WO2005034907A1 - Skin care topical ointment - Google Patents
Skin care topical ointment Download PDFInfo
- Publication number
- WO2005034907A1 WO2005034907A1 PCT/US2004/017636 US2004017636W WO2005034907A1 WO 2005034907 A1 WO2005034907 A1 WO 2005034907A1 US 2004017636 W US2004017636 W US 2004017636W WO 2005034907 A1 WO2005034907 A1 WO 2005034907A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ointment
- total weight
- wax
- topical
- set forth
- Prior art date
Links
- 229940100615 topical ointment Drugs 0.000 title claims abstract description 48
- 239000002674 ointment Substances 0.000 claims abstract description 127
- 238000000518 rheometry Methods 0.000 claims abstract description 25
- 239000003974 emollient agent Substances 0.000 claims abstract description 24
- 239000003623 enhancer Substances 0.000 claims abstract description 24
- 239000011236 particulate material Substances 0.000 claims abstract description 20
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000011787 zinc oxide Substances 0.000 claims abstract description 6
- -1 skin protectants Substances 0.000 claims description 35
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 22
- 239000000194 fatty acid Substances 0.000 claims description 22
- 229930195729 fatty acid Natural products 0.000 claims description 22
- 229920001577 copolymer Polymers 0.000 claims description 20
- 239000001993 wax Substances 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 16
- 150000004665 fatty acids Chemical class 0.000 claims description 15
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 13
- 239000002480 mineral oil Substances 0.000 claims description 13
- 235000010446 mineral oil Nutrition 0.000 claims description 13
- 239000000843 powder Substances 0.000 claims description 13
- 150000002191 fatty alcohols Chemical class 0.000 claims description 12
- 239000004264 Petrolatum Substances 0.000 claims description 11
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 11
- 229940066842 petrolatum Drugs 0.000 claims description 11
- 235000019271 petrolatum Nutrition 0.000 claims description 11
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 11
- 229940008099 dimethicone Drugs 0.000 claims description 10
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 10
- 229920000642 polymer Polymers 0.000 claims description 10
- 239000004094 surface-active agent Substances 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 150000002148 esters Chemical class 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
- 235000013871 bee wax Nutrition 0.000 claims description 8
- 239000012166 beeswax Substances 0.000 claims description 8
- 229940119170 jojoba wax Drugs 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 7
- 239000010445 mica Substances 0.000 claims description 7
- 229910052618 mica group Inorganic materials 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 239000004698 Polyethylene Substances 0.000 claims description 6
- 229920002367 Polyisobutene Polymers 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000004615 ingredient Substances 0.000 claims description 6
- 229920000573 polyethylene Polymers 0.000 claims description 6
- 239000004711 α-olefin Substances 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- BXOUVIIITJXIKB-UHFFFAOYSA-N ethene;styrene Chemical group C=C.C=CC1=CC=CC=C1 BXOUVIIITJXIKB-UHFFFAOYSA-N 0.000 claims description 5
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 claims description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- 229920001353 Dextrin Polymers 0.000 claims description 4
- 239000004375 Dextrin Substances 0.000 claims description 4
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 4
- 239000005977 Ethylene Substances 0.000 claims description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical compound CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 claims description 4
- 239000004166 Lanolin Substances 0.000 claims description 4
- 244000044822 Simmondsia californica Species 0.000 claims description 4
- 235000004433 Simmondsia californica Nutrition 0.000 claims description 4
- 239000004163 Spermaceti wax Substances 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- 239000000440 bentonite Substances 0.000 claims description 4
- 229910000278 bentonite Inorganic materials 0.000 claims description 4
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 4
- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 claims description 4
- 239000004204 candelilla wax Substances 0.000 claims description 4
- 235000013868 candelilla wax Nutrition 0.000 claims description 4
- 229940073532 candelilla wax Drugs 0.000 claims description 4
- 235000019425 dextrin Nutrition 0.000 claims description 4
- 239000003205 fragrance Substances 0.000 claims description 4
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims description 4
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 claims description 4
- 229910000271 hectorite Inorganic materials 0.000 claims description 4
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 claims description 4
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims description 4
- 239000012182 japan wax Substances 0.000 claims description 4
- 235000019388 lanolin Nutrition 0.000 claims description 4
- 229940039717 lanolin Drugs 0.000 claims description 4
- 239000004200 microcrystalline wax Substances 0.000 claims description 4
- 235000019808 microcrystalline wax Nutrition 0.000 claims description 4
- 239000004170 rice bran wax Substances 0.000 claims description 4
- 235000019384 rice bran wax Nutrition 0.000 claims description 4
- 235000019385 spermaceti wax Nutrition 0.000 claims description 4
- 229920003048 styrene butadiene rubber Polymers 0.000 claims description 4
- 239000004408 titanium dioxide Substances 0.000 claims description 4
- 229930182558 Sterol Natural products 0.000 claims description 3
- 230000000843 anti-fungal effect Effects 0.000 claims description 3
- 229940121375 antifungal agent Drugs 0.000 claims description 3
- 239000003963 antioxidant agent Substances 0.000 claims description 3
- 239000003212 astringent agent Substances 0.000 claims description 3
- 239000003086 colorant Substances 0.000 claims description 3
- 239000002537 cosmetic Substances 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 claims description 3
- 150000002195 fatty ethers Chemical class 0.000 claims description 3
- 235000015110 jellies Nutrition 0.000 claims description 3
- 239000008274 jelly Substances 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 230000003020 moisturizing effect Effects 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- 150000003432 sterols Chemical class 0.000 claims description 3
- 235000003702 sterols Nutrition 0.000 claims description 3
- 239000000454 talc Substances 0.000 claims description 3
- 229910052623 talc Inorganic materials 0.000 claims description 3
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 2
- ROGIWVXWXZRRMZ-UHFFFAOYSA-N 2-methylbuta-1,3-diene;styrene Chemical compound CC(=C)C=C.C=CC1=CC=CC=C1 ROGIWVXWXZRRMZ-UHFFFAOYSA-N 0.000 claims description 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000005995 Aluminium silicate Substances 0.000 claims description 2
- 244000144725 Amygdalus communis Species 0.000 claims description 2
- 235000011437 Amygdalus communis Nutrition 0.000 claims description 2
- 229910052582 BN Inorganic materials 0.000 claims description 2
- PZNSFCLAULLKQX-UHFFFAOYSA-N Boron nitride Chemical compound N#B PZNSFCLAULLKQX-UHFFFAOYSA-N 0.000 claims description 2
- 244000180278 Copernicia prunifera Species 0.000 claims description 2
- 235000010919 Copernicia prunifera Nutrition 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims description 2
- 229920001908 Hydrogenated starch hydrolysate Polymers 0.000 claims description 2
- 229920001202 Inulin Polymers 0.000 claims description 2
