WO2005009498A3 - Decellularized bone marrow extracellular matrix - Google Patents

Decellularized bone marrow extracellular matrix Download PDF

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Publication number
WO2005009498A3
WO2005009498A3 PCT/US2004/023188 US2004023188W WO2005009498A3 WO 2005009498 A3 WO2005009498 A3 WO 2005009498A3 US 2004023188 W US2004023188 W US 2004023188W WO 2005009498 A3 WO2005009498 A3 WO 2005009498A3
Authority
WO
WIPO (PCT)
Prior art keywords
bone marrow
extracellular matrix
decellularized bone
marrow extracellular
decellularized
Prior art date
Application number
PCT/US2004/023188
Other languages
French (fr)
Other versions
WO2005009498A2 (en
Inventor
Toby Freyman
Original Assignee
Scimed Life Systems Inc
Toby Freyman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scimed Life Systems Inc, Toby Freyman filed Critical Scimed Life Systems Inc
Priority to EP04757127A priority Critical patent/EP1654015B1/en
Priority to DE602004019337T priority patent/DE602004019337D1/en
Publication of WO2005009498A2 publication Critical patent/WO2005009498A2/en
Publication of WO2005009498A3 publication Critical patent/WO2005009498A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention is directed to compositions comprising decellularized bone marrow extracellular matrix and uses thereof. Methods for repairing or regenerating defective, diseased, damaged or ischemic tissues or organs in a subject, preferably a human, using the decellularized bone marrow extracellular matrix of the invention are also provided. The invention is further directed to a medical device, preferably a stent or an artificial heart, and biocompatible materials, preferably a tissue regeneration scaffold, comprising decellularized bone marrow extracellular matrix for implantation into a subject.
PCT/US2004/023188 2003-07-17 2004-07-16 Decellularized bone marrow extracellular matrix WO2005009498A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP04757127A EP1654015B1 (en) 2003-07-17 2004-07-16 Decellularized bone marrow extracellular matrix
DE602004019337T DE602004019337D1 (en) 2003-07-17 2004-07-16 DECELLULARIZED EXTRACELLULAR MATRIX OF BONE MARROW

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/622,674 US7326571B2 (en) 2003-07-17 2003-07-17 Decellularized bone marrow extracellular matrix
US10/622,674 2003-07-17

Publications (2)

Publication Number Publication Date
WO2005009498A2 WO2005009498A2 (en) 2005-02-03
WO2005009498A3 true WO2005009498A3 (en) 2005-03-24

Family

ID=34063242

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/023188 WO2005009498A2 (en) 2003-07-17 2004-07-16 Decellularized bone marrow extracellular matrix

Country Status (4)

