WO2005018469A1 - Apparatus for improved shock-wave lithotripsy (swl) using a piezoelectric annular array (peaa) shock-wave generator in combination with a primary shock wave - Google Patents
Apparatus for improved shock-wave lithotripsy (swl) using a piezoelectric annular array (peaa) shock-wave generator in combination with a primary shock wave Download PDFInfo
- Publication number
- WO2005018469A1 WO2005018469A1 PCT/US2003/025305 US0325305W WO2005018469A1 WO 2005018469 A1 WO2005018469 A1 WO 2005018469A1 US 0325305 W US0325305 W US 0325305W WO 2005018469 A1 WO2005018469 A1 WO 2005018469A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- shock wave
- wave source
- primary
- piezoelectric
- primary shock
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
-
- G—PHYSICS
- G10—MUSICAL INSTRUMENTS; ACOUSTICS
- G10K—SOUND-PRODUCING DEVICES; METHODS OR DEVICES FOR PROTECTING AGAINST, OR FOR DAMPING, NOISE OR OTHER ACOUSTIC WAVES IN GENERAL; ACOUSTICS NOT OTHERWISE PROVIDED FOR
- G10K15/00—Acoustics not otherwise provided for
- G10K15/04—Sound-producing devices
- G10K15/043—Sound-producing devices producing shock waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B2017/22005—Effects, e.g. on tissue
- A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
- A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B2017/22027—Features of transducers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B2017/22027—Features of transducers
- A61B2017/22028—Features of transducers arrays, e.g. phased arrays
Definitions
- the present invention relates to a method for disintegration of concretions in vivo with reduced tissue injury, by the forced concentration of acoustically induced transient cavitation energy towards the target concretion through use of a piezoelectric annular array shock-wave generator of particular design in combination with a primary shock wave source.
- 4,888,746 disclose the use of piezoelectric elements arranged in mosaic form on a spheroidal cap to produce focused high-intensity shock waves at the geometric center of the cap, where the concretion must be placed.
- Many other shock wave generating systems are known in the art. Despite the different principles used for shock wave generation, all of these devices produce shock waves of a similar waveform, which can be characterized by a compressive phase consisting of a rapid shock front with a positive peak pressure up to 100 MPa, followed by a rarefaction (negative) phase with a negative peak pressure up to 10 MPa and with a few microseconds duration.
- the collapse of a cavitation bubble cluster can be controlled so as to cause increased concretion comminution by imposing an impinging shock wave of appropriate shape and intensity to collapse the bubble cluster from its outer layer into an inner layer collectively.
- the collapse of a cavitation bubble by an impinging shock wave is found to be asymmetric, leading to the formation of a liquid jet which travels along the direction of the impinging shock wave. When occurring in waterthe liquid jet will be a water jet. It has been discovered in the past that the collapse of a cavitation bubble can be controlled and guided by an incident shock wave, provided that this shock wave is applied at the correct time in the life of a cavitation bubble.
- Cathiqnol et al. in U.S. Patent No. 5,219,401 disclose an apparatus for the selective destruction of biological materials, including cells, soft tissues, and bones.
- the injection of gas bubble precursor microcapsules, having diameters preferably in the 0.5 to 300 micron range and made from materials such as lecithin, into the blood stream is used by Cathiqnol et al. as the primary means of generating gas bubbles in vivo.
- the phenomenon of cavitation provoked by an ultrasonic wave generator working in a frequency range of 10 to 100 kHz is described, the sonic pulse sequence is not specified.
- 4,664,111 discloses a shock wave tube for generating time-staggered shock waves by means of a splitting device, such as a cone, for the fragmentation of concrements in vivo.
- Reichenberger discloses that the effects of the shock waves can be improved if they are so closely spaced in time that they overlap in their action on the concrement. The effects of shock wave induced cavitation are not considered or mentioned by Reichenberger.
- none of the prior art described hereinabove teaches the use of a secondary shock wave, imposed at a specified time delay, to control the collapse of a transient cavitation bubble cluster induced by a primary shock wave.
- 5,582,578 provides such a method for generating a sequence of shock wave pulses with a specified very short time delay (less than 400 microseconds), and with pressure relationships between the individual pulses that provide both a means of inducing a transient cavitation cluster, and a means of controlling the growth and subsequent collapse of the cavitation bubble cluster near the target concretions in vivo, to achieve increased fragmentation efficiency with reduced tissue injury.