- 239000005909 Kieselgur Substances 0.000 claims description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 2
- 241000772415 Neovison vison Species 0.000 claims description 2
- 239000004677 Nylon Substances 0.000 claims description 2
- AZUZXOSWBOBCJY-UHFFFAOYSA-N Polyethylene, oxidized Polymers OC(=O)CCC(=O)C(C)C(O)CCCCC=O AZUZXOSWBOBCJY-UHFFFAOYSA-N 0.000 claims description 2
- 239000004793 Polystyrene Substances 0.000 claims description 2
- 108010009736 Protein Hydrolysates Proteins 0.000 claims description 2
- 235000019485 Safflower oil Nutrition 0.000 claims description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims description 2
- 239000004147 Sorbitan trioleate Substances 0.000 claims description 2
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 239000002174 Styrene-butadiene Substances 0.000 claims description 2
- 235000019486 Sunflower oil Nutrition 0.000 claims description 2
- IJCWFDPJFXGQBN-RYNSOKOISA-N [(2R)-2-[(2R,3R,4S)-4-hydroxy-3-octadecanoyloxyoxolan-2-yl]-2-octadecanoyloxyethyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCCCCCCCCCCCC IJCWFDPJFXGQBN-RYNSOKOISA-N 0.000 claims description 2
- 239000006096 absorbing agent Substances 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 150000001336 alkenes Chemical class 0.000 claims description 2
- 235000012211 aluminium silicate Nutrition 0.000 claims description 2
- 239000012164 animal wax Substances 0.000 claims description 2
- 230000000845 anti-microbial effect Effects 0.000 claims description 2
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 239000002518 antifoaming agent Substances 0.000 claims description 2
- 235000021302 avocado oil Nutrition 0.000 claims description 2
- 239000008163 avocado oil Substances 0.000 claims description 2
- 239000012179 bayberry wax Substances 0.000 claims description 2
- 239000011324 bead Substances 0.000 claims description 2
- 229940005787 behenyl benzoate Drugs 0.000 claims description 2
- 229940073609 bismuth oxychloride Drugs 0.000 claims description 2
- 235000021324 borage oil Nutrition 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 239000000828 canola oil Substances 0.000 claims description 2
- 235000019519 canola oil Nutrition 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000003240 coconut oil Substances 0.000 claims description 2
- 235000019864 coconut oil Nutrition 0.000 claims description 2
- 230000003750 conditioning effect Effects 0.000 claims description 2
- 235000005687 corn oil Nutrition 0.000 claims description 2
- 239000002285 corn oil Substances 0.000 claims description 2
- 235000012343 cottonseed oil Nutrition 0.000 claims description 2
- 239000002385 cottonseed oil Substances 0.000 claims description 2
- 229940086555 cyclomethicone Drugs 0.000 claims description 2
- 239000002781 deodorant agent Substances 0.000 claims description 2
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims description 2
- IACXYDVFQDGXJF-UHFFFAOYSA-N docosyl benzoate Chemical compound CCCCCCCCCCCCCCCCCCCCCCOC(=O)C1=CC=CC=C1 IACXYDVFQDGXJF-UHFFFAOYSA-N 0.000 claims description 2
- VHBIJZUKAGFIJJ-UHFFFAOYSA-N ethyl hexanoate;hexadecanoic acid Chemical compound CCCCCC(=O)OCC.CCCCCCCCCCCCCCCC(O)=O VHBIJZUKAGFIJJ-UHFFFAOYSA-N 0.000 claims description 2
- 229920006213 ethylene-alphaolefin copolymer Polymers 0.000 claims description 2
- 235000008524 evening primrose extract Nutrition 0.000 claims description 2
- 239000010475 evening primrose oil Substances 0.000 claims description 2
- 229940089020 evening primrose oil Drugs 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- 125000005908 glyceryl ester group Chemical group 0.000 claims description 2
- 229940075529 glyceryl stearate Drugs 0.000 claims description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims description 2
- 229920001519 homopolymer Polymers 0.000 claims description 2
- 239000010514 hydrogenated cottonseed oil Substances 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 229940029339 inulin Drugs 0.000 claims description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 2
- 229940094522 laponite Drugs 0.000 claims description 2
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 claims description 2
- 239000000314 lubricant Substances 0.000 claims description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 2
- 239000001095 magnesium carbonate Substances 0.000 claims description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 2
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000391 magnesium silicate Substances 0.000 claims description 2
- 229910052919 magnesium silicate Inorganic materials 0.000 claims description 2
- 235000019792 magnesium silicate Nutrition 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 235000010755 mineral Nutrition 0.000 claims description 2
- 239000012184 mineral wax Substances 0.000 claims description 2
- 229920001778 nylon Polymers 0.000 claims description 2
- KPWVFNOPNOTYNJ-UHFFFAOYSA-N octadecyl benzoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)C1=CC=CC=C1 KPWVFNOPNOTYNJ-UHFFFAOYSA-N 0.000 claims description 2
- 125000005375 organosiloxane group Chemical group 0.000 claims description 2
- 239000012168 ouricury wax Substances 0.000 claims description 2
- BWOROQSFKKODDR-UHFFFAOYSA-N oxobismuth;hydrochloride Chemical compound Cl.[Bi]=O BWOROQSFKKODDR-UHFFFAOYSA-N 0.000 claims description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 229920013639 polyalphaolefin Polymers 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims description 2
- 239000011347 resin Substances 0.000 claims description 2
- 229920005989 resin Polymers 0.000 claims description 2
- 235000005713 safflower oil Nutrition 0.000 claims description 2
- 239000003813 safflower oil Substances 0.000 claims description 2
- 239000012176 shellac wax Substances 0.000 claims description 2
- 229960004029 silicic acid Drugs 0.000 claims description 2
- 229920002379 silicone rubber Polymers 0.000 claims description 2
- 239000001540 sodium lactate Substances 0.000 claims description 2
- 229940005581 sodium lactate Drugs 0.000 claims description 2
- 235000011088 sodium lactate Nutrition 0.000 claims description 2
- CRPCXAMJWCDHFM-UHFFFAOYSA-M sodium;5-oxopyrrolidine-2-carboxylate Chemical compound [Na+].[O-]C(=O)C1CCC(=O)N1 CRPCXAMJWCDHFM-UHFFFAOYSA-M 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000001593 sorbitan monooleate Substances 0.000 claims description 2
- 235000011069 sorbitan monooleate Nutrition 0.000 claims description 2
- 229940035049 sorbitan monooleate Drugs 0.000 claims description 2
- 229950011392 sorbitan stearate Drugs 0.000 claims description 2
- 235000019337 sorbitan trioleate Nutrition 0.000 claims description 2
- 229960000391 sorbitan trioleate Drugs 0.000 claims description 2
- 239000001589 sorbitan tristearate Substances 0.000 claims description 2
- 235000011078 sorbitan tristearate Nutrition 0.000 claims description 2
- 229960004129 sorbitan tristearate Drugs 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- 235000012424 soybean oil Nutrition 0.000 claims description 2
- 239000004458 spent grain Substances 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 229940070720 stearalkonium Drugs 0.000 claims description 2
- 125000005502 stearalkonium group Chemical group 0.000 claims description 2
- 229940102548 stearalkonium hectorite Drugs 0.000 claims description 2
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 239000011115 styrene butadiene Substances 0.000 claims description 2
- 239000002600 sunflower oil Substances 0.000 claims description 2
- YAIHETNVSHUZMY-UHFFFAOYSA-N trimethyl-(methyl-octadecyl-trimethylsilyloxysilyl)oxysilane Chemical compound CCCCCCCCCCCCCCCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C YAIHETNVSHUZMY-UHFFFAOYSA-N 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 239000012178 vegetable wax Substances 0.000 claims description 2
- 239000010408 film Substances 0.000 claims 1
