WO2005065018A3 - Crystalline forms of (6r) -l-erythro-tetrahydrobiopterin dihydrochloride - Google Patents

Crystalline forms of (6r) -l-erythro-tetrahydrobiopterin dihydrochloride Download PDF

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Publication number
WO2005065018A3
WO2005065018A3 PCT/IB2004/004447 IB2004004447W WO2005065018A3 WO 2005065018 A3 WO2005065018 A3 WO 2005065018A3 IB 2004004447 W IB2004004447 W IB 2004004447W WO 2005065018 A3 WO2005065018 A3 WO 2005065018A3
Authority
WO
WIPO (PCT)
Prior art keywords
erythro
crystalline forms
tetrahydrobiopterin dihydrochloride
preparation
crystal forms
Prior art date
Application number
PCT/IB2004/004447
Other languages
French (fr)
Other versions
WO2005065018A2 (en
Inventor
Rudolf Moser
Viola Groehn
Thomas Egger
Fritz Blatter
Original Assignee
Merck Eprova Ag
Rudolf Moser
Viola Groehn
Thomas Egger
Fritz Blatter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34748739&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005065018(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Eprova Ag, Rudolf Moser, Viola Groehn, Thomas Egger, Fritz Blatter filed Critical Merck Eprova Ag
Priority to CN2004800377483A priority Critical patent/CN1894251B/en
Priority to JP2006539001A priority patent/JP2007536210A/en
Priority to CA002545968A priority patent/CA2545968C/en
Priority to ES04820966T priority patent/ES2755334T3/en
Priority to AU2004311544A priority patent/AU2004311544A1/en
Priority to EP04820966.2A priority patent/EP1687308B1/en
Publication of WO2005065018A2 publication Critical patent/WO2005065018A2/en
Publication of WO2005065018A3 publication Critical patent/WO2005065018A3/en
Priority to HK07107279.0A priority patent/HK1103294A1/en
Priority to AU2012200512A priority patent/AU2012200512C1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Crystal forms of (6R)-L-erythro-tetrahydrobiopterin dihydrochloride, hydrates and solvates and processes for their preparation are provided. These crystal forms are either intermedi­ates for the preparation of stable polymorphic form B or are suitable for solid formulations.
PCT/IB2004/004447 2003-11-17 2004-11-17 Crystalline forms of (6r) -l-erythro-tetrahydrobiopterin dihydrochloride WO2005065018A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CN2004800377483A CN1894251B (en) 2003-11-17 2004-11-17 Crystalline forms of (6R)-l-erythro-tetrahydrobiopterin dihydrochloride
JP2006539001A JP2007536210A (en) 2003-11-17 2004-11-17 Crystalline form of (6R) -L-erythro-tetrahydrobiopterin dihydrochloride
CA002545968A CA2545968C (en) 2003-11-17 2004-11-17 Crystalline forms of (6r)-l-erythro-tetrahydrobiopterin dihydrochloride
ES04820966T ES2755334T3 (en) 2003-11-17 2004-11-17 Process for the preparation of crystalline forms B of (6R) -L-erythro-tetrahydrobiopterin hydrochloride from other crystalline forms
AU2004311544A AU2004311544A1 (en) 2003-11-17 2004-11-17 Crystalline forms of (6R) -L-erythro-tetrahydrobiopterin dihydrochloride
EP04820966.2A EP1687308B1 (en) 2003-11-17 2004-11-17 Process for preparating (6R)-L-erythrotetrahydrobiopterin hydrochloride crystalline form B from other crystalline forms
HK07107279.0A HK1103294A1 (en) 2003-11-17 2007-07-06 Crystalline forms of (6r)-l-erythro-tetrahydrobiopterin dihydrochloride (6r)-l--
AU2012200512A AU2012200512C1 (en) 2003-11-17 2012-01-30 Crystalline forms of (6R) -L-erythro-tetrahydrobiopterin dihydrochloride

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52037703P 2003-11-17 2003-11-17
US60/520,377 2003-11-17

Publications (2)

Publication Number Publication Date
WO2005065018A2 WO2005065018A2 (en) 2005-07-21
WO2005065018A3 true WO2005065018A3 (en) 2005-10-20

Family

ID=34748739

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/004447 WO2005065018A2 (en) 2003-11-17 2004-11-17 Crystalline forms of (6r) -l-erythro-tetrahydrobiopterin dihydrochloride

Country Status (10)

Country Link
US (3) US7727987B2 (en)
EP (1) EP1687308B1 (en)
JP (2) JP2007536210A (en)
CN (1) CN1894251B (en)
AU (1) AU2004311544A1 (en)
CA (4) CA2678124C (en)
ES (1) ES2755334T3 (en)
HK (1) HK1103294A1 (en)
RU (1) RU2434870C2 (en)
WO (1) WO2005065018A2 (en)

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US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin

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HUE029533T2 (en) 2003-11-17 2017-03-28 Biomarin Pharm Inc Treatment of phenylketonuria with bh4
AU2004311544A1 (en) 2003-11-17 2005-07-21 Merck & Cie Crystalline forms of (6R) -L-erythro-tetrahydrobiopterin dihydrochloride
US8003126B2 (en) * 2004-11-17 2011-08-23 Biomarin Pharmaceutical Inc. Stable tablet formulation
PL1869048T3 (en) * 2005-04-14 2009-05-29 Shiratori Pharmaceutical Co Ltd Method for producing alpha form crystals of sapropterin hydrochloride
DK2139485T3 (en) 2007-04-11 2013-01-21 Biomarin Pharm Inc METHODS OF ADMINISTRATION OF TETRAHYDROBIOPTERIN, ASSOCIATED COMPOSITIONS, AND METHODS OF MEASUREMENT
CL2009000007A1 (en) 2008-01-07 2010-02-19 Biomarin Pharm Inc Method to prepare biopterin by hydrolysis of diacetylbiopterin in the presence of a base in a biphasic mixture of water and an organic solvent immiscible in water at a pH of 10.
CN102443006B (en) 2010-10-13 2016-02-24 因华生技制药股份有限公司 (6R) preparation method of-Tetrahydrobiopterin hydrochloride
TWI526437B (en) * 2011-09-09 2016-03-21 台灣神隆股份有限公司 Crystalline forms of cabazitaxel
PL2926805T3 (en) * 2014-03-31 2016-12-30 Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
WO2016117663A1 (en) 2015-01-21 2016-07-28 味の素株式会社 Precipitation accelerator and precipitation method in which same is used
JP7148532B2 (en) 2016-11-29 2022-10-05 ピーティーシー セラピューティクス エムピー，インコーポレイテッド Polymorphs of Sepipterin
CA3043502A1 (en) 2016-11-29 2018-06-07 Censa Pharmaceuticals Inc. Polymorphs of sepiapterin and salts thereof
BR112020003865A8 (en) 2017-09-01 2022-08-16 Censa Pharmaceuticals Inc PHARMACEUTICAL COMPOSITIONS INCLUDING SEPIAPTERIN AND THEIR USES
CN108033963A (en) * 2017-12-29 2018-05-15 天津凯莱英制药有限公司 R-THBP dihydrochloride crystal form B and preparation method thereof
JP2021525729A (en) 2018-05-30 2021-09-27 ピーティーシー セラピューティクス エムピー，インコーポレイテッド Sepiapterin Methods for Increasing Plasma Exposure
AU2022350669A1 (en) * 2021-09-23 2024-04-04 Fritz Blatter Egfr inhibitor polymorph forms

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EP0191335A2 (en) * 1985-01-28 1986-08-20 Shiratori Pharmaceutical Co. Ltd. Preparation process of (6R)-tetrahydro-l-biopterin
EP0385335A2 (en) * 1989-02-28 1990-09-05 Nisshin Flour Milling Co., Ltd. Stabilized fat-soluble vitamin compositions

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US6821502B2 (en) * 2002-06-12 2004-11-23 Chevron U.S.A. Inc. Method of making aluminum-containing zeolite with IFR structure
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EP0079574A1 (en) * 1981-11-13 1983-05-25 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for preparing biopterin and its derivatives
EP0191335A2 (en) * 1985-01-28 1986-08-20 Shiratori Pharmaceutical Co. Ltd. Preparation process of (6R)-tetrahydro-l-biopterin
EP0385335A2 (en) * 1989-02-28 1990-09-05 Nisshin Flour Milling Co., Ltd. Stabilized fat-soluble vitamin compositions

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin

Also Published As

Publication number Publication date
RU2434870C2 (en) 2011-11-27
HK1103294A1 (en) 2007-12-14
US20100099685A1 (en) 2010-04-22
US7727987B2 (en) 2010-06-01
JP2007536210A (en) 2007-12-13
CA2678124C (en) 2014-10-07
US8344139B2 (en) 2013-01-01
US20060035900A1 (en) 2006-02-16
CA2545968A1 (en) 2005-07-21
CN1894251A (en) 2007-01-10
CA2678125C (en) 2014-10-14
CN1894251B (en) 2011-06-29
CA2545968C (en) 2010-03-09
JP2011162568A (en) 2011-08-25
CA2678125A1 (en) 2005-07-21
RU2006121341A (en) 2008-01-10
ES2755334T3 (en) 2020-04-22
WO2005065018A2 (en) 2005-07-21
US20100240667A1 (en) 2010-09-23
EP1687308A2 (en) 2006-08-09
CA2678165C (en) 2013-11-05
AU2004311544A1 (en) 2005-07-21
US8318745B2 (en) 2012-11-27
CA2678165A1 (en) 2005-07-21
CA2678124A1 (en) 2005-07-21
EP1687308B1 (en) 2019-06-12

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