- a shock wave generator comprising a piezoelectric annular array (PEAA) shock-wave generator that can be retrofitted on a clinical (for example, a DORNIER HM-3) lithotripter to generate a sequence of shock wave pulses.
- the PEAA generator was intended to produce an auxiliary shock wave to control and force the collapse of Iithotripter-induced bubbles toward the target concretion for improved stone comminution.
- a prototype PEAA generator was combined with an experimental electrohydraulic (EH) shock- wave lithotripter with a truncated HM-3 reflector in previous experiments.
- the present invention provides an improved apparatus and method for generating a sequence of shock-wave pulses with a specified very short time delay, and with pressure relationships between the individual pulses that provide a means of inducing a transient cavitation cluster, and a means of controlling the growth and subsequent collapse of the cavitation bubble cluster near the target concretions in vivo, to achieve increased fragmentation efficiency with reduced tissue injury.
- Figure 1 shows a concretion in a living body and a prior art Shockwave generation system generating two Shockwave pulses in sequence separated by a specified time delay for the comminution of concretions inside a living body
- Figure 2 shows two Shockwave pulses in sequence separated by specified time delay of 50 - 400 microseconds ( ⁇ s) to induce, by the tensile phase of the first shock wave pulse, a transient acoustic cavitation bubble cluster near a target concretion and to collapse, by the second shock wave pulse, the induced cavitation bubble cluster after it expands to its maximum size, to concentrate the cavitation energy in the form of liquid microjets towards the target concretion for improved fragmentation efficiency with reduced tissue injury (prior art);
- Figure 3 is a front elevation view of a prior art combined electrohydraulic and piezoelectric annular array Shockwave generator wherein the piezoelectric annular array generator consists of eight individual transducers arranged
- FIG. 6A is a schematic vertical cross-sectional view of the improved combined electrohydraulic (EH) and piezoelectric annular array (PEAA) generator of the present invention
- Figure 6B is a schematic front elevation view of the improved apparatus shown in Figure 6A.
- EH electrohydraulic
- PEAA piezoelectric annular array
- the shock wave pulses 1 , 2 are produced by a shock wave generation system 6 and aimed confocally at a target concretion 4 inside a living being 5, for the comminution of the target concretion 4 with improved fragmentation efficiency and reduced tissue injury.
- These two pulses consist, respectively, of a first shock wave pulse 1 and second shock wave pulse 2, separated in time by a time delay ⁇ t 3. It has been discovered that for optimal effect, this delay should be 50 to 400 microseconds ( ⁇ s).
- the pressure waveform 7 of the first Shockwave pulse 1 consists of a compressive phase with a positive peak pressure amplitude in the 20 to 100 million pascals (MPa) range and with a positive duration of 1 to 2 microseconds, followed by a tensile phase with a negative peak pressure amplitude of minus 1 to minus 10 MPa and with a duration of 2 to 5 microseconds.
- the pressure waveform 8 of the second shock wave pulse 2 consists of essentially a compressive phase with a positive peak pressure amplitude of 2 to 100 MPa and a duration of 5 to 40 microseconds.
- the time delay ⁇ t 3 between the first shock wave pulse 1 and the second shock wave pulse 2 should be in a range of 50 to 400 microseconds for achieving improved stone comminution and reduction in tissue damage.
- the tensile phase of the first shock wave pulse 1 is used to induce a transient cavitation bubble cluster 9 near a concretion 4 surface, with the induced cavitation bubble cluster 9 growing to its maximum size in 50 to 400 microseconds, depending on the intensity of the first shock wave pulse 1.
- the second shock wave pulse 2, separated from the first shock wave pulse 1 by a specified time delay is used to collapse the cavitation bubble cluster 9 at its maximum expansion, leading to a concerted collapse of the cavitation bubble cluster 9 towards the target concretion 4.
- This forced collapse has been found to result in the formation of high-speed liquid jets 10 impinging towards the target concretion 4 and to cause disintegration of the stone 4 with increased rapidity as compared to the uncontrolled collapse of the cavitation bubble cluster.
- the first shock wave pulse 1 can be generated by an electrohydraulic device, utilizing a spark gap discharge in water within an ellipsoidal reflector, such as the apparatus disclosed by Hoff et al. in U.S. Patent No. 3,942,531.
