-17 2023-10-04 Mikhail Aleksandrovich Meshchaninov Electrostatic friction pulse generator
US11890398B2 (en) 2022-02-17 2024-02-06 Mikhail Aleksandrovich Meshchaninov Air cleaning device

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5678535A (en) * 1995-04-21 1997-10-21 Dimarco; Anthony Fortunato Method and apparatus for electrical stimulation of the respiratory muscles to achieve artificial ventilation in a patient
US5814086A (en) * 1996-10-18 1998-09-29 Pacesetter Ab Perex respiratory system stimulation upon tachycardia detection
US6463327B1 (en) * 1998-06-11 2002-10-08 Cprx Llc Stimulatory device and methods to electrically stimulate the phrenic nerve

Family Cites Families (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1693734A (en) 1923-06-29 1928-12-04 Mcintosh Electrical Corp Switching means for effecting electrotherapeutic treatment
US2532788A (en) 1948-01-03 1950-12-05 Stanley J Sarnoff Artificial respiration by electronic stimulation
US2664880A (en) 1951-11-23 1954-01-05 Jr Nathaniel B Wales Electric stimulator for artificial respiration
US6194217B1 (en) 1980-01-14 2001-02-27 Esa, Inc. Method of diagnosing or categorizing disorders from biochemical profiles
US6210970B1 (en) 1980-01-14 2001-04-03 Esa, Inc. Method of diagnosing or categorizing disorders from biochemical profiles
US4699875A (en) 1982-11-24 1987-10-13 Baylor College Of Medicine Diagnosis of amyotrophic lateral sclerosis by neurotrophic factors
FR2566276B1 (en) 1984-06-21 1988-07-08 Medtronic Bv DIAPHRAGMATIC STIMULATION METHOD AND APPARATUS
US4863438A (en) * 1985-11-29 1989-09-05 Applied Medical Technology, Inc. Low profile gastrostomy device
US4827935A (en) 1986-04-24 1989-05-09 Purdue Research Foundation Demand electroventilator
US4773393A (en) 1986-07-03 1988-09-27 C. R. Bard, Inc. Hypodermically implantable genitourinary prosthesis
US4830008A (en) * 1987-04-24 1989-05-16 Meer Jeffrey A Method and system for treatment of sleep apnea
US5368035A (en) 1988-03-21 1994-11-29 Boston Scientific Corporation Ultrasound imaging guidewire
US4989617A (en) 1989-07-14 1991-02-05 Case Western Reserve University Intramuscular electrode for neuromuscular stimulation system
US5056519A (en) 1990-05-14 1991-10-15 Vince Dennis J Unilateral diaphragmatic pacer
US5074846A (en) 1990-09-13 1991-12-24 Abbott Laboratories Stoma creator gastrostomy device and method for placement of a feeding tube
US5146918A (en) 1991-03-19 1992-09-15 Medtronic, Inc. Demand apnea control of central and obstructive sleep apnea
US5241957A (en) 1991-11-18 1993-09-07 Medtronic, Inc. Bipolar temporary pacing lead and connector and permanent bipolar nerve wire
US7429262B2 (en) 1992-01-07 2008-09-30 Arthrocare Corporation Apparatus and methods for electrosurgical ablation and resection of target tissue
EP0645014A4 (en) 1992-06-12 1996-12-18 Baylor College Medicine Method and kit for diagnosing amyotrophic lateral sclerosis.