- 229920005996 polystyrene-poly(ethylene-butylene)-polystyrene Polymers 0.000 claims 1
- 230000000699 topical effect Effects 0.000 abstract description 36
- 206010012444 Dermatitis diaper Diseases 0.000 abstract description 13
- 208000003105 Diaper Rash Diseases 0.000 abstract description 12
- 210000003491 skin Anatomy 0.000 description 66
- 239000000047 product Substances 0.000 description 13
- 201000004624 Dermatitis Diseases 0.000 description 12
- 230000008901 benefit Effects 0.000 description 10
- 230000002745 absorbent Effects 0.000 description 8
- 239000002250 absorbent Substances 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- 239000007787 solid Substances 0.000 description 7
- 210000002700 urine Anatomy 0.000 description 7
- 210000003608 fece Anatomy 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000002085 irritant Substances 0.000 description 5
- 231100000021 irritant Toxicity 0.000 description 5
- 206010021639 Incontinence Diseases 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000003094 microcapsule Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 230000036559 skin health Effects 0.000 description 4
- 235000013980 iron oxide Nutrition 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 229940061720 alpha hydroxy acid Drugs 0.000 description 2
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000013872 defecation Effects 0.000 description 2
- 229940126534 drug product Drugs 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000001023 inorganic pigment Substances 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000012860 organic pigment Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- 206010012434 Dermatitis allergic Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 244000042664 Matricaria chamomilla Species 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 108010046334 Urease Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 125000005376 alkyl siloxane group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- IRERQBUNZFJFGC-UHFFFAOYSA-L azure blue Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[S-]S[S-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] IRERQBUNZFJFGC-UHFFFAOYSA-L 0.000 description 1
- GSEGKBMSKPDICA-UHFFFAOYSA-L barium(2+) 2-[(3-carboxy-2-oxidonaphthalen-1-yl)diazenyl]-5-methylbenzenesulfonate Chemical compound [Ba++].Cc1ccc(N=Nc2c(O)c(cc3ccccc23)C([O-])=O)c(c1)S([O-])(=O)=O GSEGKBMSKPDICA-UHFFFAOYSA-L 0.000 description 1
- 150000001277 beta hydroxy acids Chemical class 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 235000012745 brilliant blue FCF Nutrition 0.000 description 1
- 229940067573 brown iron oxide Drugs 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000003822 cell turnover Effects 0.000 description 1
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 1
- PZTQVMXMKVTIRC-UHFFFAOYSA-L chembl2028348 Chemical compound [Ca+2].[O-]S(=O)(=O)C1=CC(C)=CC=C1N=NC1=C(O)C(C([O-])=O)=CC2=CC=CC=C12 PZTQVMXMKVTIRC-UHFFFAOYSA-L 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000021384 green leafy vegetables Nutrition 0.000 description 1
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 description 1
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- LDHBWEYLDHLIBQ-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide;hydrate Chemical compound O.[OH-].[O-2].[Fe+3] LDHBWEYLDHLIBQ-UHFFFAOYSA-M 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- AAAQKTZKLRYKHR-UHFFFAOYSA-N triphenylmethane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8117—Homopolymers or copolymers of aromatic olefines, e.g. polystyrene; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8135—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid; Compositions of derivatives of such polymers, e.g. vinyl esters (polyvinylacetate)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
Definitions
- the present invention relates to formulations that may be topically applied to the skin to improve skin health. More particularly, the present invention relates to a topical ointment that can be applied directly to skin, or applied to an absorbent article to be used next to the skin, comprising an emollient, a structurant, and a rheology enhancer.
- the novel topical ointment has improved spreadability over the skin, enhanced aesthetics, and provides improved film formation properties to block water borne irritants from entering the skin.
- Diaper rash and related skin problems are common forms of skin irritation and inflammation of those parts of an infant's or adult's body normally covered by an absorbent product such as a diaper or incontinence garment. Also, the skin irritation may be seen in areas adjacent the covered skin. This skin condition may also be commonly referred to as diaper dermatitis, napkin dermatitis, napkin rash, and nappy rash. [0003] Although the precise number of infants who suffer from diaper rash is unknown, it is believed to be substantial. Further, while certainly more common in infants, this condition is not limited solely to infants. Any individual who suffers from incontinence may also develop this type of dermatitis. This includes both the elderly, critically ill, and non-ambulatory individuals.
- Symptoms from this type of dermatitis can range from moderate to very severe .
- the principal cause of diaper dermatitis is the holding of urine and/or feces against the skin. With urine, urea contained therein is broken down into ammonium hydroxide by the ureases, which leads to an increase in pH on the skin's surface. When the pH becomes basic on the skin's surface, numerous enzymes may be activated and interfere with several naturally occurring skin components .
- Conventional methods for combating diaper rash have been diverse . Several methods have included an attempt to minimize the contact of the skin with feces or urine present in a soiled diaper. Typically, an artificial barrier is employed to accomplish this.
- the high viscosity associated with these products keeps the diaper rash ointment from being substantially washed off of the skin by urine and/or feces.
- the high viscosity of the ointment is the result of the inclusion of zinc oxide, or another particulate, as a component.
- zinc oxide or another particulate
- conventional topical ointments have been somewhat satisfactory in combating various skin ailments including diaper dermatitis, many of the ointments do not spread easily or evenly across the skin surface, and may feel greasy or gritty upon application to the skin.
- the present invention relates to topical ointments for direct application to the skin for preventing and treating diaper dermatitis and related rashes and skin ailments.
- the topical ointments can be applied directly onto an absorbent product, such as a diaper or incontinence garment, such that upon use of the product, the ointment is transferred to the skin of the wearer and provides a benefit in reducing diaper dermatitis.
- the topical ointments In order to ensure that any particulate materials present in the topical ointment are evenly suspended therein after processing and introduction into a container, the topical ointments have a process temperature viscosity as defined herein of from about 50 cPs to about 50,000 cPs.
- the topical ointments comprise the following components: (a) an emoll ient ; (b) a structurant ; (c) a rheology enhancer; and (d) other optional components.
- compositions suitable for use in the topical ointments described herein include, for example, particulate materials, low HLB surfactants, (water-in-oil emulsifiers) , ant i-inflammatories, antibiotics, anti-fungals, anti-histamines, moisturizers, vitamins, botanical extracts, skin protectants, astringents, lipids, sterols, powders, fragrances, antioxidants, colorants, microcapsules, microsponges, polymeric entrapment particles, preservatives, fragrances, optical brighteners, sunscreens, alpha hydroxy acids, and combinations thereof.