Country Link
US (2) US7326571B2 (en)
EP (1) EP1654015B1 (en)
DE (1) DE602004019337D1 (en)
WO (1) WO2005009498A2 (en)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US20050013870A1 (en) * 2003-07-17 2005-01-20 Toby Freyman Decellularized extracellular matrix of conditioned body tissues and uses thereof
US20070244568A1 (en) * 2003-12-26 2007-10-18 Cardio Incorporated Decellularized Tissue and Method of Preparing the Same
US7764995B2 (en) * 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
WO2010022074A1 (en) * 2008-08-18 2010-02-25 William Marsh Rice University A decellularization method for scaffoldless tissue engineered articular cartilage or native cartilage tissue
US20110212894A1 (en) * 2004-07-09 2011-09-01 Athanasiou Kyriacos A Decellularization method for scaffoldless tissue engineered articular cartilage or native cartilage tissue
US7442206B2 (en) * 2004-10-28 2008-10-28 Cook Incorporated Methods and systems for modifying vascular valves
US8874204B2 (en) * 2004-12-20 2014-10-28 Cardiac Pacemakers, Inc. Implantable medical devices comprising isolated extracellular matrix
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US8060219B2 (en) * 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US20060134071A1 (en) * 2004-12-20 2006-06-22 Jeffrey Ross Use of extracellular matrix and electrical therapy
CA2602100A1 (en) * 2005-03-16 2006-09-28 Musculoskeletal Transplant Foundation Soft tissue processing
US20100112543A1 (en) * 2005-03-16 2010-05-06 Manh-Dan Ngo Processing soft tissue, methods and compositions related thereto
US20070065415A1 (en) * 2005-09-16 2007-03-22 Kleinsek Donald A Compositions and methods for the augmentation and repair of defects in tissue
US8921109B2 (en) 2005-09-19 2014-12-30 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
WO2007056547A2 (en) * 2005-11-08 2007-05-18 Georgia Tech Research Corporation Acellularized biomaterial from embryonic stem cells
US7521221B2 (en) * 2005-11-21 2009-04-21 Board Of Trustees Of The University Of Arknasas Staphylococcus aureus strain CYL1892
EP1790350A1 (en) * 2005-11-24 2007-05-30 Interstitial Therapeutics Use of keratinocyte composition for the treatment of restenosis
US8834912B2 (en) * 2005-12-30 2014-09-16 Boston Scientific Scimed, Inc. Medical devices having multiple charged layers
US20070178137A1 (en) * 2006-02-01 2007-08-02 Toby Freyman Local control of inflammation
US20080046070A1 (en) * 2006-03-31 2008-02-21 Obermiller F J Chemically treated extracellular matrices for affecting the cellular response
EP2019657B1 (en) 2006-04-26 2015-05-27 Micell Technologies, Inc. Coatings containing multiple drugs
WO2008027783A2 (en) * 2006-08-29 2008-03-06 Vance Products Incorporated, D/B/A Cook Urological Incorporated Prosthetic testicle
WO2008059244A2 (en) * 2006-11-16 2008-05-22 University Of Leeds Preparation of tissue for meniscal implantation
US8084023B2 (en) 2007-01-22 2011-12-27 The Board Of Trustees Of The University Of Arkansas Maintenance and propagation of mesenchymal stem cells
DE102007005946A1 (en) * 2007-02-01 2008-08-14 Stiftung Caesar Therapeutic composition and use of a cell-free substance
WO2008109407A2 (en) 2007-03-02 2008-09-12 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Extracellular matrix-derived gels and related methods
AU2008237732B2 (en) * 2007-04-16 2014-05-22 Covidien Ag Methods and compositions for tissue regeneration
CA2684012A1 (en) * 2007-04-16 2008-10-23 Tissue Science Laboratories Plc Vascular implant
US20100191346A1 (en) * 2007-04-16 2010-07-29 Stephen Bloor Bone implant
US20080294270A1 (en) * 2007-05-24 2008-11-27 Zimmer Orthobiologics, Inc. Differentially processed tissue and processing methods thereof
US20090142400A1 (en) * 2007-05-31 2009-06-04 Hiles Michael C Analgesic coated medical product
US20080306610A1 (en) * 2007-06-07 2008-12-11 Zimmer Orthobiologics, Inc. Tissue processing for nonimmunogenic implants
