WO2005035728A3 - Cell culture methods and devices utilizing gas permeable materials - Google Patents

Cell culture methods and devices utilizing gas permeable materials Download PDF

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Publication number
WO2005035728A3
WO2005035728A3 PCT/US2004/033297 US2004033297W WO2005035728A3 WO 2005035728 A3 WO2005035728 A3 WO 2005035728A3 US 2004033297 W US2004033297 W US 2004033297W WO 2005035728 A3 WO2005035728 A3 WO 2005035728A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell culture
gas permeable
culture methods
devices utilizing
permeable materials
Prior art date
Application number
PCT/US2004/033297
Other languages
French (fr)
Other versions
WO2005035728A2 (en
Inventor
John R Wilson
Douglas A Page
Dan Welch
Alison Robeck
Original Assignee
Wolf Wilson Mfg Corp
John R Wilson
Douglas A Page
Dan Welch
Alison Robeck
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34435003&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005035728(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wolf Wilson Mfg Corp, John R Wilson, Douglas A Page, Dan Welch, Alison Robeck filed Critical Wolf Wilson Mfg Corp
Priority to EP21192856.9A priority Critical patent/EP3943591A1/en
Priority to JP2006534398A priority patent/JP2007511205A/en
Priority to CN2004800326848A priority patent/CN101120083B/en
Priority to AU2004280623A priority patent/AU2004280623B2/en
Priority to CA2542116A priority patent/CA2542116C/en
Priority to EP18197251.4A priority patent/EP3450538B1/en
Priority to EP04794599A priority patent/EP1687400A4/en
Publication of WO2005035728A2 publication Critical patent/WO2005035728A2/en
Publication of WO2005035728A3 publication Critical patent/WO2005035728A3/en
Priority to AU2011200410A priority patent/AU2011200410B2/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/08Flask, bottle or test tube
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/24Gas permeable parts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/06Plates; Walls; Drawers; Multilayer plates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14Scaffolds; Matrices
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/02Atmosphere, e.g. low oxygen conditions

Abstract

Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiently and scale up efficiency.
PCT/US2004/033297 2003-10-08 2004-10-08 Cell culture methods and devices utilizing gas permeable materials WO2005035728A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP21192856.9A EP3943591A1 (en) 2003-10-08 2004-10-08 Cell culture methods and devices utilizing gas permeable materials
JP2006534398A JP2007511205A (en) 2003-10-08 2004-10-08 Method and apparatus for culturing cells using gas permeable substances
CN2004800326848A CN101120083B (en) 2003-10-08 2004-10-08 Cell culture methods and devices utilizing gas permeable materials
AU2004280623A AU2004280623B2 (en) 2003-10-08 2004-10-08 Cell culture methods and devices utilizing gas permeable materials
CA2542116A CA2542116C (en) 2003-10-08 2004-10-08 Cell culture methods and devices utilizing gas permeable materials
EP18197251.4A EP3450538B1 (en) 2003-10-08 2004-10-08 Cell culture methods and devices utilizing gas permeable materials
EP04794599A EP1687400A4 (en) 2003-10-08 2004-10-08 Cell culture methods and devices utilizing gas permeable materials
AU2011200410A AU2011200410B2 (en) 2003-10-08 2011-02-01 Cell culture methods and devices utilizing gas permeable materials

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50965103P 2003-10-08 2003-10-08
US60/509,651 2003-10-08

Publications (2)

Publication Number Publication Date
WO2005035728A2 WO2005035728A2 (en) 2005-04-21
WO2005035728A3 true WO2005035728A3 (en) 2007-02-22

Family

ID=34435003

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/033297 WO2005035728A2 (en) 2003-10-08 2004-10-08 Cell culture methods and devices utilizing gas permeable materials

Country Status (7)

Country Link
US (9) US9255243B2 (en)
EP (4) EP2336293B1 (en)
JP (5) JP2007511205A (en)
CN (2) CN101120083B (en)
AU (4) AU2004280623B2 (en)
CA (1) CA2542116C (en)
WO (1) WO2005035728A2 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846399B2 (en) 2005-07-26 2014-09-30 Corning Incorporated Multilayered cell culture apparatus
US9255243B2 (en) 2003-10-08 2016-02-09 Wilson Wolf Manufacturing Corporation Cell culture methods and devices utilizing gas permeable materials
US9260688B2 (en) 2005-07-07 2016-02-16 The Regents Of The University Of California Methods and apparatus for cell culture array
US9309491B2 (en) 2007-05-29 2016-04-12 Corning Incorporated Cell culture apparatus for co-culture of cells
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
US9376658B2 (en) 2008-01-03 2016-06-28 Emd Millipore Corporation Cell culture array system for automated assays and methods of operation and manufacture thereof
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems

