WO2005049012A3 - Tryptophan for use in promoting and maintaining abstinence - Google Patents

Tryptophan for use in promoting and maintaining abstinence Download PDF

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Publication number
WO2005049012A3
WO2005049012A3 PCT/GB2004/004787 GB2004004787W WO2005049012A3 WO 2005049012 A3 WO2005049012 A3 WO 2005049012A3 GB 2004004787 W GB2004004787 W GB 2004004787W WO 2005049012 A3 WO2005049012 A3 WO 2005049012A3
Authority
WO
WIPO (PCT)
Prior art keywords
tryptophan
promoting
withdrawal
abstinence
addictive
Prior art date
Application number
PCT/GB2004/004787
Other languages
French (fr)
Other versions
WO2005049012A2 (en
Inventor
Adrian Bonner
Colin Robert Martin
Andrew Lynch
Catherine Deering
Original Assignee
Shs Int Ltd
Adrian Bonner
Colin Robert Martin
Andrew Lynch
Catherine Deering
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shs Int Ltd, Adrian Bonner, Colin Robert Martin, Andrew Lynch, Catherine Deering filed Critical Shs Int Ltd
Publication of WO2005049012A2 publication Critical patent/WO2005049012A2/en
Publication of WO2005049012A3 publication Critical patent/WO2005049012A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Tryptophan is disclosed as the active agent for a medicament for the promotion and/or maintenance of abstinence from an addictive substance, or addictive substances. The additive substance may be alcohol. The supplemental tryptophan changes the profile of kynurenines to a more neuroprotective balance. The treatment results in improvement in cognitive and other neural functions and aids the process of withdrawal and easies the remission phase after withdrawal is complete.
PCT/GB2004/004787 2003-11-13 2004-11-15 Tryptophan for use in promoting and maintaining abstinence WO2005049012A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0326477.7 2003-11-13
GBGB0326477.7A GB0326477D0 (en) 2003-11-13 2003-11-13 Medicaments for use in promoting and maintaining abstinence

Publications (2)

Publication Number Publication Date
WO2005049012A2 WO2005049012A2 (en) 2005-06-02
WO2005049012A3 true WO2005049012A3 (en) 2005-07-21

Family

ID=29726477

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/004787 WO2005049012A2 (en) 2003-11-13 2004-11-15 Tryptophan for use in promoting and maintaining abstinence

Country Status (2)

Country Link
GB (1) GB0326477D0 (en)
WO (1) WO2005049012A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE548462T1 (en) 2006-11-02 2012-03-15 Dsm Ip Assets Bv USE OF LYSOZYME HYDROLYZATES CONTAINING TRYPTOPHAN
US20140050715A1 (en) 2011-04-28 2014-02-20 Dsm Ip Assets B.V. Protein hydrolysates as agents for overcoming addiction
WO2017085437A1 (en) * 2015-11-19 2017-05-26 The Wwk Trust Combinations for the treatment of dementia, and the enhancement of cognitive function

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761429A (en) * 1985-07-22 1988-08-02 Kenneth Blum Enkephalinase and endorphinase inhibitors as anti-craving compositions
US5189064A (en) * 1985-07-22 1993-02-23 Matrix Technologies, Inc. Treatment of cocaine addiction
BE1005200A3 (en) * 1991-08-27 1993-05-25 Vandendael Kathleen Mariette Use of tryptophan and a nutritional formulation containing tryptophan
JP3051413B2 (en) * 1989-07-20 2000-06-12 アルバート・ティー・ナイトー Substances that cross the blood-brain barrier
WO2002002091A2 (en) * 2000-06-30 2002-01-10 Cardiff & Vale National Health Service Trust Methods and compositions for the treatment of alcoholism and alcohol dependence

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761429A (en) * 1985-07-22 1988-08-02 Kenneth Blum Enkephalinase and endorphinase inhibitors as anti-craving compositions
US5189064A (en) * 1985-07-22 1993-02-23 Matrix Technologies, Inc. Treatment of cocaine addiction
JP3051413B2 (en) * 1989-07-20 2000-06-12 アルバート・ティー・ナイトー Substances that cross the blood-brain barrier
BE1005200A3 (en) * 1991-08-27 1993-05-25 Vandendael Kathleen Mariette Use of tryptophan and a nutritional formulation containing tryptophan
WO2002002091A2 (en) * 2000-06-30 2002-01-10 Cardiff & Vale National Health Service Trust Methods and compositions for the treatment of alcoholism and alcohol dependence

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BADAWY A A -B ET AL: "Tryptophan metabolites as potential new alcoholism aversion therapeutic agents", ALCOHOLISM CLINICAL AND EXPERIMENTAL RESEARCH, vol. 26, no. 5 Supplement, May 2002 (2002-05-01), & SCIENTIFIC MEETING OF THE RESEARCH SOCIETY ON ALCOHOLISM AND THE 11TH CONGRESS OF THE INTERNATIONAL; SAN FRANCISCO, CALIFORNIA, USA; JUNE 28-JULY 03, 2002, pages 83A, XP008043399, ISSN: 0145-6008 *
BOWEN D J ET AL: "TRYPTOPHAN AND HIGH-CARBOHYDRATE DIETS AS ADJUNCTS TO SMOKING CESSATION THERAPY", JOURNAL OF BEHAVIORAL MEDICINE, vol. 14, no. 2, 1991, pages 97 - 110, XP008043431, ISSN: 0160-7715 *
CHADWICK M J ET AL: "A DOUBLE-BLIND AMINO ACIDS L TRYPTOPHAN AND L TYROSINE AND PLACEBO STUDY WITH COCAINE-DEPENDENT SUBJECTS IN AN INPATIENT CHEMICAL DEPENDENCY TREATMENT CENTER", AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE, vol. 16, no. 3-4, 1990, pages 275 - 286, XP008043432, ISSN: 0095-2990 *
DATABASE WPI Section Ch Week 200032, Derwent World Patents Index; Class B05, AN 1991-112625, XP002318974 *

Also Published As

Publication number Publication date
GB0326477D0 (en) 2003-12-17
WO2005049012A2 (en) 2005-06-02

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