WO2005028663A3 - Operator independent programmable sample preparation and analysis system - Google Patents

Operator independent programmable sample preparation and analysis system Download PDF

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Publication number
WO2005028663A3
WO2005028663A3 PCT/US2004/030429 US2004030429W WO2005028663A3 WO 2005028663 A3 WO2005028663 A3 WO 2005028663A3 US 2004030429 W US2004030429 W US 2004030429W WO 2005028663 A3 WO2005028663 A3 WO 2005028663A3
Authority
WO
WIPO (PCT)
Prior art keywords
processing
detection
cells
target cells
disease
Prior art date
Application number
PCT/US2004/030429
Other languages
French (fr)
Other versions
WO2005028663A2 (en
Inventor
Teresa Bendele
Thomas Harbart
Dave Howard
Michael Kagan
Douglas Keene
Dave Lapeus
Jared Mayes
Douglas Paynter
Jerry Prohaska
Herman Rutner
Original Assignee
Immunivest Corp
Teresa Bendele
Thomas Harbart
Dave Howard
Michael Kagan
Douglas Keene
Dave Lapeus
Jared Mayes
Douglas Paynter
Jerry Prohaska
Herman Rutner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunivest Corp, Teresa Bendele, Thomas Harbart, Dave Howard, Michael Kagan, Douglas Keene, Dave Lapeus, Jared Mayes, Douglas Paynter, Jerry Prohaska, Herman Rutner filed Critical Immunivest Corp
Priority to CA002539108A priority Critical patent/CA2539108A1/en
Priority to JP2006527036A priority patent/JP4629675B2/en
Priority to EP04784320A priority patent/EP1673611A4/en
Publication of WO2005028663A2 publication Critical patent/WO2005028663A2/en
Publication of WO2005028663A3 publication Critical patent/WO2005028663A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/70—Determining position or orientation of objects or cameras
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing

Abstract

The present invention provides a protocol and apparatus for enriching circulating tumor cells and other rare cells from blood, including debris and other components, from samples with high precision and at high throughput rates. This invention discloses an improved processing system from previously described semi-automated sample processing. The system further reduces operator intervention and hands-on time from prior systems. While this system has general utility in processing diverse materials, the system is configured for sample processing of biological specimens to provide an enriched fraction suitable for detection, enumeration and identification of target cells by appropriate analytical methodologies. The presence and quantities of such target cells in a sample specimen can utilized for screening and detection in disease such as cancer, assessing early stage pre-metastatic cancer, monitoring for disease remission in response to therapy and selection of more effective dose regimens or alternative therapies in case of relapse.
PCT/US2004/030429 2003-09-18 2004-09-17 Operator independent programmable sample preparation and analysis system WO2005028663A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002539108A CA2539108A1 (en) 2003-09-18 2004-09-17 Operator independent programmable sample preparation and analysis system
JP2006527036A JP4629675B2 (en) 2003-09-18 2004-09-17 Programmable sample preparation and analysis system without operator
EP04784320A EP1673611A4 (en) 2003-09-18 2004-09-17 Operator independent programmable sample preparation and analysis system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50375403P 2003-09-18 2003-09-18
US60/503,754 2003-09-18

Publications (2)

Publication Number Publication Date
WO2005028663A2 WO2005028663A2 (en) 2005-03-31
WO2005028663A3 true WO2005028663A3 (en) 2005-12-22

Family

ID=34375391

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/030429 WO2005028663A2 (en) 2003-09-18 2004-09-17 Operator independent programmable sample preparation and analysis system

Country Status (4)

Country Link
EP (1) EP1673611A4 (en)
JP (2) JP4629675B2 (en)
CA (1) CA2539108A1 (en)
WO (1) WO2005028663A2 (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US8168389B2 (en) 2006-06-14 2012-05-01 The General Hospital Corporation Fetal cell analysis using sample splitting
US8195415B2 (en) 2008-09-20 2012-06-05 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US8969021B2 (en) 2001-10-11 2015-03-03 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8983580B2 (en) 2008-01-18 2015-03-17 The Board Of Trustees Of The University Of Illinois Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors
US8986945B2 (en) 2006-07-14 2015-03-24 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8986966B2 (en) 2002-09-27 2015-03-24 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
US9174222B2 (en) 2005-04-05 2015-11-03 The General Hospital Corporation Devices and method for enrichment and alteration of cells and other particles