Families Citing this family (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7323024B2 (en) * 2003-12-10 2008-01-29 Babcock & Wilcox Technical Services Y-12, Llc Vessel with filter and method of use
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
JP2007097407A (en) * 2005-09-30 2007-04-19 Espec Corp Cell production method and cell culture apparatus
DE102006004157A1 (en) * 2006-01-30 2007-08-02 Eppendorf Ag Device for incubating cells, comprises a sterile or sterilizable portable container, which encloses an integrated- and/or culture container for the reception of the cells, and an arrangement having a sterile filter and incubator
US7745210B2 (en) * 2006-06-30 2010-06-29 Corning Incorporated Fluid flow diverter for cell culture vessel
US8551770B2 (en) * 2006-07-07 2013-10-08 University Of Miami Enhanced oxygen cell culture platforms
US9175254B2 (en) * 2006-07-07 2015-11-03 University Of Miami Enhanced oxygen cell culture platforms
US8486692B2 (en) * 2006-11-14 2013-07-16 Acme Biosystems Llc Cell culture apparatus and associated methods
US20080131959A1 (en) * 2006-11-15 2008-06-05 Millipore Corporation Bioreactor construction
US20080176318A1 (en) * 2006-12-07 2008-07-24 Wilson John R Highly efficient devices and methods for culturing cells
US7897379B2 (en) * 2007-02-26 2011-03-01 Corning Incorporated Device and method for reducing bubble formation in cell culture
US8999703B2 (en) 2008-05-05 2015-04-07 Daniel P. Welch Cell container
WO2009136907A1 (en) * 2008-05-05 2009-11-12 Wilson Wolf Manufacturing Corporation Cell container
US8216828B2 (en) * 2008-05-30 2012-07-10 Corning Incorporated Assembly of cell culture vessels
US8518692B2 (en) * 2008-07-08 2013-08-27 Wilson Wolf Manufacturing Corporation Gas permeable cell culture device and method of use
CN102099459B (en) * 2008-07-16 2013-05-01 Emd密理博公司 A single or multitier cell culture system
US9249383B2 (en) * 2008-10-08 2016-02-02 Agency For Science Technology & Research Apparatus for culturing anchorage dependent cells
EP2346984A4 (en) * 2008-10-22 2013-10-30 Biovest Int Inc Perfusion bioreactors, cell culture systems, and methods for production of cells and cell-derived products
US9125397B2 (en) * 2009-04-29 2015-09-08 Biolife Solutions, Inc. Apparatuses and compositions for cryopreservation of cellular monolayers
JP5257960B2 (en) * 2009-06-09 2013-08-07 株式会社ジェイテック Rotating culture vessel and automatic cell culture apparatus using the same
US8778669B2 (en) 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
EP2470644B1 (en) * 2009-08-24 2016-09-21 Baylor College Of Medicine Generation of ctl lines with specificity against multiple tumor antigens or multiple viruses
US8956860B2 (en) 2009-12-08 2015-02-17 Juan F. Vera Methods of cell culture for adoptive cell therapy
CA2783550A1 (en) * 2009-12-08 2011-06-16 Wilson Wolf Manufacturing Corporation Improved methods of cell culture for adoptive cell therapy
US9353342B2 (en) 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
US9554888B2 (en) * 2010-04-20 2017-01-31 University Of Utah Research Foundation Phase separation sprayed scaffold
WO2011141512A2 (en) 2010-05-11 2011-11-17 Artelis S.A. Apparatus and methods for cell culture
WO2012051302A1 (en) * 2010-10-12 2012-04-19 Nalge Nunc International Corporation Cell culture device
WO2012129201A1 (en) 2011-03-22 2012-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
WO2012144624A1 (en) * 2011-04-21 2012-10-26 ニプロ株式会社 Cell culture method and cell culture kit
ES2598055T3 (en) 2011-10-21 2017-01-25 Cell Medica Limited Device for aseptic cell expansion
ES2870857T3 (en) 2011-12-03 2021-10-27 Emd Millipore Corp Microfluidic system for cell culture
CN104769104A (en) 2011-12-12 2015-07-08 细胞药物有限公司 Process of expanding t cells
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
JP5662927B2 (en) * 2011-12-22 2015-02-04 株式会社日立製作所 Packaging container
EP3591047B1 (en) 2012-02-09 2022-08-03 Baylor College of Medicine Pepmixes to generate multiviral ctls with broad specificity
CN102643744A (en) * 2012-04-18 2012-08-22 广州洁特生物过滤制品有限公司 High-flux cell culture apparatus and manufacturing method thereof
CN104379727A (en) * 2012-05-18 2015-02-25 威尔逊沃夫制造公司 Improved methods of cell culture for adoptive cell therapy
JP5981653B2 (en) * 2012-08-06 2016-08-31 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ Bioreactor vessel for large-scale growth of plants under aseptic conditions
US9005550B2 (en) 2012-10-29 2015-04-14 Corning Incorporated Multi-layered cell culture vessel with manifold grips
US9790465B2 (en) 2013-04-30 2017-10-17 Corning Incorporated Spheroid cell culture well article and methods thereof
CN105392876B (en) 2013-06-24 2019-07-23 威尔逊沃夫制造公司 Closed system apparatus and method for gas permeability cell cultivation process
EP3483276B1 (en) 2013-09-23 2021-03-31 Wilson Wolf Manufacturing Corporation Improved methods of genetically modifying animal cells
WO2015157636A1 (en) 2014-04-10 2015-10-15 H. Lee Moffitt Cancer Center And Research Institute, Inc. Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy
WO2015190090A1 (en) * 2014-06-09 2015-12-17 誠一 横尾 Closed culture vessel for anchorage-dependent cells
JP2016077164A (en) * 2014-10-10 2016-05-16 大日本印刷株式会社 Cell culture vessel
CN113481097A (en) 2014-10-29 2021-10-08 康宁股份有限公司 Perfusion bioreactor platform
EP3223873B1 (en) * 2014-11-24 2020-04-08 Biotronik AG Sealing structure for heart valve implants
CA3009153A1 (en) 2015-01-30 2016-08-04 The University Of North Carolina At Chapel Hill Methods to generate gastrointestinal epithelial tissue constructs
JP6706612B2 (en) * 2015-03-20 2020-06-10 積水化学工業株式会社 Method and apparatus for culturing microorganism
EP3294864A4 (en) 2015-05-08 2019-01-02 Wilson Wolf Manufacturing Improved culture methods and devices for testing
GB201508752D0 (en) * 2015-05-21 2015-07-01 Mason Christopher And Veraitch Farlan S Cell culture device, system and methods of use thereof
US11802265B2 (en) * 2015-06-25 2023-10-31 Auckland Uniservices Ltd Tissue culture apparatus and method
