WO2005050159A3 - Ion mobility spectrometry method and apparatus - Google Patents

Ion mobility spectrometry method and apparatus Download PDF

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Publication number
WO2005050159A3
WO2005050159A3 PCT/US2004/034300 US2004034300W WO2005050159A3 WO 2005050159 A3 WO2005050159 A3 WO 2005050159A3 US 2004034300 W US2004034300 W US 2004034300W WO 2005050159 A3 WO2005050159 A3 WO 2005050159A3
Authority
WO
WIPO (PCT)
Prior art keywords
ions
ion
chamber
ion mobility
migrate
Prior art date
Application number
PCT/US2004/034300
Other languages
French (fr)
Other versions
WO2005050159A2 (en
Inventor
Herbert H Hill
Maggie Tam
Original Assignee
Univ Washington
Herbert H Hill
Maggie Tam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington, Herbert H Hill, Maggie Tam filed Critical Univ Washington
Publication of WO2005050159A2 publication Critical patent/WO2005050159A2/en
Publication of WO2005050159A3 publication Critical patent/WO2005050159A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/68—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode using electric discharge to ionise a gas

Abstract

The invention includes an ion mobility spectrometer (10) having a liquid filled drift chamber (14). The chamber has an ionization region (18) partitioned from and an ion separation region (20) by a reversible ion-migration block (16b). An electrical field within the chamber allows ions to migrate toward the electrode collector (46). Passage of ions from the ionization region (18) is triggered by reversing the block (16b) allowing ions to migrate into the ion separation region (20). The invention includes a method of ion mobility analysis in liquid phase. Ions are mobilized to migrate through a drift liquid (14) and are detected at an end of a drift chamber (20).
PCT/US2004/034300 2003-10-14 2004-10-14 Ion mobility spectrometry method and apparatus WO2005050159A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51117303P 2003-10-14 2003-10-14
US60/511,173 2003-10-14

Publications (2)

Publication Number Publication Date
WO2005050159A2 WO2005050159A2 (en) 2005-06-02
WO2005050159A3 true WO2005050159A3 (en) 2007-03-01

Family

ID=34619311

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/034300 WO2005050159A2 (en) 2003-10-14 2004-10-14 Ion mobility spectrometry method and apparatus

Country Status (2)