US5843641A (en) 1993-02-26 1998-12-01 Massachusetts Institute Of Technology Methods for the daignosis, of familial amyotrophic lateral sclerosis
US5813399A (en) * 1993-03-16 1998-09-29 Puritan Bennett Corporation System and method for closed loop airway pressure control during the inspiratory cycle of a breath in a patient ventilator using the exhalation valve as a microcomputer-controlled relief valve
US5792165A (en) 1993-07-21 1998-08-11 Charles H. Klieman Endoscopic instrument with detachable end effector
US5472438A (en) 1993-07-22 1995-12-05 Case Western Reserve University Laproscopic vacuum delivery apparatus for a diaphragm daper
US5429636A (en) 1993-10-08 1995-07-04 United States Surgical Corporation Conductive body tissue penetrating device
US5524632A (en) 1994-01-07 1996-06-11 Medtronic, Inc. Method for implanting electromyographic sensing electrodes
US5527358A (en) 1994-01-21 1996-06-18 Medtronic, Inc. Temporary medical electrical lead
US5718248A (en) 1994-04-15 1998-02-17 Allegheny-Singer Research Institute Muscle energy converter pump and method of pumping fluid of a patient
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
US5483969A (en) 1994-09-21 1996-01-16 Medtronic, Inc. Method and apparatus for providing a respiratory effort waveform for the treatment of obstructive sleep apnea
US5591216A (en) 1995-05-19 1997-01-07 Medtronic, Inc. Method for treatment of sleep apnea by electrical stimulation
US6198970B1 (en) * 1995-10-27 2001-03-06 Esd Limited Liability Company Method and apparatus for treating oropharyngeal respiratory and oral motor neuromuscular disorders with electrical stimulation
US5716392A (en) 1996-01-05 1998-02-10 Medtronic, Inc. Minimally invasive medical electrical lead
AU721034B2 (en) 1996-02-15 2000-06-22 Biosense, Inc. Catheter based surgery
US6311692B1 (en) 1996-10-22 2001-11-06 Epicor, Inc. Apparatus and method for diagnosis and therapy of electrophysiological disease
US6035856A (en) 1997-03-06 2000-03-14 Scimed Life Systems Percutaneous bypass with branching vessel
US5797923A (en) 1997-05-12 1998-08-25 Aiyar; Harish Electrode delivery instrument
US6477423B1 (en) 1997-05-28 2002-11-05 Transneuronix, Inc. Medical device for use in laparoscopic surgery
ATE353689T1 (en) 1997-07-16 2007-03-15 Metacure Nv DEVICE FOR CONTROLLING A SMOOTH MUSCLE
US7006871B1 (en) 1997-07-16 2006-02-28 Metacure N.V. Blood glucose level control
US7165551B2 (en) 1998-02-19 2007-01-23 Curon Medical, Inc. Apparatus to detect and treat aberrant myoelectric activity
US6845271B2 (en) 1998-06-03 2005-01-18 Neurocontrol Corporation Treatment of shoulder dysfunction using a percutaneous intramuscular stimulation system
US6213960B1 (en) 1998-06-19 2001-04-10 Revivant Corporation Chest compression device with electro-stimulation
SE9803508D0 (en) 1998-10-14 1998-10-14 Siemens Elema Ab Assisted Breathing System
US6245053B1 (en) 1998-11-09 2001-06-12 Medtronic, Inc. Soft tip guiding catheter and method of fabrication
US6645145B1 (en) 1998-11-19 2003-11-11 Siemens Medical Solutions Usa, Inc. Diagnostic medical ultrasound systems and transducers utilizing micro-mechanical components
DE60020842T2 (en) * 1999-06-30 2006-05-18 University of Florida Research Foundation, Inc., Gainesville MONITORING SYSTEM FOR VENTILATOR
US7526342B2 (en) 1999-08-10 2009-04-28 Maquet Cardiovascular Llc Apparatus for endoscopic cardiac mapping and lead placement
US7177686B1 (en) 1999-11-10 2007-02-13 Pacesetter, Inc. Using photo-plethysmography to monitor autonomic tone and performing pacing optimization based on monitored autonomic tone