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7901950B2 (en) 2005-08-12 2011-03-08 Veridex, Llc Method for assessing disease states by profile analysis of isolated circulating endothelial cells
US9134237B2 (en) * 2005-09-20 2015-09-15 Janssen Diagnotics, LLC High sensitivity multiparameter method for rare event analysis in a biological sample
CA2623405C (en) 2005-09-20 2014-11-25 Immunivest Corporation Methods and composition to generate unique sequence dna probes labeling of dna probes and the use of these probes
US20080070792A1 (en) 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2229441B1 (en) 2007-12-12 2014-10-01 The Board of Trustees of The Leland Stanford Junior University Method and apparatus for magnetic separation of cells
US20150118728A1 (en) * 2012-04-20 2015-04-30 Agency For Science, Technology And Research Apparatus and method for separating a biological entity from a sample volume
US9212976B2 (en) * 2013-03-15 2015-12-15 Qiagen Gaithersburg, Inc. Vision-guided aspiration apparatus and methods
WO2015165850A1 (en) * 2014-04-30 2015-11-05 Ventana Medical Systems, Inc. Hematoxylin precipitate cleaning method and system
CN107850591A (en) * 2015-07-23 2018-03-27 Hycor生物医学有限责任公司 External member onboard
EP3693739A1 (en) * 2019-02-06 2020-08-12 Stefan Schreier Method and device for isolating desired cells from a sample of nonmagnetic biological material
CN111004706B (en) * 2019-12-23 2023-06-16 长春长光辰英生物科学仪器有限公司 High-flux receiving system used in micro-size target sorting instrument
CN114196516B (en) * 2020-09-02 2023-09-26 浙江康是医疗器械有限公司 Full-automatic portable virus sampling pipe rapid analysis equipment

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US5784162A (en) * 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
US6190617B1 (en) * 1992-03-27 2001-02-20 Abbott Laboratories Sample container segment assembly
US6350613B1 (en) * 1998-03-07 2002-02-26 Belton Dickinson & Co. Determination of white blood cell differential and reticulocyte counts

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US5466574A (en) * 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means
ES2208638T3 (en) * 1992-03-27 2004-06-16 Abbott Laboratories SYSTEM OF AUTOMATED ANALYSIS OF CONTINUOUS AND RANDOM ACCESS AND COMPONENTS FOR A SYSTEM OF THIS TYPE.
US6500343B2 (en) * 1995-02-21 2002-12-31 Iqbal W. Siddiqi Method for mixing and separation employing magnetic particles
US20010018192A1 (en) * 1998-02-12 2001-08-30 Terstappen Leon W.M.M. Labeled cells for use as an internal functional control in rare cell detection assays
DE69941689D1 (en) * 1998-02-12 2010-01-07 Univ Texas METHOD AND REAGENTS FOR RAPID AND EFFICIENT INSULATION OF CIRCULATING CANCER CELLS
WO2003065042A1 (en) * 2001-02-16 2003-08-07 Immunivest Corporation Methods and reagents for the rapid and efficient isolation of circulating cancer cells
DE60227678D1 (en) * 2001-08-23 2008-08-28 Immunivest Corp ANALYSIS OF CIRCULATING TUMOR CELLS, FRAGMENTS AND TRUMS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6190617B1 (en) * 1992-03-27 2001-02-20 Abbott Laboratories Sample container segment assembly
US5784162A (en) * 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
US6350613B1 (en) * 1998-03-07 2002-02-26 Belton Dickinson & Co. Determination of white blood cell differential and reticulocyte counts

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1673611A4 *

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US9556485B2 (en) 2001-10-11 2017-01-31 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US9290812B2 (en) 2001-10-11 2016-03-22 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8969021B2 (en) 2001-10-11 2015-03-03 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986966B2 (en) 2002-09-27 2015-03-24 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
US9174222B2 (en) 2005-04-05 2015-11-03 The General Hospital Corporation Devices and method for enrichment and alteration of cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US9347100B2 (en) 2006-06-14 2016-05-24 Gpb Scientific, Llc Rare cell analysis using sample splitting and DNA tags
US9273355B2 (en) 2006-06-14 2016-03-01 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US8168389B2 (en) 2006-06-14 2012-05-01 The General Hospital Corporation Fetal cell analysis using sample splitting
US9017942B2 (en) 2006-06-14 2015-04-28 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US8986945B2 (en) 2006-07-14 2015-03-24 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample
US8983580B2 (en) 2008-01-18 2015-03-17 The Board Of Trustees Of The University Of Illinois Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors
US8682594B2 (en) 2008-09-20 2014-03-25 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
US8296076B2 (en) 2008-09-20 2012-10-23 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuoploidy by sequencing
US9353414B2 (en) 2008-09-20 2016-05-31 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
US9404157B2 (en) 2008-09-20 2016-08-02 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
US8195415B2 (en) 2008-09-20 2012-06-05 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing

Also Published As

Publication number Publication date
CA2539108A1 (en) 2005-03-31
WO2005028663A2 (en) 2005-03-31
JP5215368B2 (en) 2013-06-19
JP2011097936A (en) 2011-05-19
JP4629675B2 (en) 2011-02-09
EP1673611A2 (en) 2006-06-28
JP2007505626A (en) 2007-03-15
EP1673611A4 (en) 2011-11-30

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