Country Link
US (3) US7071465B2 (en)
WO (1) WO2005050159A2 (en)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7005632B2 (en) * 2002-04-12 2006-02-28 Sionex Corporation Method and apparatus for control of mobility-based ion species identification
WO2005050159A2 (en) * 2003-10-14 2005-06-02 Washington State University Research Foundation Ion mobility spectrometry method and apparatus
GB0424426D0 (en) 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
US7417222B1 (en) * 2005-08-15 2008-08-26 Sandia Corporation Correlation ion mobility spectroscopy
US20080173809A1 (en) * 2006-07-11 2008-07-24 Excellims Corporation Methods and apparatus for the ion mobility based separation and collection of molecules
US20070189930A1 (en) * 2006-01-03 2007-08-16 Ramem, S.A. Procedure for detection of chemical species and device to carry out this procedure
EP1996316B1 (en) * 2006-02-14 2017-04-05 Excellims Corporation Ion mobility spectrometer apparatus and methods
US8785848B2 (en) * 2007-07-11 2014-07-22 Excellims Corporation Parallel ion mass and ion mobility analysis
DE102006006683B4 (en) * 2006-02-14 2008-02-21 Bruker Daltonik Gmbh Drift tube for ion mobility spectrometer with integrated gas channel
US20080073516A1 (en) * 2006-03-10 2008-03-27 Laprade Bruce N Resistive glass structures used to shape electric fields in analytical instruments
CA2650240C (en) * 2006-04-20 2016-01-19 Axel Mie Method for separation of molecules
US8963082B2 (en) * 2006-06-09 2015-02-24 Rapiscan Systems, Inc. Miniaturized ion mobility spectrometer
US7598488B2 (en) * 2006-09-20 2009-10-06 Park Melvin A Apparatus and method for field asymmetric ion mobility spectrometry combined with mass spectrometry
US8395112B1 (en) * 2006-09-20 2013-03-12 Mark E. Bier Mass spectrometer and method for using same
US7960711B1 (en) 2007-01-22 2011-06-14 Chem-Space Associates, Inc. Field-free electrospray nebulizer
CN106885838B (en) * 2007-02-05 2021-01-12 卓漂仪谱公司 Ion mobility spectrometer and method
US7863562B2 (en) * 2007-06-22 2011-01-04 Shimadzu Corporation Method and apparatus for digital differential ion mobility separation
US8173959B1 (en) * 2007-07-21 2012-05-08 Implant Sciences Corporation Real-time trace detection by high field and low field ion mobility and mass spectrometry
US7709787B2 (en) * 2007-08-24 2010-05-04 The United States Of America As Represented By The Secretary Of The Department Of Commerce Stepped electric field detector
GB0723487D0 (en) * 2007-11-30 2008-01-09 Micromass Ltd Mass spectrometer
US7880137B2 (en) * 2007-12-28 2011-02-01 Morpho Detection, Inc. Electrode design for an ion spectrometer
WO2010051518A1 (en) 2008-10-31 2010-05-06 Excellims Corporation Ion mobility based separation methods and apparatus
CN101937823B (en) * 2009-06-30 2012-05-23 同方威视技术股份有限公司 Ion collecting device of ion mobility spectrometer and ion mobility spectrometer
US8158932B2 (en) * 2010-04-16 2012-04-17 Thermo Finnigan Llc FAIMS having a displaceable electrode for on/off operation
US8502159B2 (en) 2010-04-29 2013-08-06 Battelle Energy Alliance, Llc Apparatuses and methods for generating electric fields
US8812250B2 (en) * 2010-06-18 2014-08-19 Washington State University Ion mobility spectrometry systems and associated methods of operation
CN102315076B (en) 2010-07-05 2014-08-27 同方威视技术股份有限公司 Ionic migration tube
CN103698387B (en) * 2010-12-31 2016-03-23 同方威视技术股份有限公司 For the sampling device of ionic migration spectrometer and using method thereof and ionic migration spectrometer