US6689062B1 (en) 1999-11-23 2004-02-10 Microaccess Medical Systems, Inc. Method and apparatus for transesophageal cardiovascular procedures
US6254425B1 (en) * 1999-11-30 2001-07-03 Ethicon, Inc. Electrical connector for cardiac devices
US6415183B1 (en) 1999-12-09 2002-07-02 Cardiac Pacemakers, Inc. Method and apparatus for diaphragmatic pacing
AU2001257582A1 (en) 2000-03-14 2001-09-24 Children's Medical Center Corporation, The Method for improving respiratory function and inhibiting muscular degeneration
AU2001249308A1 (en) 2000-03-24 2001-10-15 Johns Hopkins University Peritoneal cavity device and method
US6397108B1 (en) 2000-04-03 2002-05-28 Medtronic Inc. Safety adaptor for temporary medical leads
US7329489B2 (en) 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US20030148404A1 (en) 2000-07-27 2003-08-07 Ramot University Authority For Applied Research & Industrial Development Ltd. Peptides and substances, methods and devices using same for diagnosing and treating neurodegenerative disorders
AU8517001A (en) 2000-08-21 2002-03-04 Gen Hospital Corp Methods for diagnosing a neurodegenerative condition
CA2427061A1 (en) 2000-10-27 2002-08-01 Baylor College Of Medicine Methods and compositions for the identification and treatment of neurodegenerative disorders
SE0004141D0 (en) 2000-11-13 2000-11-13 Siemens Elema Ab Method of adaptive triggering of breathing devices and a breathing device
US6754536B2 (en) 2001-01-31 2004-06-22 Medtronic, Inc Implantable medical device affixed internally within the gastrointestinal tract
FR2822238B1 (en) 2001-03-16 2003-08-29 Gemac METHOD AND KIT FOR MONITORING NEURODEGENERATIVE DISEASES
US20050019915A1 (en) 2001-06-21 2005-01-27 Bennett C. Frank Antisense modulation of superoxide dismutase 1, soluble expression
US6600956B2 (en) 2001-08-21 2003-07-29 Cyberonics, Inc. Circumneural electrode assembly
US7273888B2 (en) 2001-11-16 2007-09-25 Als Therapy Development Foundation, Inc. Use of difluoromethylornithine (DFMO) for the treatment of amyotrophic lateral sclerosis
WO2003068944A2 (en) 2002-02-13 2003-08-21 Dana-Farber Cancer Institute, Inc. METHODS AND COMPOSITION FOR MODULATING TYPE I MUSCLE FORMATION USING PGC-1α-
US7166075B2 (en) 2002-03-08 2007-01-23 Wisconsin Alumni Research Foundation Elastographic imaging of in vivo soft tissue
US7463934B2 (en) 2002-04-12 2008-12-09 Medtronic, Inc. Implantable medical device with captivation fixation
US7207946B2 (en) 2002-05-09 2007-04-24 Spiration, Inc. Automated provision of information related to air evacuation from a chest cavity
US7753924B2 (en) 2003-09-04 2010-07-13 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
SE0202537D0 (en) 2002-08-28 2002-08-28 Siemens Elema Ab Nerve stimulation apparatus
AU2003272273B2 (en) 2002-09-04 2008-10-02 Washington University Methods for treating central nervous system damage
US20040064069A1 (en) 2002-09-30 2004-04-01 Reynolds Brian R. Medical device with support member
US20060041022A1 (en) 2002-11-06 2006-02-23 Pasinetti Giulio M Treatment of amyotrophic lateral sclerosis with nimesulide
EP1578494B1 (en) * 2002-12-09 2010-05-26 Medtronic, Inc. Lead connection module of a modular implantable medical device
US6945956B2 (en) 2002-12-23 2005-09-20 Medtronic, Inc. Steerable catheter
WO2004069174A2 (en) 2003-01-31 2004-08-19 Slil Biomedical Corporation Monitoring and treatment of amyotrophic lateral sclerosis