JP5538217B2 (en) * 2007-07-10 2014-07-02 ライフセル コーポレーション Cell-free tissue matrix construct for tissue repair
US20090054906A1 (en) * 2007-08-24 2009-02-26 Zimmer Orthobiologics, Inc. Medical device and method for delivering an implant to an anatomical site
WO2009089110A2 (en) * 2008-01-04 2009-07-16 Boston Scientific Scimed, Inc. Methods for repair and regeneration of bone marrow
EP2254508A4 (en) * 2008-03-03 2012-03-28 Univ Rice William M Methods of fabricating enhanced tissue-engineered cartilage
US8801725B2 (en) * 2008-03-10 2014-08-12 Zimmer Orthobiologics, Inc. Instruments and methods used when repairing a defect on a tissue surface
EP2303350A2 (en) 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprosthesis coating
HUE033504T2 (en) * 2008-09-30 2017-12-28 Univ California Compositions comprising decellularized extracellular matrix obtained from cardiac tissue
KR101056069B1 (en) * 2008-10-13 2011-08-10 아주대학교산학협력단 Method for producing porous three-dimensional scaffold using animal tissue powder
WO2010111278A1 (en) * 2009-03-23 2010-09-30 The Texas A&M University System Compositions of mesenchymal stem cells to regenerate bone
WO2010111263A1 (en) * 2009-03-23 2010-09-30 Wake Forest University Health Sciences Tissue engineering scaffolds and methods of use
CN102481195B (en) 2009-04-01 2015-03-25 米歇尔技术公司 Drug delivery medical device
EP2442837B1 (en) 2009-06-18 2014-08-20 MC2 Cell Aps Bone marrow extracellular matrix extract and therapeutic use thereof
US20110021869A1 (en) * 2009-07-24 2011-01-27 Hilary John Cholhan Single-incision minimally-invasive surgical repair of pelvic organ/vaginal prolapse conditions
WO2011133655A1 (en) * 2010-04-22 2011-10-27 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
DK2608777T3 (en) 2010-08-24 2019-10-28 Univ California Compositions and Methods for Cardiac Therapy
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
US9113916B2 (en) 2010-08-31 2015-08-25 Zimmer, Inc. Drill bit for osteochondral drilling with guiding element and uses thereof
AU2011299327B2 (en) 2010-09-07 2015-07-16 The Board Of Regents Of The University Of Texas System Tissue-specific differentiation matrices and uses thereof
TWI399209B (en) * 2010-11-01 2013-06-21 Taiwan Sugar Corp Use of porcine lung extract as metrix metalloproteinase inhibitor
WO2012103343A1 (en) * 2011-01-28 2012-08-02 The Board Of Trustees Of The Leland Stanford Junior University Functional targeted brain endoskeletonization
WO2012142569A2 (en) 2011-04-15 2012-10-18 The Regents Of The University Of California Decellularized extracellular matrix
US20140154220A1 (en) * 2011-04-25 2014-06-05 University of Southern Califonia Methods and Compositions for Improved Tissue Regeneration by Suppression of Interferon-Gamma and Tumor Necrosis Factor-Alpha
WO2013009595A2 (en) * 2011-07-08 2013-01-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Injectable cns-derived ecm for tissue reconstruction
WO2013036708A2 (en) 2011-09-07 2013-03-14 The Regents Of The University Of California Compositions and methods for tissue repair with extracellular matrices
WO2013102048A2 (en) * 2011-12-30 2013-07-04 University Of Miami Regenerative tissue matrix
JP6466323B2 (en) * 2012-06-14 2019-02-06 グライナー バイオ‐ワン ノース アメリカ，インコーポレイテッド Magnetic extracellular matrix
EP2883030B1 (en) 2012-08-09 2022-08-31 The Board of Trustees of the Leland Stanford Junior University Methods and compositions for preparing biological specimens for microscopic analysis
KR102284982B1 (en) 2013-01-09 2021-08-03 넥스트젠 바이오로직스, 아이엔씨. Decellularized biomaterial form non-mammalian tissue
WO2014152629A1 (en) * 2013-03-15 2014-09-25 Miller Leonard B Combination therapy to improve soft tissue healing, fat graft healing, endochondral bone healing and osteointegration
US9861662B2 (en) * 2013-07-03 2018-01-09 University of Pittsburgh—of the Commonwealth System of Higher Education Bone-derived extra cellular matrix gel
