WO2005030041A3 - Detection of hpv - Google Patents

Detection of hpv Download PDF

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Publication number
WO2005030041A3
WO2005030041A3 PCT/US2004/031680 US2004031680W WO2005030041A3 WO 2005030041 A3 WO2005030041 A3 WO 2005030041A3 US 2004031680 W US2004031680 W US 2004031680W WO 2005030041 A3 WO2005030041 A3 WO 2005030041A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
present
provides compositions
hpv
detection
Prior art date
Application number
PCT/US2004/031680
Other languages
French (fr)
Other versions
WO2005030041A2 (en
Inventor
Angela Hudson
Tamara Sander
Poonam Agarwal
Michelle Garsha
Hon Ip
Robert W Kwiatkowski Jr
Slava Elagin
Marilyn Olson-Munoz
Michelle Curtis
Sarah Olson
Ilse Tyler
Original Assignee
Third Wave Tech Inc
Angela Hudson
Tamara Sander
Poonam Agarwal
Michelle Garsha
Hon Ip
Robert W Kwiatkowski Jr
Slava Elagin
Marilyn Olson-Munoz
Michelle Curtis
Sarah Olson
Ilse Tyler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Third Wave Tech Inc, Angela Hudson, Tamara Sander, Poonam Agarwal, Michelle Garsha, Hon Ip, Robert W Kwiatkowski Jr, Slava Elagin, Marilyn Olson-Munoz, Michelle Curtis, Sarah Olson, Ilse Tyler filed Critical Third Wave Tech Inc
Priority to BRPI0414801-0A priority Critical patent/BRPI0414801A/en
Priority to AU2004275865A priority patent/AU2004275865B2/en
Priority to EP04785150.6A priority patent/EP1664348B8/en
Priority to CA2539703A priority patent/CA2539703C/en
Priority to JP2006528294A priority patent/JP4498357B2/en
Publication of WO2005030041A2 publication Critical patent/WO2005030041A2/en
Publication of WO2005030041A3 publication Critical patent/WO2005030041A3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/708Specific hybridization probes for papilloma

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of HPV sequences. The present invention also provides compositions, methods and kits for screening sets of HPV sequences in a single reaction container.
PCT/US2004/031680 2003-09-25 2004-09-27 Detection of hpv WO2005030041A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
BRPI0414801-0A BRPI0414801A (en) 2003-09-25 2004-09-27 hpv detection
AU2004275865A AU2004275865B2 (en) 2003-09-25 2004-09-27 Detection of HPV
EP04785150.6A EP1664348B8 (en) 2003-09-25 2004-09-27 Detection of hpv
CA2539703A CA2539703C (en) 2003-09-25 2004-09-27 Detection of human papilloma virus (hpv) utilizing invasive cleavage structure assays
JP2006528294A JP4498357B2 (en) 2003-09-25 2004-09-27 HPV detection method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50578603P 2003-09-25 2003-09-25
US60/505,786 2003-09-25

Publications (2)

Publication Number Publication Date
WO2005030041A2 WO2005030041A2 (en) 2005-04-07
WO2005030041A3 true WO2005030041A3 (en) 2006-02-09

Family

ID=34393068

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/031680 WO2005030041A2 (en) 2003-09-25 2004-09-27 Detection of hpv

Country Status (7)

