WO2005016936A3 - Process for selective preparation of z-isomer of cefditoren and pharmaceutically acceptable salts and esters thereof - Google Patents

Process for selective preparation of z-isomer of cefditoren and pharmaceutically acceptable salts and esters thereof Download PDF

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Publication number
WO2005016936A3
WO2005016936A3 PCT/IB2004/002648 IB2004002648W WO2005016936A3 WO 2005016936 A3 WO2005016936 A3 WO 2005016936A3 IB 2004002648 W IB2004002648 W IB 2004002648W WO 2005016936 A3 WO2005016936 A3 WO 2005016936A3
Authority
WO
WIPO (PCT)
Prior art keywords
cefditoren
isomer
esters
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
PCT/IB2004/002648
Other languages
French (fr)
Other versions
WO2005016936A2 (en
Inventor
Yatendra Kumar
Mohan Prasad
Kaptan Singh
Ashok Prasad
Santosh Richhariya
Original Assignee
Ranbaxy Lab Ltd
Yatendra Kumar
Mohan Prasad
Kaptan Singh
Ashok Prasad
Santosh Richhariya
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Yatendra Kumar, Mohan Prasad, Kaptan Singh, Ashok Prasad, Santosh Richhariya filed Critical Ranbaxy Lab Ltd
Priority to EP04744275A priority Critical patent/EP1660505A2/en
Publication of WO2005016936A2 publication Critical patent/WO2005016936A2/en
Publication of WO2005016936A3 publication Critical patent/WO2005016936A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Abstract

The present invention relates to a selective process for preparation of Z-isomer of cefditoren of Formula I and pharmaceutically acceptable salts and esters thereof. cefditoren possesses a wide spectrum of antibacterial activity against Gram-positive and Gram-negative bacteria.
PCT/IB2004/002648 2003-08-14 2004-08-13 Process for selective preparation of z-isomer of cefditoren and pharmaceutically acceptable salts and esters thereof WO2005016936A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04744275A EP1660505A2 (en) 2003-08-14 2004-08-13 Process for selective preparation of z-isomer of cefditoren and pharmaceutically acceptable salts and esters thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1004DE2003 2003-08-14
IN1004/DEL/2003 2003-08-14

Publications (2)

Publication Number Publication Date
WO2005016936A2 WO2005016936A2 (en) 2005-02-24
WO2005016936A3 true WO2005016936A3 (en) 2005-08-11

Family

ID=34179269

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/002648 WO2005016936A2 (en) 2003-08-14 2004-08-13 Process for selective preparation of z-isomer of cefditoren and pharmaceutically acceptable salts and esters thereof

Country Status (2)

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EP (1) EP1660505A2 (en)
WO (1) WO2005016936A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005003141A2 (en) 2003-07-04 2005-01-13 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of cefditoren
WO2005100369A1 (en) * 2004-04-13 2005-10-27 Ranbaxy Laboratories Limited Depletion of e-isomers in preparation of z-enriched 3-(2-substituted vinyl) cephalosporins
JP4064948B2 (en) 2004-06-04 2008-03-19 明治製菓株式会社 3-Alkenylcephem compound and production method
WO2011093294A1 (en) * 2010-01-27 2011-08-04 日本化学工業株式会社 Process for preparation of cephalosporin derivative
CN104513256B (en) * 2013-10-07 2018-07-31 鲁南贝特制药有限公司 A kind of preparation method of Cefditoren pivoxil Cephalosporins
CN103665002B (en) * 2013-12-18 2016-02-03 成都医路康医学技术服务有限公司 A kind of preparation method of Cefditoren pivoxil Cephalosporins
CN104788471B (en) * 2015-03-23 2017-06-27 浙江华方药业股份有限公司 A kind of synthetic method of Cefditoren pivoxil Cephalosporins parent nucleus
CN105175432B (en) * 2015-09-09 2017-05-24 山东罗欣药业集团股份有限公司 Preparation method of cefditore
CN106366097A (en) * 2016-08-19 2017-02-01 陕西思尔生物科技有限公司 Preparation method of cefditoren pivoxil
CN108997377B (en) * 2018-07-27 2020-04-28 湖北凌晟药业有限公司 Preparation method of E-type 7-ATCA
CN110655527A (en) * 2019-09-20 2020-01-07 北京济美堂医药研究有限公司 Preparation method of high-purity cefditoren pivoxil
CN113788844A (en) * 2021-09-08 2021-12-14 湖北凌晟药业有限公司 Preparation method of E-type cefditoren sodium