- Electromagnetic shock wave generators may also be used such as the apparatus disclosed by Hahn et al. in U.S. Patent No. 4,655,220.
- piezoelectric Shockwave generators are equally well known to those skilled in the art and may also be used, such as the apparatus disclosed by Wurster et al. in U.S. Patent No. 4,821 ,730.
- These previously disclosed devices generate a distribution of high-intensity shock waves in a focal volume embracing the target concretions 4. It is well known in the art that the beam diameter of the shock wave pulses in the focal plane and the depth of focus along the shock wave axis are in the range of 2 to 15, and 12 to 120 mm, respectively.
- the second shock wave pulse 2 can be generated piezoeletrically by the superposition of individual shock wave pulses of different amplitudes, frequencies and phases, as disclosed by Wurster et al. in U.S. Patent No. 4,888,746.
- Wurster et al. disclose a focussing ultrasound transducer comprising of mosaic assemblies of piezoelectric materials mounted on an inner surface of a spherical cap, with the energizing of individual piezoelectric elements being controlled electronically.
- the prototype PEAA generator consisted of eight individual transducers 112 assembled in an annular format on a supporting frame 114 that connects mechanically to the EH source 110.
- DORNIER HM-3 reflector not shown
- the combined shock-wave generator 100 was mounted horizontally in a Plexiglas tank (51 x 64 x 76, H x W X L cm) filled with degassed (O 2 concentration ⁇ 4 mg/L) and deionized water.
- Figure 4 shows a schematic diagram of the previously developed experimental lithotripter and the high-speed imaging system used for characterization of the in situ shock wave-bubble interaction generated by the combined EH/PEAA shock-wave generator 100.
- the PEAA generators 120 and EH generator 110 were energized individually by two independent high-voltage pulse generators 116 of local design.
- the pulse generator for the PEAA source used a 0.5 ⁇ F capacitor and a discharge voltage adjustable between 10 and 20 kV; the pulse generator for the EH source used two 40-nF capacitors in parallel, and operated between 20 and 30 kV with a standard DORNIER electrode.
- the PEAA generator 120 was operated at 15 kV, and the EH generator 110 at 24 kV, either individually or combined. Both generators were shielded and grounded to reduce the emission of electromagnetic noise produced by the high-voltage discharge.
- trigger signals for the generators were provided by optical-to-electrical converters through optical fibers to prevent cross-talking between the two shock-wave sources in operation.
- the EH source 110 was fired first.
- the spark discharge from the electrode was then picked up by a fast photodetector 118 (PDA450, Thorlabs, Newton, NJ) and relayed through a digital delay generator 122 (DG535, Stanford Research Systems, Sunnyvale, CA) to provide a time-delayed signal to trigger the PEAA generator 120.
- the jitter for the PEAA generator 120 was found to be less than 5 ⁇ s. Because bubbles induced by an EH lithotripter usually expand and then collapse within 200 to 400 ⁇ s, the shock wave produced by the PEAA generator 120 could be used reliably to interact with the bubbles at different stages of their oscillation.
- the pressure waveform produced by either the PEAA 120 or EH 110 source individually was measured using a calibrated polyvinylidene difluoride (PVDF) membrane hydrophone 124 (Sonic Industries, Halboro, PA) that had a frequency bandwidth of 20 MHz, a minimal rise time resolution of 11 ns and a sensitivity of 6.8 kPa/mV.
- PVDF polyvinylidene difluoride
- the PVDF hydrophone was scanned at 1 - or 2-mm steps, either along or transverse to the shock-wave axis.
- the output signal of the hydrophone was recorded on a LECROY digital oscilloscope 126 (Model 9314) at 100 MHz sampling rate.
- the -6-dB beam diameter of the focused hydrophone was estimated to be about 3 mm, so that bubble activity within a small volume around F2 could be detected.
- the focused hydrophone was aligned perpendicular to the lithotripter axis and confocally with F 2 .
- Figure 5 shows an example of the typical acoustic emission (AE) signals associated with the bubble oscillation produced by the EH 110 and PEAA 120 source, respectively.
