WO2005042723A3 - Novel multipotent stem cells and use thereof - Google Patents

Novel multipotent stem cells and use thereof Download PDF

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Publication number
WO2005042723A3
WO2005042723A3 PCT/US2004/036298 US2004036298W WO2005042723A3 WO 2005042723 A3 WO2005042723 A3 WO 2005042723A3 US 2004036298 W US2004036298 W US 2004036298W WO 2005042723 A3 WO2005042723 A3 WO 2005042723A3
Authority
WO
WIPO (PCT)
Prior art keywords
stem cells
multipotent stem
disclosed
cells
novel multipotent
Prior art date
Application number
PCT/US2004/036298
Other languages
French (fr)
Other versions
WO2005042723A9 (en
WO2005042723A2 (en
Inventor
Young-Sup Yoon
Douglas W Losordo
Original Assignee
Caritas St Elizabeths Boston
Young-Sup Yoon
Douglas W Losordo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caritas St Elizabeths Boston, Young-Sup Yoon, Douglas W Losordo filed Critical Caritas St Elizabeths Boston
Priority to AU2004286322A priority Critical patent/AU2004286322A1/en
Priority to CA002543794A priority patent/CA2543794A1/en
Priority to EP04796882A priority patent/EP1685237A4/en
Priority to JP2006538403A priority patent/JP2007519397A/en
Publication of WO2005042723A2 publication Critical patent/WO2005042723A2/en
Publication of WO2005042723A9 publication Critical patent/WO2005042723A9/en
Publication of WO2005042723A3 publication Critical patent/WO2005042723A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Abstract

Disclosed is an isolated bone marrow stem cell (MBSC) having undetectable or low levels of selected cell markers including those typical of endothelial, neuronal and smooth muscle cells. Also disclosed are grafts pharmaceutical products that include such cells. Methods of making the BMSCs are also provided. The invention has a wide spectrum of useful applications including use in the prevention and treatment of cardiovascular disease.
PCT/US2004/036298 2003-10-28 2004-10-28 Novel multipotent stem cells and use thereof WO2005042723A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2004286322A AU2004286322A1 (en) 2003-10-28 2004-10-28 Novel multipotent stem cells and use thereof
CA002543794A CA2543794A1 (en) 2003-10-28 2004-10-28 Novel multipotent stem cells and use thereof
EP04796882A EP1685237A4 (en) 2003-10-28 2004-10-28 Novel multipotent stem cells and use thereof
JP2006538403A JP2007519397A (en) 2003-10-28 2004-10-28 Novel pluripotent stem cells and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51532003P 2003-10-28 2003-10-28
US60/515,320 2003-10-28

Publications (3)

Publication Number Publication Date
WO2005042723A2 WO2005042723A2 (en) 2005-05-12
WO2005042723A9 WO2005042723A9 (en) 2005-08-18
WO2005042723A3 true WO2005042723A3 (en) 2007-03-29

Family

ID=34549391

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/036298 WO2005042723A2 (en) 2003-10-28 2004-10-28 Novel multipotent stem cells and use thereof

Country Status (7)

Country Link
EP (1) EP1685237A4 (en)
JP (1) JP2007519397A (en)
KR (1) KR20070007030A (en)
CN (1) CN101072867A (en)
AU (1) AU2004286322A1 (en)
CA (1) CA2543794A1 (en)
WO (1) WO2005042723A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007047963A2 (en) * 2005-10-20 2007-04-26 Caritas St. Elizabeth Medical Center Of Boston, Inc. Use of bone-marrow derived stem cells to treat ischemia
CN101573441A (en) * 2005-12-08 2009-11-04 路易斯维尔大学研究基金会有限公司 Very small embryonic-like (vsel) stem cells and methods of isolating and using the same
US9155762B2 (en) 2005-12-08 2015-10-13 University Of Louisville Research Foundation, Inc. Uses and isolation of stem cells from bone marrow
WO2007127408A2 (en) * 2006-04-28 2007-11-08 Tulane University Health Sciences Center Methods for treating diabetes
WO2009042173A1 (en) * 2007-09-24 2009-04-02 University Of South Florida Materials and methods for treating allergic and inflammatory conditions
JP5936547B2 (en) * 2009-10-30 2016-06-22 ユニバーシティ オブ ノース カロライナ アット チャペル ヒル Pluripotent stem cells from extrahepatic bile trees and methods for isolating them
US11312940B2 (en) 2015-08-31 2022-04-26 University Of Louisville Research Foundation, Inc. Progenitor cells and methods for preparing and using the same
EP3423568A4 (en) 2016-03-04 2019-11-13 University Of Louisville Research Foundation, Inc. Methods and compositions for ex vivo expansion of very small embryonic-like stem cells (vsels)
CN115369077B (en) * 2022-07-29 2023-07-18 佛山市中科律动生物科技有限公司 MEFLC cell strain, construction method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291240B1 (en) * 1998-01-29 2001-09-18 Advanced Tissue Sciences, Inc. Cells or tissues with increased protein factors and methods of making and using same
US20020026235A1 (en) * 1999-04-27 2002-02-28 Sulzer Biologics, Inc. Prosthetic grafts
US6387369B1 (en) * 1997-07-14 2002-05-14 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387369B1 (en) * 1997-07-14 2002-05-14 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
US6291240B1 (en) * 1998-01-29 2001-09-18 Advanced Tissue Sciences, Inc. Cells or tissues with increased protein factors and methods of making and using same
US20020026235A1 (en) * 1999-04-27 2002-02-28 Sulzer Biologics, Inc. Prosthetic grafts

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PITTENGER M.F. ET AL.: "Multilineage Potential of Adult Human Mesenchymal Stem Cells", SCIENCE, vol. 284, no. 5411, 2 April 1999 (1999-04-02), pages 143 - 147, XP002942313 *
See also references of EP1685237A4 *

Also Published As

Publication number Publication date
EP1685237A2 (en) 2006-08-02
CN101072867A (en) 2007-11-14
JP2007519397A (en) 2007-07-19
AU2004286322A1 (en) 2005-05-12
EP1685237A4 (en) 2007-12-26
CA2543794A1 (en) 2005-05-12
KR20070007030A (en) 2007-01-12
WO2005042723A9 (en) 2005-08-18
WO2005042723A2 (en) 2005-05-12

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