- low HLB surfactants water-in-oil emulsifiers
- ant i-inflammatories include, for example, particulate materials, low HLB surfactants, (water-in-oil emulsifiers) , ant i-inflammatories, antibiotics, anti-fungals, anti-histamines, moisturizers, vitamins
- the present invention is directed to a topical ointment comprising from about 10% (by total weight of the ointment) to about 89% (by total weight of the ointment) of an emollient, from about 10% (by total weight of the ointment) to about 50% (by total weight of the ointment) of a structurant, and from about 0.1% (by total weight of the ointment) to about 40% (by total weight of the ointment) of a rheology enhancer.
- the present invention is further directed to a topical ointment comprising from about 10% (by total weight of the ointment) to about 89% (by total weight of the ointment) of an emollient, from about 10% (by total weight of the ointment) to about 50% (by total weight of the ointment) of a structurant, from about 0.1% (by total weight of the ointment) to about 40% (by total weight of the ointment) of a rheology enhancer, from about 0.1% (by total weight of the ointment) to about 25% (by total weight of the ointment) of a particulate material, and from about 0.1% (by total weight of the ointment) to about 10% (by total weight of the ointment) of a low HLB surf ctant .
- rheology enhancers can be introduced into a topical ointment for preventing and treating diaper rash to improve various properties of the topical ointment.
- the rheology enhancers result in improved spreadability of the ointment across the surface of the skin, and provide enhanced aesthetics of the ointment.
- the rheology enhancers result in improved film formation properties, which result in a blocking of water borne irritants from entering the skin.
- the topical ointments described herein are suitable for preventing and treating diaper rash and other related skin ailments and diseases including eczema, dermatitis, and allergic skin reactions.
- the topical ointments are effective in treating such skin conditions as cracking, chaffing, and redness, and are particularly suited for restoring the skin to its natural healthy condition.
- the topical ointments may suitably be applied directly to the skin. Once applied to the skin, the topical ointment provides a barrier layer between the skin and potential skin irritants, such as urine and feces.
- topical ointments are viscous materials, they do not wash away from the skin easily after urination and/or defecation and provide a substantial barrier layer.
- the topical ointments described herein may also be applied directly onto an absorbent article, such as a diaper or incontinence garment.
- the topical ointment is applied to the absorbent article in the crotch and/or buttock-contacting area of the article as these areas on the wearer are most susceptible to diaper rash.
- the topical ointment can transfer from the article to the wearer's skin where it forms a barrier layer protecting the skin from irritants that can ultimately lead to diaper rash and other skin conditions. Further, the topical ointment can be applied both directly to the skin and to an absorbent article to ensure a sufficient amount is on the sk-in after urination and/or defecation.
- the topical ointments described herein are either solid or semi-solid at room temperature, and are easily spreadable over the skin in the form of a cream, salve, jelly, stick:, or other commercially acceptable form.
- the term "semi-solid" means that the topical ointment has a rheology typical of pseudoplastic or plastic fluids.
- the topical ointments described herein impart a soft, lubricious, lotion-like feel to the touch.
- the topical ointments of the present invention comprise an emollient, a structurant, and a rheology enhancer.
- Other optional components, such as particulate materials, low HLB surfactants, and others may also be included in the topical ointments as discussed herein to impart additional benefits to the topical ointment.
- An emollient is an active ingredient in a formulation that typically softens, soothes, supples, coats, lubricates and/or moisturizes the skin. Generally, emollients accomplish several of these objectives simultaneously. Typically, emollients suitable for use in the topical ointments described herein are fluids at room temperature such that they impart a soft, lubricious lotionlike feel upon use.
- the emollient is present in the topical ointment in an amount of from about 10% (by total weight of the ointment) to about 89% (by total weight of the ointment) , more desirably from about 30% (by total weight of the ointment) to about 80% (by total weight of the ointment) , and still more desirably from about 60% (by total weight of the ointment) to about 80% (by total weight of the ointment) .
- Suitable emollients for use in the topical ointments of the present invention are typically substantially water free.
- the emollient may contain trace amounts of water as a contaminant without substantially harming the topical ointment, it is preferred that the amount of water be less than about 5% by weight of the emollient component of the topical ointment to reduce the likelihood of icrobial growth and product destruction.
- Suitable emollients for use in the topical ointments of the present invention include, for example, petrolatum, mineral oil, mineral jelly, isoparaffins , vegetable oils such as avocado oil, borage oil, canola oil, castor oil, chamomile, coconut oil, corn oil, cottonseed oil, evening primrose oil, safflower oil, sunflower oil, soybean oil, sweet almond, and the like, sterols and derivates, lanolin, partially hydrogenated vegetable oils, polydimethylsilox-anes such as methicone, cyclomethicone, dimethicone, dimethiconol, and trimethicone, organo-siloxanes (i.e., where the organic functionality can be selected from alkyl, phenyl, amine, polyethylene glycol, amine-glycol, alkylaryl, carboxal, and the like), silicone elastomer, gums, resins, fatty acid esters (esters of C
- emollients are solids at room temperature, and may have a dual benefit of being solid emollients (at room temperature) as well as structuring agents.
- Compounds that act as both emollients and structuring agents include, for example, C ⁇ 4 -C 28 fatty acid esters (esters of C 12 -C 2 8 fatty acids and C ⁇ 2 -C 2 8 fatty alcohols) , Ci4-C 28 fatty alcohols, C 14 -C 28 fatty acids, C 14 -C 28 fatty acid ethoxylates, C ⁇ 4 -C 28 fatty ethers and C ⁇ 6 -C 3 o alkyl siloxanes .
- the structurant utilized in the topical ointments described herein help to solidify the emollient and other components into a solid or semi-solid cream or paste.
- the structurant is present in the topical ointment in an amount of from about 10% (by total weight of the ointment) to about 50% (by total weight of the ointment) , desirably from about 20% (by total weight of the ointment) to about 40% (by total weight of the ointment) .
- Suitable structurants for use in the topical ointments disclosed herein have a melting point of about 45°C to about 85°C and may include, for example, waxes including animal waxes, vegetable waxes, mineral waxes, synthetic waxes, and polymers.
- Exemplary waxes include bayberry wax, beeswax, stearyl dimethicone, stearyl trimethicone, C 20 -C 22 dimethicone, C20-C22 trimethicone, C 2 4-C 2 8 dimethicone, C20-C22 trimethicone, C 30 alkyl dimethicone, candelilla wax, carnauba, ceresin, cetyl esters, stearyl benzoate, behenyl benzoate, esparto, hydrogenated cottonseed oil, hydrogenated jojoba oil, hydrogenated jojoba wax, hydrogenated microcrystalline wax, hydrogenated rice bran wax, japan wax, jojoba buffer, jojoba esters, jojoba wax, lanolin wax, microcrystalline wax, mink wax, motan acide wax, motan wax, ouricury wax, ozokerite parrafin, PEG-6 beeswax, PEG-8 beeswax
- the rheology enhancers present in the topical ointments impart numerous desirable characteristics and properties to the ointments.