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839350A (en) * 1984-09-07 1989-06-13 Meiji Seika Kaisha, Ltd. Cephalosporin compounds and the production thereof
US4918068A (en) * 1986-03-03 1990-04-17 Meiji Seika Kaisha, Ltd. Cephem compounds
US5233035A (en) * 1989-09-26 1993-08-03 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin derivatives
EP0597429A2 (en) * 1992-11-10 1994-05-18 Biochemie Gesellschaft M.B.H. Process for the production of 3-vinylcephalosporins
EP0658558A1 (en) * 1993-11-17 1995-06-21 Biochemie Gesellschaft M.B.H. Separation of cephalosporin isomers
EP0723965A1 (en) * 1993-09-29 1996-07-31 Meiji Seika Kaisha Ltd. Novel cephalosporin derivative
EP1016665A1 (en) * 1997-06-24 2000-07-05 Meiji Seika Kaisha, Ltd. Process for the selective preparation of z-isomers of 3-(2-substituted vinyl)cephalosporins
US20020002279A1 (en) * 1996-09-20 2002-01-03 Kiyoshi Yasui Crystalline substance of cefditoren pivoxyl and the production of the same
WO2003091230A1 (en) * 2002-04-26 2003-11-06 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of 4-methyl-thiazole-5-carbaldehyde intermediate

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839350A (en) * 1984-09-07 1989-06-13 Meiji Seika Kaisha, Ltd. Cephalosporin compounds and the production thereof
US4918068A (en) * 1986-03-03 1990-04-17 Meiji Seika Kaisha, Ltd. Cephem compounds
US5233035A (en) * 1989-09-26 1993-08-03 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin derivatives
EP0597429A2 (en) * 1992-11-10 1994-05-18 Biochemie Gesellschaft M.B.H. Process for the production of 3-vinylcephalosporins
EP0723965A1 (en) * 1993-09-29 1996-07-31 Meiji Seika Kaisha Ltd. Novel cephalosporin derivative
EP0658558A1 (en) * 1993-11-17 1995-06-21 Biochemie Gesellschaft M.B.H. Separation of cephalosporin isomers
US20020002279A1 (en) * 1996-09-20 2002-01-03 Kiyoshi Yasui Crystalline substance of cefditoren pivoxyl and the production of the same
EP1016665A1 (en) * 1997-06-24 2000-07-05 Meiji Seika Kaisha, Ltd. Process for the selective preparation of z-isomers of 3-(2-substituted vinyl)cephalosporins
WO2003091230A1 (en) * 2002-04-26 2003-11-06 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of 4-methyl-thiazole-5-carbaldehyde intermediate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KENJI SAKAGAMI ET AL.: "Synthesis and Oral Activity of ME1207, a New Orally Active Cephalosporin", THE JOURNAL OF ANTIBIOTICS, vol. XLIII, no. 8, 1990, pages 1047 - 1050, XP009049100 *
SAKAGAMI K ET AL: "SYNTHESIS AND ORAL ACTIVITY OF PIVALOYLOCYMETHYL7-Ä(Z)-2-(2-AMINOTHIA ZOL-4-YL)-2-METHOXYIMINOACETAMIDOÜ-3-(Z)-(4-METHYLTHIAZOL-5-YL)VINYL- 3-CEPHEM-4-CARBOXYLATE (ME1207) AND ITS RELATED COMPOUND", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 39, no. 9, September 1991 (1991-09-01), pages 2433 - 2436, XP009042230, ISSN: 0009-2363 *

Also Published As

Publication number Publication date
EP1660505A2 (en) 2006-05-31
WO2005016936A2 (en) 2005-02-24

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