WO2005065242A3 - Method of treating cancer using platelet releasate - Google Patents
Method of treating cancer using platelet releasate Download PDFInfo
- Publication number
- WO2005065242A3 WO2005065242A3 PCT/US2004/043088 US2004043088W WO2005065242A3 WO 2005065242 A3 WO2005065242 A3 WO 2005065242A3 US 2004043088 W US2004043088 W US 2004043088W WO 2005065242 A3 WO2005065242 A3 WO 2005065242A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treating cancer
- platelet releasate
- platelets
- releasate
- patient
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000013019 agitation Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000007972 injectable composition Substances 0.000 abstract 1
- 238000002604 ultrasonography Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0644—Platelets; Megakaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
- A61K41/13—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultrasonic waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/80—Undefined extracts from animals
- C12N2500/84—Undefined extracts from animals from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/305—Growth hormone [GH], aka. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/581,577 US7678780B2 (en) | 2003-12-29 | 2004-12-23 | Method of treating cancer using platelet releasate |
US12/700,087 US20100135969A1 (en) | 2003-12-29 | 2010-02-04 | Method of treating cancer using platelet releasate |
US13/631,662 US20130121979A1 (en) | 2003-12-29 | 2012-09-28 | Method of treating cancer using platelet compositions |
US14/332,194 US20140329322A1 (en) | 2003-12-29 | 2014-07-15 | Method of differentiating glioblastoma cells |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53336703P | 2003-12-29 | 2003-12-29 | |
US53341503P | 2003-12-29 | 2003-12-29 | |
US60/533,367 | 2003-12-29 | ||
US60/533,415 | 2003-12-29 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/581,577 A-371-Of-International US7678780B2 (en) | 2003-12-29 | 2004-12-23 | Method of treating cancer using platelet releasate |
US12/700,087 Continuation US20100135969A1 (en) | 2003-12-29 | 2010-02-04 | Method of treating cancer using platelet releasate |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005065242A2 WO2005065242A2 (en) | 2005-07-21 |
WO2005065242A3 true WO2005065242A3 (en) | 2006-06-22 |
Family
ID=34752994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/043088 WO2005065242A2 (en) | 2003-12-29 | 2004-12-23 | Method of treating cancer using platelet releasate |
Country Status (2)
Country | Link |
---|---|
US (2) | US7678780B2 (en) |
WO (1) | WO2005065242A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9320762B2 (en) | 2002-04-13 | 2016-04-26 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete tissue repair |
US9351999B2 (en) | 2008-10-07 | 2016-05-31 | Bioparadox, Llc | Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities |
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---|---|---|---|---|
US7608258B2 (en) | 2002-04-13 | 2009-10-27 | Allan Mishra | Method for treatment of tendinosis using platelet rich plasma |
US7618948B2 (en) | 2002-11-26 | 2009-11-17 | Medtronic, Inc. | Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA |
US7605249B2 (en) | 2002-11-26 | 2009-10-20 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
US7829694B2 (en) | 2002-11-26 | 2010-11-09 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of siRNA |
US7732591B2 (en) * | 2003-11-25 | 2010-06-08 | Medtronic, Inc. | Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna |
US7994149B2 (en) | 2003-02-03 | 2011-08-09 | Medtronic, Inc. | Method for treatment of Huntington's disease through intracranial delivery of sirna |