- the rheology enhancers help the topical ointments to maintain a high viscosity at elevated temperatures, such as those encountered during storage and transportation as well as during cooling of the product .
- the rheology enhancer increases the viscosity of the lubricating formulation by at least about 50%, more desirably at least about 500%, and even more desirably at least about 1000%. This helps ensure that the topical ointments do not substantially separate out during processing, storage, and transportation. Additionally, the rheology enhancers impart excellent spreadability characteristics to the topical ointments such that the ointment is easily spreadable across the skin evenly and efficiently. This allows a user to easily introduce an even coating of the ointment onto the skin and assures that there will be no bare spots on the treated skin that could be susceptible to urine and/or feces contact, which can result in diaper rash.
- the rheology enhancer provides the ointment with an improved film formation property such that water borne irritants are blocked from entering the skin when present at or near the skin surface.
- the rheology enhancers have the ability to uniformly suspend particulate materials, such as zinc oxide, titanium dioxide, microcapsules, or microsponges, in the formulation. This uniform suspension of particulate materials, which can provide additional skin health benefits, ensures an even application of the particulate materials on the skin during the application of the topical ointment.
- the rheology enhancer is present in the topical ointment in an amount of from about 0.1% (by total weight of the ointment) to about 40% (by total weight of the ointment) , desirably from about 0.5% (by total weight of the ointment) to about 30% (by total weight of the ointment) and even more desirably from about 1% (by total weight of the ointment) to about 25% (by total weight of the ointment) .
- Suitable rheology enhancers include combinations of alpha-olefins and styrene alone or in combination with mineral oil or petrolatum, combinations of di-functional alpha-olefins and styrene alone or in combination with mineral oil or petrolatum, combinations of alpha olefins and isobutene, ethylene/propylene/styrene copolymers alone or in combination with, mineral oil or petrolatum, butylene/ethylene/styrene copolymers alone or in combination with mineral oil or petrolatum, ethylene/vinyl acetate copolymers, polyethylene polyisobutylenes, polyisobutenes, polyisobutylene, dextrin palmitate, dextrin palmitate ethylhexanoate, stearoyl inulin, stearalkonium bentonite, distearadimonium hectorite, and stearalkonium hectorite
- rheology enhancers such as mineral oil and ethylene/propylene/styrene copolymers, and mineral oil and butylene/ethylene/styrene copolymers (Versagel blend from Penreco) are particularly preferred. Also, Vistanex: (Exxon) and Presperse (Amoco) polymers are particularly suitable rheology enhancers.
- the topical ointments described herein have a specific process temperature viscosity, as defined herein.
- the process temperature viscosities defined herein for the topical ointments allow the ointments to keep suspended various particles in the ointment during the cooling of the ointment in the container after processing.
- the topical ointments described herein have a process temperature viscosity of from about 50 cPs to about 50,000 cPs, desirably from about 75 cPs to about 10,000 cPs, and more desirably from about 80 cPs to about 5,000 cPs .
- the process temperature is typically from about 5°C to about 20°C above the melting point of the topical ointment.
- the topical ointments described herein may also comprise a particulate material, which can impart additional benefits to the skin upon application.
- particulate material is meant to include a dry, particulate material having a size of from about 0.001 micrometers to about 150 micrometers, desirably from about 0.01 micrometers to about 100 micrometers, and still more desirably from about 0.1 micrometers to about 30 micrometers.
- the particulate materials may be colored or non-colored, and may provide one or more benefits to the topical ointments or skin such as, for example, coloration, light diffraction, oil absorption, translucency, opacification, pearlescence, matte appearance, lubricious feel, skin coverage, and the like.
- the particulate material may be present in the topical ointment in an amount of from about 0.1% (by total weight of the ointment) to about 35% (by total weight of the ointment) .
- Suitable particulate materials include various organic and inorganic pigments that color the composition or the skin upon use.
- Organic pigments are generally various types including azo, indigold, triphenylmethane, anthraquinone, and xanthine dyes, which are designated as D&C and FD&C blues, browns, greens, oranges, reds, yellows, etc.
- Inorganic pigments are generally insoluble metallic salts of certified color additives referred to as lakes or iron oxides. Suitable pigments include, for example, red iron oxide, yellow iron oxide, black iron oxide, brown iron oxide, ultramarine, FD&C Red, Nos . 2, 5, 6, 7, 10, 11, 12, 13, 30 and 34, FD&C Yellow No.
- Aluminum Lakes Yellow 5, 6, and 10 Aluminum Lakes, Orange 5 Aluminum Lake, Blue 1 Aluminum Lake, Red 6 Barium Lake, Red 7 Calcium Lake, and the like.
- Other useful particulate materials include talc, mica, titanated mica (mica coated with titanium dioxide) , iron oxide titanated mica, magnesium carbonate, calcium carbonate, magnesium silicate, silica (including spherical silica, hydrated silica, and silica beads) , titanium dioxide, zinc oxide, nylon powder, polyethylene powder, ethylene acrylates copolymer powder, methacrylate powder, polystyrene powder, silk powder, crystalline cellulose, starch, bismuth oxychloride, guanine, kaolin, bentonite, hectorite, laponite, chalk, diatomaceous earth, microsponges , microcapsules, boron nitride, and the like.
- an optional low HLB (hydrophilic/lipophilic balance) surfactant can be added to the topical ointment which is capable of emulsifying or dispersing one or more components in the topical ointment.
- the low HLB surfactant has an HLB in the range of from about 2 to about 7.
- the amount of low HLB surfactant can be from about 0.1% (by total weight of the ointment) to about 20% (by total weight of the ointment) , more desirably from about 0.1% (by total weight of the ointment) to about 10% (by total weight of the ointment) .
- Low HLB sur actants are employed typically to form emulsions or dispersions of various components.
- Suitable surfactants for use in the topical ointments include, for example, sorbitan monooleate, sorbitan sequioleate, sorbitan trioleate, glyceryl stearate, sorbitan stearate, sorbitan tristearate, and the like, as well as mixtures thereof.
- the topical ointments described herein may additionally comprise a hydrophilic skin care active to impart a skin care benefit to the ointment.
- the skin care active may be present in the ointment in an amount of from about 0.1% (by total weight of ointment) to about 10% (by total weight of the ointment) .
- Suitable skin care actives include, for example, botanicals, glycerin, hydrogenated starch hydrolysate, propylene glycol, sodium PCA, sodium lactate, sorbitol, and mixtures thereof. [0036] In order to better enhance the benefits to consumers, additional ingredients can be incorporated into the lubrication formulation described herein.