Country Link
US (3) US7527948B2 (en)
EP (1) EP1664348B8 (en)
JP (2) JP4498357B2 (en)
AU (2) AU2004275865B2 (en)
BR (1) BRPI0414801A (en)
CA (1) CA2539703C (en)
WO (1) WO2005030041A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0414801A (en) * 2003-09-25 2006-11-14 Third Wave Tech Inc hpv detection
NZ555620A (en) * 2004-12-03 2008-08-29 Human Genetic Signatures Pty Methods for simplifying microbial nucleic acids by chemical modification of cytosines
WO2006063065A2 (en) 2004-12-08 2006-06-15 Gen-Probe Incorporated Detection of nucleic acids from multiple types of human papillomaviruses
US20090029346A1 (en) * 2004-12-23 2009-01-29 Human Genetic Signatures Pty., Ltd. Detection of human papilloma virus
AU2006251866B2 (en) * 2005-05-26 2007-11-29 Human Genetic Signatures Pty Ltd Isothermal strand displacement amplification using primers containing a non-regular base
US8343738B2 (en) * 2005-09-14 2013-01-01 Human Genetic Signatures Pty. Ltd. Assay for screening for potential cervical cancer
EP2343385B1 (en) 2006-04-11 2014-05-21 Bio-Rad Innovations HPV detection and quantification by real-time multiplex amplification
EP2121956B1 (en) 2006-12-21 2016-08-17 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
EP2215250B1 (en) * 2007-11-27 2013-02-27 Human Genetic Signatures Pty Ltd Enzymes for amplification and copying bisulphite modified nucleic acids
US20110003700A1 (en) * 2007-12-20 2011-01-06 Human Genetic Signatures Pty Ltd. Elimination of contaminants associated with nucleic acid amplification
KR101419980B1 (en) 2008-03-15 2014-07-15 홀로직, 인크. Compositions and methods for analysis of nucleic acid molecules during amplification reactions
CN102822189B (en) * 2010-01-29 2016-06-29 奇亚根盖瑟斯堡股份有限公司 The method and composition of (multiplex analysis) is analyzed for the sequence-specific purification of nucleic acid and MULTIPLE COMPOSITE body
WO2011099664A1 (en) * 2010-02-12 2011-08-18 엠앤디(주) Probe for hpv genotype diagnosis and analysis method thereof
AU2011258501B2 (en) 2010-05-25 2016-07-07 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically-truncated probes
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
US8715937B2 (en) 2010-11-15 2014-05-06 Exact Sciences Corporation Mutation detection assay
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
EP2683833B1 (en) 2011-03-10 2018-09-26 Gen-Probe Incorporated Methods for the selection and optimization of oligonucleotide tag sequences
CN103874766B (en) 2011-09-07 2017-07-18 人类遗传标记控股有限公司 Molecular Detection is determined
WO2014158628A1 (en) 2013-03-14 2014-10-02 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules
US11149322B2 (en) * 2019-06-07 2021-10-19 Chapter Diagnostics, Inc. Methods and compositions for human papillomaviruses and sexually transmitted infections detection, identification and quantification
US11254989B2 (en) * 2020-03-16 2022-02-22 The University Of North Carolina At Chapel Hill Compositions and methods for the selective detection of tumor-derived viral DNA

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994069A (en) * 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US6858412B2 (en) * 2000-10-24 2005-02-22 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic DNA