US7044921B2 (en) 2003-02-03 2006-05-16 Scimed Life Systems, Inc Medical device with changeable tip flexibility
US20040167437A1 (en) 2003-02-26 2004-08-26 Sharrow James S. Articulating intracorporal medical device
US7182735B2 (en) 2003-02-26 2007-02-27 Scimed Life Systems, Inc. Elongated intracorporal medical device
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
US20040254419A1 (en) 2003-04-08 2004-12-16 Xingwu Wang Therapeutic assembly
US7155278B2 (en) 2003-04-21 2006-12-26 Medtronic, Inc. Neurostimulation to treat effects of sleep apnea
US20040254572A1 (en) 2003-04-25 2004-12-16 Mcintyre Jon T. Self anchoring radio frequency ablation array
GB0309916D0 (en) 2003-04-30 2003-06-04 Ares Trading Sa Secreted protein family
US20060287679A1 (en) 2003-05-16 2006-12-21 Stone Robert T Method and system to control respiration by means of confounding neuro-electrical signals
US20060111755A1 (en) 2003-05-16 2006-05-25 Stone Robert T Method and system to control respiration by means of neuro-electrical coded signals
US7738952B2 (en) 2003-06-09 2010-06-15 Palo Alto Investors Treatment of conditions through modulation of the autonomic nervous system
US20040260337A1 (en) 2003-06-18 2004-12-23 Scimed Life Systems, Inc. Endoscopic instruments and methods of manufacture
US8469993B2 (en) 2003-06-18 2013-06-25 Boston Scientific Scimed, Inc. Endoscopic instruments
US6918871B2 (en) 2003-06-19 2005-07-19 Ethicon Endo-Surgery, Inc. Method for accessing cavity
US7824368B2 (en) 2003-06-19 2010-11-02 Ethicon Endo-Surgery, Inc. Method for endoscopic, transgastric access into the abdominal cavity
US8579804B2 (en) 2003-06-23 2013-11-12 Boston Scientific Scimed, Inc. Variable length nephrostomy sheath
US7206641B2 (en) 2003-07-23 2007-04-17 University Hospitals Of Cleveland Mapping probe system for neuromuscular electrical stimulation apparatus
WO2005009291A2 (en) 2003-07-23 2005-02-03 Synapse Biomedical, Inc. System and method for conditioning a diaphragm of a patient
US7187982B2 (en) * 2003-08-08 2007-03-06 Medtronic, Inc. Medical electrical lead anchoring
US7787946B2 (en) * 2003-08-18 2010-08-31 Cardiac Pacemakers, Inc. Patient monitoring, diagnosis, and/or therapy systems and methods
US8002553B2 (en) * 2003-08-18 2011-08-23 Cardiac Pacemakers, Inc. Sleep quality data collection and evaluation
US7887493B2 (en) * 2003-09-18 2011-02-15 Cardiac Pacemakers, Inc. Implantable device employing movement sensing for detecting sleep-related disorders
US7616988B2 (en) * 2003-09-18 2009-11-10 Cardiac Pacemakers, Inc. System and method for detecting an involuntary muscle movement disorder
US7641621B2 (en) 2003-08-25 2010-01-05 Boston Scientific Scimed, Inc. Elongated intra-lumenal medical device
US20050054952A1 (en) * 2003-09-05 2005-03-10 Scimed Life Systems, Inc. Elongated medical device for intracorporal use
US7833175B2 (en) * 2003-09-05 2010-11-16 Boston Scientific Scimed, Inc. Medical device coil
US7540845B2 (en) 2003-09-05 2009-06-02 Boston Scientific Scimed, Inc Medical device coil
WO2005033341A2 (en) * 2003-10-03 2005-04-14 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Use of cripto-1 as a biomarker for neurodegenerative disease and method of inhibiting progression thereof
NO319063B1 (en) * 2003-10-06 2005-06-13 Laerdal Medical As Medical patient simulator
US8467876B2 (en) * 2003-10-15 2013-06-18 Rmx, Llc Breathing disorder detection and therapy delivery device and method
US8160711B2 (en) 2003-10-15 2012-04-17 Rmx, Llc Multimode device and method for controlling breathing