US9068943B2 (en) 2011-04-27 2015-06-30 Implant Sciences Corporation Chemical analysis using hyphenated low and high field ion mobility
US9395333B2 (en) 2011-06-22 2016-07-19 Implant Sciences Corporation Ion mobility spectrometer device with embedded faims
CN102592938B (en) * 2012-01-06 2016-03-30 同方威视技术股份有限公司 Transference tube signal extracting circuit, method and ion migration detector
US9070542B2 (en) * 2012-04-06 2015-06-30 Implant Sciences Corporation Selective ionization using high frequency filtering of reactive ions
GB201208843D0 (en) * 2012-05-18 2012-07-04 Fasmatech Science And Technology Llc Improvements in and relating to mass or size measurement of ions
CN103871824A (en) * 2012-12-12 2014-06-18 中国科学院大连化学物理研究所 Electrospray ion source ion migration tube and application thereof
US9029763B2 (en) 2013-08-30 2015-05-12 Agilent Technologies, Inc. Ion deflection in time-of-flight mass spectrometry
US10175196B2 (en) * 2014-06-11 2019-01-08 The Mitre Corporation Hybrid ion mobility spectrometer
CN107003283B (en) * 2014-11-17 2020-08-07 株式会社岛津制作所 Ion mobility analysis device
US9958891B1 (en) 2015-05-26 2018-05-01 Arrowhead Center, Inc. High-voltage micro-ampere current regulator
GB201513472D0 (en) * 2015-07-30 2015-09-16 Smiths Detection Watford Ltd Apparatus and method
US20190025254A1 (en) * 2015-08-28 2019-01-24 Shimadzu Corporation Ion mobility spectrometer
US9704701B2 (en) 2015-09-11 2017-07-11 Battelle Memorial Institute Method and device for ion mobility separations
SG10201906362TA (en) 2015-10-07 2019-08-27 Battelle Memorial Institute Method and Apparatus for Ion Mobility Separations Utilizing Alternating Current Waveforms
US10361074B2 (en) 2016-12-28 2019-07-23 Rapiscan Systems, Inc. Ionization chamber having a potential-well for ion trapping and ion compression
DE102017104794B4 (en) * 2017-03-08 2020-03-26 Bruker Daltonik Gmbh Ion-mobility spectrometer
GB2579314A (en) 2017-08-16 2020-06-17 Battelle Memorial Institute Methods and systems for ion manipulation
US10692710B2 (en) * 2017-08-16 2020-06-23 Battelle Memorial Institute Frequency modulated radio frequency electric field for ion manipulation
CN107505382A (en) * 2017-09-19 2017-12-22 同方威视技术股份有限公司 Automatic calibration device and ionic migration spectrometer
EP3692564A1 (en) 2017-10-04 2020-08-12 Battelle Memorial Institute Methods and systems for integrating ion manipulation devices
EP3821237A4 (en) * 2018-07-10 2022-04-20 W. Henry Benner Ion mobility spectrometer with center rod
US11029282B2 (en) * 2018-08-24 2021-06-08 Analytical Detection LLC Liquid phase ion mobility spectrometer
CN109243961A (en) * 2018-09-30 2019-01-18 镇江华智睿安物联科技有限公司 A kind of microflow control technique electrode ion migration tube and preparation method thereof
CN111199868B (en) * 2018-11-20 2020-11-20 中国科学院大连化学物理研究所 Micro-array ion migration tube
CN109449074B (en) * 2018-12-18 2024-02-06 中国科学院合肥物质科学研究院 Ion extraction device for ionization source of mass spectrometer
CN112986373A (en) * 2019-12-12 2021-06-18 中国科学院大连化学物理研究所 Ion mobility spectrometry and application thereof
CN112490108B (en) * 2020-11-24 2021-07-27 中国科学院大连化学物理研究所 Ion gate control method for automatically enriching ions
CN113533551B (en) * 2021-06-08 2023-10-03 广西科技大学 GC-IMS-based extraction method of fragrant rice sharing flavor fingerprint spectrum
CN114018849B (en) * 2021-11-24 2023-10-03 云南孚尔质量检验检测有限公司 Water quality detection system with remote monitoring function