- the classes of ingredients and their corresponding benefits include, without limitation: antifoaming agents (reduce the tendency of foaming during processing) ; antimicrobial actives; antivirul actives: antifungal actives; antiseptic actives; antioxidants (product integrity to prevent oxidation of natural oils and other ingredients on the formulation or composition) ; astringents--cosmetic (induce a tightening or tingling sensation on skin) ; astringents- -drug (a drug product which checks oozing, discharge, or bleeding when applied to skin or mucous membrane and works by coagulating protein) ; biological additives (enhance the performance or consumer appeal of the product including vitamins) ; colorants (impart color to the product) ; deodorants (reduce or eliminate unpleasant odor and protect against the formation of malodor on body surfaces) ; film formers (to hold active ingredients on the skin by producing a continuous film on skin upon drying) ; fragrances (consumer appeal) ; lubricants, such as silicones and organ
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04754283A EP1667650A1 (en) | 2003-09-11 | 2004-06-03 | Skin care topical ointment |
MXPA06002166A MXPA06002166A (en) | 2003-09-11 | 2004-06-03 | Skin care topical ointment. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/659,967 | 2003-09-11 | ||
US10/659,967 US7547443B2 (en) | 2003-09-11 | 2003-09-11 | Skin care topical ointment |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005034907A1 true WO2005034907A1 (en) | 2005-04-21 |
WO2005034907A8 WO2005034907A8 (en) | 2005-10-06 |
Family
ID=34273558
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/017636 WO2005034907A1 (en) | 2003-09-11 | 2004-06-03 | Skin care topical ointment |
Country Status (5)
Country | Link |
---|---|
US (1) | US7547443B2 (en) |
EP (1) | EP1667650A1 (en) |
KR (1) | KR20060123067A (en) |
MX (1) | MXPA06002166A (en) |
WO (1) | WO2005034907A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210161779A1 (en) * | 2015-06-23 | 2021-06-03 | Carrie D. Alspaugh, M.D., P.A. | Hand Sanitizing Compositions |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7547443B2 (en) | 2003-09-11 | 2009-06-16 | Kimberly-Clark Worldwide, Inc. | Skin care topical ointment |
US20050059941A1 (en) * | 2003-09-11 | 2005-03-17 | Kimberly-Clark Worldwide, Inc. | Absorbent product with improved liner treatment |
US7485373B2 (en) * | 2003-09-11 | 2009-02-03 | Kimberly-Clark Worldwide, Inc. | Lotioned tissue product with improved stability |
EP1895961B1 (en) * | 2005-06-29 | 2019-03-20 | The Procter and Gamble Company | Disposable absorbent article containing an adhesively bonded elastic member |
US20090283505A1 (en) * | 2005-07-13 | 2009-11-19 | Dr Industries | Interface suspension for alloy based laser welding |
US8663665B2 (en) * | 2006-03-02 | 2014-03-04 | Momentive Performance Materials Inc. | Anti-chafing compositions comprising boron nitride |
WO2007105147A1 (en) * | 2006-03-14 | 2007-09-20 | The Procter & Gamble Company | Absorbent articles with lotions |
US20080145443A1 (en) * | 2006-12-15 | 2008-06-19 | Kimberly-Clark Worldwide, Inc. | Diaper rash composition and method |
US20080287896A1 (en) * | 2007-05-15 | 2008-11-20 | The Procter & Gamble Company | Absorbent Article With Hydrophilic Lotion And High Barrier Cuffs |
EP1992367B1 (en) | 2007-05-15 | 2012-06-27 | The Procter & Gamble Company | Absorbent article comprising a lotion composition for reducing adherence of feces or menses to the skin |
EP1992366B1 (en) * | 2007-05-15 | 2011-07-06 | The Procter & Gamble Company | Use of a lotion composition on an absorbent article for reducing adherence of feces or menses to the skin |
FR2928548B1 (en) * | 2008-03-14 | 2015-07-03 | Basf Beauty Care Solutions F | SUBSTANCES INCREASING THRESHOLD OF ACTIVATION OF IMMUNE CELLS |
US8623386B2 (en) * | 2008-04-11 | 2014-01-07 | Kobo Products, Inc. | Natural ester, wax or oil treated pigment, process for production thereof, and cosmetic made therewith |
US7902134B1 (en) * | 2008-11-24 | 2011-03-08 | The Clorox Company | Natural personal cleanser compositions |
WO2012064720A2 (en) * | 2010-11-08 | 2012-05-18 | Barone Salvatore J | Lipstick and other cosmetics and method of making |
US8642645B2 (en) | 2011-05-20 | 2014-02-04 | Brooks Kelly Research, LLC. | Pharmaceutical composition comprising Cannabinoids |
US9320288B2 (en) | 2012-11-30 | 2016-04-26 | Cellresin Technologies, Llc | Controlled release compositions and methods of using |
US9744115B2 (en) | 2014-02-04 | 2017-08-29 | The Clorox Company | Natural personal care cream to powder compositions |
US9421793B2 (en) | 2014-06-26 | 2016-08-23 | Cellresin Technologies, Llc | Electrostatic printing of cyclodextrin compositions |
EP3227395A4 (en) | 2014-12-05 | 2018-06-27 | Western Michigan University Research Foundation | Colored special effect inks |
WO2016109517A1 (en) | 2014-12-29 | 2016-07-07 | Kimberly-Clark Worldwide, Inc. | Cosmetic emulsions |
MX369773B (en) | 2014-12-29 | 2019-11-20 | Kimberly Clark Co | Multifunctional base emulsion. |
CN105997529A (en) * | 2016-06-24 | 2016-10-12 | 南京为绿生物科技有限公司 | Membrane type healthy itching-relieving mosquito repellent |
ES2682844B1 (en) * | 2017-03-21 | 2019-06-26 | Perez Ingrid Caballero | A composition for topical application comprising natural waxes and their uses |
US20210299010A1 (en) * | 2020-03-31 | 2021-09-30 | Derma Jam LLC | Skin Protecting Cosmetic Concealer Ointment |
KR102440713B1 (en) * | 2020-07-29 | 2022-09-07 | 유한킴벌리 주식회사 | Lotion composition comprising D-panthenol and sanitary articles comprising thereof |
US20220330635A1 (en) * | 2021-04-14 | 2022-10-20 | Yty Industry Sdn Bhd | Elastomeric rubber gloves with improved skin hydration characteristics |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000064503A1 (en) * | 1999-04-23 | 2000-11-02 | Kimberly-Clark Worldwide, Inc. | Skin-friendly absorbent articles and compositions |
US20010014350A1 (en) * | 1999-08-24 | 2001-08-16 | Krzysik Duane Gerard | Absorbent articles providing skin health benefits |
WO2002034305A2 (en) * | 2000-10-20 | 2002-05-02 | Kimberly-Clark Worldwide, Inc. | Absorbent articles enhancing skin barrier function |
WO2003004070A1 (en) * | 2001-07-03 | 2003-01-16 | The Procter & Gamble Company | Film-forming compositions for protecting skin from body fluids and articles made therefrom |
