WO2005014026A3 - Use of cxcl6 chemokine in the prevention or repair of cartilage defects - Google Patents

Use of cxcl6 chemokine in the prevention or repair of cartilage defects Download PDF

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Publication number
WO2005014026A3
WO2005014026A3 PCT/BE2004/000117 BE2004000117W WO2005014026A3 WO 2005014026 A3 WO2005014026 A3 WO 2005014026A3 BE 2004000117 W BE2004000117 W BE 2004000117W WO 2005014026 A3 WO2005014026 A3 WO 2005014026A3
Authority
WO
WIPO (PCT)
Prior art keywords
repair
cxcl6
prevention
cartilage
cartilage defects
Prior art date
Application number
PCT/BE2004/000117
Other languages
French (fr)
Other versions
WO2005014026A2 (en
Inventor
Frank Luyten
Bari Cosimo De
Accio Francesco Dell
Original Assignee
Tigenix Nv
Frank Luyten
Bari Cosimo De
Accio Francesco Dell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34135345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005014026(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP04761478A priority Critical patent/EP1653994B1/en
Priority to PL04761478T priority patent/PL1653994T3/en
Priority to AT04761478T priority patent/ATE449608T1/en
Priority to NZ545702A priority patent/NZ545702A/en
Priority to US10/595,072 priority patent/US7485310B2/en
Priority to DE602004024312T priority patent/DE602004024312D1/en
Priority to CA2533124A priority patent/CA2533124C/en
Priority to JP2006522851A priority patent/JP4920412B2/en
Priority to AU2004262451A priority patent/AU2004262451B2/en
Priority to DK04761478.9T priority patent/DK1653994T3/en
Application filed by Tigenix Nv, Frank Luyten, Bari Cosimo De, Accio Francesco Dell filed Critical Tigenix Nv
Publication of WO2005014026A2 publication Critical patent/WO2005014026A2/en
Publication of WO2005014026A3 publication Critical patent/WO2005014026A3/en
Priority to NO20060464A priority patent/NO338152B1/en
Priority to IL173544A priority patent/IL173544A/en
Priority to HK06105628.3A priority patent/HK1085656A1/en
Priority to US12/345,369 priority patent/US7842502B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/195—Chemokines, e.g. RANTES
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention disclosed the expression of CXCL6 by cells which are able to form stable cartilage. The invention describes the use of these cells and of CXCL6 to promote cartilage (and underlying bone) formation e.g. in the repair of cartilage or osteochondral defects. The invention further describes the use of chemokines in the modulation of progenitor cell differentiation.
PCT/BE2004/000117 2003-08-12 2004-08-12 Use of cxcl6 chemokine in the prevention or repair of cartilage defects WO2005014026A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP2006522851A JP4920412B2 (en) 2003-08-12 2004-08-12 Use of CXCL6 chemokine in the prevention or recovery of cartilage tissue defects
DK04761478.9T DK1653994T3 (en) 2003-08-12 2004-08-12 Use of CXCL6 chemokine in the prevention or recovery of cartilage defects
AU2004262451A AU2004262451B2 (en) 2003-08-12 2004-08-12 Use of CXCL6 chemokine in the prevention or repair of cartilage defects
NZ545702A NZ545702A (en) 2003-08-12 2004-08-12 Use of CXCL6 chemokine in the prevention or repair of cartilage defects
PL04761478T PL1653994T3 (en) 2003-08-12 2004-08-12 Use of cxcl6 chemokine in the prevention or repair of cartilage defects
DE602004024312T DE602004024312D1 (en) 2003-08-12 2004-08-12 USE OF CXCL6 CHEMOKIN IN THE PREVENTION OR REPAIR OF CARTILAGE DEFECTS
CA2533124A CA2533124C (en) 2003-08-12 2004-08-12 Use of cxcl6 chemokine in the prevention or repair of cartilage defects
EP04761478A EP1653994B1 (en) 2003-08-12 2004-08-12 Use of cxcl6 chemokine in the prevention or repair of cartilage defects
AT04761478T ATE449608T1 (en) 2003-08-12 2004-08-12 USE OF CXCL6 CHEMOKINE IN PREVENTING OR REPAIRING CARTILAGE DEFECTS
US10/595,072 US7485310B2 (en) 2003-08-12 2004-08-12 Use of CXCL6 chemokine in the prevention or repair of cartilage defects
NO20060464A NO338152B1 (en) 2003-08-12 2006-01-30 The use of CXCL6 chemokine in the prevention or repair of cartilage defects
IL173544A IL173544A (en) 2003-08-12 2006-02-05 Use of cxcl6 in the preparation of a medicament for the promotion of cartilage and/or bone formation
HK06105628.3A HK1085656A1 (en) 2003-08-12 2006-05-16 Use of cxcl6 chemokine in the prevention or repair of cartilage defects
US12/345,369 US7842502B2 (en) 2003-08-12 2008-12-29 Use of CXCL6 chemokine for inducing precursor cells into chondrocytes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49451603P 2003-08-12 2003-08-12
US60/494,516 2003-08-12