- AE acoustic emission
- the first burst (1°) represents the initial compression and subsequent rapid expansion of pre- existing cavitation nuclei by the incident shock wave
- the second burst (2°) corresponds to the primary collapse of the bubble cluster
- a distinctive third burst (3°) corresponding to the subsequent collapse of large rebound bubbles, could also be identified. Because of the distinct burst structure, the collapse time of the bubbles with respect to the arrival of the lithotripter shock wave at F2 (T ⁇ -2 for the bubble cluster and T ⁇ -3 for the rebound bubbles) could be easily measured. Subsequently, corresponding values for the EH source 110 were used to control the trigger of the PEAA generator 120, so that forced collapse of the bubbles could be produced at various stages of their oscillation.
- a PEAA generator 120 that is combined with an experimental EH lithotripter 110, it was previously demonstrated in vitro that stone fragmentation could be significantly improved when appropriate shock-wave sequence was used.
- the auxiliary shock wave produced by the PEAA generator 120 was on the order of 8 MPa in peak positive pressure, which, acting by itself, is not sufficiently strong to produce stone fragmentation.
- this auxiliary shock wave was found to greatly intensify the collapse of lithotripter-induced bubbles near the stone surface, leading to significantly improved stone comminution.
- an array of six focused sets of piezoelectric elements 212 is positioned around the reflector R and the axis of a primary shock wave source 210 to form combined shock-wave generator 200 although between 6 and 2000 piezoelectric elements 212 could be used.
- Alternative positioning of the piezoelectric elements is also possible provided they are operatively associated with the circumference of the reflector of the primary shock wave source.
- the piezoelectric element consists of piezoceramics embedded in epoxy resin to form composite piezoelectric blocks.
- each individual composite piezoelectric block must be itself made spherically concave and focused on a convergence spot that is essentially congruent with the target concretion. Furthermore the ensemble of piezoelectric block elements must also be focused in such a way that each individually focused piezoelectric block element does not interfere with the output of any other piezoelectric block element. It has been discovered that the piezoelectric elements 212 are preferably arranged in a spherically concave configuration around the reflector R of the primary shock wave source 210. In this preferred embodiment, six such elements 212 are used. However, as few as two elements or as many as twenty elements 212 may be used.
- Peak pressure from 9 to 30 MPa is produced by the ensemble of piezoelectric elements 212 at the focus of the primary shock wave source 210.
- this peak pressure produced by the piezoelectric elements be produced within at least 401 ⁇ s, but less than 1000 ⁇ s after the peak pressure of the primary shock wave source is produced although a range of 10 ⁇ s to 1000 ⁇ s is possible.
- the primary shock wave source 210 is an electrohydraulic spark generator.
- an electromagnetic shock wave generator can also be used.
- the primary shock wave source 210 produce a peak pressure of at least 20 MPa, but less than 130 MPa.
- the duration of the tensile component of the primary shock wave must be at least 2 ⁇ s, but less than 10 ⁇ s.
- the duration of the compressive component of the primary shock wave must be at least 0.5 ⁇ s, but less than 3 ⁇ s.
- the array of piezoelectric elements 212 and the primary shock wave source 210 are additionally provided with at least two self-focused hydrophones H that are confocally aligned with the primary shock wave focus and with the piezoelectric shock wave focus.
- the self-focused hydrophones H are PANAMETRICS hydrophones whose focal length is 150 mm and whose nominal element diameters is 37.5 mm.
- the preferred embodiment operates as follows: the primary shock wave source 210 is trigged to generate a shock wave that induces cavitation bubbles around the targeted kidney stones, which are located at the focus of the primary Shockwave source. The duration of the bubble oscillation (expansion and collapse) is determined from the acoustic emission signals picked up by the two self-focused hydrophones H, which are aligned confocally with the primary shock wave source 210.
- This acoustic emission information is used to determine the interpulse delay between the shock waves generated by the primary shock wave source 210 and those generated by the piezoelectric elements 212. Improved stone comminution is achieved when the Shockwave produced by the piezoelectric elements 212 arrive at the focus of the primary shock wave during the collapse phase of the cavitation bubbles produced by the primary shock wave 210. In this way, it has been found that intensified collapse of cavitation bubbles towards the target kidney stones is produced, leading to improved comminution of the targeted kidney stones.
- prior research using a combined EH/PEAA shock-wave generator 100 with optimal pulse sequence resulted in significant enhancement in stone comminution in vitro.