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020125423A1 (en) * 2001-03-08 2002-09-12 Ebeling Daniel D. Charge reduction electrospray ionization ion source
US6630664B1 (en) * 1999-02-09 2003-10-07 Syagen Technology Atmospheric pressure photoionizer for mass spectrometry
US20040149902A1 (en) * 2001-06-15 2004-08-05 Park Melvin A. Means and method for guiding ions in a mass spectrometer
US6797948B1 (en) * 2000-08-10 2004-09-28 Bruker Daltonics, Inc. Multipole ion guide
US20050109930A1 (en) * 2003-10-14 2005-05-26 Hill Herbert H.Jr. Ion mobility spectrometry method and apparatus

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839143A (en) * 1985-02-15 1989-06-13 Allied-Signal Inc. Selective ionization of gas constituents using electrolytic reactions
US5053343A (en) * 1985-02-15 1991-10-01 Environmental Technologies Group, Inc. Selective ionization of gas constituents using electrolytic reactions
US4633083A (en) * 1985-04-08 1986-12-30 Washington State University Research Foundation, Inc. Chemical analysis by time dispersive ion spectrometry
US4855595A (en) * 1986-07-03 1989-08-08 Allied-Signal Inc. Electric field control in ion mobility spectrometry
US4777363A (en) * 1986-08-29 1988-10-11 Research Corporation Technologies, Inc. Ion mobility spectrometer
US4712008A (en) * 1986-09-18 1987-12-08 Allied Corporation Ion mobility spectrometer
US5021654A (en) * 1989-04-28 1991-06-04 Environmental Technologies Group, Inc. All ceramic ion mobility spectrometer cell
US5306910A (en) * 1992-04-10 1994-04-26 Millipore Corporation Time modulated electrified spray apparatus and process
US5400614A (en) * 1992-08-12 1995-03-28 Feola; Anthony V. Frozen dessert apparatus
US5405781A (en) * 1993-09-21 1995-04-11 Barringer Research Limited Ion mobility spectrometer apparatus and method, incorporating air drying
GB2291200A (en) * 1994-07-15 1996-01-17 Ion Track Instr Ion mobility spectrometer and method of operation for enhanced detection of narotics
US5552600A (en) * 1995-06-07 1996-09-03 Barringer Research Limited Pressure stabilized ion mobility spectrometer
DE19528290C1 (en) * 1995-08-02 1997-01-23 Ges Foerderung Spektrochemie Procedure for monitoring the quality of the filling gas sulfur hexafluoride in gas-filled systems
US5838002A (en) * 1996-08-21 1998-11-17 Chem-Space Associates, Inc Method and apparatus for improved electrospray analysis
US6278111B1 (en) * 1995-08-21 2001-08-21 Waters Investments Limited Electrospray for chemical analysis
US5925225A (en) * 1997-03-27 1999-07-20 Applied Materials, Inc. Method of producing smooth titanium nitride films having low resistivity
US6960761B2 (en) * 1997-06-02 2005-11-01 Advanced Research & Technology Institute Instrument for separating ions in time as functions of preselected ion mobility and ion mass
US6498342B1 (en) * 1997-06-02 2002-12-24 Advanced Research & Technology Institute Ion separation instrument
US5905258A (en) * 1997-06-02 1999-05-18 Advanced Research & Techology Institute Hybrid ion mobility and mass spectrometer
US6323482B1 (en) * 1997-06-02 2001-11-27 Advanced Research And Technology Institute, Inc. Ion mobility and mass spectrometer
US6040573A (en) * 1997-09-25 2000-03-21 Indiana University Advanced Research & Technology Institute Inc. Electric field generation for charged particle analyzers
US6124592A (en) * 1998-03-18 2000-09-26 Technispan Llc Ion mobility storage trap and method
US6713758B2 (en) * 1998-08-05 2004-03-30 National Research Council Of Canada Spherical side-to-side FAIMS
US6504149B2 (en) * 1998-08-05 2003-01-07 National Research Council Canada Apparatus and method for desolvating and focussing ions for introduction into a mass spectrometer
US6630663B2 (en) * 1998-10-21 2003-10-07 Raytheon Company Miniature ion mobility spectrometer
US6407382B1 (en) * 1999-06-04 2002-06-18 Technispan Llc Discharge ionization source
US6291821B1 (en) * 1999-12-02 2001-09-18 Barringer Research Limited Method of monitoring the status of the gas drying system in an ion mobility spectrometer
US6897437B2 (en) * 2000-02-29 2005-05-24 Ionwerks Mobility spectrometer
US7164122B2 (en) * 2000-02-29 2007-01-16 Ionwerks, Inc. Ion mobility spectrometer
US6806466B2 (en) * 2000-03-14 2004-10-19 National Research Council Canada Parallel plate geometry FAIMS apparatus and method
EP1266395A2 (en) * 2000-03-14 2002-12-18 National Research Council of Canada Tandem faims/ion-trapping apparatus and method
US6459079B1 (en) * 2000-07-11 2002-10-01 The United States As Represented By The Secretary Of The Navy Shipboard chemical agent monitor-portable (SCAMP)
US6627878B1 (en) * 2000-07-11 2003-09-30 The United States Of America As Represented By The Secretary Of The Navy (Chemical agent) point detection system (IPDS) employing dual ion mobility spectrometers
US6690005B2 (en) 2000-08-02 2004-02-10 General Electric Company Ion mobility spectrometer
DE10120335C2 (en) * 2001-04-26 2003-08-07 Bruker Daltonik Gmbh Ion mobility spectrometer with non-radioactive ion source
US6784424B1 (en) 2001-05-26 2004-08-31 Ross C Willoughby Apparatus and method for focusing and selecting ions and charged particles at or near atmospheric pressure
US6727495B2 (en) * 2002-01-17 2004-04-27 Agilent Technologies, Inc. Ion mobility spectrometer with high ion transmission efficiency
US6797943B2 (en) 2002-05-07 2004-09-28 Siemens Ag Method and apparatus for ion mobility spectrometry
US6906319B2 (en) * 2002-05-17 2005-06-14 Micromass Uk Limited Mass spectrometer
US7417225B2 (en) * 2002-09-25 2008-08-26 Thermo Finnigan Llc Apparatus and method for adjustment of ion separation resolution in FAIMS
US6949741B2 (en) * 2003-04-04 2005-09-27 Jeol Usa, Inc. Atmospheric pressure ion source
US7223970B2 (en) * 2003-09-17 2007-05-29 Sionex Corporation Solid-state gas flow generator and related systems, applications, and methods
EP1676291B1 (en) * 2003-10-20 2013-04-24 Ionwerks, Inc. Ion mobility tof/maldi/ms using drift cell alternating high and low electric field regions
US7405401B2 (en) * 2004-01-09 2008-07-29 Micromass Uk Limited Ion extraction devices, mass spectrometer devices, and methods of selectively extracting ions and performing mass spectrometry
US7078680B1 (en) * 2004-02-06 2006-07-18 The United States Of America As Represented By The Secretary Of The Navy Ion mobility spectrometer using ion beam modulation and wavelet decomposition
JP4679570B2 (en) * 2004-03-19 2011-04-27 アドヴァンスド アプライド フィジックス ソリューションズ，インコーポレイテッド Gamma ray detector and method for detecting the location of energetic particle interactions within the detector
US7498570B2 (en) * 2004-08-02 2009-03-03 Owistone Ltd. Ion mobility spectrometer
US20060192107A1 (en) * 2004-10-07 2006-08-31 Devoe Donald L Methods and apparatus for porous membrane electrospray and multiplexed coupling of microfluidic systems with mass spectrometry
US7358487B2 (en) * 2005-09-19 2008-04-15 Owlstone Nanotech, Inc. Ion gate
CN102646570B (en) * 2006-01-02 2016-03-09 卓漂仪谱公司 Multi-dimensional ion mobility spectrometry apparatus and method

