WO2005032524A3 - Osmotically driven active agent delivery device providing an ascending release profile - Google Patents

Osmotically driven active agent delivery device providing an ascending release profile Download PDF

Info

Publication number
WO2005032524A3
WO2005032524A3 PCT/US2004/031983 US2004031983W WO2005032524A3 WO 2005032524 A3 WO2005032524 A3 WO 2005032524A3 US 2004031983 W US2004031983 W US 2004031983W WO 2005032524 A3 WO2005032524 A3 WO 2005032524A3
Authority
WO
WIPO (PCT)
Prior art keywords
active agent
rate
osmotic pump
controlling membrane
osmotic
Prior art date
Application number
PCT/US2004/031983
Other languages
French (fr)
Other versions
WO2005032524A2 (en
Inventor
Guohua Chen
Rupal A Ayer
Scott Lautenbach
Original Assignee
Alza Corp
Guohua Chen
Rupal A Ayer
Scott Lautenbach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp, Guohua Chen, Rupal A Ayer, Scott Lautenbach filed Critical Alza Corp
Priority to JP2006534056A priority Critical patent/JP2007507513A/en
Priority to BRPI0414941-6A priority patent/BRPI0414941A/en
Priority to MXPA06002967A priority patent/MXPA06002967A/en
Priority to AU2004277980A priority patent/AU2004277980A1/en
Priority to EP04785259A priority patent/EP1682099A2/en
Priority to CA002538043A priority patent/CA2538043A1/en
Publication of WO2005032524A2 publication Critical patent/WO2005032524A2/en
Publication of WO2005032524A3 publication Critical patent/WO2005032524A3/en
Priority to IL174294A priority patent/IL174294A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion

Abstract

In one aspect, the present invention is directed to an osmotic pump that automatically provides an ascending release rate of active agent as the osmotic pump functions in an environment of operation and may be designed for implantation within a desired animal or human subject. An osmotic pump according to the present invention includes a reservoir, a rate controlling membrane, an expandable osmotic composition, an active agent formulation and an exit orifice. Once administered to an environment of operation, water passes through the rate controlling membrane and into the osmotic composition, which causes the osmotic composition to expand and expel the active agent formulation through the exit orifice at a rate that is directly proportional to the rate at which water passes through the rate controlling membrane. An osmotic pump according to the present invention permits the flow of water through the rate controlling membrane to increase automatically without the need for manipulation of the osmotic pump after administration. As the flow of water through the rate controlling membrane increases, the rate at which active agent is delivered from the osmotic pump will also increase proportionally.
PCT/US2004/031983 2003-09-30 2004-09-29 Osmotically driven active agent delivery device providing an ascending release profile WO2005032524A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2006534056A JP2007507513A (en) 2003-09-30 2004-09-29 Osmotically-driven activator supply device producing an upward trending release characteristic
BRPI0414941-6A BRPI0414941A (en) 2003-09-30 2004-09-29 osmotically driven active agent dispensing device providing an upward release profile
MXPA06002967A MXPA06002967A (en) 2003-09-30 2004-09-29 Osmotically driven active agent delivery device providing an ascending release profile.
AU2004277980A AU2004277980A1 (en) 2003-09-30 2004-09-29 Osmotically driven active agent delivery device providing an ascending release profile
EP04785259A EP1682099A2 (en) 2003-09-30 2004-09-29 Osmotically driven active agent delivery device providing an ascending release profile
CA002538043A CA2538043A1 (en) 2003-09-30 2004-09-29 Osmotically driven active agent delivery device providing an ascending release profile
IL174294A IL174294A0 (en) 2003-09-30 2006-03-13 Osmotically driven active agent delivery device providing an ascending release profile

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50792003P 2003-09-30 2003-09-30
US60/507,920 2003-09-30

Publications (2)

Publication Number Publication Date
WO2005032524A2 WO2005032524A2 (en) 2005-04-14
WO2005032524A3 true WO2005032524A3 (en) 2005-05-26

Family

ID=34421688

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/031983 WO2005032524A2 (en) 2003-09-30 2004-09-29 Osmotically driven active agent delivery device providing an ascending release profile

Country Status (12)

Country Link
US (1) US7241457B2 (en)
EP (1) EP1682099A2 (en)
JP (1) JP2007507513A (en)
KR (1) KR20060097008A (en)
CN (1) CN1859900A (en)
AU (1) AU2004277980A1 (en)
BR (1) BRPI0414941A (en)
CA (1) CA2538043A1 (en)
IL (1) IL174294A0 (en)
MX (1) MXPA06002967A (en)
WO (1) WO2005032524A2 (en)
ZA (1) ZA200603420B (en)

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US8309060B2 (en) 2003-08-06 2012-11-13 Grunenthal Gmbh Abuse-proofed dosage form
US8420056B2 (en) 2003-08-06 2013-04-16 Grunenthal Gmbh Abuse-proofed dosage form

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Publication number Priority date Publication date Assignee Title
US8309060B2 (en) 2003-08-06 2012-11-13 Grunenthal Gmbh Abuse-proofed dosage form
US8420056B2 (en) 2003-08-06 2013-04-16 Grunenthal Gmbh Abuse-proofed dosage form
US8114384B2 (en) 2004-07-01 2012-02-14 Gruenenthal Gmbh Process for the production of an abuse-proofed solid dosage form

Also Published As

Publication number Publication date
MXPA06002967A (en) 2006-06-14
CA2538043A1 (en) 2005-04-14
WO2005032524A2 (en) 2005-04-14
AU2004277980A1 (en) 2005-04-14
KR20060097008A (en) 2006-09-13
ZA200603420B (en) 2007-07-25
BRPI0414941A (en) 2006-11-07
US20050107772A1 (en) 2005-05-19
JP2007507513A (en) 2007-03-29
US7241457B2 (en) 2007-07-10
CN1859900A (en) 2006-11-08
IL174294A0 (en) 2006-08-01
EP1682099A2 (en) 2006-07-26

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