EP3019094B1 (en) * 2013-07-09 2019-11-20 AMS Research, LLC Biodegradable articles and their use for treating pelvic floor disorders including extracellular matrix material
WO2015048136A1 (en) * 2013-09-24 2015-04-02 The Johns Hopkins University Tissue extracellular matrix particles and applications
US9486483B2 (en) * 2013-10-18 2016-11-08 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9539286B2 (en) * 2013-10-18 2017-01-10 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9427335B2 (en) * 2014-03-18 2016-08-30 Biomet Biologics, LLC. Method for rinsing and delivering bone graft
JP6681872B2 (en) 2014-03-21 2020-04-15 ユニバーシティ オブ ピッツバーグ −オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション Method for preparing final sterile hydrogel derived from extracellular matrix
EP3149534A4 (en) 2014-05-30 2018-01-31 The Board of Trustees of The Leland Stanford Junior University Methods and devices for imaging large intact tissue samples
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
WO2016100846A1 (en) * 2014-12-19 2016-06-23 Northwestern University Thromboresistant-anticoagulant extracellular matrix
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
CN104740684A (en) * 2015-03-03 2015-07-01 上海市闸北区中心医院 Canine uterus whole-organ acellular matrix and preparation method as well as application of canine uterus whole-organ acellular matrix
US11160904B2 (en) 2017-05-09 2021-11-02 Vivex Biologies Group, Inc. Biological composition in a protectant shroud and methods
US9687511B2 (en) * 2015-03-06 2017-06-27 Vivex Biomedical, Inc. Acellular biologic composition and method of manufacture
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
WO2017008035A1 (en) * 2015-07-08 2017-01-12 The Trustees Of The University Of Pennesylvania Decellularized organ-derived tissue engineering scaffolds
US11077147B2 (en) * 2015-07-20 2021-08-03 Vivex Biologics Group, Inc. Acellular biologic composition and method of manufacture
CN105311681B (en) * 2015-12-07 2018-12-25 杭州华迈医疗器械有限公司 Injectable composite material for bone repair and preparation method thereof
CA3007417A1 (en) 2015-12-11 2017-06-15 Lifecell Corporation Methods and systems for stiffening of tissue for improved processing
US11254974B2 (en) 2016-02-10 2022-02-22 The Board Of Trustees Of The Leland Stanford Junior University RNA fixation and detection in clarity-based hydrogel tissue
CN107456603A (en) * 2016-06-03 2017-12-12 香港大学深圳医院 A kind of bone holder material and preparation method for being enriched with magnesium ion
AU2017286715B2 (en) 2016-06-15 2022-03-03 The General Hospital Corporation Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions
CN107913436A (en) 2016-10-09 2018-04-17 刘英芹 Act on the bone and soft tissue synchronizing regeneration derivant of disability tissue in situ
AU2018226871B2 (en) 2017-03-02 2023-08-10 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Extracellular matrix (ECM) hydrogel and soluble fraction thereof for the treatment of cancer
KR20190120258A (en) 2017-03-02 2019-10-23 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 ECM hydrogel for the treatment of esophageal inflammation
KR102196026B1 (en) * 2020-04-06 2020-12-29 주식회사 티앤알바이오팹 Manufacturing method of bio-materials from animal tissue, bio-materials from animal tissue manufactured thereby and 3D printing method using the same
CN111476775B (en) * 2020-04-07 2021-11-16 广州柏视医疗科技有限公司 DR symptom identification device and method
CN112029727A (en) * 2020-09-14 2020-12-04 首都医科大学附属北京天坛医院 Brain acellular matrix particle scaffold and preparation method and application thereof
EP4019035A1 (en) * 2020-12-23 2022-06-29 Institut National De La Sante Et De La Recherche Medicale - Inserm Novel recombinant fragments of fibrillin-1 and methods of use thereof
CN114984320B (en) * 2022-05-31 2022-11-22 南开大学 Preparation method and application of acellular matrix tissue paper
CN115227868B (en) * 2022-07-20 2023-07-07 中南大学湘雅医院 Bone defect repair material and magnesium pretreatment decellularized tissue engineering bone scaffold