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/595,072 A-371-Of-International US7485310B2 (en) 2003-08-12 2004-08-12 Use of CXCL6 chemokine in the prevention or repair of cartilage defects
US12/345,369 Division US7842502B2 (en) 2003-08-12 2008-12-29 Use of CXCL6 chemokine for inducing precursor cells into chondrocytes

Publications (2)

Publication Number Publication Date
WO2005014026A2 WO2005014026A2 (en) 2005-02-17
WO2005014026A3 true WO2005014026A3 (en) 2005-03-17

Family

ID=34135345

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BE2004/000117 WO2005014026A2 (en) 2003-08-12 2004-08-12 Use of cxcl6 chemokine in the prevention or repair of cartilage defects

Country Status (16)

Country Link
US (2) US7485310B2 (en)
EP (1) EP1653994B1 (en)
JP (1) JP4920412B2 (en)
AT (1) ATE449608T1 (en)
AU (1) AU2004262451B2 (en)
CA (1) CA2533124C (en)
DE (1) DE602004024312D1 (en)
DK (1) DK1653994T3 (en)
ES (1) ES2337469T3 (en)
HK (1) HK1085656A1 (en)
IL (1) IL173544A (en)
NO (1) NO338152B1 (en)
NZ (1) NZ545702A (en)
PL (1) PL1653994T3 (en)
RU (1) RU2363491C2 (en)
WO (1) WO2005014026A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067123B2 (en) * 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US20050222687A1 (en) * 2004-04-02 2005-10-06 Gordana Vunjak-Novakovic Cartilage implant assembly and method for implantation
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20090291112A1 (en) * 2003-05-16 2009-11-26 Truncale Katherine G Allograft osteochondral plug combined with cartilage particle mixture
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20080220044A1 (en) * 2007-03-06 2008-09-11 Semler Eric J Cancellous construct with support ring for repair of osteochondral defects
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
EP1926459B1 (en) 2005-09-19 2015-01-07 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
EP2224884A2 (en) * 2007-12-05 2010-09-08 Musculoskeletal Transplant Foundation Cancellous bone implant for cartilage repair
WO2009111069A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
EP2331581A1 (en) 2008-09-22 2011-06-15 Arcarios B.V. Carboxyethylated cyclodextrin polysulfates useful as medicaments
GB0820492D0 (en) 2008-11-07 2008-12-17 Sportcell Cell compositions and uses thereof
DK2459224T3 (en) * 2009-07-27 2016-07-25 Baxalta GmbH Blodstørkningsproteinkonjugater
US8808682B2 (en) * 2009-10-23 2014-08-19 Rnl Bio Co., Ltd Method for inducing migration of adipose-derived adult stem cells
US8687070B2 (en) * 2009-12-22 2014-04-01 Apple Inc. Image capture device having tilt and/or perspective correction
CA2901340C (en) 2013-03-15 2019-04-09 W. L. Gore & Associates, Inc. Aqueous delivery system for low surface energy structures
WO2014160932A1 (en) * 2013-03-29 2014-10-02 Merrimack Pharmaceuticals, Inc. Compositions and methods for treating osteolytic bone disorders
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CN116904520B (en) * 2023-09-13 2024-01-09 中国人民解放军军事科学院军事医学研究院 Method for preparing recombinant cartilage progenitor cells, obtained recombinant cartilage progenitor cells and application