KR101714010B1 (en) * 2015-07-13 2017-03-08 재단법인 아산사회복지재단 Stackable cell culture apparatus for 3d membrane regeneration and culture method using the same
US9683208B2 (en) * 2015-07-31 2017-06-20 Ernest Louis Stadler Horizontal single use pressurizable modular multi-agitator microbial fermentator
WO2017049291A1 (en) 2015-09-18 2017-03-23 Baylor College Of Medicine Immunogenic antigen identification from a pathogen and correlation to clinical efficacy
EP3386554A4 (en) * 2015-12-11 2019-08-21 University Of Iowa Research Foundation Methods of producing biosynthetic bacterial cellulose membranes
US20190264159A1 (en) * 2016-03-28 2019-08-29 Sony Corporation Cell culture container, cell culture system, cell culture kit, and cell culture method
KR102428530B1 (en) 2016-05-05 2022-08-02 사우스웨스트 리서치 인스티튜트 3D bioreactor for cell expansion and related applications
US10813342B2 (en) 2016-05-10 2020-10-27 Excet Incorporated Methods of using training aid delivery devices (TADD)
US11141434B2 (en) 2016-07-07 2021-10-12 Iovance Biotherapeutics, Inc. Programmed death 1 ligand 1 (PD-L1) binding proteins and methods of use thereof
CN110050058B (en) * 2016-07-12 2023-05-02 加州理工学院 Matrix for high density cell growth and metabolite exchange
JP2018033387A (en) * 2016-08-31 2018-03-08 株式会社アステック Cell culture vessel
MA46669A (en) 2016-10-26 2019-09-04 Iovance Biotherapeutics Inc RE-STIMULATION OF LYMPHOCYTES INFILTRATION OF CRYOPRESERVED TUMORS
TWI788307B (en) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion
CN110199016A (en) 2016-11-17 2019-09-03 艾欧凡斯生物治疗公司 Tumors remaining lymphocyte infiltration and its preparation and application
US20200121719A1 (en) 2017-01-06 2020-04-23 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes (tils) with tumor necrosis factor receptor superfamily (tnfrsf) agonists and therapeutic combinations of tils and tnfrsf agonists
US11357841B2 (en) 2017-01-06 2022-06-14 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof
JP2018143210A (en) * 2017-03-08 2018-09-20 株式会社アステック Cell culture container
US11254913B1 (en) 2017-03-29 2022-02-22 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
JOP20190224A1 (en) 2017-03-29 2019-09-26 Iovance Biotherapeutics Inc Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
WO2018195014A1 (en) 2017-04-19 2018-10-25 Neubiser Richard Bioreactor for biological material
US20200224161A1 (en) 2017-05-10 2020-07-16 Iovance Biotherapeutics, Inc. Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
US10821134B2 (en) 2017-05-17 2020-11-03 Board Of Regents, The University Of Texas System BK virus specific T cells
TW201919662A (en) 2017-06-05 2019-06-01 美商艾歐凡斯生物治療公司 Methods of using tumor infiltrating lymphocytes in double-refractory melanoma
US11767499B2 (en) 2017-07-14 2023-09-26 Corning Incorporated Cell culture vessel
US11857970B2 (en) 2017-07-14 2024-01-02 Corning Incorporated Cell culture vessel
JP7245222B2 (en) 2017-07-14 2023-03-23 コーニング インコーポレイテッド 3D cell culture vessel for manual or automatic medium exchange
EP3652292A1 (en) 2017-07-14 2020-05-20 Corning Incorporated Cell culture vessel for 3d culture and methods of culturing 3d cells
EP3710576A1 (en) 2017-11-17 2020-09-23 Iovance Biotherapeutics, Inc. Til expansion from fine needle aspirates and small biopsies
CA3083118A1 (en) 2017-11-22 2019-05-31 Iovance Biotherapeutics, Inc. Expansion of peripheral blood lymphocytes (pbls) from peripheral blood
JP2021508104A (en) 2017-12-15 2021-02-25 アイオバンス バイオセラピューティクス,インコーポレイテッド Systems and methods for determining beneficial administration of tumor-infiltrating lymphocytes and their use, as well as beneficial administration of tumor-infiltrating lymphocytes and their use.
US11713446B2 (en) 2018-01-08 2023-08-01 Iovance Biotherapeutics, Inc. Processes for generating TIL products enriched for tumor antigen-specific T-cells
BR112020013848A2 (en) 2018-01-08 2020-12-01 Iovance Biotherapeutics, Inc. methods for expanding tumor-infiltrating lymphocytes and for treating an individual with cancer, tumor-infiltrating lymphocyte population, and, method for evaluating transcription factors
WO2019136459A1 (en) 2018-01-08 2019-07-11 Iovance Biotherapeutics, Inc. Processes for generating til products enriched for tumor antigen-specific t-cells
US11932842B2 (en) 2018-02-09 2024-03-19 Global Life Sciences Solutions Usa Llc Bioprocessing apparatus
US11920119B2 (en) 2018-02-09 2024-03-05 Global Life Sciences Solutions Usa Llc Systems and methods for bioprocessing
US20210087511A1 (en) * 2018-02-09 2021-03-25 Global Life Sciences Solutions Usa Llc Bioprocessing methods for cell therapy
US10889792B2 (en) 2018-02-09 2021-01-12 Global Life Sciences Solutions Usa Llc Cell expansion vessel systems and methods
MX2020010264A (en) 2018-03-29 2020-11-06 Iovance Biotherapeutics Inc Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy.
US11149244B2 (en) 2018-04-04 2021-10-19 Southwest Research Institute Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy
KR20210005138A (en) 2018-04-27 2021-01-13 이오반스 바이오테라퓨틱스, 인크. Closure method for expansion and gene editing of tumor infiltrating lymphocytes and their use in immunotherapy
WO2019217753A1 (en) 2018-05-10 2019-11-14 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
CA3093581A1 (en) * 2018-05-15 2019-11-21 The University Of North Carolina At Chapel Hill Devices, systems and apparatuses for generating self-sustaining hypoxic conditions and gaseous and non-gaseous chemical gradients for in vitro cell culture
WO2020013847A1 (en) 2018-07-13 2020-01-16 Corning Incorporated Microcavity dishes with sidewall including liquid medium delivery surface
PL3649229T3 (en) 2018-07-13 2021-12-06 Corning Incorporated Cell culture vessels with stabilizer devices
WO2020013851A1 (en) 2018-07-13 2020-01-16 Corning Incorporated Fluidic devices including microplates with interconnected wells
TW202031273A (en) 2018-08-31 2020-09-01 美商艾歐凡斯生物治療公司 Treatment of nsclc patients refractory for anti-pd-1 antibody