US7678780B2 (en) | 2003-12-29 | 2010-03-16 | Allan Mishra | Method of treating cancer using platelet releasate |
US7354515B2 (en) | 2004-02-23 | 2008-04-08 | Millennium Medical Technologies, Inc. | Fluid concentrator |
US7462268B2 (en) | 2004-08-20 | 2008-12-09 | Allan Mishra | Particle/cell separation device and compositions |
US20060253068A1 (en) * | 2005-04-20 | 2006-11-09 | Van Bilsen Paul | Use of biocompatible in-situ matrices for delivery of therapeutic cells to the heart |
US7902352B2 (en) * | 2005-05-06 | 2011-03-08 | Medtronic, Inc. | Isolated nucleic acid duplex for reducing huntington gene expression |
EP1885854B1 (en) * | 2005-05-06 | 2012-10-17 | Medtronic, Inc. | Methods and sequences to suppress primate huntington gene expression |
US20080280843A1 (en) * | 2006-05-24 | 2008-11-13 | Van Bilsen Paul | Methods and kits for linking polymorphic sequences to expanded repeat mutations |
US9133517B2 (en) | 2005-06-28 | 2015-09-15 | Medtronics, Inc. | Methods and sequences to preferentially suppress expression of mutated huntingtin |
US9273356B2 (en) | 2006-05-24 | 2016-03-01 | Medtronic, Inc. | Methods and kits for linking polymorphic sequences to expanded repeat mutations |
US20080039415A1 (en) * | 2006-08-11 | 2008-02-14 | Gregory Robert Stewart | Retrograde transport of sirna and therapeutic uses to treat neurologic disorders |
US20080089867A1 (en) * | 2006-10-13 | 2008-04-17 | Brian Fernandes | Method of increasing retention, survival and proliferation of transplanted cells in vivo |
US9375440B2 (en) * | 2006-11-03 | 2016-06-28 | Medtronic, Inc. | Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity |
US8324367B2 (en) | 2006-11-03 | 2012-12-04 | Medtronic, Inc. | Compositions and methods for making therapies delivered by viral vectors reversible for safety and allele-specificity |
US7819842B2 (en) | 2006-11-21 | 2010-10-26 | Medtronic, Inc. | Chronically implantable guide tube for repeated intermittent delivery of materials or fluids to targeted tissue sites |
US7988668B2 (en) * | 2006-11-21 | 2011-08-02 | Medtronic, Inc. | Microsyringe for pre-packaged delivery of pharmaceuticals |
US20080171906A1 (en) * | 2007-01-16 | 2008-07-17 | Everaerts Frank J L | Tissue performance via hydrolysis and cross-linking |
JP5577569B2 (en) * | 2007-03-07 | 2014-08-27 | 株式会社ジェイ・エム・エス | Serum preparation method |
US7901344B2 (en) * | 2007-05-11 | 2011-03-08 | Biomet Biologics, Llc | Methods of reducing surgical complications in cancer patients |
PL2259774T3 (en) * | 2008-02-27 | 2013-04-30 | Biomet Biologics Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
DK3095856T3 (en) | 2008-09-16 | 2019-10-21 | Mayo Found Medical Education & Res | COMPOSITIONS WITH TROMBOCYTIC CONTENTS |
WO2011028733A1 (en) * | 2009-09-04 | 2011-03-10 | Allan Mishra | Compositions and minimally invasive methods for treating cancer |
WO2012037283A2 (en) * | 2010-09-14 | 2012-03-22 | Mount Sinai School Of Medicine | Admimistration of sns neuroprotective agents to promote hematopoietic regeration |
US9011684B2 (en) | 2011-03-07 | 2015-04-21 | Spinesmith Holdings, Llc | Fluid concentrator with removable cartridge |
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JP2015535262A (en) | 2012-11-05 | 2015-12-10 | ザ プロクター アンド ギャンブルカンパニー | Heat treated precipitated silica |
US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
US20140356893A1 (en) | 2013-06-04 | 2014-12-04 | Allan Mishra | Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation |
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WO2020099530A1 (en) * | 2018-11-14 | 2020-05-22 | Onderzoeks- En Ontwikkelingsfonds Rode Kruis-Vlaanderen | Methods for preparing platelet releasate |
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US20200208110A1 (en) | 2018-11-30 | 2020-07-02 | Cellphire, Inc. | PLATELETS LOADED WITH mRNA |
US20220088589A1 (en) | 2019-01-21 | 2022-03-24 | Eclipse Medcorp, Llc | Methods, Systems and Apparatus for Separating Components of a Biological Sample |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5599558A (en) * | 1989-09-15 | 1997-02-04 | Curative Technologies, Inc. | Selecting amounts of platelet releasate for efficacious treatment of tissue |
US5834418A (en) * | 1996-03-20 | 1998-11-10 | Theratechnologies, Inc. | Process for the preparation of platelet growth factors extract |
US6214338B1 (en) * | 1994-12-07 | 2001-04-10 | Plasmaseal Llc | Plasma concentrate and method of processing blood for same |
US20030152639A1 (en) * | 2001-07-03 | 2003-08-14 | Calvin Britton | Novel wound healing composition not containing bovine-derived activating reagents |
US20040126885A1 (en) * | 2002-11-05 | 2004-07-01 | Cines Douglas B. | Delivery vehicle for recombinant proteins |
Family Cites Families (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1244774A (en) | 1983-11-09 | 1988-11-15 | Thomas Jefferson University | Medium for storing blood platelets |
AU4634685A (en) | 1984-06-22 | 1986-01-24 | R.L. Veech | Electrolyte solutions and in vivo use thereof |
US5178883A (en) | 1984-11-29 | 1993-01-12 | Regents Of The University Of Minnesota | Method for promoting hair growth |
US5165938A (en) | 1984-11-29 | 1992-11-24 | Regents Of The University Of Minnesota | Wound healing agents derived from platelets |
US4760131A (en) * | 1986-04-23 | 1988-07-26 | Collagen Corporation | Wound-healing composition |
US5124316A (en) | 1986-11-14 | 1992-06-23 | President And Fellows Of Harvard College | Method for periodontal regeneration |
US4931395A (en) | 1986-12-08 | 1990-06-05 | Dana-Farber Cancer Institute | Monoclonal antibody specific to neutrophils |
US5079236A (en) | 1987-05-27 | 1992-01-07 | Hyal Pharmaceutical Corporation | Pure, sterile, pyrogen-free hyaluronic acid formulations their methods of preparation and methods of use |
US5428008A (en) | 1989-04-14 | 1995-06-27 | Prp, Inc. | Therapeutic composition of micellar structures capable of promoting hemotasis |
IL95641A0 (en) | 1989-09-15 | 1991-06-30 | Curative Tech Inc | Preparation of a platelet releasate product |
US5147776A (en) | 1990-02-26 | 1992-09-15 | University Of Iowa Research Foundation | Use of 2,5-anhydromannitol for control of pH during blood storage |
DE69102651T2 (en) | 1990-07-23 | 1994-10-06 | Zymogenetics Inc | PROTEASER-RESISTANT PDGF AND ITS USES. |
US5385937A (en) | 1991-04-10 | 1995-01-31 | Brigham & Women's Hospital | Nitrosation of homocysteine as a method for treating homocysteinemia |
US5474891A (en) | 1991-10-30 | 1995-12-12 | Thomas Jefferson University | Plasma-based platelet concentrate preparations with additive |
US5403272A (en) | 1992-05-29 | 1995-04-04 | Baxter International Inc. | Apparatus and methods for generating leukocyte free platelet concentrate |
US5494590A (en) | 1992-06-11 | 1996-02-27 | Becton Dickinson | Method of using anticoagulant solution in blood separation |
US5449688A (en) | 1993-03-30 | 1995-09-12 | The United States Of America As Represented By The Department Of Health And Human Services | Method of treating chronic inflammatory diseases |
US5510102A (en) | 1995-01-23 | 1996-04-23 | The Regents Of The University Of California | Plasma and polymer containing surgical hemostatic adhesives |