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786217A (en) * 1994-05-05 1998-07-28 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US6410268B1 (en) * 1996-03-18 2002-06-25 Human Genome Sciences, Inc. Polynucleotides encoding chemokine alpha-3
US6413511B1 (en) * 1990-12-20 2002-07-02 University Of Pittsburgh Of The Commonwealth System Of Higher Education Cartilage alterations by administering to joints chondrocytes comprising a heterologous polynucleotide
US20020123483A1 (en) * 2001-03-05 2002-09-05 Geeta Saxena IL-8 receptor ligands - drugs for inflammatory and autoimmune diseases
EP1312614A1 (en) * 2001-11-16 2003-05-21 GenOdyssee Polynucleotides and polypeptides of the GCP-2 gene

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AU5628394A (en) * 1992-11-27 1994-06-22 Rega Institute Leuven University Granulocyte chemotactic protein
GB9502022D0 (en) 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
DE19814405C2 (en) * 1998-03-31 2000-03-02 Schastak Astrid Porphyrins and their use as photosensitizers
JP2005500847A (en) * 2001-08-24 2005-01-13 アドバンスド セル テクノロジー、インコーポレイテッド Screening assay for identification of differentiation inducers and preparation of differentiated cells for cell therapy
JP2003199816A (en) * 2002-01-10 2003-07-15 Takehisa Matsuda Auxiliary material for regenerating cartilaginous tissue, kit for regenerating cartilaginous tissue and method for regenerating cartilaginous tissue
EP2298908B1 (en) * 2002-07-26 2014-08-20 Ajinomoto Co., Inc. Novel peptide-forming enzyme gene
AU2004252567B2 (en) * 2003-06-27 2011-10-06 Ethicon, Incorporated Repair and regeneration of ocular tissue using postpartum-derived cells

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
US6413511B1 (en) * 1990-12-20 2002-07-02 University Of Pittsburgh Of The Commonwealth System Of Higher Education Cartilage alterations by administering to joints chondrocytes comprising a heterologous polynucleotide
US5786217A (en) * 1994-05-05 1998-07-28 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US6410268B1 (en) * 1996-03-18 2002-06-25 Human Genome Sciences, Inc. Polynucleotides encoding chemokine alpha-3
US20020123483A1 (en) * 2001-03-05 2002-09-05 Geeta Saxena IL-8 receptor ligands - drugs for inflammatory and autoimmune diseases
EP1312614A1 (en) * 2001-11-16 2003-05-21 GenOdyssee Polynucleotides and polypeptides of the GCP-2 gene

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WUYTS ANJA ET AL: "The CXC chemokine GCP-2/CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma: Comparison with interleukin-8/CXCL8.", LABORATORY INVESTIGATION, vol. 83, no. 1, January 2003 (2003-01-01), pages 23 - 34, XP002314496, ISSN: 0023-6837 *

Also Published As

Publication number Publication date
NO338152B1 (en) 2016-08-01
RU2006107536A (en) 2006-08-10
ATE449608T1 (en) 2009-12-15
US20060246031A1 (en) 2006-11-02
CA2533124C (en) 2014-01-28
AU2004262451B2 (en) 2009-11-26
NZ545702A (en) 2008-08-29
AU2004262451A1 (en) 2005-02-17
HK1085656A1 (en) 2006-09-01
ES2337469T3 (en) 2010-04-26
EP1653994B1 (en) 2009-11-25
DE602004024312D1 (en) 2010-01-07
EP1653994A2 (en) 2006-05-10
JP2007501807A (en) 2007-02-01
NO20060464L (en) 2006-04-20
US7485310B2 (en) 2009-02-03
DK1653994T3 (en) 2010-03-15
CA2533124A1 (en) 2005-02-17
US7842502B2 (en) 2010-11-30
PL1653994T3 (en) 2010-05-31
JP4920412B2 (en) 2012-04-18
WO2005014026A2 (en) 2005-02-17
RU2363491C2 (en) 2009-08-10
US20090117652A1 (en) 2009-05-07
IL173544A (en) 2013-12-31
IL173544A0 (en) 2006-07-05

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