WO2004087092A1 (en) * | 2003-03-28 | 2004-10-14 | The Procter & Gamble Company | Tacky skin care compositions and articles having tacky skin care compositions disposed thereon |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3301746A (en) | 1964-04-13 | 1967-01-31 | Procter & Gamble | Process for forming absorbent paper by imprinting a fabric knuckle pattern thereon prior to drying and paper thereof |
US4208459A (en) | 1970-04-13 | 1980-06-17 | Becker Henry E | Bonded, differentially creped, fibrous webs and method and apparatus for making same |
US3812000A (en) | 1971-06-24 | 1974-05-21 | Scott Paper Co | Soft,absorbent,fibrous,sheet material formed by avoiding mechanical compression of the elastomer containing fiber furnished until the sheet is at least 80%dry |
US3814096A (en) | 1973-03-09 | 1974-06-04 | F Weiss | Facial tissue |
US3974025A (en) | 1974-04-01 | 1976-08-10 | The Procter & Gamble Company | Absorbent paper having imprinted thereon a semi-twill, fabric knuckle pattern prior to final drying |
US3896807A (en) | 1974-06-13 | 1975-07-29 | Gilbert Buchalter | Article impregnated with skin-care formulations |
US4112167A (en) | 1977-01-07 | 1978-09-05 | The Procter & Gamble Company | Skin cleansing product having low density wiping zone treated with a lipophilic cleansing emollient |
US4191609A (en) | 1979-03-09 | 1980-03-04 | The Procter & Gamble Company | Soft absorbent imprinted paper sheet and method of manufacture thereof |
US4300981A (en) | 1979-11-13 | 1981-11-17 | The Procter & Gamble Company | Layered paper having a soft and smooth velutinous surface, and method of making such paper |
US4637859A (en) | 1983-08-23 | 1987-01-20 | The Procter & Gamble Company | Tissue paper |
US4690821A (en) | 1984-02-10 | 1987-09-01 | Creative Products Resource Associates, Ltd. | Towel for skin moisturizing and drying |
US5176668A (en) | 1984-04-13 | 1993-01-05 | Kimberly-Clark Corporation | Absorbent structure designed for absorbing body fluids |
US4798603A (en) | 1987-10-16 | 1989-01-17 | Kimberly-Clark Corporation | Absorbent article having a hydrophobic transport layer |
US5221534A (en) | 1989-04-26 | 1993-06-22 | Pennzoil Products Company | Health and beauty aid compositions |
US4962133A (en) | 1989-09-05 | 1990-10-09 | Dow Corning Corporation | Method of making highly adsorptive copolymers |
US5176672A (en) | 1990-11-13 | 1993-01-05 | Kimberly-Clark Corporation | Pocket-like diaper or absorbent article |
JPH04295417A (en) * | 1991-01-16 | 1992-10-20 | Estee Lauder Inc | Cosmetic composition containing styrene/ethylene/ propylene copolymer and method of using same |
DE533865T1 (en) | 1991-03-16 | 1993-11-04 | Torf Establishment, Vaduz, Li | TORF-DERIVATED BIOACTIVE PRODUCTS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS THEREOF. |
ZA92308B (en) | 1991-09-11 | 1992-10-28 | Kimberly Clark Co | Thin absorbent article having rapid uptake of liquid |
US5192606A (en) | 1991-09-11 | 1993-03-09 | Kimberly-Clark Corporation | Absorbent article having a liner which exhibits improved softness and dryness, and provides for rapid uptake of liquid |
US5520917A (en) * | 1992-07-27 | 1996-05-28 | Suzuki Yushi Industries Co., Ltd. | Materials in the form of colored spherical fine particles |
US5643588A (en) | 1994-11-28 | 1997-07-01 | The Procter & Gamble Company | Diaper having a lotioned topsheet |
US6238682B1 (en) | 1993-12-13 | 2001-05-29 | The Procter & Gamble Company | Anhydrous skin lotions having antimicrobial components for application to tissue paper products which mitigate the potential for skin irritation |
JP3786686B2 (en) | 1993-12-13 | 2006-06-14 | ザ プロクター アンド ギャンブル カンパニー | Lotion composition for imparting a soft, smooth feel to tissue paper |
CA2116081C (en) | 1993-12-17 | 2005-07-26 | Ann Louise Mccormack | Breathable, cloth-like film/nonwoven composite |
MX9606375A (en) | 1994-06-17 | 1997-03-29 | Procter & Gamble | Improved lotion composition for treating tissue paper. |
MX9606376A (en) | 1994-06-17 | 1997-04-30 | Procter & Gamble | Lotioned tissue paper. |
ES2132767T3 (en) | 1994-12-19 | 1999-08-16 | Procter & Gamble | TISSUE PAPER PRODUCT WITH MEDICATION. |
US5612045A (en) | 1995-06-07 | 1997-03-18 | Kimberly-Clark Corporation | Inhibition of exoprotein in absorbent article |
US5624676A (en) | 1995-08-03 | 1997-04-29 | The Procter & Gamble Company | Lotioned tissue paper containing an emollient and a polyol polyester immobilizing agent |
US5705164A (en) | 1995-08-03 | 1998-01-06 | The Procter & Gamble Company | Lotioned tissue paper containing a liquid polyol polyester emollient and an immobilizing agent |
FR2745016B1 (en) | 1996-02-19 | 1998-04-17 | James River | COMPOSITION FOR A SOFTENING LOTION, USE OF THE LOTION FOR THE TREATMENT OF AN ABSORBENT PAPER PRODUCT AND ABSORBENT PAPER PRODUCT THUS TREATED |
DE69735190T2 (en) * | 1996-02-20 | 2006-07-13 | Penreco, Houston | SOLID OR HALF-RESISTANT HYDROCARBONS |
NZ331962A (en) | 1996-03-29 | 1999-05-28 | Kimberly Clark Co | Absorbent article comprising a vapour permeable material with a specified water vapour transmission rate |
US6211139B1 (en) | 1996-04-26 | 2001-04-03 | Goldschmidt Chemical Corporation | Polyester polyquaternary compounds, compositions containing them, and use thereof |
US5843056A (en) | 1996-06-21 | 1998-12-01 | Kimberly-Clark Worldwide, Inc. | Absorbent article having a composite breathable backsheet |
US6433068B1 (en) | 1997-03-07 | 2002-08-13 | David S. Morrison | Hydrocarbon gels as suspending and dispersing agents and products |
US6063335A (en) | 1997-03-24 | 2000-05-16 | Henkel Corporation | Method for disinfecting surfaces |
US6179961B1 (en) | 1997-10-08 | 2001-01-30 | The Procter & Gamble Company | Tissue paper having a substantive anhydrous softening mixture deposited thereon |
US6261580B1 (en) | 1997-10-22 | 2001-07-17 | The Procter & Gamble Company | Tissue paper with enhanced lotion transfer |
CA2322503A1 (en) | 1998-03-12 | 1999-09-16 | Donald Carroll Roe | Disposable absorbent article having a skin care composition containing an enzyme inhibitor |
US6149934A (en) | 1999-04-23 | 2000-11-21 | Kimberly-Clark Worldwide, Inc. | Absorbent article having a lotionized bodyside liner |
US6217890B1 (en) * | 1998-08-25 | 2001-04-17 | Susan Carol Paul | Absorbent article which maintains or improves skin health |