SG11202101787XA (en) 2018-09-20 2021-04-29 Iovance Biotherapeutics Inc Expansion of tils from cryopreserved tumor samples
KR20210064299A (en) 2018-09-24 2021-06-02 사우스웨스트 리서치 인스티튜트 3D Bioreactor
US11445723B2 (en) * 2018-10-02 2022-09-20 The Doshisha Method and container for preserving corneal endothelial cells
JP2022506586A (en) 2018-11-05 2022-01-17 アイオバンス バイオセラピューティクス,インコーポレイテッド Process for the production of tumor-infiltrating lymphocytes and their use in immunotherapy
KR20210099573A (en) 2018-11-05 2021-08-12 이오반스 바이오테라퓨틱스, 인크. Selection of improved tumor-reactive T-cells
KR20210091212A (en) 2018-11-05 2021-07-21 이오반스 바이오테라퓨틱스, 인크. Treatment of NSCLC Patients Refractory to Anti-PD-1 Antibodies
CA3118493A1 (en) 2018-11-05 2020-05-14 Iovance Biotherapeutics, Inc. Expansion of tils utilizing akt pathway inhibitors
GB201818243D0 (en) 2018-11-08 2018-12-26 Gammadelta Therapeutics Ltd Methods for isolating and expanding cells
AU2019374488A1 (en) 2018-11-08 2021-05-27 GammaDelta Therapeutics Limited Methods for isolating and expanding cells
CA3123392A1 (en) 2018-12-19 2020-06-25 Iovance Biotherapeutics, Inc. Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof
US11447729B2 (en) 2018-12-21 2022-09-20 Global Life Sciences Solutions Usa Llc Apparatus and method for bioprocessing
KR20210111796A (en) 2019-01-04 2021-09-13 오리바이오테크 엘티디 Cell processing platforms, cell processing systems and methods of use thereof
EP3722410A1 (en) 2019-03-29 2020-10-14 Fenwal, Inc. Automated systems and methods for cell culturing
US10772914B1 (en) 2019-04-18 2020-09-15 Baylor College Of Medicine EBV-specific immune cells
WO2020232029A1 (en) 2019-05-13 2020-11-19 Iovance Biotherapeutics, Inc. Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
CN110218649A (en) * 2019-07-02 2019-09-10 英诺维尔智能科技(苏州)有限公司 A kind of novel two sides gas permeable multiple shelf attached cell culture vessel structure
CN110283725A (en) * 2019-07-02 2019-09-27 英诺维尔智能科技(苏州)有限公司 A kind of novel multi-layer attached cell culture vessel structure
IL292409A (en) * 2019-10-24 2022-06-01 Octane Biotech Inc Cell culture chamber with improved cell-contacting surfaces
EP4048295A1 (en) 2019-10-25 2022-08-31 Iovance Biotherapeutics, Inc. Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
KR102417445B1 (en) * 2019-11-29 2022-07-06 주식회사 아모그린텍 Cell culture device
FR3104611B1 (en) * 2019-12-11 2022-10-07 Air Liquide Digester comprising an inner wall having expansions and/or depressions
JP2023506734A (en) 2019-12-11 2023-02-20 アイオバンス バイオセラピューティクス,インコーポレイテッド Process for the production of tumor-infiltrating lymphocytes (TIL) and methods of using same
CN115551989A (en) * 2020-02-14 2022-12-30 艾克斯赛尔生物科学公司 Gas and liquid flow regulation system for cell culture
EP4118179A1 (en) * 2020-03-09 2023-01-18 Oribiotech Ltd Cell culture container
GB202003406D0 (en) 2020-03-09 2020-04-22 Oribiotech Ltd A bioreactor having sensors therin
EP4107247A2 (en) 2020-03-10 2022-12-28 Cellares Corporation Systems, devices, and methods for cell processing
US20230149459A1 (en) 2020-03-20 2023-05-18 GammaDelta Therapeutics Limited V delta1+ t cells for the treatment of myeloid malignancies
CN115997008A (en) 2020-04-22 2023-04-21 艾欧凡斯生物治疗公司 Systems and methods for coordinating the manufacture of cells for patient-specific immunotherapy
JP2023523855A (en) 2020-05-04 2023-06-07 アイオバンス バイオセラピューティクス,インコーポレイテッド Method for producing tumor-infiltrating lymphocytes and their use in immunotherapy
TW202208616A (en) 2020-05-04 2022-03-01 美商艾歐凡斯生物治療公司 Selection of improved tumor reactive t-cells
GB202006989D0 (en) 2020-05-12 2020-06-24 Gammadelta Therapeutics Ltd Methods for isolating gamma delta t cells
EP4225330A1 (en) 2020-10-06 2023-08-16 Iovance Biotherapeutics, Inc. Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
WO2022076606A1 (en) 2020-10-06 2022-04-14 Iovance Biotherapeutics, Inc. Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
WO2022125941A1 (en) 2020-12-11 2022-06-16 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with braf inhibitors and/or mek inhibitors
WO2022133149A1 (en) 2020-12-17 2022-06-23 Iovance Biotherapeutics, Inc. Treatment of cancers with tumor infiltrating lymphocytes
JP2023554395A (en) 2020-12-17 2023-12-27 アイオバンス バイオセラピューティクス,インコーポレイテッド Treatment with tumor-infiltrating lymphocyte therapy in combination with CTLA-4 and PD-1 inhibitors
CN112682606B (en) * 2021-01-21 2022-01-07 江苏丰禾机械制造股份有限公司 Corrugated pipe compensator with built-in elastic connection structure
KR20240037185A (en) 2021-04-19 2024-03-21 이오반스 바이오테라퓨틱스, 인크. Chimeric costimulatory receptors, chemokine receptors, and their uses in cellular immunotherapy
WO2023009716A1 (en) 2021-07-28 2023-02-02 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
GB2609490A (en) 2021-08-05 2023-02-08 Oribiotech Ltd Outlet valve for a container
WO2023015293A2 (en) * 2021-08-06 2023-02-09 The Regents Of The University Of California Devices for growing cultures of microorganisms
AR127482A1 (en) 2021-10-27 2024-01-31 Iovance Biotherapeutics Inc SYSTEMS AND METHODS TO COORDINATE THE MANUFACTURE OF CELLS FOR PATIENT-SPECIFIC IMMUNOTHERAPY
WO2023086803A1 (en) 2021-11-10 2023-05-19 Iovance Biotherapeutics, Inc. Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
WO2023147486A1 (en) 2022-01-28 2023-08-03 Iovance Biotherapeutics, Inc. Tumor infiltrating lymphocytes engineered to express payloads
TW202334388A (en) * 2022-02-25 2023-09-01 通用幹細胞股份有限公司 Cell proliferation apparatuses and uses thereof
GB202204926D0 (en) 2022-04-04 2022-05-18 Gammadelta Therapeutics Ltd Method for expanding gammadelta T cells
WO2024030758A1 (en) 2022-08-01 2024-02-08 Iovance Biotherapeutics, Inc. Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5437998A (en) * 1993-09-09 1995-08-01 Synthecon, Inc. Gas permeable bioreactor and method of use
US5659997A (en) * 1993-09-29 1997-08-26 Compac International, Inc. Bag for the cultivation of mushroom spawn
US20050032205A1 (en) * 2003-08-05 2005-02-10 Smith Sidney T. In vitro cell culture employing a fibrin network in a flexible gas permeable container

