WO2005046649A3 - Mehrschichtige arzneiform, enthaltend eine in bezug auf die wirkstoffreigabe modularisch wirkende substanz - Google Patents

Mehrschichtige arzneiform, enthaltend eine in bezug auf die wirkstoffreigabe modularisch wirkende substanz Download PDF

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Publication number
WO2005046649A3
WO2005046649A3 PCT/EP2004/010297 EP2004010297W WO2005046649A3 WO 2005046649 A3 WO2005046649 A3 WO 2005046649A3 EP 2004010297 W EP2004010297 W EP 2004010297W WO 2005046649 A3 WO2005046649 A3 WO 2005046649A3
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WO
WIPO (PCT)
Prior art keywords
substance
acts
release
optionally
active substances
Prior art date
Application number
PCT/EP2004/010297
Other languages
English (en)
French (fr)
Other versions
WO2005046649A2 (de
Inventor
Rosario Lizio
Hans-Ulrich Petereit
Manfred Assmus
Hema Ravishankar
Original Assignee
Roehm Gmbh
Rosario Lizio
Hans-Ulrich Petereit
Manfred Assmus
Hema Ravishankar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SI200430816T priority Critical patent/SI1684729T1/sl
Priority to MX2007010611A priority patent/MX2007010611A/es
Priority to PL04765211T priority patent/PL1684729T3/pl
Priority to US10/572,963 priority patent/US20060269605A1/en
Priority to BRPI0416501-2A priority patent/BRPI0416501A/pt
Priority to DE502004007172T priority patent/DE502004007172D1/de
Application filed by Roehm Gmbh, Rosario Lizio, Hans-Ulrich Petereit, Manfred Assmus, Hema Ravishankar filed Critical Roehm Gmbh
Priority to JP2006538671A priority patent/JP2007510676A/ja
Priority to CA002544497A priority patent/CA2544497A1/en
Priority to EP04765211A priority patent/EP1684729B1/de
Publication of WO2005046649A2 publication Critical patent/WO2005046649A2/de
Publication of WO2005046649A3 publication Critical patent/WO2005046649A3/de
Priority to IL175561A priority patent/IL175561A0/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Die Erfindung betrifft eine mehrschichtige Arzneiform für die kontrollierte Wirkstofffreisetzung, enthaltend a) eine Kernschicht, enthaltend eine in Bezug auf die Wirkstoffabgabe modulatorisch wirkende Substanz, gegebenenfalls einen neutralen Kern und/oder einen Wirkstoff, b) eine innere Kontrollschicht, die die Abgabe der modulatorisch wirkenden Substanz und des gegebenenfalls enthaltenen Wirkstoffs aus der Kernschicht beeinflusst, enthaltend pharmazeutisch verwendbare Polymere, Wachse, Harze und/oder Proteine, c) eine Wirkstoffschicht, enthaltend einen pharmazeutischen Wirkstoff und gegebenenfalls eine modulatorisch wirkende Substanz, d) eine äußere Kontrollschicht, enthaltend ein oder eine Mischung aus mehreren (Meth)acrylatcopolymeren, aus 98 bis 85 Cl- bis C4-­Alkylestern der (Meth)acrylsäure und 2 bis 15 Gew.-% Methacrylatmonomeren mit einer quaternären Ammoniumgruppe im Alkylrest, und gegebenenfalls weitere in Wasser unlösliche pharmazeutisch verwendbare Polymere, wobei die Schichten zusätzlich und in an sich bekannter Weise pharmazeutisch übliche Hilfsstoffe enthalten können.
PCT/EP2004/010297 2003-11-13 2004-09-15 Mehrschichtige arzneiform, enthaltend eine in bezug auf die wirkstoffreigabe modularisch wirkende substanz WO2005046649A2 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
MX2007010611A MX2007010611A (es) 2003-11-13 2004-09-15 Forma farmaceutica multiparticulada que comprende microesferas con una matriz que tiene influencia en la entrega de una sustancia moduladora.
PL04765211T PL1684729T3 (pl) 2003-11-13 2004-09-15 Wielowarstwowa postać leku, zawierająca substancję działającą modulująco co do uwalniania substancji czynnej
US10/572,963 US20060269605A1 (en) 2003-11-13 2004-09-15 Multilayer pharmaceutical dosage form containing a substance that acts in a modulatory manner with regard to the release of active substances
BRPI0416501-2A BRPI0416501A (pt) 2003-11-13 2004-09-15 forma de dosagem farmacêutica com múltiplas camadas contendo uma substáncia que age de uma forma modulatória, no que diz respeito á liberação das substáncias ativas
DE502004007172T DE502004007172D1 (de) 2003-11-13 2004-09-15 Mehrschichtige arzneiform, enthaltend eine in bezug auf die wirkstoffreigabe modularisch wirkende substanz
SI200430816T SI1684729T1 (sl) 2003-11-13 2004-09-15 Večplastna farmacevtska oblika, ki vsebuje snov,ki ima modulacijski učinek glede na sproščanjeučinkovine
JP2006538671A JP2007510676A (ja) 2003-11-13 2004-09-15 作用物質放出に関して調節作用のある物質を含有する、多層の剤形
CA002544497A CA2544497A1 (en) 2003-11-13 2004-09-15 Multilayer pharmaceutical form comprising a substance having a modular effect in relation to active ingredient release
EP04765211A EP1684729B1 (de) 2003-11-13 2004-09-15 Mehrschichtige arzneiform, enthaltend eine in bezug auf die wirkstoffreigabe modularisch wirkende substanz
IL175561A IL175561A0 (en) 2003-11-13 2006-05-11 Multilayer pharmaceutical dosage form containing a substance that acts in a modulatory manner with regard to the release of active substances