- the concretion By focusing high-pressure acoustic impulses on a human concretion in a living body, the concretion may be fragmented by means of both sound pressure effects and cavitation bubble effects. It has been found that a secondary acoustic pulse, of intensity not high enough to cause stone fragmentation by itself, if properly timed with respect to the initial acoustic pulse, can cause the cavitation bubbles produced by the high-intensity initial pulse to collapse towards the concretion before reaching a size large enough to burst capillary vessels. It has now been discovered that an improved shock wave lithotripter apparatus for comminuting renal concretions may be made by combining a primary shock wave source, whether it is electrohydraulic or electromagnetic, with secondary Shock wave sources.
- the second shock wave sources of a particular type and arrangement when mounted on the circumference of the reflector which is used to focus the acoustic impulses from the electrohydraulic shock wave source on renal concretions can under particular conditions produce improved stone comminution in wVo with reduced tissue injury.
- the primary shock wave source has a maximum pressure that produces cavitation bubbles around the focus of the primary shock wave source.
- piezoelectric generators are oriented to have a common convergence spot, which is congruent with the focus of the primary shock wave source.
- Each of these piezoelectric generators consists of at least one spherically concave piezoelectric element. By making each piezoelectric element spherically concave, the acoustic impulse that each produces must itself be focused on the target concretion. Flat piezoelectric elements cannot themselves be individually focused.
- the plurality of piezoelectric generators should comprise between 2 and 2000 piezoelectric elements although six piezoelectric elements may be advantageous in terms of the combined consideration of economics and physical effects.
- These combined piezoelectric generators should provide a peak pressure between 9 and 30 MPa near the target concretions in order to be effective, and in addition, should produce this peak pressure with a time delay within the range of 10 to 1000 ⁇ s after the peak pressure of the primary Shockwave source is produced, although 401 to 1000 ⁇ s can be advantageous in certain cases.
- the primary shock wave source should produce a peak pressure between 20 and 130 MPa and have a tensile component with a pulse duration between 2 and 10 ⁇ s and a compressive component with a pulse duration between 0.5 and 3 ⁇ s in order to generate a profusion of cavitation bubbles.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03818331A EP1701659A4 (en) | 2003-08-14 | 2003-08-14 | Apparatus for improved shock-wave lithotripsy (swl) using a piezoelectric annular array (peaa) shock-wave generator in combination with a primary shock wave |
DE10394286T DE10394286T5 (en) | 2003-08-14 | 2003-08-14 | Apparatus for improved shockwave renal fragmentation (SWL) using a piezoelectric ring assembly (PEAA) shockwave generator in combination with a primary shockwave source |
PCT/US2003/025305 WO2005018469A1 (en) | 2003-08-14 | 2003-08-14 | Apparatus for improved shock-wave lithotripsy (swl) using a piezoelectric annular array (peaa) shock-wave generator in combination with a primary shock wave |
AU2003262631A AU2003262631A1 (en) | 2003-08-14 | 2003-08-14 | Apparatus for improved shock-wave lithotripsy (swl) using a piezoelectric annular array (peaa) shock-wave generator in combination with a primary shock wave |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2003/025305 WO2005018469A1 (en) | 2003-08-14 | 2003-08-14 | Apparatus for improved shock-wave lithotripsy (swl) using a piezoelectric annular array (peaa) shock-wave generator in combination with a primary shock wave |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005018469A1 true WO2005018469A1 (en) | 2005-03-03 |
Family
ID=34215308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/025305 WO2005018469A1 (en) | 2003-08-14 | 2003-08-14 | Apparatus for improved shock-wave lithotripsy (swl) using a piezoelectric annular array (peaa) shock-wave generator in combination with a primary shock wave |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1701659A4 (en) |