Family Cites Families (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459176A (en) 1966-06-24 1969-08-05 Beckman Instruments Inc Apparatus and method of sampling a dialyzable component of blood
GB1376131A (en) 1971-02-09 1974-12-04 Nat Res Dev Hydrostatic power transmission system
DE2128744C3 (en) 1971-06-09 1979-03-29 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen Process for the mass cultivation of cells and tissues
US3839155A (en) 1972-07-27 1974-10-01 Merck & Co Inc Cell and vaccine production
US3870602A (en) * 1973-04-30 1975-03-11 California Lab Ind Inc Gas permeable sterile culture bottle
US3948732A (en) 1973-05-31 1976-04-06 Instrumentation Laboratory, Inc. Cell culture assembly
US3941661A (en) 1974-01-16 1976-03-02 The Curators Of The University Of Missouri Roller culture bottle insert
US4096577A (en) * 1975-03-03 1978-06-20 Ferber Leon A Thin flexible electronic calculator
JPS5238082A (en) 1975-09-13 1977-03-24 Heraeus Gmbh W C Cultivating container for microorganism * bacterium and tissue
US4228243A (en) 1978-07-13 1980-10-14 Toray Industries, Inc. Cell culture propagation apparatus
JPS564989A (en) 1979-06-27 1981-01-19 Sony Corp Writing method for horizontal linearity corrected signal in horizontal llnearity correcting memory of beam index type color television receiver
US4296205A (en) 1980-02-22 1981-10-20 Verma Dharmvir S Cell culture and continuous dialysis flask and method
US4321330A (en) 1980-04-04 1982-03-23 Baker Fraser L Tissue culture device
US4317886A (en) 1980-08-11 1982-03-02 Becton, Dickinson And Company Multiple interior surface roller bottle
JPS5876792U (en) 1981-11-18 1983-05-24 東洋リノリユ−ム株式会社 desktop
US4435508A (en) 1981-11-20 1984-03-06 Gabridge Michael G Tissue culture vessel
JPS59220182A (en) * 1983-05-27 1984-12-11 Ishikawa Seisakusho:Kk Cultivation tank
DE3322004A1 (en) 1983-06-18 1984-12-20 Robert Bosch Gmbh, 7000 Stuttgart INDUCTIVE ELEMENT, ESPECIALLY TRANSMITTER
US4578588A (en) 1983-08-12 1986-03-25 Galkin Benjamin M Volume reduction in liquid scintillation counting
DE3409501A1 (en) 1984-03-15 1985-10-24 Sandoz-Patent-GmbH, 7850 Lörrach METHOD FOR CULTIVATING CELLS
US4748124A (en) 1984-10-30 1988-05-31 E. I. Du Pont De Nemours And Company Compartmentalized cell-culture device and method
NZ214417A (en) * 1984-12-21 1988-06-30 Univ Texas Microbially produced cellulose
US4668632A (en) 1985-02-06 1987-05-26 Vxr, Inc. Sparger and apparatus for and method of growing cells
JPH053724Y2 (en) 1985-04-15 1993-01-28
US4654308A (en) 1985-06-19 1987-03-31 La Corporation De L'ecole Polytechnique Bioreactor
JPS6232875A (en) * 1985-08-06 1987-02-12 Toyo Eng Corp Tank
EP0264464B1 (en) * 1985-10-19 1992-05-13 Daikin Industries, Limited Culture vessel
US4661455A (en) 1986-01-16 1987-04-28 Dorr-Oliver Incorporated Membrane cell culturing device
US4829002A (en) 1986-05-12 1989-05-09 Baxter International Inc. System for metering nutrient media to cell culture containers and method
US4937194A (en) 1986-05-12 1990-06-26 Baxter International Inc. Method for metering nutrient media to cell culture containers
US4734373A (en) 1986-06-24 1988-03-29 Bartal Arie H Apparatus for enhancing cell growth, preservation and transport
US4945203A (en) 1986-11-06 1990-07-31 American Fluoroseal Corporation Method and apparatus for making fluorocarbon film plastic bags using a laser
US4847462A (en) 1986-11-06 1989-07-11 American Fluoroseal Corporation Method and apparatus for making fluorocarbon film plastic bags using a laser
US4717668A (en) * 1986-12-12 1988-01-05 Baxter Travenol Laboratories, Inc. Plastic roller bottle for suspension cultures
US5786215A (en) 1987-05-20 1998-07-28 Baxter International Inc. Method for culturing animal cells
JP2509630B2 (en) * 1987-07-29 1996-06-26 三井石油化学工業株式会社 Culture method and culture device
US5047347A (en) 1987-08-17 1991-09-10 Cline Martin J Gas permeable culture flask and method for culturing mammalian cells
US4839292B1 (en) 1987-09-11 1994-09-13 Joseph G Cremonese Cell culture flask utilizing membrane barrier
US4829004A (en) 1987-11-24 1989-05-09 The University Of Michigan Roller bottle system
US4824787A (en) 1987-12-09 1989-04-25 In Vitro Scientific Products, Inc. Roller bottle for tissue culture growth
US5153131A (en) 1990-12-11 1992-10-06 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration High aspect reactor vessel and method of use
US5026650A (en) 1988-06-30 1991-06-25 The United States Of Amercia As Represented By The Administrator Of The National Aeronautics And Space Administration Horizontally rotated cell culture system with a coaxial tubular oxygenator
CA1307225C (en) 1988-07-19 1992-09-08 David W. Armstrong Cell culture bioreactor
DE68926421T2 (en) 1988-08-20 1996-09-12 Nitto Denko Corp Process for removing dissolved gases from a liquid
US4939151A (en) 1988-10-31 1990-07-03 Baxter International Inc. Adherent cell culture flask
US5068195A (en) 1988-11-02 1991-11-26 Du Pont Merck Pharmaceutical Company Dot matrix membrane cell expansion and maintenance vessel
US4960706A (en) 1989-03-27 1990-10-02 Baxter International, Inc. Static oxygenator for suspension culture of animal cells
US4912058A (en) 1989-04-27 1990-03-27 Becton, Dickinson And Company Roller bottle
CA2015294A1 (en) 1989-04-28 1990-10-28 John J. Rinehart Generation and expansion of lak cells
US5240854A (en) 1989-06-05 1993-08-31 Berry Eric S Continuous high-density cell culture system
US4937196A (en) 1989-08-18 1990-06-26 Brunswick Corporation Membrane bioreactor system
JPH0734699Y2 (en) 1990-01-22 1995-08-09 東洋ガラス株式会社 calendar
US5173225A (en) 1990-05-07 1992-12-22 Bowolfe, Inc. Method for making ultra-thin dense skin membrane