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10353186A DE10353186A1 (de) 2003-11-13 2003-11-13 Mehrschichtige Arzneiform, enthaltend eine in Bezug auf die Wirkstoffabgabe modulatorisch wirkende Substanz
DE10353186.6 2003-11-13

Publications (2)

Publication Number Publication Date
WO2005046649A2 WO2005046649A2 (de) 2005-05-26
WO2005046649A3 true WO2005046649A3 (de) 2005-10-27

Family

ID=34585088

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/010297 WO2005046649A2 (de) 2003-11-13 2004-09-15 Mehrschichtige arzneiform, enthaltend eine in bezug auf die wirkstoffreigabe modularisch wirkende substanz

Country Status (15)

Country Link
US (1) US20060269605A1 (de)
EP (1) EP1684729B1 (de)
JP (1) JP2007510676A (de)
KR (1) KR20060121182A (de)
CN (1) CN1863515A (de)
AT (1) ATE395046T1 (de)
BR (1) BRPI0416501A (de)
CA (1) CA2544497A1 (de)
DE (2) DE10353186A1 (de)
ES (1) ES2307044T3 (de)
IL (1) IL175561A0 (de)
MX (1) MX2007010611A (de)
PL (1) PL1684729T3 (de)
SI (1) SI1684729T1 (de)
WO (1) WO2005046649A2 (de)

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Also Published As

Publication number Publication date
JP2007510676A (ja) 2007-04-26
EP1684729B1 (de) 2008-05-14
MX2007010611A (es) 2009-02-19
SI1684729T1 (sl) 2008-10-31
DE502004007172D1 (de) 2008-06-26
DE10353186A1 (de) 2005-06-16
PL1684729T3 (pl) 2008-10-31
IL175561A0 (en) 2006-09-05
ATE395046T1 (de) 2008-05-15
BRPI0416501A (pt) 2007-01-09
US20060269605A1 (en) 2006-11-30
ES2307044T3 (es) 2008-11-16
WO2005046649A2 (de) 2005-05-26
KR20060121182A (ko) 2006-11-28
EP1684729A2 (de) 2006-08-02
CN1863515A (zh) 2006-11-15
CA2544497A1 (en) 2005-05-26

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