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2524487B1 (en) 1982-04-05 1985-11-22 Pasteur Institut DNA FRAGMENTS ENCODING POLYPEPTIDES CONTAINING AT LEAST ONE ANTIGENIC DETERMINANT OF PAPILLOMAVIRUS, IN PARTICULAR OF THE HPV 1A TYPE AND CORRESPONDING POLYPEPTIDES
US5876922A (en) 1985-07-31 1999-03-02 Institute Pasteur Papillomavirus probe and a process for in vitro diagnosis of papillomavirus infections
CA1276575C (en) 1984-11-30 1990-11-20 Sylvie Beaudenon Papillomavirus probes and process for the in vitro diagnostic of papillomavirus infections
US5411857A (en) 1985-07-31 1995-05-02 Institut Nationale De La Sante Probes for papillomaviruses and an in vitro diagnostic procedure for papilloma infections
ATE79138T1 (en) 1985-04-04 1992-08-15 Univ Georgetown TYPE-SPECIFIC PAPILLOMAVIRUS DNA SEQUENCES AND PEPTIDES.
JP2633275B2 (en) 1986-03-21 1997-07-23 アンステイテユ・パストウール DNA or DNA fragment derived from the genome of papilloma virus (HPV) -33
DE3853678T2 (en) 1987-02-26 1995-08-31 Univ Sydney METHOD FOR DETECTING THE CARCINOGENIC HUMAN PAPILLOMAVIRUS.
US4849332A (en) 1987-05-26 1989-07-18 Life Technologies, Inc. Human papillomavirus 35 nucleic acid hybridization probes and methods for employing the same
US4849334A (en) 1987-06-09 1989-07-18 Life Technologies, Inc. Human papillomavirus 43 nucleic acid hybridization probes and methods for employing the same
US4849331A (en) 1987-06-09 1989-07-18 Life Technologies, Inc. Human papillomavirus 44 nucleic acid hybridization probes and methods for employing the same
US4908306A (en) 1987-06-12 1990-03-13 Life Technologies, Inc. Human papillomavirus 56 nucleic acid hybridization probes and methods for employing the same
FR2632956B2 (en) 1988-05-13 1991-07-12 Pasteur Institut PAPILLOMAVIRUS PROBES HPV49, HPV50, HPV54, HPV55; GENETICALLY AND IMMUNOLOGICALLY RELATED PRODUCTS TO THIS PAPILLOMAVIRUS HPV49, HPV50, HPV54, HPV55; METHOD FOR IN VITRO DIAGNOSIS OF PAPILLOMAVIRUS INFECTIONS AND IN VIVO IMMUNIZATION AGAINST THESE PAPILLOMAVIRUS
DE3826793A1 (en) 1988-08-06 1990-03-08 Behringwerke Ag HUMAN PAPILLOMVIRUS TYPE 57, ITS DNA AND THE PROTEINS CODED THEREOF
US5639871A (en) 1988-09-09 1997-06-17 Roche Molecular Systems, Inc. Detection of human papillomavirus by the polymerase chain reaction
US5182377A (en) 1988-09-09 1993-01-26 Hoffmann-La Roche Inc. Probes for detection of human papillomavirus
US5447839A (en) 1988-09-09 1995-09-05 Hoffmann-La Roche Inc. Detection of human papillomavirus by the polymerase chain reaction
CA1339729C (en) 1988-10-26 1998-03-17 Wayne D. Lancaster Human papillomavirus type 52 dna sequences and methods for employing thesame
US5863717A (en) 1989-11-03 1999-01-26 Abbott Laboratories Use of conserved oligonucleotide primers to amplify human papillomavirus DNA sequences
US5580970A (en) 1989-12-01 1996-12-03 Amoco Corporation Detection of HPV transcripts
US5811232A (en) 1989-12-04 1998-09-22 Isis Pharmaceuticals, Inc. Oligonucleotides for Papillomavirus
US5457189A (en) 1989-12-04 1995-10-10 Isis Pharmaceuticals Antisense oligonucleotide inhibition of papillomavirus
FR2656627B1 (en) 1989-12-28 1992-04-17 Pasteur Institut PAPILLOMAVIRUS PROBE (HVPV63), ESPECIALLY FOR THE IN VITRO DIAGNOSIS OF PAPILLOMAVIRUS INFECTIONS, WHICH MAY BE ACCOMPANIED BY GENITAL NEOPLASIA, AND GENETICALLY AND IMMUNOLOGICALLY LINKED PRODUCTS TO THIS PAPILLOMAVIRUS.
NL9000134A (en) 1990-01-19 1991-08-16 Stichting Res Fonds Pathologie PRIMERS AND METHOD FOR DETECTING HUMAN PAPILLOMA VIRUS GENOTYPS BY M.B.V. PCR.
FR2661921B1 (en) 1990-05-11 1992-08-07 Pasteur Institut PAPILLOMAVIRUS PROBE (HPV66), ESPECIALLY FOR THE IN VITRO DIAGNOSIS OF PAPILLOMAVIRUS INFECTIONS, WHICH MAY BE ACCOMPANIED BY GENITAL NEOPLASIA, AND GENETICALLY AND IMMUNOLOGICALLY RELATED PRODUCTS TO THIS PAPILLOMAVIRUS.
GB9015845D0 (en) 1990-07-19 1990-09-05 Emery Vincent C Diagnostic method
US5484699A (en) 1990-09-28 1996-01-16 Abbott Laboratories Nucleotide sequences useful as type specific probes, PCR primers and LCR probes for the amplification and detection of human papilloma virus, and related kits and methods
FR2670797A1 (en) 1990-12-20 1992-06-26 Pasteur Institut DETERMINED DNA SEQUENCES DERIVED FROM THE PAPILLOMAVIRUS HPV39 GENOME, APPLICATION OF THESE SEQUENCES TO IN VITRO DIAGNOSIS OF PAPILLOMAVIRUS INFECTION, AND TO THE PRODUCTION OF IMMUNOGENIC COMPOSITION.
FR2678284B1 (en) 1991-06-28 1993-10-08 Pasteur Institut DNA SEQUENCES DERIVED FROM THE GENOME OF PAPILLOMAVIRUS HPV42, APPLICATION OF THESE SEQUENCES TO IN VITRO DIAGNOSIS OF PAPILLOMAVIRUS INFECTION AND TO THE PRODUCTION OF IMMUNOGENIC COMPOSITIONS.
DE122007000019I1 (en) 1991-07-19 2007-07-26 Univ Queensland Vaccines against papillomavirus