EP0471947A1 (en) 1990-06-29 1992-02-26 Sekisui Chemical Co., Ltd. Culture bag
FR2666094A1 (en) 1990-08-22 1992-02-28 Cyclopore Sa Cell mass-culture bottle and method for its assembly
US5139951A (en) 1990-10-10 1992-08-18 Costar Corporation Culture device having a detachable cell or tissue growth surface
US5650325A (en) 1990-11-29 1997-07-22 Spielmann; Richard Apparatus having a rotatable stack of parallel trays with culturing surfaces on opposite sides for liquid/gas exchange
CA2055966C (en) 1990-12-19 1995-08-01 Oresta Natalia Fedun Cell culture insert
CA2062100C (en) 1991-03-05 2000-10-31 Hirotoshi Fujisawa Disc cartridge
JPH0734699B2 (en) 1991-03-14 1995-04-19 アース製薬株式会社 Aerosol agent for controlling indoor mites and method for controlling indoor mites using the same
GB9112836D0 (en) 1991-06-14 1991-07-31 Medical Res Council Production of monoclonal antibodies
JPH053724A (en) * 1991-06-27 1993-01-14 Kiriyuu Kogyo Kk Culture vessel for mushroom
JPH05123182A (en) 1991-10-30 1993-05-21 Nakano Vinegar Co Ltd Production of microbial cellulose by standing culture and apparatus therefor
US5310676A (en) 1991-11-15 1994-05-10 A/S Nunc Cell cultivating device
DE4206585C2 (en) 1992-03-03 1994-11-24 Augustinus Dr Med Bader Device for mass culture of cells
DE4214157C1 (en) * 1992-04-29 1993-08-05 Degussa Ag, 6000 Frankfurt, De
GB2268187A (en) * 1992-07-01 1994-01-05 Univ Hull Cell culture vessels
DE4229334C2 (en) 1992-09-02 1995-12-21 Heraeus Instr Gmbh Culture flask similar to a roller bottle for cell cultures
DE4229325C2 (en) 1992-09-02 1995-12-21 Heraeus Instr Gmbh Culture vessel for cell cultures
US5330908A (en) 1992-12-23 1994-07-19 The United States Of America As Represented By The Administrator, National Aeronautics And Space Administration High density cell culture system
JP2749245B2 (en) * 1993-06-25 1998-05-13 鹿島建設株式会社 Culture method of attached microalgae
US5324428A (en) 1993-07-19 1994-06-28 Spectrum Medical Industries, Inc. Disposable dialysis apparatus
JPH0734699A (en) 1993-07-21 1995-02-03 Ishikawajima Harima Heavy Ind Co Ltd Elevator type parking device
AT401476B (en) * 1993-08-20 1996-09-25 Sy Lab Vertriebsges M B H THERMAL CHAMBER
US5686301A (en) 1993-09-02 1997-11-11 Heraeus Instruments Gmbh Culture vessel for cell cultures
US5702941A (en) 1993-09-09 1997-12-30 Synthecon, Inc. Gas permeable bioreactor and method of use
ATE191366T1 (en) 1993-09-22 2000-04-15 Pierce Chemical Co DEVICE FOR DIALYZING SAMPLES
US5534423A (en) 1993-10-08 1996-07-09 Regents Of The University Of Michigan Methods of increasing rates of infection by directing motion of vectors
JPH0734699U (en) * 1993-12-07 1995-06-27 信越ポリマー株式会社 Aerobic culture container
KR0184295B1 (en) 1994-02-10 1999-05-15 도키와 후미가츠 Process for producing acyloxybenzenesulfonic acid or salt thereof
JP2766182B2 (en) * 1994-04-14 1998-06-18 株式会社バイオポリマー・リサーチ Method for producing bacterial cellulose
EP0760008A1 (en) * 1994-05-19 1997-03-05 Dako A/S Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis
US5565353A (en) 1994-06-22 1996-10-15 Board Of Regents, The University Of Texas System Perfusable culture device
US5714384A (en) 1994-06-28 1998-02-03 Wilson; John R. Compartmentalized tissue culture bag
US5707869A (en) 1994-06-28 1998-01-13 Wolf; Martin L. Compartmentalized multiple well tissue culture plate
US5693537A (en) 1994-06-28 1997-12-02 Wilson; John R. Compartmentalized tissue culture flask
CA2193810C (en) 1994-06-28 2009-06-02 John Wilson Compartmentalized tissue culture flask
JPH0834802A (en) * 1994-07-21 1996-02-06 Gun Ei Chem Ind Co Ltd Bacterial cellulose, production thereof and processed product made therefrom
US5527705A (en) 1994-09-12 1996-06-18 Becton, Dickinson And Company Roller bottle for trans-membrane co-culture of cells and method for its use
US5935847A (en) 1994-10-28 1999-08-10 Baxter International Inc. Multilayer gas-permeable container for the culture of adherent and non-adherent cells
US6297046B1 (en) 1994-10-28 2001-10-02 Baxter International Inc. Multilayer gas-permeable container for the culture of adherent and non-adherent cells
DE19504958C1 (en) 1995-02-15 1995-11-02 Heraeus Instr Gmbh Appts. and method for the cultivation of cells on a carrier
BE1009306A5 (en) 1995-04-28 1997-02-04 Baxter Int Bioreactor.
CA2175626C (en) 1995-05-18 1999-08-03 Timothy A. Stevens Tissue culture flask
US5985653A (en) 1995-06-07 1999-11-16 Aastrom Biosciences, Inc. Incubator apparatus for use in a system for maintaining and growing biological cells
DE19529099C2 (en) 1995-08-08 1997-12-04 Forschungszentrum Juelich Gmbh Device for the serial cultivation of microorganisms or cells in fumigated liquid columns
DE69621470T2 (en) 1995-08-31 2002-09-12 Ashby Scient Ltd Method and device for cultivating biological material
US5614412A (en) 1995-09-08 1997-03-25 Smith; Stephen L. Apparatus for carrying flexible containers and method of transferring fluids to containers
US5686304A (en) 1995-12-15 1997-11-11 Avecor Cardiovascular, Inc. Cell culture apparatus and method
US6145688A (en) 1996-07-17 2000-11-14 Smith; James C. Closure device for containers
US5866419A (en) 1996-09-16 1999-02-02 Meder; Martin G. Roller bottle
US5876604A (en) 1996-10-24 1999-03-02 Compact Membrane Systems, Inc Method of gasifying or degasifying a liquid
US6306491B1 (en) 1996-12-20 2001-10-23 Gore Enterprise Holdings, Inc. Respiratory aids
US5736398A (en) * 1997-01-16 1998-04-07 Board Of Regents, The University Of Texas System Gas permeable pouches for growing cultures
US5817509A (en) 1997-03-19 1998-10-06 Becton Dickinson And Company Culture vessel assembly