AU (1) | AU2003262631A1 (en) |
DE (1) | DE10394286T5 (en) |
WO (1) | WO2005018469A1 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006021049A1 (en) * | 2006-05-05 | 2007-11-08 | Siemens Ag | Shock wave head for a shock wave treatment device and method for fragmentation and control of fragmentation of a fragmentation object located in an examination subject |
WO2010043190A1 (en) * | 2008-10-18 | 2010-04-22 | Gosbert Weth | Pulse wave generator |
WO2015003142A1 (en) | 2013-07-03 | 2015-01-08 | Histosonics, Inc. | Histotripsy excitation sequences optimized for bubble cloud formation using shock scattering |
US9636133B2 (en) | 2012-04-30 | 2017-05-02 | The Regents Of The University Of Michigan | Method of manufacturing an ultrasound system |
US9642634B2 (en) | 2005-09-22 | 2017-05-09 | The Regents Of The University Of Michigan | Pulsed cavitational ultrasound therapy |
US9833373B2 (en) | 2010-08-27 | 2017-12-05 | Les Solutions Médicales Soundbite Inc. | Mechanical wave generator and method thereof |
US9901753B2 (en) | 2009-08-26 | 2018-02-27 | The Regents Of The University Of Michigan | Ultrasound lithotripsy and histotripsy for using controlled bubble cloud cavitation in fractionating urinary stones |
US9943708B2 (en) | 2009-08-26 | 2018-04-17 | Histosonics, Inc. | Automated control of micromanipulator arm for histotripsy prostate therapy while imaging via ultrasound transducers in real time |
US10071266B2 (en) | 2011-08-10 | 2018-09-11 | The Regents Of The University Of Michigan | Lesion generation through bone using histotripsy therapy without aberration correction |
US10219815B2 (en) | 2005-09-22 | 2019-03-05 | The Regents Of The University Of Michigan | Histotripsy for thrombolysis |
US10780298B2 (en) | 2013-08-22 | 2020-09-22 | The Regents Of The University Of Michigan | Histotripsy using very short monopolar ultrasound pulses |
US11058399B2 (en) | 2012-10-05 | 2021-07-13 | The Regents Of The University Of Michigan | Bubble-induced color doppler feedback during histotripsy |
US11135454B2 (en) | 2015-06-24 | 2021-10-05 | The Regents Of The University Of Michigan | Histotripsy therapy systems and methods for the treatment of brain tissue |
US11432900B2 (en) | 2013-07-03 | 2022-09-06 | Histosonics, Inc. | Articulating arm limiter for cavitational ultrasound therapy system |
US11648424B2 (en) | 2018-11-28 | 2023-05-16 | Histosonics Inc. | Histotripsy systems and methods |
US11813485B2 (en) | 2020-01-28 | 2023-11-14 | The Regents Of The University Of Michigan | Systems and methods for histotripsy immunosensitization |
CN117340692A (en) * | 2023-12-05 | 2024-01-05 | 太原理工大学 | Acoustic-magnetic coupling field auxiliary liquid jet polishing device for metal additive manufacturing part |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4888746A (en) | 1987-09-24 | 1989-12-19 | Richard Wolf Gmbh | Focussing ultrasound transducer |
US5219401A (en) * | 1989-02-21 | 1993-06-15 | Technomed Int'l | Apparatus for selective destruction of cells by implosion of gas bubbles |
US5827204A (en) * | 1996-11-26 | 1998-10-27 | Grandia; Willem | Medical noninvasive operations using focused modulated high power ultrasound |
US6309355B1 (en) * | 1998-12-22 | 2001-10-30 | The Regents Of The University Of Michigan | Method and assembly for performing ultrasound surgery using cavitation |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5582578A (en) * | 1995-08-01 | 1996-12-10 | Duke University | Method for the comminution of concretions |
US6298264B1 (en) * | 1998-08-31 | 2001-10-02 | Duke University | Apparatus and method for macromolecule delivery into living cells |
EP1450697A4 (en) * | 2001-11-09 | 2009-09-09 | Univ Duke | Method and apparatus to reduce tissue injury in shock wave lithotripsy |
-
2003
- 2003-08-14 EP EP03818331A patent/EP1701659A4/en not_active Ceased
- 2003-08-14 DE DE10394286T patent/DE10394286T5/en not_active Ceased
- 2003-08-14 WO PCT/US2003/025305 patent/WO2005018469A1/en not_active Application Discontinuation
- 2003-08-14 AU AU2003262631A patent/AU2003262631A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4888746A (en) | 1987-09-24 | 1989-12-19 | Richard Wolf Gmbh | Focussing ultrasound transducer |