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018842A1 (en) * 1995-11-20 1997-05-29 Fidia Advanced Biopolymers S.R.L. A biologic material comprising an efficient culture of bone marrow stem cells partially or completely differentiated into connective tissue cells and a three-dimensional biocompatible and biodegradable matrix consisting of a hyaluronic acid derivative
WO2001003750A1 (en) * 1999-07-09 2001-01-18 Advanced Tissue Sciences, Inc. Human naturally secreted extracellular matrix-coated device

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513754A (en) * 1978-03-03 1985-04-30 Southland Instruments, Inc. Biopsy and aspiration unit with a replaceable cannula
US4314565A (en) * 1978-03-03 1982-02-09 Lee Peter F Biopsy and aspiration needle unit
US4481946A (en) * 1980-08-14 1984-11-13 Altshuler John H Bone marrow transplant method and apparatus
US4486188A (en) * 1980-08-14 1984-12-04 Applied Medical Devices, Inc. Bone marrow transplant method and apparatus
ATE37983T1 (en) * 1982-04-22 1988-11-15 Ici Plc DELAYED RELEASE AGENT.
SE445884B (en) * 1982-04-30 1986-07-28 Medinvent Sa DEVICE FOR IMPLANTATION OF A RODFORM PROTECTION
US4664128A (en) * 1983-12-16 1987-05-12 Peter F. Lee, Inc Single-hand controlled aspiration device
US4630616A (en) * 1984-06-15 1986-12-23 Berkley And Company, Inc. Bone marrow needle
US5128326A (en) * 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US5102417A (en) * 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
SE453258B (en) * 1986-04-21 1988-01-25 Medinvent Sa ELASTIC, SELF-EXPANDING PROTEST AND PROCEDURE FOR ITS MANUFACTURING
US5650148A (en) * 1988-12-15 1997-07-22 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
US5082670A (en) * 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
US5012818A (en) * 1989-05-04 1991-05-07 Joishy Suresh K Two in one bone marrow surgical needle
WO1990013332A1 (en) 1989-05-11 1990-11-15 Cedars-Sinai Medical Center Stent with sustained drug delivery
AU6430190A (en) 1989-10-10 1991-05-16 Pitman-Moore, Inc. Sustained release composition for macromolecular proteins
JP2571874B2 (en) * 1989-11-06 1997-01-16 アルカーメス コントロールド セラピューティクス，インコーポレイテッド Protein microsphere composition
AU7954191A (en) 1990-05-30 1991-12-31 Cellco, Inc. Culturing bone marrow cells for adoptive immunotherapy
US5192312A (en) * 1991-03-05 1993-03-09 Colorado State University Research Foundation Treated tissue for implantation and methods of treatment and use
US5912015A (en) * 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US5800537A (en) * 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
US5257632A (en) * 1992-09-09 1993-11-02 Symbiosis Corporation Coaxial bone marrow biopsy coring and aspirating needle assembly and method of use thereof
US5331972A (en) * 1992-12-03 1994-07-26 Baxter International Inc. Bone marrow biopsy, aspiration and transplant needles
WO1994016646A1 (en) 1993-01-19 1994-08-04 Schneider (Usa) Inc. Clad composite stent
KR100365573B1 (en) * 1994-03-14 2004-08-25 크라이어라이프, 인크. Transplantation tissue and its manufacturing method
US5449373A (en) * 1994-03-17 1995-09-12 Medinol Ltd. Articulated stent
US5857998A (en) * 1994-06-30 1999-01-12 Boston Scientific Corporation Stent and therapeutic delivery system
WO1996020698A2 (en) 1995-01-05 1996-07-11 The Board Of Regents Acting For And On Behalf Of The University Of Michigan Surface-modified nanoparticles and method of making and using same
US5830708A (en) * 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
EP0850051A2 (en) * 1995-08-31 1998-07-01 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
KR100448298B1 (en) 1995-09-08 2004-12-03 리서치 디벨럽먼트 파운데이션 Glucocotricoid enhancement of gene expression
US20010009904A1 (en) 1997-12-30 2001-07-26 Jon A. Wolff Process of delivering a polynucleotide to a cell via the vascular system
US5630616A (en) * 1996-02-14 1997-05-20 Lear Seating Corporation Seat frame integrated air bag inflator
US6241981B1 (en) * 1996-09-16 2001-06-05 Purdue Research Foundation Composition and method for repairing neurological tissue
ATE296117T1 (en) 1997-03-07 2005-06-15 Wistar Inst USE OF ADENOVIRAL VECTORS EXPRESSING PDGF OR VEGF TO HEAL TISSUE DEFECTS AND TO INDUCE HYPERVASCULISM IN MAMMAL TISSUES
US5989463A (en) * 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
SE512663C2 (en) 1997-10-23 2000-04-17 Biogram Ab Active substance encapsulation process in a biodegradable polymer