US5928936A (en) 1997-04-09 1999-07-27 Huntington Medical Research Institutes Cell culture container that self-seals after cannula penetration made of porous sheets
DE19719751A1 (en) 1997-05-10 1998-11-12 Augustinus Dr Med Bader Device for growing and / or treating cells
US5914154A (en) 1997-05-30 1999-06-22 Compact Membrane Systems, Inc. Non-porous gas permeable membrane
US5783075A (en) 1997-06-23 1998-07-21 Spectrum Medical Laboratories, Inc. Disposable dialyzer apparatus
JP3761676B2 (en) 1997-07-11 2006-03-29 株式会社メニコン Cell culture vessel
US6190913B1 (en) 1997-08-12 2001-02-20 Vijay Singh Method for culturing cells using wave-induced agitation
US6596532B1 (en) 1997-12-12 2003-07-22 BIOMéRIEUX, INC. Device for isolation and surface culture of microorganisms from bulk fluids
GB9803362D0 (en) 1998-02-17 1998-04-15 Cellon Sa A cell culture vessel
US5989913A (en) * 1998-07-02 1999-11-23 Charles Daniel Anderson Culture vessel for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using the same
DE29817223U1 (en) 1998-09-24 1998-11-19 Marotzki Stefan Dr Device for taking up a cell culture
EP1183187A4 (en) 1998-10-21 2004-03-17 Wei K Hsu A sterilizable cultivation system with separately attachable microfiltration membrane
US6900055B1 (en) * 1998-10-28 2005-05-31 Cellon S.A. Preparation of porous silicone rubber for growing cells or living tissue
GB9912641D0 (en) 1999-05-28 1999-07-28 Ashby Scient Ltd Textured and porous silicone rubber
US6410309B1 (en) 1999-03-23 2002-06-25 Biocrystal Ltd Cell culture apparatus and methods of use
US6455310B1 (en) 1999-03-23 2002-09-24 Biocrystal Ltd. Cell culture apparatus and method for culturing cells
DE19915611A1 (en) 1999-04-07 2000-11-16 Augustinus Bader Roll holder
US7560274B1 (en) 1999-05-28 2009-07-14 Cellon S.A. Culture chamber
US6562616B1 (en) 1999-06-21 2003-05-13 The General Hospital Corporation Methods and devices for cell culturing and organ assist systems
MXPA01013423A (en) 1999-06-21 2002-12-05 Gen Hospital Corp Cell culture systems and methods for organ assist devices.
US6569675B2 (en) 2000-06-16 2003-05-27 Corning Incorporated Cell cultivating flask and method for using the cell cultivating flask
US20030077816A1 (en) 2000-12-27 2003-04-24 Richard Kronenthal Bioreactor and method for using
DE10109706B4 (en) * 2001-02-11 2006-03-09 In Vitro Systems & Services Gmbh Process for the production of culture vessels
US20020155594A1 (en) 2001-03-27 2002-10-24 Hsieh Helen V. Method and apparatus for culturing cells
KR20020088848A (en) 2001-05-21 2002-11-29 (주)코아바이오텍 Cell Culture Tube and Multiple Roller Tube Cell Culture System Using The Same
JP2003018365A (en) * 2001-07-05 2003-01-17 Nisca Corp Image reader and image read method
US20040072347A1 (en) 2001-07-27 2004-04-15 Gerold Schuler Generation of fully mature and stable dendritic cells from leukaphereses products for clinical applications
US6855542B2 (en) 2001-12-21 2005-02-15 Organogenesis Inc. Chamber with adjustable volume for cell culture and organ assist
TW547111U (en) 2002-01-10 2003-08-11 Dcd Inc Exercise apparatus
US7033823B2 (en) 2002-01-31 2006-04-25 Cesco Bioengineering, Inc. Cell-cultivating device
DE10204531A1 (en) 2002-02-01 2003-08-21 Inst Chemo Biosensorik cover element
US7507579B2 (en) 2002-05-01 2009-03-24 Massachusetts Institute Of Technology Apparatus and methods for simultaneous operation of miniaturized reactors
US7229820B2 (en) 2002-06-13 2007-06-12 Wilson Wolf Manufacturing Corporation Apparatus and method for culturing and preserving tissue constructs
US20040029266A1 (en) 2002-08-09 2004-02-12 Emilio Barbera-Guillem Cell and tissue culture device
AU2003270004A1 (en) 2002-08-28 2004-03-19 Mt Technologies, Inc. Microfluidic affinity system using polydimethylsiloxane and a surface modification process
US20040067585A1 (en) 2002-10-07 2004-04-08 Yu-Chi Wang Cell cultivation surface and method of making the same
EP2336293B1 (en) 2003-10-08 2016-02-10 Wilson Wolf Manufacturing Corporation Cell culture methods and devices utilizing gas permeable materials
US7078228B2 (en) 2003-12-31 2006-07-18 Corning Incorporated Cell cultivating flask
BRPI0405989A (en) 2004-12-22 2006-09-05 Unilever Nv plasticised skin care article
JP4649224B2 (en) 2005-02-09 2011-03-09 株式会社カネカ Method and apparatus for culturing adherent cells
US7745209B2 (en) 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
CN101243475B (en) 2005-08-17 2013-04-17 皇家飞利浦电子股份有限公司 Method and apparatus featuring simple click style interactions according to a clinical task workflow
JP4878195B2 (en) 2006-03-30 2012-02-15 株式会社 ジャパン・ティッシュ・エンジニアリング Cultured tissue packaging container
JP5659448B2 (en) 2006-08-23 2015-01-28 株式会社フコク Cultivation container and cell culture method using the same
US20080176318A1 (en) 2006-12-07 2008-07-24 Wilson John R Highly efficient devices and methods for culturing cells
US7897379B2 (en) 2007-02-26 2011-03-01 Corning Incorporated Device and method for reducing bubble formation in cell culture
US20090160975A1 (en) 2007-12-19 2009-06-25 Ncr Corporation Methods and Apparatus for Improved Image Processing to Provide Retroactive Image Focusing and Improved Depth of Field in Retail Imaging Systems
US8518692B2 (en) 2008-07-08 2013-08-27 Wilson Wolf Manufacturing Corporation Gas permeable cell culture device and method of use
JP6232875B2 (en) 2013-09-19 2017-11-22 コベルコ建機株式会社 Power control device for hybrid construction machinery
US10183132B2 (en) 2014-09-11 2019-01-22 Ethicon Llc Methods and devices for co-delivery of liquid and powdered hemostats and sealants
JP6434283B2 (en) 2014-11-18 2018-12-05 株式会社栗本鐵工所 Radio control transmitter