US5614204A (en) | 1995-01-23 | 1997-03-25 | The Regents Of The University Of California | Angiographic vascular occlusion agents and a method for hemostatic occlusion |
US5643786A (en) | 1995-01-27 | 1997-07-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for isolating dendritic cells |
AUPN166195A0 (en) | 1995-03-13 | 1995-04-06 | Norvet Research Pty Limited | Process for glucan extraction |
JP2000506365A (en) * | 1996-01-11 | 2000-05-30 | ヒューマン ジノーム サイエンシーズ,インコーポレイテッド | Human G protein chemokine receptor HSATU68 |
US6280473B1 (en) | 1996-08-19 | 2001-08-28 | Macropore, Inc. | Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration |
US5935850A (en) | 1996-09-30 | 1999-08-10 | The Research Foundation Of State University Of New York | Model for cell migration and use thereof |
US6254784B1 (en) * | 1997-10-30 | 2001-07-03 | Baxter International Inc. | Optical interface detection system for centrifugal blood processing |
US6098631A (en) | 1998-01-21 | 2000-08-08 | The Regents Of The University Of Michigan | Compositions and methods for treating autoimmune disease |
US6712851B1 (en) | 1998-01-23 | 2004-03-30 | Macropore Biosurgery, Inc. | Resorbable, macro-porous non-collapsing and flexible membrane barrier for skeletal repair and regeneration |
US6183442B1 (en) | 1998-03-02 | 2001-02-06 | Board Of Regents Of The University Of Texas System | Tissue penetrating device and methods for using same |
JP2002519155A (en) | 1998-07-02 | 2002-07-02 | スティヒティング・スケルトル・ティシュー・エンジニアリング・グループ・アムステルダム | Bone cement with antimicrobial peptide |
JP2000214965A (en) * | 1999-01-25 | 2000-08-04 | Toshiba Corp | Computer system and method for managing battery event |
US6322785B1 (en) | 1999-03-02 | 2001-11-27 | Natrex Technologies | Methods and compositions for bone graft implants |
US6432119B1 (en) | 1999-03-17 | 2002-08-13 | Angiotrax, Inc. | Apparatus and methods for performing percutaneous myocardial revascularization and stimulating angiogenesis using autologous materials |
US6315992B1 (en) | 1999-06-30 | 2001-11-13 | Tissuegene Co. | Generating cartilage in a mammal using fibroblasts transfected with a vector encoding TGF-β-1 |
US6454804B1 (en) | 1999-10-08 | 2002-09-24 | Bret A. Ferree | Engineered tissue annulus fibrosis augmentation methods and apparatus |
US6592566B2 (en) | 2000-02-03 | 2003-07-15 | Arizona Board Of Regents | Method for forming an endovascular occlusion |
US20020006437A1 (en) | 2000-05-01 | 2002-01-17 | Grooms Jamie M. | Non-migration tissue capsule |
AU2001259449A1 (en) | 2000-05-03 | 2001-11-12 | Eligix, Inc. | Whole blood separator apparatus and method of use |
DK1294414T3 (en) | 2000-06-29 | 2006-07-24 | Biosyntech Canada Inc | Preparation and method of healing and regenerating cartilage and other tissues |
US20020032155A1 (en) | 2000-06-30 | 2002-03-14 | Ferree Bret A. | Method of treating disc herniation and disc degeneration with concentrated growth and differentiation factors |
US20030185812A1 (en) | 2000-06-30 | 2003-10-02 | Ferree Bret A. | Method of treating dural leaks with platelet-rich plasma (PRP) |
US7740623B2 (en) | 2001-01-13 | 2010-06-22 | Medtronic, Inc. | Devices and methods for interstitial injection of biologic agents into tissue |
JP2005500881A (en) | 2001-08-09 | 2005-01-13 | アイボクラー ヴィヴェイデント インコーポレイテッド | Tissue implant and method for making and using the same |
CA2455964A1 (en) | 2001-12-05 | 2003-06-19 | Gambro, Inc. | Methods and apparatus for separation of blood components |
US20030192554A1 (en) | 2002-04-11 | 2003-10-16 | Ferree Bret A. | Methods and apparatus for adhering musculoskeletal tissues |
US6811777B2 (en) | 2002-04-13 | 2004-11-02 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