US6716204B1 (en) | 1998-10-28 | 2004-04-06 | The Procter & Gamble Company | Absorbent article with improved feces containment characteristics |
AR023933A1 (en) | 1999-04-23 | 2002-09-04 | Kimberly Clark Co | AN ABSORBENT PRODUCT THAT PROVIDES A BARRIER INCREASE FOR THE SKIN, A METHOD FOR MAKING SUCH PRODUCT AND THE COMPOSITION OBTAINED. |
US6458343B1 (en) | 1999-05-07 | 2002-10-01 | Goldschmidt Chemical Corporation | Quaternary compounds, compositions containing them, and uses thereof |
AU5146500A (en) | 1999-05-19 | 2000-12-05 | Procter & Gamble Company, The | Absorbent article with skin care composition |
DE60023485T2 (en) | 1999-05-21 | 2006-07-20 | The Procter & Gamble Company, Cincinnati | VACCINATED ARTICLE WITH A BODY CARE |
US6570054B1 (en) | 1999-05-21 | 2003-05-27 | The Procter & Gamble Company | Absorbent article having a stable skin care composition |
US6410039B1 (en) | 1999-09-15 | 2002-06-25 | First Scientific, Inc. | Protective topical composition, products including the same, and methods |
DE10034491A1 (en) | 2000-07-15 | 2002-01-24 | Scs Skin Care Systems Gmbh | Foil dermatics |
US6503412B1 (en) | 2000-08-24 | 2003-01-07 | Kimberly-Clark Worldwide, Inc. | Softening composition |
US20020128615A1 (en) | 2000-12-22 | 2002-09-12 | Tyrrell David John | Absorbent articles with non-aqueous compositions containing anionic polymers |
US6749860B2 (en) | 2000-12-22 | 2004-06-15 | Kimberly-Clark Worldwide, Inc. | Absorbent articles with non-aqueous compositions containing botanicals |
DE10133399A1 (en) | 2001-07-13 | 2003-01-23 | Cognis Deutschland Gmbh | Low water-content wax-based composition for impregnating tissue paper or wet wipes to give body-care material contains dialkyl(ene) ether, dialkyl(ene) carbonate, dicarboxylic acid and/or hydroxyfatty alcohol |
US20030082219A1 (en) | 2001-10-01 | 2003-05-01 | The Procter & Gamble Company | Skin care compositions comprising low concentrations of skin treatment agents |
DE10162184A1 (en) | 2001-10-26 | 2003-05-08 | Cognis Deutschland Gmbh | Impregnation solution for facial tissues |
DE10154627A1 (en) | 2001-11-07 | 2003-05-15 | Beiersdorf Ag | Cosmetic or dermatological impregnated wipes |
US7547443B2 (en) | 2003-09-11 | 2009-06-16 | Kimberly-Clark Worldwide, Inc. | Skin care topical ointment |
-
2003
- 2003-09-11 US US10/659,967 patent/US7547443B2/en not_active Expired - Fee Related
-
2004
- 2004-06-03 MX MXPA06002166A patent/MXPA06002166A/en active IP Right Grant
- 2004-06-03 KR KR1020067003823A patent/KR20060123067A/en not_active Application Discontinuation
- 2004-06-03 EP EP04754283A patent/EP1667650A1/en not_active Withdrawn
- 2004-06-03 WO PCT/US2004/017636 patent/WO2005034907A1/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000064503A1 (en) * | 1999-04-23 | 2000-11-02 | Kimberly-Clark Worldwide, Inc. | Skin-friendly absorbent articles and compositions |
US20010014350A1 (en) * | 1999-08-24 | 2001-08-16 | Krzysik Duane Gerard | Absorbent articles providing skin health benefits |
WO2002034305A2 (en) * | 2000-10-20 | 2002-05-02 | Kimberly-Clark Worldwide, Inc. | Absorbent articles enhancing skin barrier function |
WO2003004070A1 (en) * | 2001-07-03 | 2003-01-16 | The Procter & Gamble Company | Film-forming compositions for protecting skin from body fluids and articles made therefrom |
WO2004087092A1 (en) * | 2003-03-28 | 2004-10-14 | The Procter & Gamble Company | Tacky skin care compositions and articles having tacky skin care compositions disposed thereon |
Non-Patent Citations (1)
Title |
---|
E.W. FLICK: "Cosmetic and toiletry formulations", 1984, NOYES PUBLICATIONS, UNITED STATES, XP002303389 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210161779A1 (en) * | 2015-06-23 | 2021-06-03 | Carrie D. Alspaugh, M.D., P.A. | Hand Sanitizing Compositions |
Also Published As
Publication number | Publication date |
---|---|
WO2005034907A8 (en) | 2005-10-06 |
KR20060123067A (en) | 2006-12-01 |
MXPA06002166A (en) | 2006-04-27 |
US20050058669A1 (en) | 2005-03-17 |
US7547443B2 (en) | 2009-06-16 |
EP1667650A1 (en) | 2006-06-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7547443B2 (en) | Skin care topical ointment | |
US20050059941A1 (en) | Absorbent product with improved liner treatment | |
AU768087B2 (en) | Skin-friendly absorbent articles and compositions | |
US6534074B2 (en) | Absorbent articles providing skin health benefits | |
JP2002515414A (en) | Antibacterial agent | |
JPH07309717A (en) | Solid lipophilic composition and its preparation | |
JP2005504591A (en) | Sanitary napkin with hydrophobic lotion | |
MX2008011419A (en) | Absorbent articles with lotions. | |
WO1997044008A1 (en) | Topical barrier composition containing silicone and bentonite | |
US8663665B2 (en) | Anti-chafing compositions comprising boron nitride | |
KR100361892B1 (en) | Topical compositions comprising dispersed surfactant complex | |
KR20050017589A (en) | Sprayable skin protectant compositions | |
JP2002515412A (en) | Composition for topical application | |
KR101832484B1 (en) | Delivery product for topical compositions | |
US20160175214A1 (en) | Anhydrous cosmetic composition for topical application | |
KR100754750B1 (en) | Oleaginous Solid Cosmetic Composition For Cleansing Comprising Anionic Surfactant as Powder Type | |
JPH11263721A (en) | Oil-in-water type gommage (peeling) cosmetic | |
JP2003192563A (en) | Composition for impregnating use, and impregnated material for skin protection | |
JP2003012490A (en) | Absorptive article and lotion for the same | |
BRPI1005530A2 (en) | PRODUCT DISPENSER | |
RU2571423C2 (en) | Liquid repellent compositions and use thereof | |
EP3233044B1 (en) | Anhydrous cosmetic composition for topical application in intimate areas | |
JP2003063929A (en) | Water-in-oil type emulsion composition | |
JP2002172131A (en) | Adsorptive article and barrier agent for adsorptive article | |
JPH0768116B2 (en) | Skin cleansing and cleaning composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WR | Later publication of a revised version of an international search report | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2004754283 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2006/002166 Country of ref document: MX Ref document number: 1020067003823 Country of ref document: KR Ref document number: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 2004754283 Country of ref document: EP |