US5679509A (en) 1993-09-28 1997-10-21 University Of New Mexico Methods and a diagnostic aid for distinguishing a subset of HPV that is associated with an increased risk of developing cervical dysplasia and cervical cancer
DE69527776T2 (en) 1994-02-21 2003-04-30 Stichting Res Fonds Pathologie DETECTING HUMAN PAPILLOMVIRUS WITH NUCLEIC ACID AMPLIFICATION USED BY GENERAL PRIMER
US5888724A (en) 1995-02-17 1999-03-30 The Trustees Of Columbia University In The City Of New York Detection of high oncogenic-risk papilloma virus in high grade cervical lesions and cancers by a PCR/ELISA assay
US5840306A (en) 1995-03-22 1998-11-24 Merck & Co., Inc. DNA encoding human papillomavirus type 18
IL117591A0 (en) 1995-03-30 1996-07-23 Merck & Co Inc Synthetic DNA encoding human papillomavirus type 11 L1 protein
US6458940B2 (en) 1995-06-06 2002-10-01 Hybridon, Inc. HPV-specific oligonucleotides
US6509149B2 (en) 1995-06-06 2003-01-21 Hybridon, Inc. HPV-specific oligonucleotides
JP2000500342A (en) 1995-11-15 2000-01-18 ジェン−プローブ・インコーポレーテッド Nucleic acid probes complementary to human papillomavirus nucleic acids and related methods and kits
US7195871B2 (en) * 1996-01-24 2007-03-27 Third Wave Technologies, Inc Methods and compositions for detecting target sequences
US5981173A (en) 1996-02-14 1999-11-09 Institut Pasteur Genital human papillomavirus type 68a (HPV-68a), related to the potentially oncogenic HPV-39
US6511805B1 (en) 1996-03-15 2003-01-28 The Penn State Research Foundation Methods for detecting papillomavirus DNA in blood plasma and serum
US6265154B1 (en) 1996-10-25 2001-07-24 Abbott Laboratories Nucleic acid primers and probes for detecting oncogenic human papillomaviruses
WO1998046793A1 (en) * 1997-04-16 1998-10-22 Trevigen, Inc. Detection and mapping of point mutations using partial digestion
US5883897A (en) 1997-04-25 1999-03-16 Motorola, Inc. Method and apparatus for providing synchronization during transcoder switching in a communication system
ATE219153T1 (en) 1997-09-16 2002-06-15 Innogenetics Nv DETECTION AND IDENTIFICATION OF HUMAN PAPILLOMAVIRUS BY PCR AND TYPE-SPECIFIC REVERSE HYBRIDIZATION
US20020039584A1 (en) 1998-02-20 2002-04-04 Medigene Ag Papilloma virus capsomere vaccine formulations and methods of use
US6045993A (en) 1998-05-30 2000-04-04 Visible Genetics Inc. Method, reagent and kit for genotyping of human papillomavirus
DE69936841D1 (en) 1998-10-26 2007-09-27 Ventana Med Syst Inc PROOF OF THE HUMAN PAPILLOMA VIRUS WITH THE HELP OF THE PAPANICOLAU TEST
US6420106B1 (en) 1999-06-09 2002-07-16 Quantovir Ab Method and kit for early cancer prediction
AU2001256976A1 (en) * 2000-04-03 2001-10-15 Cytyc Corporation Detection and typing of human papillomavirus using pna probes
JP2002330768A (en) * 2001-05-11 2002-11-19 Hitachi Software Eng Co Ltd Probe designing method and biochip
US20020152942A1 (en) * 2001-04-23 2002-10-24 Steller Mitchell E. Ballast tank arrangement for double-hull tanker
AU2002311897A1 (en) 2001-05-09 2002-11-18 Third Wave Technologies, Inc. Nucleic acid detection in pooled samples
US6506111B2 (en) 2001-05-16 2003-01-14 Sanmina-Sci Corporation Cooling airflow distribution device
BR0306723A (en) * 2002-01-07 2004-12-21 Norchip As In vitro methods for selecting human subjects to assess their risk of developing cervical carcinoma, and for selecting human subjects for the presence of integrated hpv or a modified episomal hpv genome, in vitro method for identifying human subjects presenting abnormal cell changes in the cervix, and kit for use in detecting mpna transcripts of hpv l1 and e6 genes
AU2003210259A1 (en) 2002-02-21 2003-09-09 Nanogen Recognomics Gmbh Method for detecting single nucleotide polymorphisms
US20040170982A1 (en) * 2003-02-14 2004-09-02 Morris David W. Novel therapeutic targets in cancer
BRPI0414801A (en) * 2003-09-25 2006-11-14 Third Wave Tech Inc hpv detection

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994069A (en) * 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US6858412B2 (en) * 2000-10-24 2005-02-22 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic DNA

Also Published As

Publication number Publication date
CA2539703A1 (en) 2005-04-07
US8765418B2 (en) 2014-07-01
JP5537080B2 (en) 2014-07-02
EP1664348A4 (en) 2007-01-10
EP1664348B1 (en) 2019-04-03
US20070111200A1 (en) 2007-05-17
CA2539703C (en) 2011-06-07
AU2008264200B2 (en) 2012-02-02
JP2009291199A (en) 2009-12-17
EP1664348B8 (en) 2019-06-12
AU2008264200A1 (en) 2009-01-29
US20080176215A1 (en) 2008-07-24
EP1664348A2 (en) 2006-06-07
US7527948B2 (en) 2009-05-05
AU2004275865B2 (en) 2008-09-25
US20130149697A1 (en) 2013-06-13
JP2007526760A (en) 2007-09-20
US8389245B2 (en) 2013-03-05
AU2004275865A1 (en) 2005-04-07
WO2005030041A2 (en) 2005-04-07
JP4498357B2 (en) 2010-07-07
BRPI0414801A (en) 2006-11-14

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