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5437998A (en) * 1993-09-09 1995-08-01 Synthecon, Inc. Gas permeable bioreactor and method of use
US5659997A (en) * 1993-09-29 1997-08-26 Compac International, Inc. Bag for the cultivation of mushroom spawn
US20050032205A1 (en) * 2003-08-05 2005-02-10 Smith Sidney T. In vitro cell culture employing a fibrin network in a flexible gas permeable container

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9255243B2 (en) 2003-10-08 2016-02-09 Wilson Wolf Manufacturing Corporation Cell culture methods and devices utilizing gas permeable materials
US9410114B2 (en) 2003-10-08 2016-08-09 Wilson Wolf Manufacturing Cell culture methods and devices utilizing gas permeable materials
US9441192B2 (en) 2003-10-08 2016-09-13 Wilson Wolf Manufacturing Cell culture methods and devices utilizing gas permeable materials
US9260688B2 (en) 2005-07-07 2016-02-16 The Regents Of The University Of California Methods and apparatus for cell culture array
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US8846399B2 (en) 2005-07-26 2014-09-30 Corning Incorporated Multilayered cell culture apparatus
US9290730B2 (en) 2005-07-26 2016-03-22 Corning Incorporated Multilayered cell culture apparatus
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
US9309491B2 (en) 2007-05-29 2016-04-12 Corning Incorporated Cell culture apparatus for co-culture of cells
US9376658B2 (en) 2008-01-03 2016-06-28 Emd Millipore Corporation Cell culture array system for automated assays and methods of operation and manufacture thereof

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