US5219401A (en) * | 1989-02-21 | 1993-06-15 | Technomed Int'l | Apparatus for selective destruction of cells by implosion of gas bubbles |
US5827204A (en) * | 1996-11-26 | 1998-10-27 | Grandia; Willem | Medical noninvasive operations using focused modulated high power ultrasound |
US6309355B1 (en) * | 1998-12-22 | 2001-10-30 | The Regents Of The University Of Michigan | Method and assembly for performing ultrasound surgery using cavitation |
Non-Patent Citations (2)
Title |
---|
See also references of EP1701659A4 * |
XI, ZHONG: "Improvement of Stone Fragmentation During Shock Wave Lithotripsy Using a Combined EH/PEAA Shock Wave Generator - In Vitro Experiments", ULTRASOUND IN MEDICINE AND BIOLOGY, vol. 26, 2000, pages 457 - 467, XP004295535, DOI: doi:10.1016/S0301-5629(99)00124-6 |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10219815B2 (en) | 2005-09-22 | 2019-03-05 | The Regents Of The University Of Michigan | Histotripsy for thrombolysis |
US11701134B2 (en) | 2005-09-22 | 2023-07-18 | The Regents Of The University Of Michigan | Histotripsy for thrombolysis |
US11364042B2 (en) | 2005-09-22 | 2022-06-21 | The Regents Of The University Of Michigan | Histotripsy for thrombolysis |
US9642634B2 (en) | 2005-09-22 | 2017-05-09 | The Regents Of The University Of Michigan | Pulsed cavitational ultrasound therapy |
DE102006021049A1 (en) * | 2006-05-05 | 2007-11-08 | Siemens Ag | Shock wave head for a shock wave treatment device and method for fragmentation and control of fragmentation of a fragmentation object located in an examination subject |
WO2010043190A1 (en) * | 2008-10-18 | 2010-04-22 | Gosbert Weth | Pulse wave generator |
US9901753B2 (en) | 2009-08-26 | 2018-02-27 | The Regents Of The University Of Michigan | Ultrasound lithotripsy and histotripsy for using controlled bubble cloud cavitation in fractionating urinary stones |
US9943708B2 (en) | 2009-08-26 | 2018-04-17 | Histosonics, Inc. | Automated control of micromanipulator arm for histotripsy prostate therapy while imaging via ultrasound transducers in real time |
US9833373B2 (en) | 2010-08-27 | 2017-12-05 | Les Solutions Médicales Soundbite Inc. | Mechanical wave generator and method thereof |
US10071266B2 (en) | 2011-08-10 | 2018-09-11 | The Regents Of The University Of Michigan | Lesion generation through bone using histotripsy therapy without aberration correction |
US9636133B2 (en) | 2012-04-30 | 2017-05-02 | The Regents Of The University Of Michigan | Method of manufacturing an ultrasound system |
US11058399B2 (en) | 2012-10-05 | 2021-07-13 | The Regents Of The University Of Michigan | Bubble-induced color doppler feedback during histotripsy |
EP4166194A1 (en) * | 2013-07-03 | 2023-04-19 | Histosonics, Inc. | Histotripsy excitation sequences optimized for bubble cloud formation using shock scattering |
WO2015003142A1 (en) | 2013-07-03 | 2015-01-08 | Histosonics, Inc. | Histotripsy excitation sequences optimized for bubble cloud formation using shock scattering |
EP3016594A4 (en) * | 2013-07-03 | 2017-06-14 | Histosonics, Inc. | Histotripsy excitation sequences optimized for bubble cloud formation using shock scattering |
US10293187B2 (en) | 2013-07-03 | 2019-05-21 | Histosonics, Inc. | Histotripsy excitation sequences optimized for bubble cloud formation using shock scattering |
JP2016527945A (en) * | 2013-07-03 | 2016-09-15 | ヒストソニックス,インコーポレーテッド | Optimized histotripsy excitation sequence for bubble cloud formation using shock scattering |
US11432900B2 (en) | 2013-07-03 | 2022-09-06 | Histosonics, Inc. | Articulating arm limiter for cavitational ultrasound therapy system |
CN105530869A (en) * | 2013-07-03 | 2016-04-27 | 希斯托索尼克斯公司 | Histotripsy excitation sequences optimized for bubble cloud formation using shock scattering |
US10780298B2 (en) | 2013-08-22 | 2020-09-22 | The Regents Of The University Of Michigan | Histotripsy using very short monopolar ultrasound pulses |
US11819712B2 (en) | 2013-08-22 | 2023-11-21 | The Regents Of The University Of Michigan | Histotripsy using very short ultrasound pulses |
US11135454B2 (en) | 2015-06-24 | 2021-10-05 | The Regents Of The University Of Michigan | Histotripsy therapy systems and methods for the treatment of brain tissue |