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630664B1 (en) * 1999-02-09 2003-10-07 Syagen Technology Atmospheric pressure photoionizer for mass spectrometry
US6797948B1 (en) * 2000-08-10 2004-09-28 Bruker Daltonics, Inc. Multipole ion guide
US20020125423A1 (en) * 2001-03-08 2002-09-12 Ebeling Daniel D. Charge reduction electrospray ionization ion source
US6649907B2 (en) * 2001-03-08 2003-11-18 Wisconsin Alumni Research Foundation Charge reduction electrospray ionization ion source
US20040149902A1 (en) * 2001-06-15 2004-08-05 Park Melvin A. Means and method for guiding ions in a mass spectrometer
US6956205B2 (en) * 2001-06-15 2005-10-18 Bruker Daltonics, Inc. Means and method for guiding ions in a mass spectrometer
US20050109930A1 (en) * 2003-10-14 2005-05-26 Hill Herbert H.Jr. Ion mobility spectrometry method and apparatus
US7071465B2 (en) * 2003-10-14 2006-07-04 Washington State University Research Foundation Ion mobility spectrometry method and apparatus
US20060186333A1 (en) * 2003-10-14 2006-08-24 Washington State University Research Foundation Ion Mobility Spectrometry Method and Apparatus

Also Published As

Publication number Publication date
US20090078861A1 (en) 2009-03-26
US7071465B2 (en) 2006-07-04
US20060186333A1 (en) 2006-08-24
US7777180B2 (en) 2010-08-17
WO2005050159A2 (en) 2005-06-02
US7414242B2 (en) 2008-08-19
US20050109930A1 (en) 2005-05-26

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