US6082364A (en) * 1997-12-15 2000-07-04 Musculoskeletal Development Enterprises, Llc Pluripotential bone marrow cell line and methods of using the same
WO1999043270A1 (en) 1998-02-24 1999-09-02 Gerigene Medical Corporation Augmentation and repair of dermal, subcutaneous, and vocal cord tissue defects
US6872819B1 (en) 1998-05-27 2005-03-29 Fidia Advanced Biopolymers S.R.L. Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells
AU1472501A (en) 1999-11-05 2001-05-14 Gerigene Medical Corporation Augmentation and repair of age-related soft tissue defects
US20050002986A1 (en) 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20020077693A1 (en) * 2000-12-19 2002-06-20 Barclay Bruce J. Covered, coiled drug delivery stent and method
EP1315796B1 (en) 2000-08-16 2006-07-12 Duke University Decellularized tissue engineered constructs and tissues
US20020082679A1 (en) 2000-12-22 2002-06-27 Avantec Vascular Corporation Delivery or therapeutic capable agents
WO2003002165A1 (en) 2001-06-28 2003-01-09 Cook Biotech Incorporated Graft prosthesis devices containing renal capsule collagen
JP4451658B2 (en) 2001-10-18 2010-04-14 ライフセル コーポレーション Tissue and organ remodeling
US7674250B2 (en) 2002-08-05 2010-03-09 Boston Scientific Scimed, Inc. Methods of delivering therapeutic agents
US20040142014A1 (en) 2002-11-08 2004-07-22 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
US20040175366A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US7892205B2 (en) 2003-06-06 2011-02-22 Boston Scientific Scimed, Inc. Device and method for delivering micronized therapeutic agents in the body
WO2005010172A2 (en) 2003-07-16 2005-02-03 Boston Scientific Limited Aligned scaffolds for improved myocardial regeneration
US20050013870A1 (en) 2003-07-17 2005-01-20 Toby Freyman Decellularized extracellular matrix of conditioned body tissues and uses thereof
US8740844B2 (en) 2003-08-20 2014-06-03 Boston Scientific Scimed, Inc. Medical device with drug delivery member
US6984411B2 (en) 2003-10-14 2006-01-10 Boston Scientific Scimed, Inc. Method for roll coating multiple stents
US20050233443A1 (en) 2004-03-30 2005-10-20 Toby Freyman Restenosis therapy using mesenchymal stem cells
US20060029720A1 (en) 2004-08-03 2006-02-09 Anastasia Panos Methods and apparatus for injection coating a medical device
US20070005011A1 (en) 2005-06-20 2007-01-04 Boston Scientific Scimed, Inc. Method, system, apparatus, and kit for remote therapeutic delivery
US20070055352A1 (en) 2005-09-07 2007-03-08 Wendy Naimark Stent with pockets for containing a therapeutic agent
US20070065414A1 (en) 2005-09-16 2007-03-22 Boston Scientific Scimed, Inc. Enhanced delivery of cells
US20070178137A1 (en) 2006-02-01 2007-08-02 Toby Freyman Local control of inflammation
US20080085294A1 (en) 2006-10-04 2008-04-10 Toby Freyman Apparatuses and methods to treat atherosclerotic plaques
JP5284282B2 (en) 2007-01-30 2013-09-11 ボストン サイエンティフィック リミテッド A medical device that delivers therapeutic agents to the heart valve

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018842A1 (en) * 1995-11-20 1997-05-29 Fidia Advanced Biopolymers S.R.L. A biologic material comprising an efficient culture of bone marrow stem cells partially or completely differentiated into connective tissue cells and a three-dimensional biocompatible and biodegradable matrix consisting of a hyaluronic acid derivative
WO2001003750A1 (en) * 1999-07-09 2001-01-18 Advanced Tissue Sciences, Inc. Human naturally secreted extracellular matrix-coated device

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LEE M ET AL: "Comparison of bone marrow extracellular matrices", BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 1428, no. 2-3, 5 August 1999 (1999-08-05), pages 300 - 304, XP004276451, ISSN: 0304-4165 *
PETERS CHARLES ET AL: "Ovine bone marrow extracellular matrix and soluble protein extraction: Fetuin amino terminus microheterogeneity", AMERICAN JOURNAL OF THE MEDICAL SCIENCES, vol. 309, no. 5, 1995, pages 285 - 294, XP009042490, ISSN: 0002-9629 *
VITURI C L ET AL: "Alterations in proteins of bone marrow extracellular matrix in undernourished mice", BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, vol. 33, no. 8, August 2000 (2000-08-01), pages 889 - 895, XP009042495, ISSN: 0100-879X *

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