US7608258B2 (en) | 2002-04-13 | 2009-10-27 | Allan Mishra | Method for treatment of tendinosis using platelet rich plasma |
US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
US6905612B2 (en) | 2003-03-21 | 2005-06-14 | Hanuman Llc | Plasma concentrate apparatus and method |
US20040182795A1 (en) | 2003-03-21 | 2004-09-23 | Randel Dorian | Apparatus and method for concentration of plasma from whole blood |
US7166133B2 (en) * | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
AR047712A1 (en) | 2002-09-07 | 2006-02-15 | Royal Veterinary College | TREATMENT METHOD OF A NATURAL SOFT SKELETTIC TISSUE INJURY MANAGING A COMPOSITION OF MESENQUIMATOSE MOTHER CELLS |
US20050064042A1 (en) | 2003-04-29 | 2005-03-24 | Musculoskeletal Transplant Foundation | Cartilage implant plug with fibrin glue and method for implantation |
US20040244806A1 (en) | 2003-06-09 | 2004-12-09 | Ferree Bret A. | Treating disc herniation and other conditions with leukocytes |
US7338494B2 (en) | 2003-08-19 | 2008-03-04 | Synthes (U.S.A.) | Spring-loaded awl |
US20070122906A1 (en) | 2003-12-29 | 2007-05-31 | Allan Mishra | Method of culturing cells |
US7678780B2 (en) * | 2003-12-29 | 2010-03-16 | Allan Mishra | Method of treating cancer using platelet releasate |
US20070110737A1 (en) | 2003-12-29 | 2007-05-17 | Allan Mishra | Compositions and method for decreasing the appearance of skin wrinkles |
US7462268B2 (en) | 2004-08-20 | 2008-12-09 | Allan Mishra | Particle/cell separation device and compositions |
US8092475B2 (en) | 2005-04-15 | 2012-01-10 | Integra Lifesciences (Ireland) Ltd. | Ultrasonic horn for removal of hard tissue |
WO2007002554A2 (en) | 2005-06-23 | 2007-01-04 | Medtronic Vascular, Inc. | Methods and systems for treating injured cardiac tissue |
WO2010042762A1 (en) * | 2008-10-09 | 2010-04-15 | Bioparadox, Llc | Platelet rich plasma formulations for cardiac treatments |
-
2004
- 2004-12-23 US US10/581,577 patent/US7678780B2/en active Active
- 2004-12-23 WO PCT/US2004/043088 patent/WO2005065242A2/en active Application Filing
-
2010
- 2010-02-04 US US12/700,087 patent/US20100135969A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5599558A (en) * | 1989-09-15 | 1997-02-04 | Curative Technologies, Inc. | Selecting amounts of platelet releasate for efficacious treatment of tissue |
US6214338B1 (en) * | 1994-12-07 | 2001-04-10 | Plasmaseal Llc | Plasma concentrate and method of processing blood for same |
US5834418A (en) * | 1996-03-20 | 1998-11-10 | Theratechnologies, Inc. | Process for the preparation of platelet growth factors extract |
US20030152639A1 (en) * | 2001-07-03 | 2003-08-14 | Calvin Britton | Novel wound healing composition not containing bovine-derived activating reagents |
US20040126885A1 (en) * | 2002-11-05 | 2004-07-01 | Cines Douglas B. | Delivery vehicle for recombinant proteins |
Non-Patent Citations (1)
Title |
---|
MARTINEZ-GONZALEZ ET AL.: "Do ambulatory-use Platelet-Rich Plasma (PRP) concentrates present risks?", MEDICINA ORAL, vol. 7, 2002, pages 375 - 390, XP002998091 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9320762B2 (en) | 2002-04-13 | 2016-04-26 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete tissue repair |
US9351999B2 (en) | 2008-10-07 | 2016-05-31 | Bioparadox, Llc | Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities |
Also Published As
Publication number | Publication date |
---|---|
US20070184029A1 (en) | 2007-08-09 |
US7678780B2 (en) | 2010-03-16 |
US20100135969A1 (en) | 2010-06-03 |
WO2005065242A2 (en) | 2005-07-21 |
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