US11813484B2 (en) | 2018-11-28 | 2023-11-14 | Histosonics, Inc. | Histotripsy systems and methods |
US11648424B2 (en) | 2018-11-28 | 2023-05-16 | Histosonics Inc. | Histotripsy systems and methods |
US11813485B2 (en) | 2020-01-28 | 2023-11-14 | The Regents Of The University Of Michigan | Systems and methods for histotripsy immunosensitization |
CN117340692A (en) * | 2023-12-05 | 2024-01-05 | 太原理工大学 | Acoustic-magnetic coupling field auxiliary liquid jet polishing device for metal additive manufacturing part |
CN117340692B (en) * | 2023-12-05 | 2024-02-20 | 太原理工大学 | Acoustic-magnetic coupling field auxiliary liquid jet polishing device for metal additive manufacturing part |
Also Published As
Publication number | Publication date |
---|---|
DE10394286T5 (en) | 2006-06-29 |
EP1701659A4 (en) | 2010-04-07 |
AU2003262631A1 (en) | 2005-03-10 |
EP1701659A1 (en) | 2006-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20050038361A1 (en) | Apparatus for improved shock-wave lithotripsy (SWL) using a piezoelectric annular array (PEAA) shock-wave generator in combination with a primary shock wave source | |
US5582578A (en) | Method for the comminution of concretions | |
US5800365A (en) | Microsecond tandem-pulse electrohydraulic shock wave generator with confocal reflectors | |
WO2005018469A1 (en) | Apparatus for improved shock-wave lithotripsy (swl) using a piezoelectric annular array (peaa) shock-wave generator in combination with a primary shock wave | |
US6770039B2 (en) | Method to reduce tissue injury in shock wave lithotripsy | |
US6298264B1 (en) | Apparatus and method for macromolecule delivery into living cells | |
Cleveland et al. | Physics of shock‐wave lithotripsy | |
US4526168A (en) | Apparatus for destroying calculi in body cavities | |
Loske et al. | Tandem shock wave cavitation enhancement for extracorporeal lithotripsy | |
TWI382860B (en) | Noninvasively low-frequency ultrasonic apparatus for the brain therapy and the method thereof | |
EP1833449A2 (en) | Ultrasonic medical treatment device with variable focal zone | |
Zhong et al. | Suppression of large intraluminal bubble expansion in shock wave lithotripsy without compromising stone comminution: Methodology and in vitro experiments | |
Zhong et al. | Controlled, forced collapse of cavitation bubbles for improved stone fragmentation during shock wave lithotripsy | |
PRIETO et al. | Bifocal reflector for electrohydraulic lithotripters | |
US7485101B1 (en) | Multiple shockwave focal treatment apparatus with targeting positioning and locating apparatus | |
Zhou | Reduction of bubble cavitation by modifying the diffraction wave from a lithotripter aperture | |
JP4139916B2 (en) | Ultrasonic irradiation method and ultrasonic irradiation apparatus | |
Davros et al. | Gallstone lithotripsy: relevant physical principles and technical issues. | |
Zhou et al. | Characteristics of the secondary bubble cluster produced by an electrohydraulic shock wave lithotripter | |
Chapelon et al. | Effects of cavitation in the high intensity therapeutic ultrasound | |
Lewin et al. | A novel method to control p+/p-ratio of the shock wave pulses used in the extracorporeal piezoelectric lithotripsy (EPL) | |
Alavi Tamaddoni et al. | Enhanced shockwave lithotripsy with active cavitation mitigation | |
JPH02289244A (en) | Localized breaking device for flexible structure, using elastic wave with negative pressure | |
Woodacre et al. | A 5 mm× 5 mm square, aluminum lens based histotripsy transducer: Reaching the endoscopic form factor | |
Fernández et al. | The importance of an expansion chamber during standard and tandem extracorporeal shock wave lithotripsy |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 103942866 Country of ref document: DE |
|
RET | De translation (de og part 6b) |
Ref document number: 10394286 Country of ref document: DE Date of ref document: 20060629 Kind code of ref document: P |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10394286 Country of ref document: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003818331 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2003818331 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: DE |
|
NENP | Non-entry into the national phase |
Ref country code: JP |