US9259573B2 (en) * 2003-10-15 2016-02-16 Rmx, Llc Device and method for manipulating exhalation
US8244358B2 (en) * 2003-10-15 2012-08-14 Rmx, Llc Device and method for treating obstructive sleep apnea
US20060167523A1 (en) * 2003-10-15 2006-07-27 Tehrani Amir J Device and method for improving upper airway functionality
US7970475B2 (en) * 2003-10-15 2011-06-28 Rmx, Llc Device and method for biasing lung volume
CA2542391A1 (en) * 2003-10-23 2005-05-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education Biomarkers for amyotrophic lateral sclerosis
US20050113901A1 (en) * 2003-10-24 2005-05-26 Cardiac Pacemakers, Inc. Myocardial lead attachment system
US7306595B2 (en) * 2003-11-18 2007-12-11 Boston Scientific Scimed, Inc. System and method for tissue ablation
US7802571B2 (en) * 2003-11-21 2010-09-28 Tehrani Fleur T Method and apparatus for controlling a ventilator
US7237313B2 (en) * 2003-12-05 2007-07-03 Boston Scientific Scimed, Inc. Elongated medical device for intracorporal use
US7824345B2 (en) * 2003-12-22 2010-11-02 Boston Scientific Scimed, Inc. Medical device with push force limiter
US20050149072A1 (en) * 2003-12-31 2005-07-07 Devries Robert B. Devices and methods for tissue invagination
US7519425B2 (en) * 2004-01-26 2009-04-14 Pacesetter, Inc. Tiered therapy for respiratory oscillations characteristic of Cheyne-Stokes respiration
US20050209653A1 (en) 2004-03-16 2005-09-22 Medtronic, Inc. Intra-luminal device for gastrointestinal electrical stimulation
JP2007530029A (en) * 2004-03-26 2007-11-01 クアーク・ファーマスーティカルス、インコーポレイテッド Annexin II and uses thereof
US7931661B2 (en) 2004-06-14 2011-04-26 Usgi Medical, Inc. Apparatus and methods for performing transluminal gastrointestinal procedures
US7225016B1 (en) * 2004-06-16 2007-05-29 Pacesetter, Inc. Implantable medical device with nerve signal sensing
US9050005B2 (en) 2005-08-25 2015-06-09 Synapse Biomedical, Inc. Method and apparatus for transgastric neurostimulation
CN101495177A (en) 2005-12-02 2009-07-29 突触生物医学有限公司 Transvisceral neurostimulation mapping device and method
WO2007103585A2 (en) 2006-03-09 2007-09-13 Synapse Biomedical, Inc. Ventilator assist system and method to improve respiratory function
US20080097153A1 (en) * 2006-08-24 2008-04-24 Ignagni Anthony R Method and apparatus for grasping an abdominal wall
US9079016B2 (en) * 2007-02-05 2015-07-14 Synapse Biomedical, Inc. Removable intramuscular electrode
US9820671B2 (en) 2007-05-17 2017-11-21 Synapse Biomedical, Inc. Devices and methods for assessing motor point electromyogram as a biomarker
US8478412B2 (en) 2007-10-30 2013-07-02 Synapse Biomedical, Inc. Method of improving sleep disordered breathing
US8428726B2 (en) * 2007-10-30 2013-04-23 Synapse Biomedical, Inc. Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5678535A (en) * 1995-04-21 1997-10-21 Dimarco; Anthony Fortunato Method and apparatus for electrical stimulation of the respiratory muscles to achieve artificial ventilation in a patient
US5814086A (en) * 1996-10-18 1998-09-29 Pacesetter Ab Perex respiratory system stimulation upon tachycardia detection
US6463327B1 (en) * 1998-06-11 2002-10-08 Cprx Llc Stimulatory device and methods to electrically stimulate the phrenic nerve

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US8406885B2 (en) 2013-03-26
US20110060381A1 (en) 2011-03-10
US8706236B2 (en) 2014-04-22
WO2005009291A2 (en) 2005-02-03
US7840270B2 (en) 2010-11-23
US20050021102A1 (en) 2005-01-27

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