WO2005053652A8 - Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride - Google Patents

Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride

Info

Publication number
WO2005053652A8
WO2005053652A8 PCT/IB2004/003808 IB2004003808W WO2005053652A8 WO 2005053652 A8 WO2005053652 A8 WO 2005053652A8 IB 2004003808 W IB2004003808 W IB 2004003808W WO 2005053652 A8 WO2005053652 A8 WO 2005053652A8
Authority
WO
WIPO (PCT)
Prior art keywords
poloxamer
glyceride
compositions containing
drug compositions
crystalline drug
Prior art date
Application number
PCT/IB2004/003808
Other languages
French (fr)
Other versions
WO2005053652A1 (en
Inventor
Leah Elizabeth Appel
Marshall David Crew
Dwayne Thomas Friesen
Scott M Herbig
Julian Belknap Lo
David Keith Lyon
Scott Baldwin Mccray
Roderick Jack Ray
James Blair West
Original Assignee
Pfizer Prod Inc
Leah Elizabeth Appel
Marshall David Crew
Dwayne Thomas Friesen
Scott M Herbig
Julian Belknap Lo
David Keith Lyon
Scott Baldwin Mccray
Roderick Jack Ray
James Blair West
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, Leah Elizabeth Appel, Marshall David Crew, Dwayne Thomas Friesen, Scott M Herbig, Julian Belknap Lo, David Keith Lyon, Scott Baldwin Mccray, Roderick Jack Ray, James Blair West filed Critical Pfizer Prod Inc
Publication of WO2005053652A1 publication Critical patent/WO2005053652A1/en
Publication of WO2005053652A8 publication Critical patent/WO2005053652A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Abstract

A multiparticulate for controlled release of a drug comprises crystalline drug, a glyceride having at least one alkylate substituent of at least 16 carbon atoms, and a poloxamer, wherein at least 70 wt% of the drug in the multiparticulate is crystalline.
PCT/IB2004/003808 2003-12-04 2004-11-22 Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride WO2005053652A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52732903P 2003-12-04 2003-12-04
US60/527,329 2003-12-04

Publications (2)

Publication Number Publication Date
WO2005053652A1 WO2005053652A1 (en) 2005-06-16
WO2005053652A8 true WO2005053652A8 (en) 2005-08-04

Family

ID=34652493

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/003808 WO2005053652A1 (en) 2003-12-04 2004-11-22 Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride

Country Status (2)

Country Link
US (1) US7887844B2 (en)
WO (1) WO2005053652A1 (en)

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US8197499B2 (en) * 2006-06-21 2012-06-12 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
US8608760B2 (en) * 2006-06-21 2013-12-17 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
BRPI0820785A2 (en) * 2007-12-20 2015-06-16 Tautona Group L P Compositions and methods for joining unjoined lumens
US8563037B2 (en) * 2009-02-06 2013-10-22 Tautona Group, L.P. Compositions and methods for joining non-conjoined lumens
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WO2011039686A1 (en) 2009-09-30 2011-04-07 Pfizer Inc. Latrepirdine oral sustained release dosage forms
EP2366378A1 (en) 2010-03-01 2011-09-21 Dexcel Pharma Technologies Ltd. Sustained-release donepezil formulations
EP2964243B1 (en) 2013-03-06 2022-11-23 Capsugel Belgium NV Curcumin solid lipid particles and methods for their preparation and use
JP6041823B2 (en) 2013-03-16 2016-12-14 ファイザー・インク Tofacitinib oral sustained release dosage form
CN106414552B (en) 2014-03-25 2020-08-25 豪夫迈·罗氏有限公司 Methods of preparing poloxamers for use in cell culture media
EP3766480A1 (en) 2014-06-10 2021-01-20 Capsugel Belgium NV Orally disintegrating tablet containing solid lipid particles and methods for their preparation and use
WO2016087261A1 (en) 2014-12-04 2016-06-09 Capsugel Belgium N.V. Lipid multiparticulate formulations
EP3280448B1 (en) 2015-04-10 2020-12-30 Capsugel Belgium NV Abiraterone acetate lipid formulations
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WO2021014360A1 (en) 2019-07-23 2021-01-28 Pfizer Inc. Oral modified release dosage forms
CN114727950A (en) 2019-11-14 2022-07-08 辉瑞大药厂 1- (((2S,3S,4S) -3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl) methoxy) -7-methoxyisoquinoline-6-carboxamide combinations and oral dosage forms
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Also Published As

Publication number Publication date
WO2005053652A1 (en) 2005-06-16
US7887844B2 (en) 2011-02-15
US20050181062A1 (en) 2005-08-18

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